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ONTOLOGY REPORT - ANNOTATIONS

Term:alcohol dehydrogenase (NAD+) activity
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Accession:GO:0004022 term browser browse the term
Definition:Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
Synonyms:exact_synonym: aldo-keto reductase (NAD) activity
 narrow_synonym: aldehyde dehydrogenase (NAD) activity;   aliphatic alcohol dehydrogenase;   ethanol dehydrogenase;   yeast alcohol dehydrogenase
 broad_synonym: alcohol dehydrogenase activity;   primary alcohol dehydrogenase
 related_synonym: ADH;   NAD-dependent alcohol dehydrogenase;   NAD-specific aromatic alcohol dehydrogenase;   NADH-alcohol dehydrogenase;   NADH-aldehyde dehydrogenase;   alcohol:NAD+ oxidoreductase
 xref: EC:1.1.1.1;   Reactome:R-HSA-71707 "ethanol + NAD+ => acetaldehyde + NADH + H+";   reactome:R-HSA-2162078 "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+"


show annotations for term's descendants           Sort by:
alcohol dehydrogenase (NAD+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide enables TAS
IEA
IBA
ISO
IDA		 GO_REF:0000107
GO_REF:0000033
(PMID:3996732), (PMID:518534), (PMID:6370228), (PMID:6816803), (PMID:7026729)
(PMID:6391957)		 Ensembl
GO_Central
RGD		 PMID:518534 PMID:3996732 PMID:6370228 PMID:6391957 PMID:6816803 More... GO_REF:0000033 GO_REF:0000107, RGD:631178, RGD:1642949 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide enables IEA
ISO
IBA		 GO_REF:0000003
(PMID:10514444), (PMID:518534)
(PMID:10407146), (PMID:16787387), (PMID:3466164)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:518534 PMID:3466164 PMID:10407146 PMID:10514444 PMID:16787387 GO_REF:0000003 GO_REF:0000033 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide enables IDA
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000003
(PMID:3996732)		 GO_Central
UniProt
RGD		 PMID:3996732 PMID:18207224 GO_REF:0000003 GO_REF:0000033, RGD:5129089 NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adh6 alcohol dehydrogenase 6 (class V) enables ISO
IEA
IBA		 (PMID:1755855)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:1755855 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:226,903,208...226,934,564
Ensembl chr 2:226,903,250...226,934,534 		JBrowse link
G Adh6a alcohol dehydrogenase 6A (class V) enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:226,823,775...226,846,005
Ensembl chr 2:226,823,730...226,846,003 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide enables TAS
ISO
IBA
IDA		 (PMID:10969996), (PMID:7876099)
GO_REF:0000033
(PMID:518534), (PMID:6372555), (PMID:7026729)		 RGD
GO_Central		 PMID:518534 PMID:6372555 PMID:7026729 PMID:7876099 PMID:10969996 More... GO_REF:0000033 MGI:52973, RGD:631178, RGD:631904 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182 		JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 enables IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 enables ISS
ISO		 GO_REF:0000024
(PMID:11304534)		 UniProt
RGD		 PMID:11304534 GO_REF:0000024 NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241 		JBrowse link
all-trans-retinol dehydrogenase (NAD+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide enables IDA
IBA
ISO		 GO_REF:0000033
MGI:97876 (PMID:15193143)		 GO_Central
RGD		 PMID:15193143 PMID:2940107 GO_REF:0000033, RGD:2315740 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide enables ISS
ISO		 GO_REF:0000024
(PMID:10514444), (PMID:15369820), (PMID:16787387), (PMID:17279314)		 UniProt
RGD		 PMID:10514444 PMID:15369820 PMID:16787387 PMID:17279314 GO_REF:0000024 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adh6 alcohol dehydrogenase 6 (class V) enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:226,903,208...226,934,564
Ensembl chr 2:226,903,250...226,934,534 		JBrowse link
G Adh6a alcohol dehydrogenase 6A (class V) enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:226,823,775...226,846,005
Ensembl chr 2:226,823,730...226,846,003 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide enables ISO
IEA
ISS
IBA		 (PMID:11997393), (PMID:15369820), (PMID:16787387), (PMID:7876099), (PMID:9600267)
GO_REF:0000107
GO_REF:0000024
GO_REF:0000033
(PMID:3663136)		 RGD
Ensembl
UniProt
GO_Central		 PMID:3663136 PMID:7876099 PMID:9600267 PMID:11997393 PMID:15369820 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182 		JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 NOT|enables ISO
ISS		 (PMID:12732097)
GO_REF:0000024		 RGD
UniProt		 PMID:12732097 GO_REF:0000024 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 enables ISO (PMID:21851338) RGD PMID:21851338 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Bloc1s1 biogenesis of lysosomal organelles complex-1, subunit 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:1,347,495...1,351,103
