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ONTOLOGY REPORT - ANNOTATIONS

Term:somatic diversification of immune receptors via germline recombination within a single locus
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Accession:GO:0002562 term browser browse the term
Definition:The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.

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immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POLB DNA polymerase beta acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:40,332,165...40,368,065
Ensembl chr 8:40,332,208...40,372,582 		JBrowse link
G YY1 YY1 transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:78,199,172...78,243,081
Ensembl chr24:78,199,039...78,237,165 		JBrowse link
immunoglobulin V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYREN cell cycle regulator of NHEJ involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:103,838,218...103,843,151
Ensembl chr21:103,838,988...103,842,620 		JBrowse link
G FOXP1 forkhead box P1 acts_upstream_of_or_within ISO (PMID:16819554) MGI PMID:16819554 NCBI chr22:31,907,941...32,538,294
Ensembl chr22:31,912,460...32,154,502 		JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:86,576,200...86,587,097
Ensembl chr 3:86,577,304...86,580,039 		JBrowse link
G NHEJ1 non-homologous end joining factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:104,981,313...105,071,828
Ensembl chr10:104,982,380...105,068,999 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9768755) MGI
TreeGrafter		 PMID:9768755 GO_REF:0000118 NCBI chr 8:43,915,226...44,119,547
Ensembl chr 8:43,914,636...44,119,541 		JBrowse link
G TCF3 transcription factor 3 involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:1,393,147...1,440,515
Ensembl chr 6:1,393,107...1,440,479 		JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9875844) MGI
TreeGrafter		 PMID:9875844 GO_REF:0000118 NCBI chr 4:77,182,569...77,468,786
Ensembl chr 4:77,182,793...77,468,775 		JBrowse link
isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase acts_upstream_of_or_within
involved_in		 ISO (PMID:17713479)
(PMID:21518874)		 MGI
UniProt		 PMID:17713479 PMID:21518874 NCBI chr11:8,426,920...8,438,331
Ensembl chr11:8,428,922...8,431,641 		JBrowse link
G ATAD5 ATPase family AAA domain containing 5 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr16:25,536,911...25,597,911
Ensembl chr16:25,538,131...25,597,695 		JBrowse link
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:52,761,569...52,785,999
Ensembl chr24:52,761,651...52,785,978 		JBrowse link
G CD40LG CD40 ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:111,655,301...111,667,602
Ensembl chr  X:111,655,397...111,666,639 		JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 6:38,857,067...38,900,177
Ensembl chr 6:38,854,803...38,872,967 		JBrowse link
G EXO1 exonuclease 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr25:78,934,337...78,976,346
Ensembl chr25:78,934,459...78,976,219 		JBrowse link
G EXOSC3 exosome component 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:42,798,609...42,819,431
Ensembl chr12:42,799,067...42,803,471 		JBrowse link
G EXOSC6 exosome component 6 involved_in ISO (PMID:21255825) UniProt PMID:21255825 NCBI chr 5:53,397,973...53,399,526 JBrowse link
G LIG4 DNA ligase 4 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:86,576,200...86,587,097
Ensembl chr 3:86,577,304...86,580,039 		JBrowse link
G MLH1 mutL homolog 1 acts_upstream_of_or_within ISO (PMID:12743174) MGI PMID:12743174 NCBI chr15:2,364,537...2,418,379
Ensembl chr15:2,364,738...2,418,393 		JBrowse link
G MSH2 mutS homolog 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819 		JBrowse link
G MSH6 mutS homolog 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:59,375,602...59,400,252
Ensembl chr14:59,375,691...59,400,174 		JBrowse link
G NBN nibrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:85,017,807...85,069,219
Ensembl chr 8:85,015,752...85,069,028 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:79,044,624...79,077,736
Ensembl chr22:79,044,619...79,055,776 		JBrowse link
G PCYT1A phosphate cytidylyltransferase 1A, choline involved_in ISO (PMID:19139091) UniProt PMID:19139091 NCBI chr15:90,905,691...90,944,485 JBrowse link
G RNF168 ring finger protein 168 involved_in ISO (PMID:20080757) UniProt PMID:20080757 NCBI chr15:90,702,740...90,735,279
Ensembl chr15:90,702,765...90,737,687 		JBrowse link
G RNF8 ring finger protein 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:34,754,186...34,787,676
Ensembl chr17:34,751,945...34,787,632 		JBrowse link
G SANBR SANT and BTB domain regulator of CSR involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:45,865,697...45,920,403
Ensembl chr14:45,864,838...45,920,782 		JBrowse link
G SWAP70 switching B cell complex subunit SWAP70 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:55,074,255...55,156,632
