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ONTOLOGY REPORT - ANNOTATIONS

Term:somatic diversification of immune receptors via germline recombination within a single locus
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Accession:GO:0002562 term browser browse the term
Definition:The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.

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immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Polb DNA polymerase beta acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624780:884,896...941,587 JBrowse link
G Yy1 YY1 transcription factor involved_in ISO (PMID:23531880) MGI PMID:23531880 NCBI chrNW_004624734:3,846,753...3,875,294
Ensembl chrNW_004624734:3,846,765...3,875,294 		JBrowse link
immunoglobulin V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyren cell cycle regulator of NHEJ involved_in ISO (PMID:30017584), (PMID:31795137) UniProt PMID:30017584 PMID:31795137 NCBI chrNW_004624765:15,491,582...15,495,958
Ensembl chrNW_004624765:15,492,165...15,494,214 		JBrowse link
G Foxp1 forkhead box P1 acts_upstream_of_or_within ISO (PMID:16819554) MGI PMID:16819554 NCBI chrNW_004624773:5,543,529...6,076,522
Ensembl chrNW_004624773:5,543,536...5,883,131 		JBrowse link
G Lig4 DNA ligase 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9823897) MGI
TreeGrafter		 PMID:9823897 GO_REF:0000118 NCBI chrNW_004624793:3,699,394...3,706,591
Ensembl chrNW_004624793:3,699,506...3,706,073 		JBrowse link
G Nhej1 non-homologous end joining factor 1 involved_in ISO (PMID:20558749) UniProt PMID:20558749 NCBI chrNW_004624823:5,859,157...5,944,573
Ensembl chrNW_004624823:5,864,003...5,946,583 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9768755) MGI
TreeGrafter		 PMID:9768755 GO_REF:0000118 NCBI chrNW_004624735:7,534,483...7,702,079
Ensembl chrNW_004624735:7,534,506...7,700,305 		JBrowse link
G Tcf3 transcription factor 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16428437) MGI
TreeGrafter		 PMID:16428437 GO_REF:0000118 NCBI chrNW_004624828:7,090,562...7,119,970
Ensembl chrNW_004624828:7,090,605...7,121,428 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9875844) MGI
TreeGrafter		 PMID:9875844 GO_REF:0000118 NCBI chrNW_004624743:3,299,329...3,549,182
Ensembl chrNW_004624743:3,317,351...3,552,161 		JBrowse link
isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation induced cytidine deaminase acts_upstream_of_or_within
involved_in		 ISO (PMID:17713479)
(PMID:21518874)		 MGI
UniProt		 PMID:17713479 PMID:21518874 NCBI chrNW_004624860:4,912,938...4,927,846
Ensembl chrNW_004624860:4,912,656...4,926,634 		JBrowse link
G Atad5 ATPase family AAA domain containing 5 acts_upstream_of ISO (PMID:25404367) MGI PMID:25404367 NCBI chrNW_004624875:97,048...154,420
Ensembl chrNW_004624875:97,670...151,080 		JBrowse link
G Batf basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:26,118,840...26,139,328
Ensembl chrNW_004624734:26,118,754...26,139,468 		JBrowse link
G Cd40lg CD40 ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624808:10,472,028...10,484,407
Ensembl chrNW_004624808:10,472,572...10,484,338 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit acts_upstream_of_or_within ISO (PMID:15280420) MGI PMID:15280420 NCBI chrNW_004624907:2,288,380...2,298,909
Ensembl chrNW_004624907:2,288,423...2,298,373 		JBrowse link
G Exo1 exonuclease 1 acts_upstream_of_or_within ISO (PMID:14716311) MGI PMID:14716311 NCBI chrNW_004624771:12,215,957...12,230,908 JBrowse link
G Exosc3 exosome component 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624930:1,393,087...1,403,483
Ensembl chrNW_004624930:1,393,087...1,398,347 		JBrowse link
