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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of production of molecular mediator of immune response
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Accession:GO:0002701 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response.
Synonyms:exact_synonym: down regulation of production of molecular mediator of immune response;   downregulation of production of molecular mediator of immune response
 narrow_synonym: inhibition of production of molecular mediator of immune response



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negative regulation of antibacterial peptide production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spink5 serine peptidase inhibitor, Kazal type 5 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr18:36,264,452...36,333,143
Ensembl chr18:36,264,452...36,332,185
JBrowse link
negative regulation of cytokine production involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:20060382)
Ensembl
RGD
PMID:20060382 GO_REF:0000107 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
JBrowse link
G Apoa1 apolipoprotein A1 involved_in ISO
IEA
(PMID:12458630)
GO_REF:0000107
RGD
Ensembl
PMID:12458630 GO_REF:0000107 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apoa2 apolipoprotein A2 involved_in ISO (PMID:12458630) RGD PMID:12458630 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
JBrowse link
G Il10 interleukin 10 involved_in ISS
ISO
GO_REF:0000024
(PMID:10443688)
UniProt
RGD
PMID:10443688 GO_REF:0000024 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:10443688) RGD PMID:10443688 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
negative regulation of dendritic cell cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak3 Janus kinase 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:16020505)
BHF-UCL
RGD
PMID:16020505 GO_REF:0000024 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,386,405...18,398,536
JBrowse link
negative regulation of immunoglobulin production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd22 CD22 molecule involved_in ISO UniProtKB:Q80ZE3 (PMID:20200274) RGD PMID:20200274 NCBI chr 1:86,116,376...86,132,782
Ensembl chr 1:86,117,459...86,132,322
JBrowse link
G Fcgr2b Fc gamma receptor 2B acts_upstream_of_or_within ISO MGI:1857166 (PMID:12385742) RGD PMID:12385742 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Ifnb1 interferon beta 1 IDA RGD PMID:10494101 RGD:401854240 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2653910 (PMID:15944273)
Ensembl
RGD
PMID:15944273 GO_REF:0000107 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381
JBrowse link
G Il33 interleukin 33 involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P08226 (PMID:18268038)
Ensembl
RGD
PMID:18268038 GO_REF:0000107 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Siglec10 sialic acid binding Ig-like lectin 10 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:93,817,301...93,826,376
Ensembl chr 1:93,817,335...93,825,931
JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 involved_in ISO (PMID:19328063) RGD PMID:19328063 NCBI chr 7:130,527,313...130,542,567
Ensembl chr 7:130,527,316...130,543,633
JBrowse link
G Zpbp2 zona pellucida binding protein 2 acts_upstream_of_or_within ISO MGI:3762590 (PMID:29536159) RGD PMID:29536159 NCBI chr10:83,558,772...83,567,511
Ensembl chr10:83,559,016...83,567,508
JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in ISO (PMID:26000965) RGD PMID:26000965 NCBI chr 8:107,111,010...107,117,073
Ensembl chr 8:107,111,012...107,116,782
JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:103034|MGI:2158438 (PMID:10490661) RGD PMID:10490661 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:3696705 (PMID:16275384) RGD PMID:16275384 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3695433 (PMID:17137798)
Ensembl
RGD
PMID:17137798 GO_REF:0000107 NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311
JBrowse link
negative regulation of macrophage cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2180086 (PMID:11168643)
Ensembl
RGD
PMID:11168643 GO_REF:0000107 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Atg9a autophagy related 9A acts_upstream_of_or_within ISO (PMID:24670807) RGD PMID:24670807 NCBI chr 9:76,677,403...76,688,050
Ensembl chr 9:76,677,404...76,687,986
JBrowse link
G Axl Axl receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:107670 (PMID:16831897) RGD PMID:16831897 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265
JBrowse link
G Cuedc2 CUE domain containing 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:24882011)
MGI:5635142 (PMID:24882011)
GO_REF:0000107
RGD
Ensembl
PMID:24882011 GO_REF:0000107 NCBI chr 1:245,192,057...245,200,594
Ensembl chr 1:245,192,063...245,200,339
JBrowse link
G Epx eosinophil peroxidase acts_upstream_of_or_within ISO MGI:2182952 (PMID:16926417) RGD PMID:16926417 NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 involved_in ISO (PMID:12150927) RGD PMID:12150927 NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:55,653,962...55,713,121
JBrowse link
G Nlrx1 NLR family member X1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5141085 (PMID:21703540)
Ensembl
RGD
PMID:21703540 GO_REF:0000107 NCBI chr 8:44,588,476...44,606,678
Ensembl chr 8:44,590,048...44,606,484
