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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of myeloid leukocyte differentiation
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Accession:GO:0002762 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.
Synonyms:exact_synonym: down regulation of myeloid leukocyte differentiation;   downregulation of myeloid leukocyte differentiation
 narrow_synonym: inhibition of myeloid leukocyte differentiation


show annotations for term's descendants           Sort by:
negative regulation of myeloid leukocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:11672542) RGD PMID:11672542 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 IDA RGD PMID:7737424 RGD:2299083 NCBI chr10:79,403,939...79,426,620
Ensembl chr10:78,906,083...78,916,408 		JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 IDA RGD PMID:7737424 RGD:2299083 NCBI chr10:79,394,999...79,400,418
Ensembl chr10:78,897,770...78,903,538
Ensembl chr20:78,897,770...78,903,538 		JBrowse link
negative regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO
ISS		 (PMID:10961870)
GO_REF:0000024		 RGD
UniProt		 PMID:10961870 GO_REF:0000024 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G C1qc complement C1q C chain involved_in ISO
IEA		 (PMID:10961870)
GO_REF:0000107		 RGD
Ensembl		 PMID:10961870 GO_REF:0000107 NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:21029969)		 UniProt
RGD		 PMID:21029969 GO_REF:0000024 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Cul4a cullin 4A acts_upstream_of_or_within ISO (PMID:12393421) RGD PMID:12393421 NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO MGI:2386884 (PMID:9620849) RGD PMID:9620849 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Prdm16 PR/SET domain 16 involved_in ISO (PMID:12816872) RGD PMID:12816872 NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601 		JBrowse link
G Rara retinoic acid receptor, alpha involved_in ISO (PMID:19917671) RGD PMID:19917671 NCBI chr10:84,379,780...84,424,371
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Runx1 RUNX family transcription factor 1 involved_in ISO (PMID:9199349) RGD PMID:9199349 NCBI chr11:45,325,778...45,560,300
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within ISO MGI:5320483 (PMID:22615127) RGD PMID:22615127 NCBI chr 3:168,497,294...168,567,799
Ensembl chr 3:168,499,583...168,568,782 		JBrowse link
negative regulation of macrophage differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO
ISS		 (PMID:10961870)
GO_REF:0000024		 RGD
UniProt		 PMID:10961870 GO_REF:0000024 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G C1qc complement C1q C chain involved_in ISO
IEA		 (PMID:10961870)
GO_REF:0000107		 RGD
Ensembl		 PMID:10961870 GO_REF:0000107 NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G Gata2 GATA binding protein 2 acts_upstream_of_or_within ISO (PMID:16254139) RGD PMID:16254139 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
G Mir486 microRNA 486 involved_in ISO (PMID:25857263) RGD PMID:25857263
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:16705167)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16705167 GO_REF:0000024 GO_REF:0000107 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Qki QKI, KH domain containing RNA binding involved_in ISS
ISO		 GO_REF:0000024
(PMID:22398723)		 UniProt
RGD		 PMID:22398723 GO_REF:0000024 NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831 		JBrowse link
G Thoc5 THO complex subunit 5 acts_upstream_of_or_within ISO (PMID:10597251) RGD PMID:10597251 NCBI chr14:79,758,805...79,792,718
Ensembl chr14:79,758,917...79,792,718 		JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within ISO MGI:5320483 (PMID:22615127) RGD PMID:22615127 NCBI chr 3:168,497,294...168,567,799
Ensembl chr 3:168,499,583...168,568,782 		JBrowse link
negative regulation of mast cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zfpm1 zinc finger protein, multitype 1 involved_in ISO (PMID:18063754) RGD PMID:18063754 NCBI chr19:50,334,352...50,391,029
Ensembl chr19:50,334,682...50,390,591 		JBrowse link
negative regulation of monocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apcs amyloid P component, serum involved_in IEA
ISO		 GO_REF:0000107
(PMID:14607961)		 Ensembl
RGD		 PMID:14607961 GO_REF:0000107 NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 involved_in ISO (PMID:26542173) RGD PMID:26542173 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Gpr68 G protein-coupled receptor 68 acts_upstream_of_or_within ISO MGI:3849457 (PMID:19479052) RGD PMID:19479052 NCBI chr 6:120,135,620...120,166,089
Ensembl chr 6:120,135,436...120,166,089 		JBrowse link
G Hoxa7 homeobox A7 involved_in ISO
IEA		 (PMID:14704364)
GO_REF:0000107		 RGD