G Exosc6 exosome component 6 involved_in ISO (PMID:21255825) UniProt PMID:21255825 NCBI chrNW_004624746:12,538,315...12,539,678
Ensembl chrNW_004624746:12,538,775...12,539,593 		JBrowse link
G Lig4 DNA ligase 4 acts_upstream_of_or_within ISO (PMID:17713479) MGI PMID:17713479 NCBI chrNW_004624793:3,699,394...3,706,591
Ensembl chrNW_004624793:3,699,506...3,706,073 		JBrowse link
G Mlh1 mutL homolog 1 acts_upstream_of_or_within ISO (PMID:12743174) MGI PMID:12743174 NCBI chrNW_004624788:15,110,436...15,160,462
Ensembl chrNW_004624788:15,110,658...15,160,535 		JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624738:28,780,596...28,861,523
Ensembl chrNW_004624738:28,780,614...28,861,704 		JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624738:29,083,696...29,108,792
Ensembl chrNW_004624738:29,083,692...29,108,792 		JBrowse link
G Nbn nibrin involved_in ISO (PMID:15668383) UniProt PMID:15668383 NCBI chrNW_004624744:2,013,936...2,061,726
Ensembl chrNW_004624744:2,013,922...2,061,708 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:25124037)
(PMID:31182790)		 MGI PMID:25124037 PMID:31182790 NCBI chrNW_004624789:15,612,311...15,623,878
Ensembl chrNW_004624789:15,612,335...15,624,152 		JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624730:61,417,030...61,466,028
Ensembl chrNW_004624730:61,418,013...61,466,016 		JBrowse link
G Rnf168 ring finger protein 168 involved_in ISO (PMID:20080757) UniProt PMID:20080757 NCBI chrNW_004624730:61,592,967...61,627,585
Ensembl chrNW_004624730:61,591,943...61,627,170 		JBrowse link
G Rnf8 ring finger protein 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624754:20,683,133...20,714,469
Ensembl chrNW_004624754:20,679,867...20,714,522 		JBrowse link
G Sanbr SANT and BTB domain regulator of CSR involved_in ISO (PMID:33831416) UniProt PMID:33831416 NCBI chrNW_004624833:772,761...828,302
Ensembl chrNW_004624833:771,627...825,815 		JBrowse link
G Swap70 switching B cell complex subunit SWAP70 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624766:1,794,430...1,887,927
Ensembl chrNW_004624766:1,794,530...1,885,472 		JBrowse link
G Ung uracil DNA glycosylase acts_upstream_of_or_within ISO (PMID:17015724) MGI PMID:17015724 NCBI chrNW_004624747:12,261,546...12,275,229
Ensembl chrNW_004624747:12,261,623...12,274,859 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:17713479) MGI PMID:17713479 NCBI chrNW_004624743:3,299,329...3,549,182
Ensembl chrNW_004624743:3,317,351...3,552,161 		JBrowse link
isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr6 C-C motif chemokine receptor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624785:12,190,802...12,203,924 JBrowse link
isotype switching to IgD isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdcsp follicular dendritic cell secreted protein acts_upstream_of_positive_effect ISO (PMID:17548624) MGI PMID:17548624 NCBI chrNW_004624890:1,641,993...1,645,026 JBrowse link
isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6 transcription repressor acts_upstream_of ISO (PMID:10490661) MGI PMID:10490661 NCBI chrNW_004624730:69,145,035...69,167,583
Ensembl chrNW_004624730:69,154,080...69,167,689 		JBrowse link
G Fdcsp follicular dendritic cell secreted protein acts_upstream_of_or_within_negative_effect ISO (PMID:17548624) MGI PMID:17548624 NCBI chrNW_004624890:1,641,993...1,645,026 JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679 		JBrowse link
G Il4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chrNW_004624733:39,412,800...39,420,079 JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of ISO (PMID:10490661) MGI PMID:10490661 NCBI chrNW_004624802:10,809,234...10,847,762
Ensembl chrNW_004624802:10,809,252...10,846,693 		JBrowse link
isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdcsp follicular dendritic cell secreted protein acts_upstream_of_or_within_negative_effect ISO (PMID:17548624) MGI PMID:17548624 NCBI chrNW_004624890:1,641,993...1,645,026 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:16148103) BHF-UCL PMID:16148103 NCBI chrNW_004624889:2,736,727...2,746,333 JBrowse link
G Il4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chrNW_004624733:39,412,800...39,420,079 JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly(ADP-ribose) polymerase family member 3 involved_in ISO (PMID:26000965) UniProt PMID:26000965 NCBI chrNW_004624730:5,761,635...5,768,138
Ensembl chrNW_004624730:5,762,148...5,769,094 		JBrowse link
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdcsp follicular dendritic cell secreted protein involved_in ISO (PMID:24399151) MGI PMID:24399151 NCBI chrNW_004624890:1,641,993...1,645,026 JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within ISO (PMID:10490661) MGI PMID:10490661 NCBI chrNW_004624730:69,145,035...69,167,583
Ensembl chrNW_004624730:69,154,080...69,167,689 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO (PMID:17137798) MGI PMID:17137798 NCBI chrNW_004624774:1,245,587...1,353,253
Ensembl chrNW_004624774:1,303,773...1,353,253 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:12496423) BHF-UCL PMID:12496423 NCBI chrNW_004624771:8,580,489...8,599,735 JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exosc3 exosome component 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624930:1,393,087...1,403,483
Ensembl chrNW_004624930:1,393,087...1,398,347 		JBrowse link
G Exosc6 exosome component 6 acts_upstream_of_or_within ISO (PMID:21255825) MGI PMID:21255825 NCBI chrNW_004624746:12,538,315...12,539,678
Ensembl chrNW_004624746:12,538,775...12,539,593 		JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific involved_in ISO (PMID:31806351) UniProt PMID:31806351 NCBI chrNW_004624872:344,249...353,577
Ensembl chrNW_004624872:344,262...352,936 		JBrowse link
G Kmt5b lysine methyltransferase 5B involved_in ISO (PMID:28114273) UniProt PMID:28114273 NCBI chrNW_004624767:18,654,682...18,716,087
Ensembl chrNW_004624767:18,655,193...18,716,252 		JBrowse link
G Kmt5c lysine methyltransferase 5C involved_in ISO (PMID:28114273) UniProt PMID:28114273 NCBI chrNW_004624832:1,945,194...1,951,016
Ensembl chrNW_004624832:1,945,193...1,951,247 		JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chrNW_004624818:1,274,553...1,286,750
Ensembl chrNW_004624818:1,282,082...1,286,997 		JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (PMID:20671152) UniProt PMID:20671152 NCBI chrNW_004624800:2,653,381...2,709,261
Ensembl chrNW_004624800:2,653,732...2,707,161 		JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO (PMID:23306439), (PMID:23333305), (PMID:23333306) UniProt PMID:23306439 PMID:23333305 PMID:23333306 NCBI chrNW_004624866:5,619,758...5,680,165 JBrowse link
G Shld1 shieldin complex subunit 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624741:6,630,746...6,766,314
Ensembl chrNW_004624741:6,638,889...6,721,118 		JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chrNW_004624841:21,077...133,155
Ensembl chrNW_004624841:20,431...133,163 		JBrowse link
G Tfrc transferrin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624730:61,282,650...61,313,487
Ensembl chrNW_004624730:61,285,334...61,313,550 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in ISO (PMID:23760478)
(PMID:15077110), (PMID:15159415)
(PMID:23345425)		 UniProt PMID:15077110 PMID:15159415 PMID:23345425 PMID:23760478 NCBI chrNW_004624804:10,517,531...10,612,238
Ensembl chrNW_004624804:10,517,696...10,591,688 		JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 involved_in ISO (PMID:10430621) CAFA PMID:10430621 NCBI chrNW_004624788:15,110,436...15,160,462
