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ONTOLOGY REPORT - ANNOTATIONS

Term:skeletal muscle contraction
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Accession:GO:0003009 term browser browse the term
Definition:A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.


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skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car3 carbonic anhydrase 3 IEP RGD PMID:1508229 RGD:408427360 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Ccdc78 coiled-coil domain containing 78 involved_in ISO (PMID:22818856) RGD PMID:22818856 NCBI chr10:15,312,403...15,316,800
Ensembl chr10:14,807,710...14,812,282 		JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit involved_in IDA
IEA
ISO		 GO_REF:0000107
(PMID:8872460)		 Ensembl
RGD		 PMID:8872460 PMID:22461452 GO_REF:0000107, RGD:8549758 NCBI chr 3:78,862,286...78,877,353
Ensembl chr 3:58,454,744...58,469,840 		JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit IDA RGD PMID:22461452 RGD:8549758 NCBI chr10:54,999,943...55,015,137
Ensembl chr10:54,501,093...54,516,345 		JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit IDA RGD PMID:22461452 RGD:8549758 NCBI chr 9:95,310,316...95,318,734
Ensembl chr 9:87,862,407...87,870,833 		JBrowse link
G Chrne cholinergic receptor nicotinic epsilon subunit IDA RGD PMID:22461452 RGD:8549758 NCBI chr10:55,829,835...55,838,853
Ensembl chr10:55,331,212...55,335,530 		JBrowse link
G Chrng cholinergic receptor nicotinic gamma subunit IDA RGD PMID:22461452 RGD:8549758 NCBI chr 9:95,325,984...95,332,092
Ensembl chr 9:87,878,085...87,914,482 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex IEP RGD PMID:15888549 RGD:2298664 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 IEP RGD PMID:19188248 RGD:10401231 NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Homer1 homer scaffold protein 1 acts_upstream_of_or_within ISO
IEA		 MGI:3526529 (PMID:18268005)
GO_REF:0000107		 RGD
Ensembl		 PMID:18268005 GO_REF:0000107 NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:24,543,093...24,644,785 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 IEP functional overload RGD PMID:20851858 RGD:5686398 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEP RGD PMID:15888549 RGD:2298664 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Jsrp1 junctional sarcoplasmic reticulum protein 1 involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000107		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:9,539,997...9,556,730
Ensembl chr 7:8,901,609...8,906,055 		JBrowse link
G Myh14 myosin heavy chain 14 involved_in ISO
IEA		 (PMID:21480433)
GO_REF:0000107		 RGD
Ensembl		 PMID:21480433 GO_REF:0000107 NCBI chr 1:104,232,778...104,295,369
Ensembl chr 1:95,096,266...95,158,836 		JBrowse link
G Myh3 myosin heavy chain 3 involved_in ISO
IEA		 (PMID:16642020)
GO_REF:0000107		 RGD
Ensembl		 PMID:16642020 GO_REF:0000107 NCBI chr10:52,269,185...52,293,000
Ensembl chr10:51,770,177...51,793,992 		JBrowse link
G Myh7 myosin heavy chain 7 involved_in ISO
IEA		 (PMID:7883988)
GO_REF:0000107		 RGD
Ensembl		 PMID:7883988 GO_REF:0000107 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Myh8 myosin heavy chain 8 involved_in ISO
IEA		 (PMID:17041932)
GO_REF:0000107		 RGD
Ensembl		 PMID:17041932 GO_REF:0000107 NCBI chr10:52,462,509...52,492,105
Ensembl chr10:51,963,510...51,993,232 		JBrowse link
G Rcsd1 RCSD domain containing 1 involved_in IEP
IBA		 PMID:15850461
GO_REF:0000033		 GO_Central PMID:15850461 GO_REF:0000033, RGD:8693359 NCBI chr13:80,434,878...80,497,312
Ensembl chr13:77,901,898...77,966,228 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 IEP RGD PMID:15033970 RGD:1643024 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Ryr1 ryanodine receptor 1 IEP RGD PMID:21993782 RGD:13782070 NCBI chr 1:93,420,078...93,551,305
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Stac SH3 and cysteine rich domain involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:120,409,165...120,531,394
