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ONTOLOGY REPORT - ANNOTATIONS
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Term:
aldose reductase (NADPH) activity
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Accession:
GO:0004032
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Definition:
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
Synonyms:
exact_synonym:
alditol:NADP+ 1-oxidoreductase activity
related_synonym:
aldehyde reductase activity; aldose reductase activity; polyol dehydrogenase (NADP(+)) activity
xref:
KEGG_REACTION:R02820; RHEA:12789; reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol"; reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol"
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Rat (19)
Mouse (21)
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Bonobo (8)
Dog (5)
Squirrel (4)
Pig (8)
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Genes (5)
aldose reductase (NADPH) activity
Symbol
Object Name
Qualifiers
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:47,226,787...47,248,518
Ensembl chr 7:47,226,191...47,248,234
G
AKR1A1
aldo-keto reductase family 1 member A1
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr20:87,228,348...87,245,511
Ensembl chr20:87,228,189...87,245,466
G
AKR1C3
aldo-keto reductase family 1 member C3
enables
IEA
Ensembl
GO_REF:0000107
Ensembl chr 9:5,248,610...5,263,474
G
LOC103225480
aflatoxin B1 aldehyde reductase member 2
ISO
RGD
PMID:12071861
RGD:625492
NCBI chr20:113,234,257...113,242,445
G
LOC103226928
aldo-keto reductase family 1 member B1
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr21:103,060,018...103,076,844
Ensembl chr21:103,059,991...103,077,341
Term paths to the root
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Path 1
Term
Annotations
molecular_function
18122
catalytic activity
5455
oxidoreductase activity
715
oxidoreductase activity, acting on CH-OH group of donors
127
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
119
alcohol dehydrogenase [NAD(P)+] activity
40
aldo-keto reductase (NADPH) activity
23
alcohol dehydrogenase (NADP+) activity
19
aldose reductase (NADPH) activity
5
D-xylose reductase (NADPH) activity
0
L-arabinose reductase (NADPH) activity
0