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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of systemic arterial blood pressure by renin-angiotensin
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Accession:GO:0003081 term browser browse the term
Definition:The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.
Synonyms:exact_synonym: blood pressure regulation by renin-angiotensin


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regulation of systemic arterial blood pressure by renin-angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme involved_in ISO
IBA 		GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ace2 angiotensin converting enzyme 2 involved_in ISO GO_Central GO_REF:0000119 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Ace3 angiotensin I converting enzyme 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:105,885,424...105,898,376
Ensembl chr11:105,885,501...105,896,269 		JBrowse link
G Enpep glutamyl aminopeptidase involved_in ISS
ISO 		UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 3:129,062,826...129,126,398
Ensembl chr 3:129,062,824...129,126,369 		JBrowse link
G Nox1 NADPH oxidase 1 acts_upstream_of_or_within IMP (PMID:16386251) MGI PMID:16386251 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705 		JBrowse link
angiotensin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme involved_in IMP
IDA
ISO 		(PMID:14757757)
(PMID:11303049), (PMID:18158355), (PMID:27649628) 		UniProt
GO_Central		 PMID:11303049 PMID:14757757 PMID:18158355 PMID:27649628 GO_REF:0000119 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ace2 angiotensin converting enzyme 2 involved_in IDA
IGI
IMP 		(PMID:18263657)
(PMID:23462816)
(PMID:20357030) 		MGI PMID:18263657 PMID:20357030 PMID:23462816 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Anpep alanyl aminopeptidase, membrane involved_in IMP (PMID:8876246) MGI PMID:8876246 NCBI chr 7:79,471,551...79,497,958
Ensembl chr 7:79,471,551...79,510,807 		JBrowse link
G Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 involved_in ISO
IEA 		GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr  X:12,453,998...12,483,290
Ensembl chr  X:12,454,040...12,483,288 		JBrowse link
G Cpa3 carboxypeptidase A3, mast cell involved_in IMP (PMID:15173164) MGI PMID:15173164 NCBI chr 3:20,269,780...20,296,373
Ensembl chr 3:20,269,784...20,296,345 		JBrowse link
G Enpep glutamyl aminopeptidase involved_in IDA
IMP 		(PMID:19228697)
(PMID:16889841) 		MGI PMID:16889841 PMID:19228697 NCBI chr 3:129,062,826...129,126,398
Ensembl chr 3:129,062,824...129,126,369 		JBrowse link
G Mme membrane metallo endopeptidase involved_in IGI
ISO
IMP 		(PMID:27649628)
(PMID:15283675)
(PMID:28559246) 		MGI PMID:15283675 PMID:27649628 PMID:28559246 NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451 		JBrowse link
G Prcp prolylcarboxypeptidase (angiotensinase C) involved_in IMP (PMID:27649628) MGI PMID:27649628 NCBI chr 7:92,524,461...92,583,789
Ensembl chr 7:92,523,678...92,583,791 		JBrowse link
G Prep prolyl endopeptidase involved_in IMP (PMID:27649628) MGI PMID:27649628 NCBI chr10:44,943,312...45,038,847
Ensembl chr10:44,943,299...45,043,294 		JBrowse link
G Ren1 renin 1 structural involved_in
acts_upstream_of_or_within 		ISO
IBA
IDA
IMP 		(PMID:27649628), (PMID:6337154)
(PMID:10617578) 		RGD
GO_Central
MGI		 PMID:6337154 PMID:10617578 PMID:21321306 PMID:27649628 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:5132599 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063 		JBrowse link
G Ren2 renin 2 tandem duplication of Ren1 involved_in ISO
IBA 		GO_Central GO_REF:0000033 GO_REF:0000096 GO_REF:0000119
angiotensin-mediated drinking behavior term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 involved_in ISO
IEA 		GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Agt angiotensinogen involved_in ISO RGD
GO_Central		 PMID:9622148 PMID:21281609 GO_REF:0000096 RGD:5129187 RGD:8549458 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Tacr1 tachykinin receptor 1 involved_in ISO
IEA 		RGD
GO_Central
Ensembl		 PMID:9437747 GO_REF:0000096 GO_REF:0000107 RGD:5147483 NCBI chr 6:82,378,990...82,537,085
Ensembl chr 6:82,379,315...82,537,085 		JBrowse link
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within IDA (PMID:10425188) MGI PMID:10425188 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Cyp2j5 cytochrome P450, family 2, subfamily j, polypeptide 5 acts_upstream_of_or_within IMP (PMID:18716027) MGI PMID:18716027 NCBI chr 4:96,517,010...96,552,391
Ensembl chr 4:96,517,010...96,552,391 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked acts_upstream_of_or_within IMP (PMID:15998684) MGI PMID:15998684 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Rhoa ras homolog family member A acts_upstream_of_or_within IMP (PMID:24335996) MGI PMID:24335996 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in IMP
IDA 		(PMID:10425188)
