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ONTOLOGY REPORT - ANNOTATIONS


Term:aldose reductase (NADPH) activity
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Accession:GO:0004032 term browser browse the term
Definition:Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
Synonyms:exact_synonym: alditol:NADP+ 1-oxidoreductase activity
 related_synonym: aldehyde reductase activity;   aldose reductase activity;   polyol dehydrogenase (NADP(+)) activity
 xref: KEGG_REACTION:R02820;   RHEA:12789;   reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol";   reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol"



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aldose reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide enables IEA Ensembl GO_REF:0000107 NCBI chr32:21,282,526...21,299,387
Ensembl chr32:21,282,890...21,299,328
JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 enables ISO (PMID:14667815), (PMID:15769935) MGI PMID:14667815 PMID:15769935 NCBI chr15:14,792,398...14,808,805
Ensembl chr15:14,742,012...14,808,592
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B enables ISO (PMID:7851421)
(PMID:1420136), (PMID:2112546), (PMID:8645003)
(PMID:17727625)
(PMID:8435445)
MGI
Reactome
RGD
UniProt
PMID:1420136 PMID:2112546 PMID:2114645 PMID:7851421 PMID:8435445 More... RGD:1626085 NCBI chr14:2,991,888...3,006,941
Ensembl chr14:2,991,888...3,006,940
JBrowse link
G AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) enables ISO (PMID:21232532) RGD
UniProt
PMID:8977402 PMID:21232532 RGD:10053609 NCBI chr 2:30,661,333...30,691,283
Ensembl chr 2:30,674,558...30,690,043
JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 ISO RGD PMID:12071861 RGD:625492 NCBI chr 2:79,334,179...79,343,880
Ensembl chr 2:79,334,205...79,343,007
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 18599
    catalytic activity 5534
      oxidoreductase activity 763
        oxidoreductase activity, acting on CH-OH group of donors 135
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 126
            alcohol dehydrogenase [NAD(P)+] activity 40
              aldo-keto reductase (NADPH) activity 25
                alcohol dehydrogenase (NADP+) activity 22
                  aldose reductase (NADPH) activity 5
                    D-xylose reductase (NADPH) activity 0
                    L-arabinose reductase (NADPH) activity 0
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