Ensembl chr 1:55,074,209...55,156,599 		JBrowse link
G UNG uracil DNA glycosylase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:104,302,507...104,325,160 JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:17713479) MGI PMID:17713479 NCBI chr 4:77,182,569...77,468,786
Ensembl chr 4:77,182,793...77,468,775 		JBrowse link
isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR6 C-C motif chemokine receptor 6 involved_in ISO (PMID:27174992) UniProt PMID:27174992 NCBI chr13:94,865,480...94,894,331
Ensembl chr13:94,865,936...94,894,315 		JBrowse link
isotype switching to IgD isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FDCSP follicular dendritic cell secreted protein acts_upstream_of_positive_effect ISO (PMID:17548624) MGI PMID:17548624 NCBI chr 7:18,711,145...18,721,926
Ensembl chr 7:18,716,973...18,721,350 		JBrowse link
isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr15:81,997,659...82,022,059
Ensembl chr15:81,998,545...82,009,946 		JBrowse link
G FDCSP follicular dendritic cell secreted protein acts_upstream_of_or_within_negative_effect ISO (PMID:17548624) MGI PMID:17548624 NCBI chr 7:18,711,145...18,721,926
Ensembl chr 7:18,716,973...18,721,350 		JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of ISO (PMID:16275384) MGI PMID:16275384 NCBI chr  X:46,349,890...46,365,133 JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of IEA Ensembl GO_REF:0000107 Ensembl chr  X:46,346,754...46,356,928 JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr11:53,005,378...53,020,899
Ensembl chr11:53,006,145...53,021,203 		JBrowse link
isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FDCSP follicular dendritic cell secreted protein acts_upstream_of_or_within_negative_effect ISO (PMID:17548624) MGI PMID:17548624 NCBI chr 7:18,711,145...18,721,926
Ensembl chr 7:18,716,973...18,721,350 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:83,003,266...83,017,397
Ensembl chr10:83,003,717...83,017,363 		JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G LOC103238722 60 kDa heat shock protein, mitochondrial-like involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:66,923,204...66,925,397 JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARP3 poly(ADP-ribose) polymerase family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:13,310,885...13,316,807
Ensembl chr22:13,310,938...13,320,680 		JBrowse link
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FDCSP follicular dendritic cell secreted protein involved_in ISO (PMID:24399151) MGI PMID:24399151 NCBI chr 7:18,711,145...18,721,926
Ensembl chr 7:18,716,973...18,721,350 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr15:81,997,659...82,022,059
Ensembl chr15:81,998,545...82,009,946 		JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:16275384) MGI PMID:16275384 NCBI chr  X:46,349,890...46,365,133 JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr  X:46,346,754...46,356,928 JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr23:44,737,432...44,783,409
Ensembl chr23:44,737,422...44,775,657 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:12496423) BHF-UCL PMID:12496423 NCBI chr25:55,714,291...55,998,009
Ensembl chr25:55,974,691...55,997,374 		JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EXOSC3 exosome component 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:42,798,609...42,819,431
Ensembl chr12:42,799,067...42,803,471 		JBrowse link
G EXOSC6 exosome component 6 acts_upstream_of_or_within ISO (PMID:21255825) MGI PMID:21255825 NCBI chr 5:53,397,973...53,399,526 JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:51,759,776...51,785,902
Ensembl chr22:51,759,715...51,785,987 		JBrowse link
G KMT5B lysine methyltransferase 5B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:6,308,565...6,367,272
Ensembl chr 1:6,308,742...6,367,393 		JBrowse link
G KMT5C lysine methyltransferase 5C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:47,942,100...47,950,364
Ensembl chr 6:47,944,197...47,949,693 		JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:120,099,928...120,115,954
Ensembl chr20:120,110,269...120,116,083 		JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:123,095,968...123,156,157
Ensembl chr21:123,095,966...123,155,800 		JBrowse link
G RIF1 replication timing regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:36,845,751...36,937,040
Ensembl chr10:36,845,777...36,907,015 		JBrowse link
G SHLD1 shieldin complex subunit 1 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:32,265,882...32,381,411
Ensembl chr 2:32,265,788...32,381,395 		JBrowse link
G SHLD2 shieldin complex subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:44,565,105...44,652,926
Ensembl chr 9:44,564,792...44,605,562 		JBrowse link
G SHLD3 shieldin complex subunit 3 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chr 4:61,817,386...61,823,423 JBrowse link
G TFRC transferrin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:91,102,153...91,134,994