Ensembl		 PMID:14704364 GO_REF:0000107 NCBI chr 4:81,315,730...81,317,629
Ensembl chr 4:81,314,625...81,317,659 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2386884 (PMID:9620849)		 Ensembl
RGD		 PMID:9620849 GO_REF:0000107 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Mir125b1 microRNA 125b-1 involved_in ISO (PMID:28389358) RGD PMID:28389358 NCBI chr 8:50,850,036...50,850,122
Ensembl chr 8:41,952,966...41,953,052 		JBrowse link
G Mir125b2 microRNA 125b-2 involved_in ISO (PMID:28389358) RGD PMID:28389358 NCBI chr11:16,245,620...16,245,707 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor involved_in ISO
ISS		 (PMID:9924025)
GO_REF:0000024		 RGD
UniProt		 PMID:9924025 GO_REF:0000024 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Zbtb46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within ISO MGI:5320483 (PMID:22615127) RGD PMID:22615127 NCBI chr 3:168,497,294...168,567,799
Ensembl chr 3:168,499,583...168,568,782 		JBrowse link
negative regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:2386884 (PMID:9620849)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:9620849 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Trib1 tribbles pseudokinase 1 involved_in ISO (PMID:23515163) RGD PMID:23515163 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731 		JBrowse link
negative regulation of osteoclast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cldn18 claudin 18 acts_upstream_of_or_within ISO MGI:5007067 (PMID:22437732) RGD PMID:22437732 NCBI chr 8:109,125,819...109,145,110
Ensembl chr 8:100,247,633...100,273,351 		JBrowse link
G Fbn1 fibrillin 1 involved_in ISO (PMID:24039232) RGD PMID:24039232 NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:112,554,925...112,750,889 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 involved_in ISO (PMID:29149593) RGD PMID:29149593 NCBI chr 2:172,447,738...172,609,591
Ensembl chr 2:170,149,694...170,309,941 		JBrowse link
G Tjp2 tight junction protein 2 acts_upstream_of_or_within ISO (PMID:22437732) RGD PMID:22437732 NCBI chr 1:221,709,745...221,838,291
Ensembl chr 1:221,709,745...221,838,295 		JBrowse link
negative regulation of osteoclast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha involved_in ISO (PMID:10822112) RGD PMID:10822112 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 involved_in ISO
ISS		 (PMID:21403648)
GO_REF:0000024		 RGD
UniProt		 PMID:21403648 GO_REF:0000024 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (PMID:25490771) RGD PMID:25490771 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Clec2d C-type lectin domain family 2, member D acts_upstream_of_or_within ISO (PMID:12374791) RGD PMID:12374791 NCBI chr 4:162,216,052...162,239,530
Ensembl chr 4:162,216,572...162,239,527 		JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2148567|MGI:3041864 (PMID:15866165)		 Ensembl
RGD		 PMID:15866165 GO_REF:0000107 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Erfe erythroferrone acts_upstream_of ISS
ISO		 GO_REF:0000024
(PMID:34002695)		 UniProt
RGD		 PMID:34002695 GO_REF:0000024 NCBI chr 9:91,956,971...91,964,846
Ensembl chr 9:91,956,977...91,964,846 		JBrowse link
G Fbn1 fibrillin 1 involved_in ISO (PMID:24039232) RGD PMID:24039232 NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:112,554,925...112,750,889 		JBrowse link
G Fstl3 follistatin like 3 involved_in ISO
IEA		 (PMID:15574124)
GO_REF:0000107		 RGD
Ensembl		 PMID:15574124 GO_REF:0000107 NCBI chr 7:9,923,574...9,929,223
Ensembl chr 7:9,923,576...9,939,639 		JBrowse link
G Gpr137 G protein-coupled receptor 137 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:204,129,636...204,132,622
Ensembl chr 1:204,129,636...204,133,082 		JBrowse link
G Gpr137b G protein-coupled receptor 137B involved_in ISO
IBA		 (PMID:31173907)
GO_REF:0000033		 RGD
GO_Central		 PMID:31173907 GO_REF:0000033 NCBI chr17:86,003,635...86,041,841
Ensembl chr17:85,966,921...86,041,835 		JBrowse link
G Gpr55 G protein-coupled receptor 55 involved_in ISO (PMID:19805329) RGD PMID:19805329 NCBI chr 9:94,037,748...94,081,426
Ensembl chr 9:86,590,885...86,640,613 		JBrowse link
G Iapp islet amyloid polypeptide acts_upstream_of_or_within ISO MGI:1346858|MGI:2656235 (PMID:14970190) RGD PMID:14970190 NCBI chr 4:176,968,097...176,975,363
Ensembl chr 4:175,237,115...175,242,920 		JBrowse link
G Ifnb1 interferon beta 1 acts_upstream_of_or_within ISO (PMID:17442941) RGD PMID:17442941 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (PMID:17442941) RGD PMID:17442941 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:12941478), (PMID:17442941) RGD PMID:12941478 PMID:17442941 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Inpp4b inositol polyphosphate-4-phosphatase type II B acts_upstream_of_or_within ISO MGI:102469|MGI:1100089 (PMID:21982707) RGD PMID:21982707 NCBI chr19:25,920,189...26,670,085
