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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of membrane depolarization
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Accession:GO:0003254 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.


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regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2 microglobulin involved_in ISO (PMID:23144825) RGD PMID:23144825 NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:129,549,318...129,555,356 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta involved_in ISO (PMID:22514276) RGD PMID:22514276 NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:217,698,551...217,960,276 		JBrowse link
G Fgf12 fibroblast growth factor 12 involved_in IDA PMID:12401812 BHF-UCL PMID:12401812 RGD:6484231 NCBI chr11:85,501,947...86,069,543
Ensembl chr11:85,501,936...86,069,543 		JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 involved_in IDA
IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
(PMID:16043489) 		GO_Central
Ensembl
RGD		 PMID:16043489 PMID:20806410 GO_REF:0000033 GO_REF:0000107, RGD:9686372 NCBI chr 2:51,228,710...51,632,806
Ensembl chr 2:51,228,710...51,632,806 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:10,620,422...10,639,457
Ensembl chr 7:10,620,422...10,639,457 		JBrowse link
G Hcn3 hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 involved_in ISO
IBA 		(PMID:16043489)
GO_REF:0000033 		RGD
GO_Central		 PMID:16043489 GO_REF:0000033 NCBI chr 2:176,849,635...176,867,726
Ensembl chr 2:176,849,635...176,868,538 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 involved_in IEA
IBA
ISO 		GO_REF:0000107
GO_REF:0000033
(PMID:12750403), (PMID:16043489) 		Ensembl
GO_Central
RGD		 PMID:12750403 PMID:16043489 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:68,118,062...68,155,482
Ensembl chr 8:68,118,062...68,155,495 		JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase involved_in ISO
IEA 		(PMID:15217910)
GO_REF:0000107 		RGD
Ensembl		 PMID:15217910 GO_REF:0000107 NCBI chr18:60,663,918...60,996,824
Ensembl chr18:60,663,970...60,996,824 		JBrowse link
G Npff neuropeptide FF-amide peptide precursor IDA RGD PMID:17289819 RGD:2316567 NCBI chr 7:135,533,050...135,533,839
Ensembl chr 7:135,533,051...135,533,839 		JBrowse link
G Ntsr1 neurotensin receptor 1 IMP RGD PMID:15120846 RGD:9743930 NCBI chr 3:187,983,778...188,033,934
Ensembl chr 3:187,983,778...188,033,934 		JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in IEA
ISO 		GO_REF:0000107
(PMID:23420830)
GO_REF:0000117 		Ensembl
RGD
UniProt		 PMID:23420830 GO_REF:0000107 GO_REF:0000117 NCBI chr10:54,176,325...54,177,696
Ensembl chr10:54,176,325...54,177,696 		JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in IEA
ISO 		GO_REF:0000107
(PMID:25257915) 		Ensembl
RGD		 PMID:25257915 GO_REF:0000107 NCBI chr 4:147,137,993...147,153,967
Ensembl chr 4:147,137,797...147,153,967 		JBrowse link
negative regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin involved_in IEA
ISS
ISO 		GO_REF:0000107
GO_REF:0000024
(PMID:16153637) 		Ensembl
UniProt
RGD		 PMID:16153637 GO_REF:0000024 GO_REF:0000107 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in IEA
ISO 		GO_REF:0000107
(PMID:27098698) 		Ensembl
RGD		 PMID:27098698 GO_REF:0000107 NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:101,670,625...101,681,833 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 IMP RGD PMID:29215467 RGD:13504824 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Hsh2d hematopoietic SH2 domain containing acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:15569688) 		Ensembl
RGD		 PMID:15569688 GO_REF:0000107 NCBI chr16:17,664,548...17,686,976
Ensembl chr16:17,669,345...17,682,013 		JBrowse link
G Ngfr nerve growth factor receptor IMP RGD PMID:19457114 RGD:5508731 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305 		JBrowse link
G Rbfox2 RNA binding fox-1 homolog 2 IMP RGD PMID:34731606 RGD:329845875 NCBI chr 7:110,691,230...110,934,901
Ensembl chr 7:110,691,230...110,934,987 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:19767770) RGD PMID:19767770 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
positive regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C IMP RGD PMID:18562674 RGD:152177517 NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D IDA RGD PMID:7760845 RGD:70680 NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,233,690...5,674,692 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 IMP RGD PMID:16641242 RGD:401959318 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IDA RGD PMID:18294619 RGD:616932972 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021 		JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 involved_in IMP
