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ONTOLOGY REPORT - ANNOTATIONS

Term:somatic diversification of immune receptors via germline recombination within a single locus
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Accession:GO:0002562 term browser browse the term
Definition:The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.


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immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POLB DNA polymerase beta acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:23,306,359...23,335,352
Ensembl chr16:23,306,367...23,335,322 		JBrowse link
G YY1 YY1 transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:68,539,511...68,572,796
Ensembl chr 8:68,539,353...68,568,058 		JBrowse link
immunoglobulin V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYREN cell cycle regulator of NHEJ involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:12,994,508...13,003,632
Ensembl chr16:12,994,479...12,998,435 		JBrowse link
G FOXP1 forkhead box P1 acts_upstream_of_or_within ISO (PMID:16819554) MGI PMID:16819554 NCBI chr20:20,438,631...21,020,516
Ensembl chr20:20,788,433...21,016,397 		JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within		 IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr22:56,980,333...56,987,636
Ensembl chr22:56,980,622...56,983,357 		JBrowse link
G NHEJ1 non-homologous end joining factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:25,637,214...25,719,241
Ensembl chr37:25,637,601...25,715,372 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:9768755) GO_Central
MGI		 PMID:9768755 GO_REF:0000033 NCBI chr29:24,904...243,926
Ensembl chr29:35,007...243,895 		JBrowse link
G TCF3 transcription factor 3 involved_in
acts_upstream_of_or_within		 IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr20:57,255,091...57,284,223
Ensembl chr20:57,254,384...57,283,981 		JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:9875844) MGI
GO_Central		 PMID:9875844 GO_REF:0000033 NCBI chr 3:24,316,598...24,547,463
Ensembl chr 3:24,269,974...24,533,465 		JBrowse link
isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase acts_upstream_of_or_within
involved_in		 IEA
ISO		 (PMID:21518874) Ensembl
UniProt		 PMID:21518874 GO_REF:0000107 NCBI chr27:37,064,107...37,073,791
Ensembl chr27:37,064,080...37,073,789 		JBrowse link
G ATAD5 ATPase family AAA domain containing 5 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 9:40,869,778...40,917,976
Ensembl chr 9:40,870,924...40,915,629 		JBrowse link
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:48,537,036...48,561,154 JBrowse link
G CD40LG CD40 ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:107,001,421...107,023,007
Ensembl chr  X:107,010,890...107,023,006 		JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit acts_upstream_of_or_within ISO (PMID:15280420) MGI PMID:15280420 NCBI chr 1:110,130,353...110,146,660
Ensembl chr 1:110,130,481...110,146,602 		JBrowse link
G EXO1 exonuclease 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:33,237,124...33,268,835
Ensembl chr 7:33,237,593...33,268,254 		JBrowse link
G EXOSC3 exosome component 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:54,072,993...54,079,024
Ensembl chr11:54,073,313...54,078,598 		JBrowse link
G EXOSC6 exosome component 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:76,286,286...76,287,667
Ensembl chr 5:76,286,789...76,287,976 		JBrowse link
G LIG4 DNA ligase 4 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr22:56,980,333...56,987,636
Ensembl chr22:56,980,622...56,983,357 		JBrowse link
G MLH1 mutL homolog 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116 		JBrowse link
G MSH2 mutS homolog 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210 		JBrowse link
G MSH6 mutS homolog 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:49,825,330...49,838,036
Ensembl chr10:49,803,898...49,838,028 		JBrowse link
G NBN nibrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:35,416,093...35,477,569
Ensembl chr29:35,416,093...35,477,563 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:8,147,160...8,154,401
Ensembl chr33:8,073,840...8,154,561 		JBrowse link
G PCYT1A phosphate cytidylyltransferase 1A, choline involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:29,363,282...29,414,635
Ensembl chr33:29,358,452...29,430,424 		JBrowse link
G RNF168 ring finger protein 168 involved_in ISO (PMID:20080757) UniProt PMID:20080757 NCBI chr33:29,542,209...29,575,127
Ensembl chr33:29,539,182...29,628,248 		JBrowse link