Ensembl chr 7:1,340,934...1,351,558 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 enables IBA
ISO		 GO_REF:0000033
MGI:5007106 (PMID:24005908)		 GO_Central
RGD		 PMID:24005908 GO_REF:0000033 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417 		JBrowse link
G Dhrs7c dehydrogenase/reductase 7C enables ISS
ISO		 GO_REF:0000024
(PMID:21995425)		 UniProt
RGD		 PMID:21995425 GO_REF:0000024 NCBI chr10:52,495,262...52,513,338
Ensembl chr10:52,495,262...52,513,338 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 enables IMP
ISS
ISO
IBA		 GO_REF:0000024
(PMID:11304534)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:11304534 PMID:12390888 GO_REF:0000024 GO_REF:0000033, RGD:633755 NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241 		JBrowse link
G Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr14:5,751,697...5,766,809
Ensembl chr14:5,752,132...5,768,166 		JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 enables ISO
IBA		 (PMID:10896656), (PMID:11360992)
GO_REF:0000033		 RGD
GO_Central		 PMID:10896656 PMID:11360992 GO_REF:0000033 NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425 		JBrowse link
G Rdh10 retinol dehydrogenase 10 enables ISO (PMID:12407145), (PMID:19458327)
(PMID:17473173)		 RGD PMID:12407145 PMID:17473173 PMID:19458327 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572 		JBrowse link
G Rdh12 retinol dehydrogenase 12 enables ISO (PMID:12226107)
(PMID:22621924)		 RGD PMID:12226107 PMID:22621924 NCBI chr 6:98,015,465...98,028,388
Ensembl chr 6:98,015,465...98,028,388 		JBrowse link
G Rdh16 retinol dehydrogenase 16 enables IDA
ISO
IBA		 (PMID:10329026), (PMID:12534290), (PMID:9677409)
GO_REF:0000033		 RGD
GO_Central		 PMID:9677409 PMID:10329026 PMID:12534290 PMID:7499345 GO_REF:0000033, RGD:1299624 NCBI chr 7:63,616,711...63,625,053
Ensembl chr 7:63,597,536...63,624,124 		JBrowse link
G Rdh5 retinol dehydrogenase 5 enables ISO
IBA		 (PMID:11675386)
GO_REF:0000033
(PMID:10588954)		 RGD
GO_Central		 PMID:10588954 PMID:11675386 GO_REF:0000033 NCBI chr 7:1,341,172...1,346,863
Ensembl chr 7:1,340,934...1,351,558 		JBrowse link
G Rdh7 retinol dehydrogenase 7 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:63,676,016...63,689,375
Ensembl chr 7:63,675,579...63,689,392 		JBrowse link
G Rdh8 retinol dehydrogenase 8 enables IBA
ISO		 GO_REF:0000033
(PMID:15755727)		 GO_Central
RGD		 PMID:15755727 GO_REF:0000033 NCBI chr 8:19,353,191...19,360,462
Ensembl chr 8:19,353,191...19,360,462 		JBrowse link
G Rdh9 retinol dehydrogenase 9 enables ISO (PMID:11876656) RGD PMID:11876656 NCBI chr 7:63,642,305...63,645,149 JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 enables ISO
IBA		 (PMID:18926804), (PMID:19102727)
GO_REF:0000033		 RGD
GO_Central		 PMID:18926804 PMID:19102727 GO_REF:0000033 NCBI chr 5:17,018,813...17,043,974
Ensembl chr 5:17,018,813...17,040,970 		JBrowse link
G Sdr9c7 short chain dehydrogenase/reductase family 9C, member 7 enables ISO
IBA		 (PMID:19703561)
GO_REF:0000033		 RGD
GO_Central		 PMID:19703561 GO_REF:0000033 NCBI chr 7:63,703,788...63,720,325
Ensembl chr 7:63,707,071...63,721,480 		JBrowse link
L-iditol 2-dehydrogenase (NAD+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sord sorbitol dehydrogenase enables ISO
IBA
IEA		 (PMID:32367058), (PMID:3365415), (PMID:6870831), (PMID:8487505)
MGI:3616090 (PMID:1914521), (PMID:6626150), (PMID:7171128), (PMID:722274), (PMID:9403062), (PMID:9604875)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000104		 RGD
GO_Central
Ensembl
UniProt		 PMID:722274 PMID:1914521 PMID:3365415 PMID:6626150 PMID:6870831 More... GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20633
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 152
            alcohol dehydrogenase [NAD(P)+] activity 63
              alcohol dehydrogenase (NAD+) activity 25
                3-methylbutanal reductase (NADH) activity 0
                L-iditol 2-dehydrogenase (NAD+) activity 1
                all-trans-retinol dehydrogenase (NAD+) activity 22
                aryl-alcohol dehydrogenase (NAD+) activity 0
                butanol dehydrogenase (NAD+) activity 0
                hexadecanol (NAD+) dehydrogenase activity 0
                indole-3-acetaldehyde reductase (NADH) activity 0
                inositol 2-dehydrogenase (NAD+) activity 0
                methanol dehydrogenase (NAD+) activity 0
                octanol dehydrogenase (NAD+) activity 0
                perillyl-alcohol dehydrogenase (NAD+) activity 0
                xanthoxin dehydrogenase (NAD+) activity 0
paths to the root