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ONTOLOGY REPORT - ANNOTATIONS


Term:aldose reductase (NADPH) activity
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Accession:GO:0004032 term browser browse the term
Definition:Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
Synonyms:exact_synonym: alditol:NADP+ 1-oxidoreductase activity
 related_synonym: aldehyde reductase activity;   aldose reductase activity;   polyol dehydrogenase (NADP(+)) activity
 xref: KEGG_REACTION:R02820;   RHEA:12789;   reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol";   reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol"


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aldose reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide enables IEA Ensembl GO_REF:0000107 NCBI chr 7:47,226,787...47,248,518
Ensembl chr 7:47,226,191...47,248,234
JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 enables IEA Ensembl GO_REF:0000107 NCBI chr20:87,228,348...87,245,511
Ensembl chr20:87,228,189...87,245,466
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 enables IEA Ensembl GO_REF:0000107 Ensembl chr 9:5,248,610...5,263,474 JBrowse link
G LOC103225480 aflatoxin B1 aldehyde reductase member 2 ISO RGD PMID:12071861 RGD:625492 NCBI chr20:113,234,257...113,242,445 JBrowse link
G LOC103226928 aldo-keto reductase family 1 member B1 enables IEA Ensembl GO_REF:0000107 NCBI chr21:103,060,018...103,076,844
Ensembl chr21:103,059,991...103,077,341
JBrowse link

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  molecular_function 18122
    catalytic activity 5455
      oxidoreductase activity 715
        oxidoreductase activity, acting on CH-OH group of donors 127
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 119
            alcohol dehydrogenase [NAD(P)+] activity 40
              aldo-keto reductase (NADPH) activity 23
                alcohol dehydrogenase (NADP+) activity 19
                  aldose reductase (NADPH) activity 5
                    D-xylose reductase (NADPH) activity 0
                    L-arabinose reductase (NADPH) activity 0
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