Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:3-hydroxyacyl-CoA dehydrogenase activity
go back to main search page
Accession:GO:0003857 term browser browse the term
Definition:Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+.
Comment:See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'.
Synonyms:narrow_synonym: beta-hydroxybutyrylcoenzyme A dehydrogenase activity
 broad_synonym: beta-ketoacyl-CoA reductase
 related_synonym: 3-oxoacyl-thioester reductase activity;   L-3-hydroxyacyl CoA dehydrogenase activity;   L-3-hydroxyacyl coenzyme A dehydrogenase activity;   beta-hydroxyacyl dehydrogenase activity;   beta-hydroxyacyl-coenzyme A synthetase activity;   beta-hydroxyacylcoenzyme A dehydrogenase activity;   beta-keto-reductase activity
 xref: EC:1.1.1.35;   MetaCyc:OHACYL-COA-DEHYDROG-RXN;   RHEA:22432;   UM-BBD_reactionID:r1063;   reactome:R-HSA-193455 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA";   reactome:R-HSA-193508 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA";   reactome:R-HSA-389995 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+";   reactome:R-HSA-390251 "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA";   reactome:R-HSA-508369 "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+";   reactome:R-HSA-6809264 "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA";   reactome:R-HSA-70837 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+";   reactome:R-HSA-77254 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H";   reactome:R-HSA-77283 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H";   reactome:R-HSA-77303 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H";   reactome:R-HSA-77312 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H";   reactome:R-HSA-77323 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H";   reactome:R-HSA-77331 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H";   reactome:R-HSA-77342 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H"


show annotations for term's descendants           Sort by:
3-hydroxyacyl-CoA dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase enables IDA
IBA
ISO		 GO_REF:0000033
(PMID:15060085)
PMID:12106015		 GO_Central
RGD		 PMID:15060085 PMID:4019459 PMID:12106015 GO_REF:0000033, RGD:632622, RGD:21201263 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase enables IMP
ISO
ISS
IBA		 (PMID:11489939)
(PMID:2817332)
GO_REF:0000024
GO_REF:0000033
(PMID:15240869)		 RGD
UniProt
GO_Central		 PMID:2817332 PMID:11489939 PMID:15240869 PMID:17491019 GO_REF:0000024 GO_REF:0000033, RGD:2302227 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha enables IMP
IEA
IDA		 GO_REF:0000117 UniProt
RGD		 PMID:8253773 PMID:1730633 GO_REF:0000117, RGD:632874, RGD:1600572 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:12917011), (PMID:23042678), (PMID:25925575), (PMID:28888424)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:12917011 PMID:23042678 PMID:25925575 PMID:28888424 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:21,089,142...21,091,603
Ensembl chr  X:21,089,122...21,109,488 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 enables ISS
IBA
ISO
IEA		 GO_REF:0000024
GO_REF:0000033
(PMID:9089413), (PMID:9482850)
GO_REF:0000107
(PMID:10706581), (PMID:15060085)		 UniProt
GO_Central
RGD
Ensembl		 PMID:9089413 PMID:9482850 PMID:10706581 PMID:15060085 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
long-chain-3-hydroxyacyl-CoA dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase enables ISS
ISO		 GO_REF:0000024
(PMID:15060085)		 UniProt
RGD		 PMID:15060085 GO_REF:0000024 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha enables IDA
IBA
ISO		 GO_REF:0000033
(PMID:15240869)		 GO_Central
RGD		 PMID:15240869 PMID:1730633 GO_REF:0000033, RGD:1600572 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20633
    catalytic activity 6032
      oxidoreductase activity 854
        oxidoreductase activity, acting on CH-OH group of donors 161
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 152
            3-hydroxyacyl-CoA dehydrogenase activity 5
              long-chain-3-hydroxyacyl-CoA dehydrogenase activity 2
paths to the root