Ensembl chr19:25,925,358...26,280,634 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2386884 (PMID:12161749)		 Ensembl
RGD		 PMID:12161749 GO_REF:0000107 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:18802077) RGD PMID:18802077 NCBI chr 1:78,847,685...78,853,294
Ensembl chr 1:69,805,250...69,810,660 		JBrowse link
G Lrrc17 leucine rich repeat containing 17 involved_in ISO (PMID:19336404) RGD PMID:19336404 NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:13,501,436...13,531,845 		JBrowse link
G Mafb MAF bZIP transcription factor B involved_in ISS
ISO		 GO_REF:0000024
(PMID:19440205)		 UniProt
RGD		 PMID:19440205 GO_REF:0000024 NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031 		JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1100089|MGI:1339753|MGI:97583 (PMID:17053831)		 Ensembl
RGD		 PMID:17053831 GO_REF:0000107 NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,306,301...64,536,658 		JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:17442941)		 Ensembl
RGD		 PMID:17442941 GO_REF:0000107 NCBI chr 2:186,921,384...186,930,292
Ensembl chr 2:184,232,571...184,241,480 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:97306 (PMID:17053831)		 Ensembl
RGD		 PMID:17053831 GO_REF:0000107 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pilrb1 paired immunoglobin-like type 2 receptor beta 1 involved_in ISO (PMID:18802077) RGD PMID:18802077 NCBI chr12:18,516,161...18,525,375
Ensembl chr12:18,516,156...18,525,346 		JBrowse link
G Pirb paired Ig-like receptor B involved_in ISO (PMID:18802077) RGD PMID:18802077 NCBI chr 1:65,499,195...65,506,666
Ensembl chr 1:65,499,195...65,506,666 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 acts_upstream_of_or_within
involved_in		 IMP
ISO
IEA		 MGI:3045799 (PMID:14976225)
GO_REF:0000107		 RGD
Ensembl		 PMID:14976225 PMID:17540629 GO_REF:0000107, RGD:4107086 NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286 		JBrowse link
G Tcta T-cell leukemia translocation altered involved_in ISO (PMID:19560569) RGD PMID:19560569 NCBI chr 8:108,988,588...108,992,324
Ensembl chr 8:108,988,590...108,991,564 		JBrowse link
G Tmem178a transmembrane protein 178A involved_in ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:26644563)
GO_REF:0000033
GO_REF:0000107		 UniProt
RGD
GO_Central
Ensembl		 PMID:26644563 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:14,004,629...14,063,677
Ensembl chr 6:14,004,630...14,063,549 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 involved_in ISO (PMID:18586671) RGD PMID:18586671 NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B acts_upstream_of_or_within
involved_in		 ISO (PMID:29415886)
(PMID:9168977)		 RGD PMID:9168977 PMID:29415886 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tob2 transducer of ERBB2, 2 acts_upstream_of_or_within ISO MGI:3789484 (PMID:18358842) RGD PMID:18358842 NCBI chr 7:113,362,703...113,371,423
Ensembl chr 7:113,361,148...113,372,688 		JBrowse link
G Ubash3b ubiquitin associated and SH3 domain containing, B acts_upstream_of_or_within ISO (PMID:23149425) RGD PMID:23149425 NCBI chr 8:41,385,419...41,532,248
Ensembl chr 8:41,388,341...41,532,201 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20546
    cellular process 19536
      negative regulation of cellular process 5589
        negative regulation of cell differentiation 803
          negative regulation of myeloid cell differentiation 98
            negative regulation of myeloid leukocyte differentiation 59
              negative regulation of granulocyte differentiation + 10
              negative regulation of macrophage differentiation + 8
              negative regulation of mast cell differentiation 1
              negative regulation of monocyte differentiation 9
              negative regulation of osteoclast differentiation + 35
Path 2
Term Annotations click to browse term
  biological_process 20546
    cellular process 19536
      cellular developmental process 4830
        cell differentiation 4829
          cell development 3350
            regulation of cell development 974
              regulation of hemopoiesis 447
                negative regulation of hemopoiesis 134
                  negative regulation of leukocyte differentiation 126
                    negative regulation of myeloid leukocyte differentiation 59
                      negative regulation of granulocyte differentiation + 10
                      negative regulation of macrophage differentiation + 8
                      negative regulation of mast cell differentiation 1
                      negative regulation of monocyte differentiation 9
                      negative regulation of osteoclast differentiation + 35
paths to the root