Ensembl chr 8:111,530,800...111,654,008 		JBrowse link
G Stac2 SH3 and cysteine rich domain 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:83,528,741...83,544,583
Ensembl chr10:83,032,417...83,048,260 		JBrowse link
G Stac3 SH3 and cysteine rich domain 3 involved_in ISO
IEA
IBA		 (PMID:23736855)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:23736855 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:65,227,151...65,235,884
Ensembl chr 7:63,343,186...63,350,589 		JBrowse link
G Tcap titin-cap involved_in ISO
IBA		 (PMID:9817758)
GO_REF:0000033		 RGD
GO_Central		 PMID:9817758 GO_REF:0000033 NCBI chr10:83,878,006...83,879,174
Ensembl chr10:83,381,719...83,382,887 		JBrowse link
G Tlr4 toll-like receptor 4 IEP RGD PMID:20007518 RGD:4144081 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor IEP RGD PMID:20007518 RGD:4144081 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:6,408,607...6,412,070
Ensembl chr16:6,402,171...6,405,634 		JBrowse link
G Tnnc2 troponin C2, fast skeletal type involved_in ISO
IEA
IBA		 (PMID:17194691), (PMID:33755597)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:17194691 PMID:33755597 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:173,932,611...173,935,339
Ensembl chr 3:153,513,271...153,516,029 		JBrowse link
G Tnni1 troponin I1, slow skeletal type involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:49,781,529...49,793,385
Ensembl chr13:47,229,216...47,241,644 		JBrowse link
G Tnni2 troponin I2, fast skeletal type involved_in ISO
IBA		 (PMID:17194691)
GO_REF:0000033		 RGD
GO_Central		 PMID:17194691 GO_REF:0000033 NCBI chr 1:206,882,358...207,027,034
Ensembl chr 1:197,594,813...197,597,560 		JBrowse link
G Tnni3 troponin I3, cardiac type involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Tnnt1 troponin T1, slow skeletal type involved_in ISO
IEA		 (PMID:10952871)
GO_REF:0000107		 RGD
Ensembl		 PMID:10952871 GO_REF:0000107 NCBI chr 1:78,349,035...78,359,394
Ensembl chr 1:69,306,362...69,316,721 		JBrowse link
G Tnnt3 troponin T3, fast skeletal type involved_in ISO
IBA		 (PMID:17194691)
GO_REF:0000033		 RGD
GO_Central		 PMID:17194691 GO_REF:0000033 NCBI chr 1:207,082,014...207,099,014
Ensembl chr 1:197,652,431...197,669,535 		JBrowse link
diaphragm contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 IDA RGD PMID:17362795 RGD:4145100 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 acts_upstream_of_or_within ISO
IEA		 MGI:2151208 (PMID:30391828)
GO_REF:0000107		 RGD
Ensembl		 PMID:30391828 GO_REF:0000107 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Gaa alpha glucosidase involved_in
acts_upstream_of_or_within		 ISO (PMID:16917947)
MGI:2148550 (PMID:15169761)		 RGD PMID:15169761 PMID:16917947 NCBI chr10:105,028,106...105,045,365
Ensembl chr10:104,529,747...104,546,836 		JBrowse link
G Selenon selenoprotein N acts_upstream_of_or_within ISO
IEA		 MGI:109247 (PMID:30391828)
GO_REF:0000107		 RGD
Ensembl		 PMID:30391828 GO_REF:0000107 NCBI chr 5:152,032,330...152,046,707
Ensembl chr 5:146,748,652...146,763,059 		JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type IDA RGD PMID:14985239 RGD:1598612 NCBI chr16:6,408,607...6,412,070
Ensembl chr16:6,402,171...6,405,634 		JBrowse link
fast-twitch skeletal muscle fiber contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Synm synemin involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
MGI:5548847 (PMID:25567810)		 GO_Central
Ensembl
RGD		 PMID:25567810 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:130,743,891...130,774,254
Ensembl chr 1:121,333,720...121,363,652 		JBrowse link
involuntary skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp8a2 ATPase phospholipid transporting 8A2 acts_upstream_of_or_within ISO
IEA		 MGI:1856273 (PMID:1634998)
GO_REF:0000107		 RGD
Ensembl		 PMID:1634998 GO_REF:0000107 NCBI chr15:37,993,507...38,526,408
Ensembl chr15:33,819,755...34,350,223 		JBrowse link
