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ONTOLOGY REPORT - ANNOTATIONS


Term:aldose reductase (NADPH) activity
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Accession:GO:0004032 term browser browse the term
Definition:Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
Synonyms:exact_synonym: alditol:NADP+ 1-oxidoreductase activity
 related_synonym: aldehyde reductase activity;   aldose reductase activity;   polyol dehydrogenase (NADP(+)) activity
 xref: KEGG_REACTION:R02820;   RHEA:12789;   reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol";   reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol"


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aldose reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 enables ISO (PMID:14667815), (PMID:15769935) MGI PMID:14667815 PMID:15769935 NCBI chrNW_004624906:1,463,201...1,474,001
Ensembl chrNW_004624906:1,462,693...1,474,214
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G LOC101720124 aldose reductase enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624783:1,945,173...1,958,073
Ensembl chrNW_004624783:1,945,073...1,958,155
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  molecular_function 16315
    catalytic activity 5042
      oxidoreductase activity 635
        oxidoreductase activity, acting on CH-OH group of donors 110
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 101
            alcohol dehydrogenase [NAD(P)+] activity 30
              aldo-keto reductase (NADPH) activity 17
                alcohol dehydrogenase (NADP+) activity 14
                  aldose reductase (NADPH) activity 2
                    D-xylose reductase (NADPH) activity 0
                    L-arabinose reductase (NADPH) activity 0
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