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ONTOLOGY REPORT - ANNOTATIONS

Term:aldose reductase (NADPH) activity
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Accession:GO:0004032 term browser browse the term
Definition:Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
Synonyms:exact_synonym: alditol:NADP+ 1-oxidoreductase activity
 related_synonym: aldehyde reductase activity;   aldose reductase activity;   polyol dehydrogenase (NADP(+)) activity
 xref: EC:1.1.1.21;   KEGG_REACTION:R02820;   MetaCyc:ALDEHYDE-REDUCTASE-RXN;   RHEA:12789;   reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol";   reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol"


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aldose reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide enables ISO (PMID:10514444) RGD PMID:10514444 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 enables IBA
ISO		 GO_REF:0000033
(PMID:14667815), (PMID:15769935)		 GO_Central
RGD		 PMID:14667815 PMID:15769935 GO_REF:0000033 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 enables IDA
ISO
IBA		 (PMID:1420136), (PMID:2112546), (PMID:8435445), (PMID:8645003)
GO_REF:0000033
(PMID:17727625), (PMID:7851421)		 RGD
GO_Central		 PMID:1420136 PMID:2112546 PMID:7851421 PMID:8435445 PMID:8645003 More... GO_REF:0000033, RGD:1626085 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:20709016 GO_REF:0000033, RGD:6903952 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 enables TAS
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:12193556 GO_REF:0000033, RGD:628357 NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502 		JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:62,997,241...63,009,815
Ensembl chr 4:62,997,161...63,010,097 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 enables ISO
IBA		 (PMID:21232532)
GO_REF:0000033		 RGD
GO_Central		 PMID:21232532 GO_REF:0000033 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c12 aldo-keto reductase family 1, member C12 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:66,045,376...66,061,496
Ensembl chr17:66,045,378...66,108,329 		JBrowse link
G Akr1c12l1 aldo-keto reductase family 1, member C12-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:65,937,834...65,948,344
Ensembl chr17:65,937,814...65,997,595 		JBrowse link
G Akr1c13 aldo-keto reductase family 1, member C13 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:65,964,186...65,997,598
Ensembl chr17:65,964,975...65,997,591 		JBrowse link
G Akr1c14 aldo-keto reductase family 1, member C14 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:66,156,286...66,173,277
Ensembl chr17:66,156,288...66,173,277 		JBrowse link
G Akr1c15 aldo-keto reductase family 1, member C15 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:66,181,493...66,208,090
Ensembl chr17:66,181,493...66,208,061 		JBrowse link
G Akr1c19 aldo-keto reductase family 1, member C19 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:66,001,358...66,027,226
Ensembl chr17:66,004,002...66,025,047 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 enables ISO
IBA		 (PMID:21232532)
GO_REF:0000033		 RGD
GO_Central		 PMID:21232532 GO_REF:0000033 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 enables IDA
ISO
IBA		 (PMID:21232532)
GO_REF:0000033		 RGD
GO_Central		 PMID:21232532 PMID:8977402 GO_REF:0000033, RGD:10053609 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G AKR1C3l1 aldo-keto reductase family 1 member C3-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488 		JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372 		JBrowse link
G Akr1e2 aldo-keto reductase family 1, member E2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:65,735,909...65,750,441
Ensembl chr17:65,735,943...65,750,441 		JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 IDA RGD PMID:12071861 RGD:625492 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20736
    catalytic activity 6109
      oxidoreductase activity 859
        oxidoreductase activity, acting on CH-OH group of donors 162
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 153
            alcohol dehydrogenase [NAD(P)+] activity 64
              aldo-keto reductase (NADPH) activity 44
                alcohol dehydrogenase (NADP+) activity 40
                  aldose reductase (NADPH) activity 19
                    D-xylose reductase (NADPH) activity 0
                    L-arabinose reductase (NADPH) activity 0
paths to the root