Ensembl chrNW_004624788:15,110,658...15,160,535 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624738:28,780,596...28,861,523
Ensembl chrNW_004624738:28,780,614...28,861,704 		JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 acts_upstream_of_or_within ISO (PMID:23241889) MGI PMID:23241889 NCBI chrNW_004624755:25,510,329...25,588,540
Ensembl chrNW_004624755:25,509,301...25,588,204 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO (PMID:10430621) CAFA PMID:10430621 NCBI chrNW_004624740:31,315,121...31,345,137 JBrowse link
G Tgfb1 transforming growth factor beta 1 acts_upstream_of_or_within
involved_in		 ISO
ISS		 (PMID:14988498) MGI
AgBase		 PMID:14988498 GO_REF:0000024 NCBI chrNW_004624907:162,567...175,696
Ensembl chrNW_004624907:161,569...176,605 		JBrowse link
G Tnfsf13 TNF superfamily member 13 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14988498) MGI
TreeGrafter		 PMID:14988498 GO_REF:0000118 NCBI chrNW_004624786:10,175,534...10,179,233
Ensembl chrNW_004624786:10,175,859...10,179,233 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcf1 cardiotrophin like cytokine factor 1 involved_in ISO (PMID:12023368) BHF-UCL PMID:12023368 NCBI chrNW_004624767:19,142,927...19,152,572
Ensembl chrNW_004624767:19,142,852...19,153,155 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:14988498) MGI PMID:14988498 NCBI chrNW_004624733:39,412,800...39,420,079 JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO (PMID:10490661) MGI PMID:10490661 NCBI chrNW_004624802:10,809,234...10,847,762
Ensembl chrNW_004624802:10,809,252...10,846,693 		JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family AAA domain containing 5 acts_upstream_of_or_within ISO (PMID:25404367) MGI PMID:25404367 NCBI chrNW_004624875:97,048...154,420
Ensembl chrNW_004624875:97,670...151,080 		JBrowse link
G Cd28 CD28 molecule acts_upstream_of_or_within ISO (PMID:7688139) MGI PMID:7688139 NCBI chrNW_004624765:12,650,092...12,667,168 JBrowse link
G Cd40 CD40 molecule acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chrNW_004624790:8,475,640...8,485,927
Ensembl chrNW_004624790:8,476,158...8,485,856 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534 		JBrowse link
G Il2 interleukin 2 acts_upstream_of_or_within ISO (PMID:1830926) MGI PMID:1830926 NCBI chrNW_004624777:2,885,537...2,890,453
Ensembl chrNW_004624777:2,885,535...2,890,453 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:12882831), (PMID:14988498) MGI PMID:12882831 PMID:14988498 NCBI chrNW_004624733:39,412,800...39,420,079 JBrowse link
G Mlh1 mutL homolog 1 involved_in ISO (PMID:10430621) CAFA PMID:10430621 NCBI chrNW_004624788:15,110,436...15,160,462
Ensembl chrNW_004624788:15,110,658...15,160,535 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624738:28,780,596...28,861,523
Ensembl chrNW_004624738:28,780,614...28,861,704 		JBrowse link
G Pagr1 PAXIP1 associated glutamate rich protein 1 involved_in ISO (PMID:26744420) UniProt PMID:26744420 NCBI chrNW_004624782:13,387,155...13,390,153
Ensembl chrNW_004624782:13,387,376...13,389,740 		JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (PMID:26744420) UniProt PMID:26744420 NCBI chrNW_004624800:2,653,381...2,709,261
Ensembl chrNW_004624800:2,653,732...2,707,161 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO (PMID:10430621) CAFA PMID:10430621 NCBI chrNW_004624740:31,315,121...31,345,137 JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C acts_upstream_of_or_within ISO (PMID:9015183) MGI PMID:9015183 NCBI chrNW_004624798:1,700,732...1,814,603
Ensembl chrNW_004624798:1,699,541...1,814,656 		JBrowse link
G Tbx21 T-box transcription factor 21 acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chrNW_004624795:4,442,188...4,453,544