G RNF8 ring finger protein 8 involved_in ISO (PMID:20080757) UniProt PMID:20080757 NCBI chr12:6,380,365...6,415,407
Ensembl chr12:6,292,459...6,415,382 		JBrowse link
G SANBR SANT and BTB domain regulator of CSR involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr10:61,143,971...61,195,058
Ensembl chr10:61,123,655...61,193,241 		JBrowse link
G SWAP70 switching B cell complex subunit SWAP70 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr21:32,910,547...32,985,617
Ensembl chr21:32,910,563...32,984,580 		JBrowse link
G UNG uracil DNA glycosylase acts_upstream_of_or_within ISO (PMID:17015724) MGI PMID:17015724 NCBI chr26:17,900,354...17,911,126
Ensembl chr26:17,901,357...17,911,288 		JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:17713479) MGI PMID:17713479 NCBI chr 3:24,316,598...24,547,463
Ensembl chr 3:24,269,974...24,533,465 		JBrowse link
isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR6 C-C motif chemokine receptor 6 involved_in ISO (PMID:27174992) UniProt PMID:27174992 NCBI chr 1:54,932,798...54,960,646
Ensembl chr 1:54,932,690...54,959,740 		JBrowse link
isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704 		JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758 		JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G RTP2 receptor transporter protein 2 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr34:20,087,395...20,091,248
Ensembl chr34:20,087,226...20,115,428 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr10:1,232,515...1,247,011
Ensembl chr10:1,233,691...1,247,075 		JBrowse link
isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPD1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:16148103) BHF-UCL PMID:16148103 NCBI chr37:7,010,421...7,025,912 JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARP3 poly(ADP-ribose) polymerase family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:37,767,336...37,774,269
Ensembl chr20:37,767,505...37,773,770 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704 		JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:36,978,148...37,065,247
Ensembl chr 2:36,961,024...37,064,303 		JBrowse link
G RTP2 receptor transporter protein 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr34:20,087,395...20,091,248
Ensembl chr34:20,087,226...20,115,428 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:12496423) BHF-UCL PMID:12496423 NCBI chr 7:25,883,297...25,909,608
Ensembl chr 7:25,883,251...25,906,892 		JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EXOSC3 exosome component 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:54,072,993...54,079,024
Ensembl chr11:54,073,313...54,078,598 		JBrowse link
G EXOSC6 exosome component 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:76,286,286...76,287,667
Ensembl chr 5:76,286,789...76,287,976 		JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:2,808,687...2,831,123
Ensembl chr20:2,808,689...2,830,462 		JBrowse link
G KMT5B lysine methyltransferase 5B involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:49,655,783...49,691,899
Ensembl chr18:49,637,610...49,827,034 		JBrowse link
G KMT5C lysine methyltransferase 5C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:102,334,687...102,342,090
Ensembl chr 1:102,333,543...102,342,118 		JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:84,539,724...84,549,402
Ensembl chr 2:84,545,226...84,549,356 		JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:18,066,289...18,116,007
Ensembl chr16:18,066,246...18,112,506 		JBrowse link
G RIF1 replication timing regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:52,661,278...52,711,969
Ensembl chr19:52,661,155...52,709,279 		JBrowse link
G SHLD1 shieldin complex subunit 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr24:15,957,863...16,037,336
Ensembl chr24:15,957,852...16,038,008 		JBrowse link
G SHLD2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chr 4:34,665,111...34,740,645
Ensembl chr 4:34,688,245...34,763,705 		JBrowse link
G SHLD3 shieldin complex subunit 3 involved_in ISO (PMID:29656893) UniProt PMID:29656893
G TFRC transferrin receptor involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr33:29,206,024...29,237,221
Ensembl chr33:29,208,609...29,238,242 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:10,263,650...10,362,646
Ensembl chr30:10,263,650...10,336,134 		JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B9D2 B9 domain containing 2 acts_upstream_of_or_within ISO (PMID:14988498) MGI PMID:14988498 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G MLH1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116 		JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210 		JBrowse link
