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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of systemic arterial blood pressure by renin-angiotensin
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Accession:GO:0003081 term browser browse the term
Definition:The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.
Synonyms:exact_synonym: blood pressure regulation by renin-angiotensin

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regulation of systemic arterial blood pressure by renin-angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 involved_in ISO (PMID:18258853) BHF-UCL PMID:18258853 NCBI chrNW_004955519:2,591,229...2,643,705
Ensembl chrNW_004955519:2,591,248...2,633,495 		JBrowse link
G Enpep glutamyl aminopeptidase involved_in ISO (PMID:19608358) UniProt PMID:19608358 NCBI chrNW_004955457:15,863,881...15,943,074 JBrowse link
G Nox1 NADPH oxidase 1 acts_upstream_of_or_within ISO (PMID:16386251) MGI PMID:16386251 NCBI chrNW_004955503:6,973,965...7,020,182
Ensembl chrNW_004955503:6,974,239...6,997,618 		JBrowse link
angiotensin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 involved_in ISO (PMID:18263657)
(PMID:23462816)
(PMID:20357030) 		MGI PMID:18263657 PMID:20357030 PMID:23462816 NCBI chrNW_004955519:2,591,229...2,643,705
Ensembl chrNW_004955519:2,591,248...2,633,495 		JBrowse link
G Anpep alanyl aminopeptidase, membrane involved_in ISO (PMID:8876246) MGI PMID:8876246 NCBI chrNW_004955416:15,415,981...15,442,032
Ensembl chrNW_004955416:15,424,932...15,444,075 		JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in ISO (PMID:12045255), (PMID:15746149) HGNC-UCL PMID:12045255 PMID:15746149 NCBI chrNW_004955565:2,006,154...2,029,921 JBrowse link
G Cpa3 carboxypeptidase A3 involved_in ISO (PMID:15173164) MGI PMID:15173164 NCBI chrNW_004955474:8,602,958...8,626,436
Ensembl chrNW_004955474:8,602,958...8,626,436 		JBrowse link
G Enpep glutamyl aminopeptidase involved_in ISO (PMID:19228697)
(PMID:16889841) 		MGI PMID:16889841 PMID:19228697 NCBI chrNW_004955457:15,863,881...15,943,074 JBrowse link
G Mme membrane metalloendopeptidase involved_in ISO (PMID:27649628)
(PMID:28559246) 		MGI PMID:27649628 PMID:28559246 NCBI chrNW_004955448:6,193,113...6,311,666
Ensembl chrNW_004955448:6,226,059...6,314,949 		JBrowse link
G Prcp prolylcarboxypeptidase involved_in ISO (PMID:27649628) MGI PMID:27649628 NCBI chrNW_004955414:9,631,223...9,700,537
Ensembl chrNW_004955414:9,631,223...9,700,184 		JBrowse link
G Prep prolyl endopeptidase involved_in ISO (PMID:27649628) MGI PMID:27649628 NCBI chrNW_004955411:30,698,112...30,797,096
Ensembl chrNW_004955411:30,698,112...30,835,923 		JBrowse link
G Ren renin involved_in
acts_upstream_of_or_within 		ISO (PMID:27649628), (PMID:6337154)
(PMID:10617578)
(PMID:12045255) 		RGD
MGI
HGNC-UCL		 PMID:6337154 PMID:10617578 PMID:12045255 PMID:21321306 PMID:27649628 RGD:5132599 NCBI chrNW_004955406:40,016,624...40,026,286
Ensembl chrNW_004955406:40,016,630...40,026,286 		JBrowse link
angiotensin-mediated drinking behavior term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 involved_in ISO (PMID:18258853) BHF-UCL PMID:18258853 NCBI chrNW_004955519:2,591,229...2,643,705
Ensembl chrNW_004955519:2,591,248...2,633,495 		JBrowse link
G Agt angiotensinogen ISO RGD PMID:9622148 PMID:21281609 RGD:5129187 RGD:8549458 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:9437747 RGD:5147483 NCBI chrNW_004955424:10,614,340...10,761,872
Ensembl chrNW_004955424:10,614,340...10,761,872 		JBrowse link
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within ISO (PMID:10425188) MGI PMID:10425188 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase acts_upstream_of_or_within ISO (PMID:15998684) MGI PMID:15998684 NCBI chrNW_004955580:1,045,294...1,058,129
Ensembl chrNW_004955580:1,045,294...1,057,083 		JBrowse link
G Rhoa ras homolog family member A acts_upstream_of_or_within ISO (PMID:24335996) MGI PMID:24335996 NCBI chrNW_004955532:1,300,821...1,347,453
Ensembl chrNW_004955532:1,300,462...1,347,451 		JBrowse link
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO (PMID:27217404)
(PMID:10425188) 		MGI PMID:10425188 PMID:27217404 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357 		JBrowse link
G Agtr2 angiotensin II receptor type 2 acts_upstream_of_or_within
involved_in 		ISO (PMID:10425188) MGI PMID:10425188 NCBI chrNW_004955534:3,653,112...3,654,248
