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ONTOLOGY REPORT - ANNOTATIONS


Term:aldose reductase (NADPH) activity
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Accession:GO:0004032 term browser browse the term
Definition:Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
Synonyms:exact_synonym: alditol:NADP+ 1-oxidoreductase activity
 related_synonym: aldehyde reductase activity;   aldose reductase activity;   polyol dehydrogenase (NADP(+)) activity
 xref: KEGG_REACTION:R02820;   RHEA:12789;   reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol";   reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol"



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aldose reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide enables IEA Ensembl GO_REF:0000107 NCBI chr 4:91,522,444...91,543,086
Ensembl chr 4:102,183,956...102,206,923
JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:44,853,867...44,871,764
Ensembl chr 1:46,211,859...46,230,072
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B enables ISO (PMID:7851421)
(PMID:8435445)
(PMID:17727625)
(PMID:1420136), (PMID:2112546), (PMID:8645003)
MGI
RGD
UniProt
Reactome
PMID:1420136 PMID:2112546 PMID:2114645 PMID:7851421 PMID:8435445 More... RGD:1626085 NCBI chr 7:126,400,861...126,417,756
Ensembl chr 7:138,912,953...138,924,095
JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 ISO RGD PMID:20709016 RGD:6903952 NCBI chr 7:126,486,012...126,499,852
Ensembl chr 7:138,992,835...139,006,003
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 enables IEA
ISO
Ensembl
RGD
PMID:8977402 GO_REF:0000107 RGD:10053609 NCBI chr10:5,079,580...5,157,572
Ensembl chr10:5,081,214...5,139,812
JBrowse link
G LOC100981962 aflatoxin B1 aldehyde reductase member 2 ISO RGD PMID:12071861 RGD:625492 NCBI chr 1:18,262,631...18,270,783
Ensembl chr 1:19,309,471...19,317,227
JBrowse link
G LOC100986729 aldo-keto reductase family 1 member C1 enables IEA Ensembl GO_REF:0000107 NCBI chr10:5,003,610...5,020,648
Ensembl chr10:4,990,110...5,003,538
JBrowse link
G LOC103783188 aldo-keto reductase family 1 member C2 enables IEA Ensembl GO_REF:0000107 NCBI chr10:5,032,692...5,047,009 JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 17684
    catalytic activity 5353
      oxidoreductase activity 695
        oxidoreductase activity, acting on CH-OH group of donors 133
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 125
            alcohol dehydrogenase [NAD(P)+] activity 45
              aldo-keto reductase (NADPH) activity 28
                alcohol dehydrogenase (NADP+) activity 22
                  aldose reductase (NADPH) activity 8
                    D-xylose reductase (NADPH) activity 0
                    L-arabinose reductase (NADPH) activity 0
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