neurotransmitter secretion involved in regulation of skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 IMP RGD PMID:29530712 RGD:40924655 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
positive regulation of fast-twitch skeletal muscle fiber contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07005775.1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Actn3 actinin alpha 3 involved_in ISO
IEA		 (PMID:18178581)
GO_REF:0000107		 RGD
Ensembl		 PMID:18178581 GO_REF:0000107 NCBI chr 1:211,588,473...211,604,401
Ensembl chr 1:202,159,082...202,175,012 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 involved_in ISO
IEA
ISS		 (PMID:12479237)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:12479237 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:190,457,198...190,475,410
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Mylk2 myosin light chain kinase 2 IMP RGD PMID:12748068 RGD:1580242 NCBI chr 3:161,836,705...161,848,609
Ensembl chr 3:141,376,691...141,387,728 		JBrowse link
positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsto1 glutathione S-transferase omega 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:11035031)		 Ensembl
RGD		 PMID:11035031 GO_REF:0000107 NCBI chr 1:256,662,377...256,672,515
Ensembl chr 1:246,721,221...246,731,468 		JBrowse link
regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmpk DM1 protein kinase acts_upstream_of_or_within ISO
IEA		 MGI:2182402 (PMID:11526199)
GO_REF:0000107		 RGD
Ensembl		 PMID:11526199 GO_REF:0000107 NCBI chr 1:87,858,294...87,868,624
Ensembl chr 1:78,730,275...78,740,593 		JBrowse link
regulation of skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrd1 adhesion G protein-coupled receptor D1 involved_in ISO (PMID:39884271) RGD PMID:39884271 NCBI chr12:33,124,981...33,239,778
Ensembl chr12:27,488,908...27,603,696 		JBrowse link
G Cav3 caveolin 3 involved_in ISO
IEA		 (PMID:17524427)
GO_REF:0000107		 RGD
Ensembl		 PMID:17524427 GO_REF:0000107 NCBI chr 4:147,137,993...147,153,967
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
G Dmd dystrophin involved_in ISO
IEA		 (PMID:19198614)
GO_REF:0000107		 RGD
Ensembl		 PMID:19198614 GO_REF:0000107 NCBI chr  X:51,070,098...53,437,845
Ensembl chr  X:47,272,331...49,504,207 		JBrowse link
G Grcc10 gene rich cluster, C10 gene involved_in ISO (PMID:23453665), (PMID:23633300), (PMID:24798461) RGD PMID:23453665 PMID:23633300 PMID:24798461 NCBI chr 4:159,237,562...159,239,223 JBrowse link
G Slc8a3 solute carrier family 8 member A3 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:14722618)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:14722618 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:106,605,611...106,739,208
Ensembl chr 6:100,874,369...101,007,508 		JBrowse link
regulation of skeletal muscle contraction by action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn4a sodium voltage-gated channel alpha subunit 4 involved_in ISO
ISS
IEA		 (PMID:12766226)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:12766226 GO_REF:0000024 GO_REF:0000107 NCBI chr10:91,745,459...91,796,452
Ensembl chr10:91,246,936...91,296,545 		JBrowse link
regulation of skeletal muscle contraction by calcium ion signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmpk DM1 protein kinase involved_in IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:9294109)		 GO_Central
Ensembl
RGD		 PMID:9294109 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:87,858,294...87,868,624
Ensembl chr 1:78,730,275...78,740,593 		JBrowse link
G Rem1 RRAD and GEM like GTPase 1 acts_upstream_of_or_within ISO
IEA		 (PMID:26078055)
GO_REF:0000107		 RGD
Ensembl		 PMID:26078055 GO_REF:0000107 NCBI chr 3:161,563,984...161,572,478
Ensembl chr 3:141,103,766...141,112,203 		JBrowse link
regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkd1 protein kinase D1 IMP RGD PMID:21041300 RGD:243065274 NCBI chr 6:73,460,640...73,774,433
Ensembl chr 6:67,725,905...68,039,042 		JBrowse link
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casq1 calsequestrin 1 involved_in