Ensembl chrNW_004955534:3,653,157...3,654,248 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase acts_upstream_of_or_within ISO (PMID:15998684) MGI PMID:15998684 NCBI chrNW_004955580:1,045,294...1,058,129
Ensembl chrNW_004955580:1,045,294...1,057,083 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor involved_in ISO (PMID:27217404) MGI PMID:27217404 NCBI chrNW_004955439:20,956,862...20,957,839
Ensembl chrNW_004955439:20,956,862...20,957,839 		JBrowse link
G Mrgprd MAS related GPR family member D involved_in ISO (PMID:27217404) MGI PMID:27217404 NCBI chrNW_004955422:16,980,896...16,981,906
Ensembl chrNW_004955422:16,980,932...16,981,903 		JBrowse link
brain renin-angiotensin system term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within ISO (PMID:15499027), (PMID:9878677) MGI PMID:9878677 PMID:15499027 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357 		JBrowse link
G Agtr2 angiotensin II receptor type 2 acts_upstream_of_or_within ISO (PMID:9878677) MGI PMID:9878677 NCBI chrNW_004955534:3,653,112...3,654,248
Ensembl chrNW_004955534:3,653,157...3,654,248 		JBrowse link
G Mif macrophage migration inhibitory factor ISO RGD PMID:17261648 RGD:1641980 NCBI chrNW_004955455:8,367,566...8,368,460
Ensembl chrNW_004955455:8,367,566...8,368,460 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 acts_upstream_of_or_within ISO (PMID:16585392) MGI PMID:16585392 NCBI chrNW_004955439:15,210,882...15,487,305
Ensembl chrNW_004955439:15,332,165...15,487,305 		JBrowse link
maintenance of blood vessel diameter homeostasis by renin-angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO (PMID:1567413) UniProt PMID:1567413 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357 		JBrowse link
G Agtr1 angiotensin II receptor type 1 involved_in ISO (PMID:25913193), (PMID:26420482)
(PMID:8168620) 		UniProt PMID:8168620 PMID:25913193 PMID:26420482 NCBI chrNW_004955474:8,733,942...8,781,305
Ensembl chrNW_004955474:8,733,942...8,781,255 		JBrowse link
G Serpinf2 serpin family F member 2 involved_in ISO (PMID:18436805) BHF-UCL PMID:18436805 NCBI chrNW_004955481:1,441,262...1,449,078
Ensembl chrNW_004955481:1,442,010...1,449,242 		JBrowse link
negative regulation of glomerular filtration by angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC102004641 cytochrome b-245 light chain ISO RGD PMID:17220186 RGD:2317863 NCBI chrNW_004955541:2,570,843...2,573,822
Ensembl chrNW_004955541:2,569,727...2,574,118 		JBrowse link
negative regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2r coagulation factor II thrombin receptor involved_in ISO (PMID:21859963) UniProt PMID:21859963 NCBI chrNW_004955425:24,144,905...24,164,498 JBrowse link
positive regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:21859963) UniProt PMID:21859963 NCBI chrNW_004955425:24,050,901...24,054,039 JBrowse link
regulation of angiotensin levels in blood term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpa3 carboxypeptidase A3 acts_upstream_of_or_within ISO (PMID:15173164) MGI PMID:15173164 NCBI chrNW_004955474:8,602,958...8,626,436
Ensembl chrNW_004955474:8,602,958...8,626,436 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ISO RGD PMID:25715999 RGD:401794570 NCBI chrNW_004955555:1,493,600...1,509,113
Ensembl chrNW_004955555:1,490,052...1,509,113 		JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 acts_upstream_of_or_within ISO (PMID:15173164) MGI PMID:15173164 NCBI chrNW_004955437:18,090,198...18,099,328
Ensembl chrNW_004955437:18,090,198...18,099,328 		JBrowse link
regulation of blood volume by renin-angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd3 dopamine receptor D3 acts_upstream_of_or_within ISO (PMID:9691085) MGI PMID:9691085 NCBI chrNW_004955427:14,219,519...14,252,178
Ensembl chrNW_004955427:14,219,594...14,252,178 		JBrowse link
G Nkx2-1 NK2 homeobox 1 ISO RGD PMID:12730191 RGD:1600160 NCBI chrNW_004955409:24,612,490...24,616,360
Ensembl chrNW_004955409:24,612,635...24,616,430 		JBrowse link
G Ren renin acts_upstream_of_or_within ISO (PMID:10617578) MGI PMID:10617578 NCBI chrNW_004955406:40,016,624...40,026,286
Ensembl chrNW_004955406:40,016,630...40,026,286 		JBrowse link
regulation of renal output by angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within ISO (PMID:11606482)
(PMID:9507198), (PMID:9852267) 		MGI PMID:9507198 PMID:9852267 PMID:11606482 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357 		JBrowse link
regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein alpha 5 acts_upstream_of_or_within ISO (PMID:17255527) MGI PMID:17255527 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ISO RGD PMID:25715999 RGD:401794570 NCBI chrNW_004955555:1,493,600...1,509,113
Ensembl chrNW_004955555:1,490,052...1,509,113 		JBrowse link
regulation of systemic arterial blood pressure by circulatory renin-angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within ISO (PMID:9466969)
(PMID:10076178), (PMID:11606482), (PMID:7989296), (PMID:9507198), (PMID:9852267)
(PMID:12574102) 		MGI PMID:7989296 PMID:9466969 PMID:9507198 PMID:9852267 PMID:10076178 More... NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357 		JBrowse link
G Agtr2 angiotensin II receptor type 2 involved_in ISO (PMID:7477267) BHF-UCL PMID:7477267 NCBI chrNW_004955534:3,653,112...3,654,248
Ensembl chrNW_004955534:3,653,157...3,654,248 		JBrowse link
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within ISO (PMID:11606482) MGI PMID:11606482 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357 		JBrowse link
renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase acts_upstream_of_or_within ISO (PMID:19139376) MGI PMID:19139376 NCBI chrNW_004955442:18,130,282...18,152,153
Ensembl chrNW_004955442:18,130,987...18,137,412 		JBrowse link
G Ednrb endothelin receptor type B involved_in ISO (PMID:16868309) MGI PMID:16868309 NCBI chrNW_004955404:29,394,253...29,425,358
Ensembl chrNW_004955404:29,394,164...29,425,358 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 involved_in ISO (PMID:8901832) BHF-UCL PMID:8901832 NCBI chrNW_004955512:2,914,834...3,333,440
Ensembl chrNW_004955512:2,917,243...3,333,688 		JBrowse link
G Sucnr1 succinate receptor 1 acts_upstream_of_or_within ISO (PMID:18535668) MGI PMID:18535668 NCBI chrNW_004955448:3,485,713...3,494,115
Ensembl chrNW_004955448:3,485,707...3,498,104 		JBrowse link
renin-angiotensin regulation of aldosterone production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within ISO (PMID:10076178), (PMID:9852267) RGD
MGI		 PMID:9852267 PMID:10076178 PMID:21318332 RGD:5129178 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357 		JBrowse link
G Agtr1 angiotensin II receptor type 1 ISO RGD PMID:21318332 RGD:5129178 NCBI chrNW_004955474:8,733,942...8,781,305
Ensembl chrNW_004955474:8,733,942...8,781,255 		JBrowse link
G Agtr2 angiotensin II receptor type 2 ISO RGD PMID:21318332 RGD:5129178 NCBI chrNW_004955534:3,653,112...3,654,248
Ensembl chrNW_004955534:3,653,157...3,654,248 		JBrowse link
G Ren renin acts_upstream_of_or_within ISO (PMID:19293336) MGI PMID:19293336 NCBI chrNW_004955406:40,016,624...40,026,286
Ensembl chrNW_004955406:40,016,630...40,026,286 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12628
    multicellular organismal process 6318
      system process 1746
        endocrine process 117
          regulation of systemic arterial blood pressure by hormone 45
            regulation of systemic arterial blood pressure by renin-angiotensin 33
              maintenance of blood vessel diameter homeostasis by renin-angiotensin + 8
              regulation of blood volume by renin-angiotensin + 11
              regulation of systemic arterial blood pressure by circulatory renin-angiotensin + 20
              regulation of systemic arterial blood pressure by local renal renin-angiotensin 0
Path 2
Term Annotations click to browse term
  biological_process 12628
    multicellular organismal process 6318
      system process 1746
        circulatory system process 525
          blood circulation 502
            regulation of blood pressure 205
              regulation of systemic arterial blood pressure 116
                regulation of systemic arterial blood pressure mediated by a chemical signal 56
                  regulation of systemic arterial blood pressure by hormone 45
                    regulation of systemic arterial blood pressure by renin-angiotensin 33
                      maintenance of blood vessel diameter homeostasis by renin-angiotensin + 8
                      regulation of blood volume by renin-angiotensin + 11
                      regulation of systemic arterial blood pressure by circulatory renin-angiotensin + 20
                      regulation of systemic arterial blood pressure by local renal renin-angiotensin 0
paths to the root