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ONTOLOGY REPORT - ANNOTATIONS


Term:aldose reductase (NADPH) activity
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Accession:GO:0004032 term browser browse the term
Definition:Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
Synonyms:exact_synonym: alditol:NADP+ 1-oxidoreductase activity
 related_synonym: aldehyde reductase activity;   aldose reductase activity;   polyol dehydrogenase (NADP(+)) activity
 xref: KEGG_REACTION:R02820;   RHEA:12789;   reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol";   reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol"



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aldose reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide enables IEA Ensembl GO_REF:0000107 NCBI chr 4:99,123,658...99,144,297
Ensembl chr 4:99,123,657...99,157,792
JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 enables IEA
TAS
IBA
(PMID:2498333) Ensembl
PINC
GO_Central
PMID:2498333 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B enables IDA
IEA
TAS
EXP
IBA
(PMID:8435445)
(PMID:2112546)
(PMID:1420136), (PMID:2112546), (PMID:8645003)
UniProt
RHEA
PINC
Reactome
Ensembl
GO_Central
PMID:1420136 PMID:2112546 PMID:8435445 PMID:8645003 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 enables ISO
IBA
RGD
GO_Central
PMID:20709016 GO_REF:0000033 RGD:6903952 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412
JBrowse link
G AKR1B15 aldo-keto reductase family 1 member B15 enables IBA GO_Central GO_REF:0000033 NCBI chr 7:134,549,110...134,579,869
Ensembl chr 7:134,549,110...134,579,875
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 enables IDA
IBA
(PMID:21232532) UniProt
GO_Central
PMID:21232532 GO_REF:0000033 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 enables IDA
IBA
(PMID:21232532) UniProt
GO_Central
PMID:21232532 GO_REF:0000033 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 enables ISO
IDA
IBA
(PMID:21232532) RGD
UniProt
GO_Central
PMID:8977402 PMID:21232532 GO_REF:0000033 RGD:10053609 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G AKR1C4 aldo-keto reductase family 1 member C4 enables IBA GO_Central GO_REF:0000033 NCBI chr10:5,196,837...5,218,949
Ensembl chr10:5,195,462...5,218,949
JBrowse link
G AKR1D1 aldo-keto reductase family 1 member D1 enables IBA GO_Central GO_REF:0000033 NCBI chr 7:138,076,459...138,118,305
Ensembl chr 7:138,002,324...138,118,305
JBrowse link
G AKR1E2 aldo-keto reductase family 1 member E2 enables IBA GO_Central GO_REF:0000033 NCBI chr10:4,824,973...4,873,237
Ensembl chr10:4,786,629...4,848,062
JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 enables ISO
TAS
(PMID:9576847) RGD
PINC
PMID:9576847 PMID:12071861 RGD:625492 NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,301,991...19,312,144
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 19543
    catalytic activity 6021
      oxidoreductase activity 768
        oxidoreductase activity, acting on CH-OH group of donors 136
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 126
            alcohol dehydrogenase [NAD(P)+] activity 53
              aldo-keto reductase (NADPH) activity 37
                alcohol dehydrogenase (NADP+) activity 30
                  aldose reductase (NADPH) activity 12
                    D-xylose reductase (NADPH) activity 0
                    L-arabinose reductase (NADPH) activity 0
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