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ONTOLOGY REPORT - ANNOTATIONS


Term:G protein activity
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Accession:GO:0003925 term browser browse the term
Definition:A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).
Synonyms:exact_synonym: signaling G protein activity
 narrow_synonym: Ras superfamily protein;   heterotrimeric G-protein GTPase activity;   large G-protein GTPase activity;   large G-protein activity;   small G-protein;   small GTPase;   small GTPase activity;   small monomeric G protein activity;   small monomeric GTPase activity
 alt_id: GO:0003927



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G protein activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf6 ADP-ribosylation factor 6 enables ISS
ISO
GO_REF:0000024
(PMID:32103017)
UniProt
RGD
PMID:32103017 GO_REF:0000024 NCBI chr 6:87,853,742...87,854,890
Ensembl chr 6:87,840,142...87,874,114
JBrowse link
G Arl8b ADP-ribosylation factor like GTPase 8B enables ISO (PMID:16537643) RGD PMID:16537643 NCBI chr 4:141,748,634...141,792,605
Ensembl chr 4:141,748,587...141,792,596
JBrowse link
G Cdc42 cell division cycle 42 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Gbp1 guanylate binding protein 1 enables ISO (PMID:16511497), (PMID:28645896), (PMID:29144452), (PMID:29233899), (PMID:7512561) RGD PMID:7512561 PMID:16511497 PMID:28645896 PMID:29144452 PMID:29233899 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131
JBrowse link
G Gna11 G protein subunit alpha 11 enables IEA
ISO
GO_REF:0000107
(PMID:26075576)
Ensembl
RGD
PMID:26075576 GO_REF:0000107 NCBI chr 7:8,163,520...8,177,863
Ensembl chr 7:8,162,750...8,179,812
JBrowse link
G Gnaq G protein subunit alpha q enables IEA
ISO
GO_REF:0000107
(PMID:26075576)
Ensembl
RGD
PMID:26075576 GO_REF:0000107 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Gnas GNAS complex locus enables IEA
ISO
GO_REF:0000107
(PMID:12145344)
Ensembl
RGD
PMID:12145344 GO_REF:0000107 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Hras HRas proto-oncogene, GTPase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Irgm immunity-related GTPase M enables ISO (PMID:30612879) RGD PMID:30612879 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578
JBrowse link
G Kras KRAS proto-oncogene, GTPase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mras muscle RAS oncogene homolog enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408
JBrowse link
G Nras NRAS proto-oncogene, GTPase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
JBrowse link
G Ppa1 inorganic pyrophosphatase 1 enables IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215
JBrowse link
G Rab10 RAB10, member RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:26,267,081...26,319,739
Ensembl chr 6:26,266,859...26,320,193
JBrowse link
G Rab11a RAB11a, member RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525
JBrowse link
G Rab11b RAB11B, member RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593
JBrowse link
G Rab1a RAB1A, member RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:94,422,219...94,448,799
Ensembl chr14:94,415,275...94,448,248
JBrowse link
G Rab1b RAB1B, member RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:202,405,759...202,413,850
Ensembl chr 1:202,405,759...202,413,868
Ensembl chr  X:202,405,759...202,413,868
JBrowse link
G Rab27a RAB27A, member RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829
JBrowse link
G Rab27b RAB27B, member RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:63,597,554...63,794,124
Ensembl chr18:63,600,937...63,757,180
JBrowse link
G Rab4a RAB4A, member RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr19:51,795,613...51,822,706
Ensembl chr19:51,795,613...51,822,703
JBrowse link
G Rab4b RAB4B, member RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:82,461,396...82,472,784
Ensembl chr 1:82,461,396...82,472,763
JBrowse link
G Rab5a RAB5A, member RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:6,483,906...6,512,877
Ensembl chr 9:6,484,469...6,512,873
JBrowse link
G Rab5al1 Rab5a, member RAS oncogene family-like 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:68,332,360...68,334,470
Ensembl chr14:68,332,558...68,333,205
JBrowse link
G Rab7a RAB7A, member RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889
JBrowse link
G Rac1 Rac family small GTPase 1 enables ISO EC:3.6.5.2 (PMID:17058265), (PMID:35263589), (PMID:35676269) RGD PMID:17058265 PMID:35263589 PMID:35676269 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rala RAS like proto-oncogene A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr17:47,092,163...47,145,192
Ensembl chr17:47,092,207...47,144,063
JBrowse link
G Ralb RAS like proto-oncogene B enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr13:30,588,036...30,624,199
Ensembl chr13:30,588,033...30,624,202
JBrowse link
G Ran RAN, member RAS oncogene family enables ISO (PMID:11336674) RGD PMID:11336674 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rap1b RAP1B, member of RAS oncogene family enables ISO (PMID:11056535) RGD PMID:11056535 NCBI chr 7:53,423,039...53,456,349
Ensembl chr 7:53,423,130...53,456,370
JBrowse link
G Rap2a RAP2A, member of RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:97,596,848...97,597,338
Ensembl chr15:97,596,020...97,624,138
JBrowse link
G Rap2b RAP2B, member of RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:145,599,714...145,600,265
Ensembl chr 2:145,599,116...145,603,069
JBrowse link
G Rap2c RAP2C, member of RAS oncogene family enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr  X:130,504,554...130,517,671
Ensembl chr  X:130,504,698...130,518,328
JBrowse link
G Rasl11a RAS-like family 11 member A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:8,258,148...8,260,909
Ensembl chr12:8,258,159...8,262,576
JBrowse link
G Rasl11b RAS-like family 11 member B enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:34,014,924...34,019,146
Ensembl chr14:34,014,509...34,019,152
JBrowse link
G Rhoa ras homolog family member A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rit2 Ras-like without CAAX 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:22,565,403...22,921,648
Ensembl chr18:22,565,404...22,921,648
JBrowse link
G Sar1a secretion associated, Ras related GTPase 1A enables IEA
ISO
GO_REF:0000107
(PMID:32358066)
Ensembl
RGD
PMID:32358066 GO_REF:0000107 NCBI chr20:29,623,529...29,635,935
Ensembl chr20:29,623,553...29,635,935
JBrowse link
G Sar1b secretion associated, Ras related GTPase 1B enables ISS
ISO
GO_REF:0000024
(PMID:32358066)
UniProt
RGD
PMID:32358066 GO_REF:0000024 NCBI chr10:36,024,415...36,054,069
Ensembl chr10:36,024,382...36,054,066
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20890
    molecular function regulator activity 2119
      G protein activity 40
Path 2
Term Annotations click to browse term
  molecular_function 20890
    catalytic activity 6118
      hydrolase activity 2630
        hydrolase activity, acting on acid anhydrides 782
          hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 779
            pyrophosphatase activity 772
              ribonucleoside triphosphate phosphatase activity 709
                GTPase activity 323
                  G protein activity 40
paths to the root