(PMID:27217404) 		MGI PMID:10425188 PMID:27217404 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 acts_upstream_of_or_within
involved_in 		IMP
IDA 		(PMID:10425188) MGI PMID:10425188 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked acts_upstream_of_or_within IMP (PMID:15998684) MGI PMID:15998684 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Mas1 MAS1 oncogene involved_in IMP (PMID:27217404) MGI PMID:27217404 NCBI chr17:13,056,981...13,087,037
Ensembl chr17:13,059,966...13,087,030 		JBrowse link
G Mrgprd MAS-related GPR, member D involved_in IMP (PMID:27217404) MGI PMID:27217404 NCBI chr 7:144,868,572...144,877,796
Ensembl chr 7:144,868,572...144,877,823 		JBrowse link
brain renin-angiotensin system term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within IDA (PMID:15499027), (PMID:9878677) MGI PMID:9878677 PMID:15499027 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a acts_upstream_of_or_within IMP (PMID:10880053)
(PMID:16585392) 		MGI PMID:10880053 PMID:16585392 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b NOT|acts_upstream_of_or_within IMP (PMID:10880053) MGI PMID:10880053 NCBI chr 3:20,368,637...20,421,341
Ensembl chr 3:20,368,637...20,421,341 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 acts_upstream_of_or_within IDA (PMID:9878677) MGI PMID:9878677 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Klk1b26 kallikrein 1-related petidase b26 acts_upstream_of_or_within IDA (PMID:16585392) MGI PMID:16585392 NCBI chr 7:43,662,102...43,666,393
Ensembl chr 7:43,661,592...43,666,392 		JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) ISO RGD PMID:17261648 RGD:1641980 NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase, polypeptide 2 acts_upstream_of_or_within IDA (PMID:16585392) MGI PMID:16585392 NCBI chr17:7,356,384...7,570,714
Ensembl chr17:7,292,942...7,570,726 		JBrowse link
maintenance of blood vessel diameter homeostasis by renin-angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a involved_in ISO
ISS 		GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b involved_in ISS
ISO 		UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 3:20,368,637...20,421,341
Ensembl chr 3:20,368,637...20,421,341 		JBrowse link
G Serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2 involved_in IMP (PMID:18436805) BHF-UCL PMID:18436805 NCBI chr11:75,322,562...75,330,327
Ensembl chr11:75,322,558...75,330,417 		JBrowse link
negative regulation of glomerular filtration by angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyba cytochrome b-245, alpha polypeptide involved_in ISO RGD
GO_Central		 PMID:17220186 GO_REF:0000096 RGD:2317863 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669 		JBrowse link
negative regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2r coagulation factor II thrombin receptor involved_in IDA (PMID:21859963) UniProt PMID:21859963 NCBI chr13:95,738,288...95,754,974
Ensembl chr13:95,738,311...95,754,995 		JBrowse link
positive regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 involved_in IDA (PMID:21859963) UniProt PMID:21859963 NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735 		JBrowse link
G Or51e2 olfactory receptor family 51 subfamily E member 2 involved_in IMP (PMID:23401498) UniProt PMID:23401498 NCBI chr 7:102,389,928...102,408,678
Ensembl chr 7:102,387,718...102,408,678 		JBrowse link
regulation of angiotensin levels in blood term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpa3 carboxypeptidase A3, mast cell acts_upstream_of_or_within IGI (PMID:15173164) MGI PMID:15173164 NCBI chr 3:20,269,780...20,296,373
Ensembl chr 3:20,269,784...20,296,345 		JBrowse link
G Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 involved_in ISO RGD
GO_Central		 PMID:25715999 GO_REF:0000096 RGD:401794570 NCBI chr 7:24,069,750...24,084,635
Ensembl chr 7:24,069,688...24,086,115 		JBrowse link
G Mcpt4 mast cell protease 4 acts_upstream_of_or_within IGI (PMID:15173164) MGI PMID:15173164 NCBI chr14:56,297,201...56,299,767
Ensembl chr14:56,297,086...56,299,770 		JBrowse link
G Ndst2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 acts_upstream_of_or_within IMP (PMID:15173164) MGI PMID:15173164 NCBI chr14:20,773,798...20,784,638
Ensembl chr14:20,773,798...20,784,630 		JBrowse link
regulation of blood volume by renin-angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd3 dopamine receptor D3 acts_upstream_of_or_within IMP
IGI 		(PMID:9691085) MGI PMID:9691085 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295 		JBrowse link
G Nkx2-1 NK2 homeobox 1 involved_in ISO RGD
GO_Central		 PMID:12730191 GO_REF:0000096 RGD:1600160 NCBI chr12:56,578,741...56,583,570
Ensembl chr12:56,578,743...56,583,693 		JBrowse link
G Ren1 renin 1 structural acts_upstream_of_or_within IMP (PMID:10617578) MGI PMID:10617578 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063 		JBrowse link
