ONTOLOGY REPORT - ANNOTATIONS
Term: aldose reductase (NADPH) activity
Accession: GO:0004032
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Definition: Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
Synonyms: exact_synonym: alditol:NADP+ 1-oxidoreductase activity
related_synonym: aldehyde reductase activity; aldose reductase activity; polyol dehydrogenase (NADP(+)) activity
xref: KEGG_REACTION:R02820; RHEA:12789; reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol"; reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol"
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ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 4:99,123,658...99,144,297
Ensembl chr 4:99,123,657...99,157,792
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AKR1A1
aldo-keto reductase family 1 member A1
enables
IEA TAS IBA
(PMID:2498333)
Ensembl PINC GO_Central
PMID:2498333
GO_REF:0000033 GO_REF:0000107
NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049
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AKR1B1
aldo-keto reductase family 1 member B
enables
IDA IEA TAS EXP IBA
(PMID:8435445) (PMID:2112546) (PMID:1420136), (PMID:2112546), (PMID:8645003)
UniProt RHEA PINC Reactome Ensembl GO_Central
PMID:1420136 PMID:2112546 PMID:8435445 PMID:8645003
GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116
NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
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AKR1B10
aldo-keto reductase family 1 member B10
enables
ISO IBA
RGD GO_Central
PMID:20709016
GO_REF:0000033 RGD:6903952
NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412
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AKR1B15
aldo-keto reductase family 1 member B15
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 7:134,549,110...134,579,869
Ensembl chr 7:134,549,110...134,579,875
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AKR1C1
aldo-keto reductase family 1 member C1
enables
IDA IBA
(PMID:21232532)
UniProt GO_Central
PMID:21232532
GO_REF:0000033
NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
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AKR1C2
aldo-keto reductase family 1 member C2
enables
IDA IBA
(PMID:21232532)
UniProt GO_Central
PMID:21232532
GO_REF:0000033
NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031
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AKR1C3
aldo-keto reductase family 1 member C3
enables
ISO IDA IBA
(PMID:21232532)
RGD UniProt GO_Central
PMID:8977402 PMID:21232532
GO_REF:0000033 RGD:10053609
NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
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AKR1C4
aldo-keto reductase family 1 member C4
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr10:5,196,837...5,218,949
Ensembl chr10:5,195,462...5,218,949
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AKR1D1
aldo-keto reductase family 1 member D1
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr 7:138,076,459...138,118,305
Ensembl chr 7:138,002,324...138,118,305
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AKR1E2
aldo-keto reductase family 1 member E2
enables
IBA
GO_Central
GO_REF:0000033
NCBI chr10:4,824,973...4,873,237
Ensembl chr10:4,786,629...4,848,062
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AKR7A2
aldo-keto reductase family 7 member A2
enables
ISO TAS
(PMID:9576847)
RGD PINC
PMID:9576847 PMID:12071861
RGD:625492
NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,301,991...19,312,144
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