Ensembl chr15:91,102,817...91,135,584 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:39,489,925...39,595,096
Ensembl chr26:39,508,600...39,594,927 		JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103242307 TNF superfamily member 13 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14988498) MGI
TreeGrafter		 PMID:14988498 GO_REF:0000118 NCBI chr16:6,935,073...6,938,792
Ensembl chr16:6,926,584...6,938,019 		JBrowse link
G LOC103246803 mismatch repair endonuclease PMS2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:15,174,359...15,209,962
Ensembl chr28:15,172,100...15,209,852 		JBrowse link
G MLH1 mutL homolog 1 involved_in ISO (PMID:10430621) CAFA PMID:10430621 NCBI chr15:2,364,537...2,418,379
Ensembl chr15:2,364,738...2,418,393 		JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819 		JBrowse link
G NSD2 nuclear receptor binding SET domain protein 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr27:46,787,325...46,896,898
Ensembl chr27:46,787,154...46,867,792 		JBrowse link
G TGFB1 transforming growth factor beta 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCF1 cardiotrophin like cytokine factor 1 involved_in ISO (PMID:12023368) BHF-UCL PMID:12023368 NCBI chr 1:6,890,751...6,900,370 JBrowse link
G CLCF1 cardiotrophin like cytokine factor 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 1:6,896,591...6,899,396 JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:14988498) MGI PMID:14988498 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:53,005,378...53,020,899
Ensembl chr11:53,006,145...53,021,203 		JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAD5 ATPase family AAA domain containing 5 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:25,536,911...25,597,911
Ensembl chr16:25,538,131...25,597,695 		JBrowse link
G CD28 CD28 molecule acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:89,471,710...89,505,152
Ensembl chr10:89,471,730...89,500,387 		JBrowse link
G CD40 CD40 molecule acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:17,753,713...17,765,134
Ensembl chr 2:17,753,394...17,764,566 		JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
G IL2 interleukin 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969 		JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:12882831), (PMID:14988498) MGI PMID:12882831 PMID:14988498 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G LOC103246803 mismatch repair endonuclease PMS2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:15,174,359...15,209,962
Ensembl chr28:15,172,100...15,209,852 		JBrowse link
G MLH1 mutL homolog 1 involved_in ISO (PMID:10430621) CAFA PMID:10430621 NCBI chr15:2,364,537...2,418,379
Ensembl chr15:2,364,738...2,418,393 		JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819 		JBrowse link
G PAGR1 PAXIP1 associated glutamate rich protein 1 involved_in ISO (PMID:26744420) UniProt PMID:26744420 NCBI chr 5:26,833,333...26,837,655
Ensembl chr 5:26,833,675...26,837,640 		JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:123,095,968...123,156,157
Ensembl chr21:123,095,966...123,155,800 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr25:30,655,014...30,777,367
Ensembl chr25:30,653,044...30,777,303 		JBrowse link
G TBX21 T-box transcription factor 21 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:68,131,258...68,145,579
Ensembl chr16:68,131,536...68,144,415 		JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLF aprataxin and PNKP like factor acts_upstream_of_or_within ISO (PMID:21211721) MGI PMID:21211721 NCBI chr14:38,539,398...38,636,666
Ensembl chr14:38,540,084...38,636,569 		JBrowse link
G SUPT6H SPT6 homolog, histone chaperone and transcription elongation factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:22,444,864...22,470,248 JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:16275384) MGI PMID:16275384 NCBI chr  X:46,349,890...46,365,133 JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr  X:46,346,754...46,356,928 JBrowse link
G IL27RA interleukin 27 receptor subunit alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 6:12,679,270...12,699,254
Ensembl chr 6:12,686,838...12,701,867 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr23:44,737,432...44,783,409
Ensembl chr23:44,737,422...44,775,657 		JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:124,170,785...124,204,358
Ensembl chr11:124,169,732...124,204,200 		JBrowse link
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103246803 mismatch repair endonuclease PMS2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr28:15,174,359...15,209,962
Ensembl chr28:15,172,100...15,209,852 		JBrowse link
G MLH1 mutL homolog 1 acts_upstream_of_or_within ISO (PMID:11828012) MGI PMID:11828012 NCBI chr15:2,364,537...2,418,379
Ensembl chr15:2,364,738...2,418,393 		JBrowse link
G MSH2 mutS homolog 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819 		JBrowse link