Ensembl chrNW_004624795:4,442,188...4,453,143 		JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplf aprataxin and PNKP like factor acts_upstream_of_or_within ISO (PMID:21211721) MGI PMID:21211721 NCBI chrNW_004624762:4,727,834...4,847,779
Ensembl chrNW_004624762:4,724,813...4,847,416 		JBrowse link
G Supt6h SPT6 homolog, histone chaperone and transcription elongation factor involved_in ISO (PMID:21518874) UniProt PMID:21518874 NCBI chrNW_004624786:1,226,131...1,271,872
Ensembl chrNW_004624786:1,238,082...1,271,875 		JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679 		JBrowse link
G Il27ra interleukin 27 receptor subunit alpha acts_upstream_of_or_within ISO (PMID:11057672) MGI PMID:11057672 NCBI chrNW_004624901:1,274,753...1,288,783
Ensembl chrNW_004624901:1,274,840...1,287,861 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO (PMID:17137798) MGI PMID:17137798 NCBI chrNW_004624774:1,245,587...1,353,253
Ensembl chrNW_004624774:1,303,773...1,353,253 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in ISO (PMID:25310967) UniProt PMID:25310967 NCBI chrNW_004624747:26,252,788...26,275,273
Ensembl chrNW_004624747:26,252,492...26,275,173 		JBrowse link
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 acts_upstream_of_or_within ISO (PMID:11828012) MGI PMID:11828012 NCBI chrNW_004624788:15,110,436...15,160,462
Ensembl chrNW_004624788:15,110,658...15,160,535 		JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624738:28,780,596...28,861,523
Ensembl chrNW_004624738:28,780,614...28,861,704 		JBrowse link
G Msh3 mutS homolog 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15238604) MGI
TreeGrafter		 PMID:15238604 GO_REF:0000118 NCBI chrNW_004624743:1,461,952...1,581,524
Ensembl chrNW_004624743:1,461,077...1,581,180 		JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624738:29,083,696...29,108,792
Ensembl chrNW_004624738:29,083,692...29,108,792 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component acts_upstream_of_or_within ISO (PMID:11828012) MGI PMID:11828012 NCBI chrNW_004624740:31,315,121...31,345,137 JBrowse link
G Ung uracil DNA glycosylase acts_upstream_of_or_within ISO (PMID:15494304) MGI PMID:15494304 NCBI chrNW_004624747:12,261,546...12,275,229
Ensembl chrNW_004624747:12,261,623...12,274,859 		JBrowse link
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 acts_upstream_of_or_within ISO (PMID:12743174) MGI PMID:12743174 NCBI chrNW_004624788:15,110,436...15,160,462
Ensembl chrNW_004624788:15,110,658...15,160,535 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624738:28,780,596...28,861,523
Ensembl chrNW_004624738:28,780,614...28,861,704 		JBrowse link
T cell receptor V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl11b BCL11 transcription factor B acts_upstream_of_or_within ISO (PMID:12717433) MGI PMID:12717433 NCBI chrNW_004624734:4,560,362...4,649,219
Ensembl chrNW_004624734:4,560,699...4,647,858 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 acts_upstream_of_or_within ISO (PMID:9462507) MGI PMID:9462507 NCBI chrNW_004624830:1,320,034...1,422,774
Ensembl chrNW_004624830:1,321,387...1,424,389 		JBrowse link
G Lig4 DNA ligase 4 acts_upstream_of_or_within ISO (PMID:10911993) MGI PMID:10911993 NCBI chrNW_004624793:3,699,394...3,706,591
Ensembl chrNW_004624793:3,699,506...3,706,073 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO (PMID:9768755) MGI PMID:9768755 NCBI chrNW_004624735:7,534,483...7,702,079
Ensembl chrNW_004624735:7,534,506...7,700,305 		JBrowse link
G Tcf7 transcription factor 7 acts_upstream_of_or_within ISO (PMID:9462507) MGI PMID:9462507 NCBI chrNW_004624733:38,076,800...38,104,265
Ensembl chrNW_004624733:38,076,410...38,104,173 		JBrowse link