acts_upstream_of_or_within		 ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000107
(PMID:22049211)
MGI:3530841 (PMID:17627988)
GO_REF:0000033		 UniProt
Ensembl
RGD
GO_Central		 PMID:17627988 PMID:22049211 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:87,203,021...87,212,710
Ensembl chr13:84,670,649...84,680,339 		JBrowse link
G Dmd dystrophin involved_in ISO
IEA		 (PMID:19198614)
GO_REF:0000107		 RGD
Ensembl		 PMID:19198614 GO_REF:0000107 NCBI chr  X:51,070,098...53,437,845
Ensembl chr  X:47,272,331...49,504,207 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO (PMID:7592869) RGD PMID:7592869 NCBI chr 3:160,500,748...160,520,492
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 involved_in ISO (PMID:17023043) RGD PMID:17023043 NCBI chr 2:198,312,179...198,316,962
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm7 glutathione S-transferase, mu 7 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:198,254,872...198,260,365
Ensembl chr 2:195,566,701...195,572,203 		JBrowse link
regulation of skeletal muscle contraction via regulation of action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 involved_in ISO
IEA		 (PMID:11371347)
GO_REF:0000107		 RGD
Ensembl		 PMID:11371347 GO_REF:0000107 NCBI chr10:96,560,225...96,570,788
Ensembl chr10:96,060,821...96,071,445 		JBrowse link
regulation of slow-twitch skeletal muscle fiber contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myh7 myosin heavy chain 7 involved_in IEA
ISO		 GO_REF:0000107
(PMID:7883988)		 Ensembl
RGD		 PMID:7883988 GO_REF:0000107 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Strit1 small transmembrane regulator of ion transport 1 involved_in ISO
IEA		 (PMID:26816378)
GO_REF:0000002		 RGD
InterPro		 PMID:26816378 GO_REF:0000002 NCBI chr 2:150,084,857...150,087,721
Ensembl chr 2:147,935,222...147,938,083 		JBrowse link
regulation of the force of skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 involved_in ISO
IEA		 (PMID:17828264)
GO_REF:0000107		 RGD
Ensembl		 PMID:17828264 GO_REF:0000107 NCBI chr 1:211,588,473...211,604,401
Ensembl chr 1:202,159,082...202,175,012 		JBrowse link
G Kbtbd13 kelch repeat and BTB domain containing 13 acts_upstream_of_or_within ISO (PMID:31671076)
MGI:6469320 (PMID:31671076)		 RGD PMID:31671076 NCBI chr 8:74,804,981...74,806,718 JBrowse link
G Myh7 myosin heavy chain 7 involved_in IEA
ISO		 GO_REF:0000107
(PMID:7883988)		 Ensembl
RGD		 PMID:7883988 GO_REF:0000107 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
slow-twitch skeletal muscle fiber contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mb myoglobin IEP RGD PMID:15981298 RGD:1582404 NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:108,759,904...108,767,383 		JBrowse link
G Tnnt1 troponin T1, slow skeletal type involved_in IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:15788488 GO_REF:0000033, RGD:1599482 NCBI chr 1:78,349,035...78,359,394
Ensembl chr 1:69,306,362...69,316,721 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    multicellular organismal process 9017
      multicellular organismal movement 81
        musculoskeletal movement 77
          skeletal muscle contraction 62
            involuntary skeletal muscle contraction + 6
            regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 1
            regulation of skeletal muscle contraction + 23
            voluntary skeletal muscle contraction + 9
Path 2
Term Annotations click to browse term
  biological_process 20558
    multicellular organismal process 9017
      system process 3580
        muscle system process 496
          muscle contraction 356
            striated muscle contraction 210
              skeletal muscle contraction 62
                involuntary skeletal muscle contraction + 6
                regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 1
                regulation of skeletal muscle contraction + 23
                voluntary skeletal muscle contraction + 9
paths to the root