G MSH3 mutS homolog 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15238604) MGI
TreeGrafter		 PMID:15238604 GO_REF:0000118 NCBI chr 4:74,811,181...75,032,067
Ensembl chr 4:74,811,198...75,032,005 		JBrowse link
G MSH6 mutS homolog 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:59,375,602...59,400,252
Ensembl chr14:59,375,691...59,400,174 		JBrowse link
G UNG uracil DNA glycosylase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:104,302,507...104,325,160 JBrowse link
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 acts_upstream_of_or_within ISO (PMID:12743174) MGI PMID:12743174 NCBI chr15:2,364,537...2,418,379
Ensembl chr15:2,364,738...2,418,393 		JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819 		JBrowse link
T cell receptor V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL11B BCL11 transcription factor B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr24:77,122,591...77,222,562
Ensembl chr24:77,122,689...77,221,454 		JBrowse link
G LEF1 lymphoid enhancer binding factor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:55,974,770...56,096,214
Ensembl chr 7:55,990,621...56,094,110 		JBrowse link
G LIG4 DNA ligase 4 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:86,576,200...86,587,097
Ensembl chr 3:86,577,304...86,580,039 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO (PMID:9768755) MGI PMID:9768755 NCBI chr 8:43,915,226...44,119,547
Ensembl chr 8:43,914,636...44,119,541 		JBrowse link
G TCF7 transcription factor 7 acts_upstream_of_or_within ISO (PMID:9462507) MGI PMID:9462507 NCBI chr23:36,919,648...36,953,088
Ensembl chr23:36,919,745...36,951,192 		JBrowse link
V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:99,653,208...99,786,889
Ensembl chr 1:99,653,139...99,791,520 		JBrowse link
G DCAF1 DDB1 and CUL4 associated factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:12,736,784...12,843,762
Ensembl chr22:12,739,665...12,823,363 		JBrowse link
G DCLRE1C DNA cross-link repair 1C acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:14,929,221...14,974,791
Ensembl chr 9:14,929,317...14,965,443 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:9166431) UniProt PMID:9166431 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G LIG1 DNA ligase 1 NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chr 6:41,354,701...41,405,417
Ensembl chr 6:41,351,389...41,403,421 		JBrowse link
G LIG3 DNA ligase 3 NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chr16:28,487,953...28,511,945
Ensembl chr16:28,490,434...28,511,130 		JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within		 IEA Ensembl GO_REF:0000107 NCBI chr 3:86,576,200...86,587,097
Ensembl chr 3:86,577,304...86,580,039 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO (PMID:23836881) MGI PMID:23836881 NCBI chr 8:43,915,226...44,119,547
Ensembl chr 8:43,914,636...44,119,541 		JBrowse link
G RAG1 recombination activating 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:2360047) Ensembl
TreeGrafter
MGI
UniProt
InterPro		 PMID:2360047 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:28,667,996...28,701,002 JBrowse link
G RAG2 recombination activating 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:2360047) MGI
Ensembl
TreeGrafter		 PMID:2360047 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:28,645,175...28,653,823
Ensembl chr 1:28,649,930...28,651,513 		JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:10716994) MGI PMID:10716994 NCBI chr 4:77,182,569...77,468,786
Ensembl chr 4:77,182,793...77,468,775 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 acts_upstream_of_or_within ISO (PMID:10716994) MGI PMID:10716994 NCBI chr19:24,160,459...24,204,237
Ensembl chr19:24,160,483...24,206,320 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19829
    immune system process 2687
      somatic diversification of immune receptors 88
        somatic diversification of immune receptors via germline recombination within a single locus 81
          V(D)J recombination + 21
          somatic recombination of T cell receptor gene segments + 5
          somatic recombination of immunoglobulin gene segments + 69
Path 2
Term Annotations click to browse term
  biological_process 19829
    cellular process 19347
      metabolic process 13115
        primary metabolic process 11543
          nucleobase-containing compound metabolic process 7292
            nucleic acid metabolic process 6760
              DNA metabolic process 932
                DNA recombination 329
                  somatic cell DNA recombination 81
                    somatic diversification of immune receptors via germline recombination within a single locus 81
                      V(D)J recombination + 21
                      somatic recombination of T cell receptor gene segments + 5
                      somatic recombination of immunoglobulin gene segments + 69
paths to the root