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within ISO MGI:2680581 (PMID:15220916) RGD PMID:15220916 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Prg2 proteoglycan 2, pro eosinophil major basic protein involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3027719 (PMID:16926417)
Ensembl
RGD
PMID:16926417 GO_REF:0000107 NCBI chr 3:70,062,535...70,066,102
Ensembl chr 3:70,062,535...70,066,101
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS
(PMID:20875417)
GO_REF:0000024
RGD
AgBase
PMID:20875417 GO_REF:0000024 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:20875417)
AgBase
RGD
PMID:20875417 GO_REF:0000024 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfb3 transforming growth factor, beta 3 involved_in ISO
ISS
(PMID:20875417)
GO_REF:0000024
RGD
AgBase
PMID:20875417 GO_REF:0000024 NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Twist1 twist family bHLH transcription factor 1 acts_upstream_of_or_within ISO MGI:104685 (PMID:16831897) RGD PMID:16831897 NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Twist2 twist family bHLH transcription factor 2 acts_upstream_of_or_within ISO MGI:3044412|MGI:98872 (PMID:16831897) RGD PMID:16831897 NCBI chr 9:92,374,740...92,419,222
Ensembl chr 9:92,374,574...92,419,222
JBrowse link
negative regulation of mast cell cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:2158436 (PMID:15950739) RGD PMID:15950739 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:17234154 RGD:1601626 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:3051384 (PMID:16533754) RGD PMID:16533754 NCBI chr12:32,096,338...32,139,949
Ensembl chr12:26,460,175...26,503,744
JBrowse link
negative regulation of natural killer cell cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd96 CD96 molecule acts_upstream_of_or_within ISO MGI:5617136 (PMID:24658051) RGD PMID:24658051 NCBI chr11:54,702,290...54,776,618
Ensembl chr11:54,702,290...54,776,621
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:24018270) RGD PMID:24018270 NCBI chr20:3,403,418...3,479,476 JBrowse link
negative regulation of plasmacytoid dendritic cell cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bst2 bone marrow stromal cell antigen 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:19564354)
UniProt
RGD
PMID:19564354 GO_REF:0000024 NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979
JBrowse link
negative regulation of T cell cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in ISO (PMID:15466453), (PMID:23169781) RGD PMID:15466453 PMID:23169781 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Hfe homeostatic iron regulator involved_in ISO UniProtKB:P04439 (PMID:24643698) RGD PMID:24643698 NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:18420485) RGD PMID:18420485 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:24018270) RGD PMID:24018270 NCBI chr20:3,403,418...3,479,476 JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 involved_in ISO (PMID:11477403) RGD PMID:11477403 NCBI chr13:84,270,316...84,305,497
Ensembl chr13:84,270,316...84,305,497
JBrowse link
G Smad7 SMAD family member 7 involved_in IEA
ISO
GO_REF:0000107
(PMID:25642768)
Ensembl
RGD
PMID:25642768 GO_REF:0000107 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Vsir V-set immunoregulatory receptor acts_upstream_of_or_within ISO (PMID:21383057) RGD PMID:21383057 NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in ISO (PMID:10887101) RGD PMID:10887101 NCBI chr13:77,248,687...77,252,343
Ensembl chr13:77,248,717...77,252,329
JBrowse link
negative regulation of T-helper 2 cell cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:19360123)
Ensembl
RGD
PMID:19360123 GO_REF:0000107 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Ifnb1 interferon beta 1 involved_in ISO (PMID:20554961) RGD PMID:20554961 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:10761931), (PMID:23616576) RGD PMID:10761931 PMID:23616576 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    immune system process 3112
      production of molecular mediator of immune response 249
        negative regulation of production of molecular mediator of immune response 47
          negative regulation of antimicrobial peptide production + 1
          negative regulation of cytokine production involved in immune response + 36
          negative regulation of granzyme A production 0
          negative regulation of granzyme B production 0
          negative regulation of immunoglobulin production + 13
Path 2
Term Annotations click to browse term
  biological_process 20536
    biological regulation 13822
      regulation of biological process 13376
        regulation of cellular process 13014
          regulation of metabolic process 6834
            regulation of biosynthetic process 5630
              regulation of macromolecule biosynthetic process 5425
                regulation of gene expression 5308
                  regulation of production of molecular mediator of immune response 215
                    negative regulation of production of molecular mediator of immune response 47
                      negative regulation of antimicrobial peptide production + 1
                      negative regulation of cytokine production involved in immune response + 36
                      negative regulation of granzyme A production 0
                      negative regulation of granzyme B production 0
                      negative regulation of immunoglobulin production + 13
paths to the root