V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase acts_upstream_of_or_within ISO (PMID:23836881) MGI PMID:23836881 NCBI chrNW_004624784:2,933,172...3,080,131
Ensembl chrNW_004624784:2,937,499...3,078,216 		JBrowse link
G Dcaf1 DDB1 and CUL4 associated factor 1 involved_in ISO (PMID:22157821) UniProt PMID:22157821 NCBI chrNW_004624730:5,176,828...5,245,548
Ensembl chrNW_004624730:5,176,828...5,240,680 		JBrowse link
G Dclre1c DNA cross-link repair 1C acts_upstream_of_or_within ISO (PMID:23836881) MGI PMID:23836881 NCBI chrNW_004624805:555,444...593,548
Ensembl chrNW_004624805:555,545...592,250 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:9166431) UniProt PMID:9166431 NCBI chrNW_004624776:7,858,400...7,862,716
Ensembl chrNW_004624776:7,793,259...7,863,184 		JBrowse link
G Lig1 DNA ligase 1 NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chrNW_004624832:5,665,855...5,708,824
Ensembl chrNW_004624832:5,665,493...5,712,258 		JBrowse link
G Lig3 DNA ligase 3 NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chrNW_004624875:2,871,944...2,907,757
Ensembl chrNW_004624875:2,872,357...2,893,967 		JBrowse link
G Lig4 DNA ligase 4 involved_in
acts_upstream_of_or_within		 ISO (PMID:9809069)
(PMID:10716994)
(PMID:15194694)		 UniProt
MGI		 PMID:9809069 PMID:10716994 PMID:15194694 NCBI chrNW_004624793:3,699,394...3,706,591
Ensembl chrNW_004624793:3,699,506...3,706,073 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO (PMID:23836881) MGI PMID:23836881 NCBI chrNW_004624735:7,534,483...7,702,079
Ensembl chrNW_004624735:7,534,506...7,700,305 		JBrowse link
G Rag1 recombination activating 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:2360047) UniProt
TreeGrafter
MGI
InterPro
Ensembl		 PMID:2360047 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624767:10,694,867...10,698,041
Ensembl chrNW_004624767:10,694,867...10,698,001 		JBrowse link
G Rag2 recombination activating 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:2360047) Ensembl
TreeGrafter
MGI		 PMID:2360047 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624767:10,678,547...10,680,130
Ensembl chrNW_004624767:10,678,359...10,680,132 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:10716994) MGI PMID:10716994 NCBI chrNW_004624743:3,299,329...3,549,182
Ensembl chrNW_004624743:3,317,351...3,552,161 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 acts_upstream_of_or_within ISO (PMID:10716994) MGI PMID:10716994 NCBI chrNW_004624752:6,987,456...7,010,834
Ensembl chrNW_004624752:6,979,271...7,010,787 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17650
    immune system process 2287
      somatic diversification of immune receptors 84
        somatic diversification of immune receptors via germline recombination within a single locus 77
          V(D)J recombination + 21
          somatic recombination of T cell receptor gene segments + 5
          somatic recombination of immunoglobulin gene segments + 65
Path 2
Term Annotations click to browse term
  biological_process 17650
    cellular process 17226
      metabolic process 11002
        primary metabolic process 9835
          nucleobase-containing compound metabolic process 5846
            nucleic acid metabolic process 5347
              DNA metabolic process 895
                DNA recombination 324
                  somatic cell DNA recombination 77
                    somatic diversification of immune receptors via germline recombination within a single locus 77
                      V(D)J recombination + 21
                      somatic recombination of T cell receptor gene segments + 5
                      somatic recombination of immunoglobulin gene segments + 65
paths to the root