G NSD2 nuclear receptor binding SET domain protein 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:62,164,888...62,228,006
Ensembl chr 3:62,167,939...62,228,035 		JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:11,411,062...11,438,767
Ensembl chr 6:11,349,453...11,438,940 		JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in
acts_upstream_of_or_within		 ISS
IEA		 AgBase
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:112,629,476...112,643,885
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G TNFSF13 TNF superfamily member 13 involved_in
acts_upstream_of_or_within		 IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:32,482,723...32,484,790
Ensembl chr 5:32,482,723...32,484,789 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCF1 cardiotrophin like cytokine factor 1 involved_in ISO (PMID:12023368) BHF-UCL PMID:12023368 NCBI chr18:50,084,120...50,093,825
Ensembl chr18:50,083,915...50,102,651 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 ISS
ISO		 (PMID:14988498) UniProt
MGI		 PMID:14988498 GO_REF:0000024 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:1,232,515...1,247,011
Ensembl chr10:1,233,691...1,247,075 		JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAD5 ATPase family AAA domain containing 5 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:40,869,778...40,917,976
Ensembl chr 9:40,870,924...40,915,629 		JBrowse link
G CD28 CD28 molecule acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr37:12,503,849...12,536,362
Ensembl chr37:12,503,811...12,532,854 		JBrowse link
G CD40 CD40 molecule acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301 		JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G IL2 interleukin 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 ISS
ISO		 (PMID:12882831), (PMID:14988498) UniProt
MGI		 PMID:12882831 PMID:14988498 GO_REF:0000024 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G MLH1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116 		JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210 		JBrowse link
G PAGR1 PAXIP1 associated glutamate rich protein 1 involved_in ISO (PMID:26744420) UniProt PMID:26744420 NCBI chr 6:17,876,740...17,879,546 JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:18,066,289...18,116,007
Ensembl chr16:18,066,246...18,112,506 		JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:11,411,062...11,438,767
Ensembl chr 6:11,349,453...11,438,940 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:4,155,876...4,282,151
Ensembl chr 7:4,137,728...4,282,124 		JBrowse link
G TBX21 T-box transcription factor 21 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:24,077,752...24,086,560
Ensembl chr 9:24,077,761...24,086,261 		JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLF aprataxin and PNKP like factor acts_upstream_of_or_within ISO (PMID:21211721) MGI PMID:21211721 NCBI chr10:67,454,500...67,522,659
Ensembl chr10:67,454,356...67,521,761 		JBrowse link
G MIR181B-2 microRNA mir-181b-2 acts_upstream_of_or_within ISO (PMID:18762567) MGI PMID:18762567 NCBI chr 9:58,301,314...58,301,373
Ensembl chr 9:58,301,300...58,301,388 		JBrowse link
G MIR181D microRNA mir-181d acts_upstream_of_or_within ISO (PMID:18762567) MGI PMID:18762567 NCBI chr20:48,593,158...48,593,221 JBrowse link
G SUPT6H SPT6 homolog, histone chaperone and transcription elongation factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:42,859,154...42,896,044
Ensembl chr 9:42,859,361...42,904,487 		JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758 		JBrowse link
G IL27RA interleukin 27 receptor subunit alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr20:48,456,766...48,475,414
Ensembl chr20:48,457,134...48,472,450 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:36,978,148...37,065,247
Ensembl chr 2:36,961,024...37,064,303 		JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:2,803,798...2,832,057
Ensembl chr26:2,802,724...2,831,530 		JBrowse link
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116 		JBrowse link
G MSH2 mutS homolog 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210 		JBrowse link
G MSH3 mutS homolog 3 acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:15238604) MGI
GO_Central		 PMID:15238604 GO_REF:0000033 NCBI chr 3:26,335,788...26,520,633
Ensembl chr 3:26,336,403...26,518,521 		JBrowse link
G MSH6 mutS homolog 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:49,825,330...49,838,036
Ensembl chr10:49,803,898...49,838,028 		JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 6:11,411,062...11,438,767
