ONTOLOGY REPORT - ANNOTATIONS
Term: aldose reductase (NADPH) activity
Accession: GO:0004032
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Definition: Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
Synonyms: exact_synonym: alditol:NADP+ 1-oxidoreductase activity
related_synonym: aldehyde reductase activity; aldose reductase activity; polyol dehydrogenase (NADP(+)) activity
xref: KEGG_REACTION:R02820; RHEA:12789; reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol"; reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol"
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ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 4:91,522,444...91,543,086
Ensembl chr 4:102,183,956...102,206,923
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AKR1A1
aldo-keto reductase family 1 member A1
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:44,853,867...44,871,764
Ensembl chr 1:46,211,859...46,230,072
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AKR1B1
aldo-keto reductase family 1 member B
enables
ISO
(PMID:7851421) (PMID:8435445) (PMID:17727625) (PMID:1420136), (PMID:2112546), (PMID:8645003)
MGI RGD UniProt Reactome
PMID:1420136 PMID:2112546 PMID:2114645 PMID:7851421 PMID:8435445 PMID:8645003 PMID:17727625 More...
RGD:1626085
NCBI chr 7:126,400,861...126,417,756
Ensembl chr 7:138,912,953...138,924,095
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AKR1B10
aldo-keto reductase family 1 member B10
ISO
RGD
PMID:20709016
RGD:6903952
NCBI chr 7:126,486,012...126,499,852
Ensembl chr 7:138,992,835...139,006,003
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AKR1C3
aldo-keto reductase family 1 member C3
enables
IEA ISO
Ensembl RGD
PMID:8977402
GO_REF:0000107 RGD:10053609
NCBI chr10:5,079,580...5,157,572
Ensembl chr10:5,081,214...5,139,812
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LOC100981962
aflatoxin B1 aldehyde reductase member 2
ISO
RGD
PMID:12071861
RGD:625492
NCBI chr 1:18,262,631...18,270,783
Ensembl chr 1:19,309,471...19,317,227
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LOC100986729
aldo-keto reductase family 1 member C1
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr10:5,003,610...5,020,648
Ensembl chr10:4,990,110...5,003,538
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LOC103783188
aldo-keto reductase family 1 member C2
enables
IEA
Ensembl
GO_REF:0000107
NCBI chr10:5,032,692...5,047,009
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