regulation of renal output by angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within IMP (PMID:11606482)
(PMID:9507198), (PMID:9852267) 		MGI PMID:9507198 PMID:9852267 PMID:11606482 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a acts_upstream_of_or_within IMP (PMID:12167595) MGI PMID:12167595 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 acts_upstream_of_or_within IMP (PMID:17255527) MGI PMID:17255527 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
G Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 involved_in ISO RGD
GO_Central		 PMID:25715999 GO_REF:0000096 RGD:401794570 NCBI chr 7:24,069,750...24,084,635
Ensembl chr 7:24,069,688...24,086,115 		JBrowse link
regulation of systemic arterial blood pressure by circulatory renin-angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within IMP (PMID:12574102)
(PMID:10076178), (PMID:11606482), (PMID:7989296), (PMID:9507198), (PMID:9852267)
(PMID:9466969) 		MGI PMID:7989296 PMID:9466969 PMID:9507198 PMID:9852267 PMID:10076178 More... NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a acts_upstream_of_or_within IGI (PMID:9466969) MGI PMID:9466969 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b acts_upstream_of_or_within IGI (PMID:9466969) MGI PMID:9466969 NCBI chr 3:20,368,637...20,421,341
Ensembl chr 3:20,368,637...20,421,341 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 involved_in IMP (PMID:7477267) BHF-UCL PMID:7477267 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 acts_upstream_of_or_within IMP (PMID:16118390) MGI PMID:16118390 NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,467...74,728,167 		JBrowse link
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within IMP (PMID:11606482) MGI PMID:11606482 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a acts_upstream_of_or_within IMP (PMID:12167595) MGI PMID:12167595 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Comt catechol-O-methyltransferase acts_upstream_of_or_within IMP (PMID:19139376) MGI PMID:19139376 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602 		JBrowse link
G Ednrb endothelin receptor type B involved_in IMP (PMID:16868309) MGI PMID:16868309 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 involved_in ISO (PMID:8901832) BHF-UCL PMID:8901832 NCBI chr19:17,409,678...17,815,076
Ensembl chr19:17,409,683...17,814,996 		JBrowse link
G Sucnr1 succinate receptor 1 acts_upstream_of_or_within IMP (PMID:18535668) MGI PMID:18535668 NCBI chr 3:59,989,290...59,994,987
Ensembl chr 3:59,989,290...59,994,987 		JBrowse link
renin-angiotensin regulation of aldosterone production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in
acts_upstream_of_or_within 		ISO
IMP 		(PMID:10076178), (PMID:9852267) RGD
GO_Central
MGI		 PMID:9852267 PMID:10076178 PMID:21318332 GO_REF:0000096 RGD:5129178 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a involved_in
acts_upstream_of_or_within 		ISO
IMP 		(PMID:12167595) RGD
GO_Central
MGI		 PMID:12167595 PMID:21318332 GO_REF:0000096 RGD:5129178 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 involved_in ISO
IEA 		RGD
GO_Central
Ensembl		 PMID:21318332 GO_REF:0000096 GO_REF:0000107 RGD:5129178 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Ren1 renin 1 structural acts_upstream_of_or_within IDA (PMID:19293336) MGI PMID:19293336 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28626
    multicellular organismal process 9119
      system process 3354
        endocrine process 131
          regulation of systemic arterial blood pressure by hormone 56
            regulation of systemic arterial blood pressure by renin-angiotensin 42
              maintenance of blood vessel diameter homeostasis by renin-angiotensin + 10
              regulation of blood volume by renin-angiotensin + 13
              regulation of systemic arterial blood pressure by circulatory renin-angiotensin + 27
              regulation of systemic arterial blood pressure by local renal renin-angiotensin 0
Path 2
Term Annotations click to browse term
  biological_process 28626
    multicellular organismal process 9119
      system process 3354
        circulatory system process 636
          blood circulation 606
            regulation of blood pressure 242
              regulation of systemic arterial blood pressure 144
                regulation of systemic arterial blood pressure mediated by a chemical signal 67
                  regulation of systemic arterial blood pressure by hormone 56
                    regulation of systemic arterial blood pressure by renin-angiotensin 42
                      maintenance of blood vessel diameter homeostasis by renin-angiotensin + 10
                      regulation of blood volume by renin-angiotensin + 13
                      regulation of systemic arterial blood pressure by circulatory renin-angiotensin + 27
                      regulation of systemic arterial blood pressure by local renal renin-angiotensin 0
paths to the root