Ensembl chr 6:11,349,453...11,438,940 		JBrowse link
G UNG uracil DNA glycosylase acts_upstream_of_or_within ISO (PMID:15494304) MGI PMID:15494304 NCBI chr26:17,900,354...17,911,126
Ensembl chr26:17,901,357...17,911,288 		JBrowse link
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr23:6,889,108...6,938,117
Ensembl chr23:6,889,135...6,938,116 		JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210 		JBrowse link
T cell receptor V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL11B BCL11 transcription factor B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:67,622,592...67,713,922
Ensembl chr 8:67,622,708...67,714,404 		JBrowse link
G LEF1 lymphoid enhancer binding factor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr32:28,516,002...28,633,759
Ensembl chr32:28,517,108...28,634,019 		JBrowse link
G LIG4 DNA ligase 4 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr22:56,980,333...56,987,636
Ensembl chr22:56,980,622...56,983,357 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO (PMID:9768755) MGI PMID:9768755 NCBI chr29:24,904...243,926
Ensembl chr29:35,007...243,895 		JBrowse link
G TCF7 transcription factor 7 acts_upstream_of_or_within ISO (PMID:9462507) MGI PMID:9462507 NCBI chr11:22,313,113...22,346,221
Ensembl chr11:22,313,105...22,344,004 		JBrowse link
V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207 		JBrowse link
G DCAF1 DDB1 and CUL4 associated factor 1 involved_in ISO (PMID:22157821) UniProt PMID:22157821 NCBI chr20:38,109,974...38,187,621
Ensembl chr20:38,125,078...38,187,107 		JBrowse link
G DCLRE1C DNA cross-link repair 1C acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:21,688,822...21,725,021
Ensembl chr 2:21,688,766...21,724,248 		JBrowse link
G HMGB1 high mobility group box 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:9,431,223...9,558,167
Ensembl chr25:9,431,218...9,558,165 		JBrowse link
G LIG1 DNA ligase 1 NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chr 1:108,105,523...108,143,954
Ensembl chr 1:108,105,987...108,143,953 		JBrowse link
G LIG3 DNA ligase 3 NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chr 9:38,346,275...38,366,634
Ensembl chr 9:38,346,199...38,366,193 		JBrowse link
G LIG4 DNA ligase 4 acts_upstream_of_or_within
involved_in		 IEA Ensembl GO_REF:0000107 NCBI chr22:56,980,333...56,987,636
Ensembl chr22:56,980,622...56,983,357 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO (PMID:23836881) MGI PMID:23836881 NCBI chr29:24,904...243,926
Ensembl chr29:35,007...243,895 		JBrowse link
G RAG1 recombination activating 1 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:2360047) UniProt
GO_Central
MGI
Ensembl
InterPro		 PMID:2360047 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr18:31,628,231...31,639,980
Ensembl chr18:31,630,737...31,641,660 		JBrowse link
G RAG2 recombination activating 2 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:2360047) Ensembl
GO_Central
MGI		 PMID:2360047 GO_REF:0000033 GO_REF:0000107 NCBI chr18:31,614,143...31,621,489
Ensembl chr18:31,618,481...31,620,064 		JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:10716994) MGI PMID:10716994 NCBI chr 3:24,316,598...24,547,463
Ensembl chr 3:24,269,974...24,533,465 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 acts_upstream_of_or_within ISO (PMID:10716994) MGI PMID:10716994 NCBI chr10:23,637,905...23,661,618
Ensembl chr10:23,638,237...23,661,480 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22141
    immune system process 2645
      somatic diversification of immune receptors 88
        somatic diversification of immune receptors via germline recombination within a single locus 81
          V(D)J recombination + 21
          somatic recombination of T cell receptor gene segments + 5
          somatic recombination of immunoglobulin gene segments + 69
Path 2
Term Annotations click to browse term
  biological_process 22141
    cellular process 21672
      metabolic process 15401
        primary metabolic process 13974
          nucleobase-containing compound metabolic process 9600
            nucleic acid metabolic process 9011
              DNA metabolic process 938
                DNA recombination 328
                  somatic cell DNA recombination 81
                    somatic diversification of immune receptors via germline recombination within a single locus 81
                      V(D)J recombination + 21
                      somatic recombination of T cell receptor gene segments + 5
                      somatic recombination of immunoglobulin gene segments + 69
paths to the root