IDA 		PMID:18180363
PMID:15579534 		BHF-UCL PMID:18180363 PMID:15579534 RGD:6767295, RGD:6484228 NCBI chr20:18,601,307...19,224,790
Ensembl chr20:18,601,826...19,084,879 		JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in ISO (PMID:18184654) RGD PMID:18184654 NCBI chr10:54,176,325...54,177,696
Ensembl chr10:54,176,325...54,177,696 		JBrowse link
positive regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy10 adenylate cyclase 10 IMP RGD PMID:31172217 RGD:329403053 NCBI chr13:80,280,595...80,366,939
Ensembl chr13:80,284,295...80,366,926 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type IMP RGD PMID:15564577 RGD:2313870 NCBI chr10:55,456,923...55,469,239
Ensembl chr10:55,456,928...55,469,199 		JBrowse link
G Dcn decorin acts_upstream_of_or_within ISO UniProtKB:P35968 (PMID:23798385) RGD PMID:23798385 NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926 		JBrowse link
G Kdr kinase insert domain receptor acts_upstream_of_or_within ISO
IEA 		UniProtKB:P07585 (PMID:23798385)
GO_REF:0000107 		RGD
Ensembl		 PMID:23798385 GO_REF:0000107 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192 		JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor involved_in ISO
IEA
IBA
ISS 		(PMID:18852119)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000024 		RGD
Ensembl
GO_Central
UniProt		 PMID:18852119 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:185,484,791...185,493,961
Ensembl chr 2:185,484,793...185,493,961 		JBrowse link
G Myoc myocilin involved_in ISO
IEA
ISS 		(PMID:17516541)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:17516541 GO_REF:0000024 GO_REF:0000107 NCBI chr13:77,509,963...77,520,361
Ensembl chr13:77,509,963...77,520,361 		JBrowse link
G Oga O-GlcNAcase IMP RGD PMID:19139380 RGD:2305938 NCBI chr 1:254,547,311...254,589,596
Ensembl chr 1:254,547,311...254,582,855 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:2386080 (PMID:16198349) RGD PMID:16198349 NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 IMP protein:increased activity:brain: RGD PMID:21616968 RGD:10413888 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Rack1 receptor for activated C kinase 1 involved_in ISO (PMID:19767770) RGD PMID:19767770 NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,670,270...33,675,948 		JBrowse link
G Tspo translocator protein IDA RGD PMID:15183124 RGD:2317155 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460 		JBrowse link
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IMP RGD PMID:20826763 RGD:10003037 NCBI chr 1:104,918,462...104,949,453
Ensembl chr 1:104,918,462...104,948,653 		JBrowse link
regulation of atrial cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1g calcium voltage-gated channel subunit alpha1 G acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2182962 (PMID:16690884) 		Ensembl
RGD		 PMID:16690884 GO_REF:0000107 NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,851,896...79,919,634 		JBrowse link
G Fhl1 four and a half LIM domains 1 involved_in ISO (PMID:18281375) RGD PMID:18281375 NCBI chr  X:139,592,794...139,652,290
Ensembl chr  X:139,592,604...139,652,282 		JBrowse link
G Gja1 gap junction protein, alpha 1 acts_upstream_of_or_within ISO MGI:1857177 (PMID:10969038) RGD PMID:10969038 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Gja5 gap junction protein, alpha 5 involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:22247482), (PMID:23348765)
MGI:2445238 (PMID:10515563), (PMID:10969038), (PMID:9501070)
GO_REF:0000107 		RGD
Ensembl		 PMID:9501070 PMID:10515563 PMID:10969038 PMID:22247482 PMID:23348765 GO_REF:0000107 NCBI chr 2:187,291,227...187,310,770
Ensembl chr 2:187,234,674...187,318,512 		JBrowse link
G Mir26a1 microRNA 26a-1 acts_upstream_of ISO (PMID:23543060) RGD PMID:23543060 NCBI chr 8:127,633,048...127,633,137
Ensembl chr 8:127,633,048...127,633,137 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:20062061), (PMID:21041692)
MGI:2180183 (PMID:20062061)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:20062061 PMID:21041692 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:128,228,424...128,340,298 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO
IEA 		(PMID:19808477), (PMID:22247482)
GO_REF:0000107 		RGD
Ensembl		 PMID:19808477 PMID:22247482 GO_REF:0000107 NCBI chr 1:95,481,298...95,491,211
Ensembl chr 1:95,481,298...95,491,197 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in ISO
IEA 		(PMID:19808477)
GO_REF:0000107 		RGD
Ensembl		 PMID:19808477 GO_REF:0000107 NCBI chr 8:54,322,383...54,334,519
Ensembl chr 8:54,322,383...54,334,519 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO
IEA 		(PMID:21051419)
(PMID:19796257)
GO_REF:0000107 		RGD
Ensembl		 PMID:19796257 PMID:21051419 GO_REF:0000107 NCBI chr 8:49,527,529...49,550,019
Ensembl chr 8:49,527,577...49,550,018 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
IBA
IEA
ISS 		(PMID:19167345), (PMID:22247482)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024 		RGD
GO_Central
Ensembl
BHF-UCL		 PMID:19167345 PMID:22247482 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470 		JBrowse link
G Tbx5 T-box transcription factor 5 acts_upstream_of_positive_effect IEA
ISO 		GO_REF:0000107
UniProtKB:Q9JJV9 (PMID:22728936) 		Ensembl
RGD		 PMID:22728936 GO_REF:0000107 NCBI chr12:42,342,926...42,399,723
Ensembl chr12:42,348,485...42,395,359 		JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 involved_in IMP PMID:8816717 UniProt PMID:8816717 RGD:405650388 NCBI chr11:93,702,382...93,716,059
Ensembl chr11:93,702,360...93,716,059 		JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 involved_in ISO (PMID:16930557) RGD PMID:16930557 NCBI chr 5:76,703,687...76,822,584
Ensembl chr 5:76,703,687...76,860,470 		JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO
IEA 		(PMID:17275750)
GO_REF:0000107 		RGD
Ensembl		 PMID:17275750 GO_REF:0000107 NCBI chr 4:147,137,993...147,153,967
Ensembl chr 4:147,137,797...147,153,967 		JBrowse link
G Gja5 gap junction protein, alpha 5 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2445238 (PMID:9501070) 		Ensembl
RGD		 PMID:9501070 GO_REF:0000107 NCBI chr 2:187,291,227...187,310,770
Ensembl chr 2:187,234,674...187,318,512 		JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in ISO
IBA 		(PMID:21621375)
GO_REF:0000033 		RGD
GO_Central		 PMID:21621375 GO_REF:0000033 NCBI chr10:54,176,325...54,177,696
Ensembl chr10:54,176,325...54,177,696 		JBrowse link
G Slmap sarcolemma associated protein involved_in ISO
IBA 		(PMID:23064965)
GO_REF:0000033 		RGD
GO_Central		 PMID:23064965 GO_REF:0000033 NCBI chr16:1,673,964...1,791,902
Ensembl chr16:1,673,964...1,791,902 		JBrowse link
regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 involved_in ISO (PMID:25583114) RGD PMID:25583114 NCBI chr  X:156,579,669...156,601,448
Ensembl chr  X:156,579,785...156,601,446 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:104995 (PMID:15288121) 		Ensembl
RGD		 PMID:15288121 GO_REF:0000107 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:104990 (PMID:15288121) 		Ensembl
RGD		 PMID:15288121 GO_REF:0000107 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO
IEA 		(PMID:22736029)
GO_REF:0000107 		RGD
Ensembl		 PMID:22736029 GO_REF:0000107 NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239 		JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3759678 (PMID:16129705) 		Ensembl
RGD		 PMID:16129705 GO_REF:0000107 NCBI chr 6:78,382,849...78,406,037
Ensembl chr 6:78,382,855...78,406,201 		JBrowse link
regulation of ventricular cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO
IEA 		(PMID:17060380)
GO_REF:0000107 		RGD
Ensembl		 PMID:17060380 GO_REF:0000107 NCBI chr 4:147,137,993...147,153,967
Ensembl chr 4:147,137,797...147,153,967 		JBrowse link
G Gja1 gap junction protein, alpha 1 acts_upstream_of_or_within ISO MGI:1857177|MGI:95716 (PMID:10969038), (PMID:9109444) RGD PMID:9109444 PMID:10969038 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Gja5 gap junction protein, alpha 5 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
(PMID:26786475)
MGI:2445238|MGI:95713 (PMID:10515563), (PMID:10969038), (PMID:9501070) 		Ensembl
RGD		 PMID:9501070 PMID:10515563 PMID:10969038 PMID:26786475 GO_REF:0000107 NCBI chr 2:187,291,227...187,310,770
Ensembl chr 2:187,234,674...187,318,512 		JBrowse link
G Gpd1l glycerol-3-phosphate dehydrogenase 1 like involved_in ISO (PMID:17967977), (PMID:19666841) RGD PMID:17967977 PMID:19666841 NCBI chr 8:123,469,282...123,498,948
Ensembl chr 8:123,466,667...123,498,908 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO
IEA 		(PMID:20042427)
GO_REF:0000107 		RGD
Ensembl		 PMID:20042427 GO_REF:0000107 NCBI chr 8:49,527,529...49,550,019
Ensembl chr 8:49,527,577...49,550,018 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
IEA
ISS 		(PMID:18065446), (PMID:22529811), (PMID:7889574)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
BHF-UCL		 PMID:7889574 PMID:18065446 PMID:22529811 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470 		JBrowse link
G Smad7 SMAD family member 7 involved_in IEA
ISO 		GO_REF:0000107
(PMID:18952608) 		Ensembl
RGD		 PMID:18952608 GO_REF:0000107 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849 		JBrowse link
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