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ONTOLOGY REPORT - ANNOTATIONS

Term:somatic diversification of immune receptors via germline recombination within a single locus
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Accession:GO:0002562 term browser browse the term
Definition:The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.


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immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POLB DNA polymerase beta acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:41,582,370...41,615,950
Ensembl chr 8:39,026,991...39,060,464 		JBrowse link
G YY1 YY1 transcription factor involved_in ISO (PMID:23531880) MGI PMID:23531880 NCBI chr14:80,859,491...80,903,651 JBrowse link
immunoglobulin V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYREN cell cycle regulator of NHEJ involved_in ISO (PMID:30017584), (PMID:31795137) UniProt PMID:30017584 PMID:31795137 NCBI chr 7:127,130,587...127,148,824 JBrowse link
G FOXP1 forkhead box P1 acts_upstream_of_or_within ISO (PMID:16819554) MGI PMID:16819554 NCBI chr 3:70,893,933...71,523,892
Ensembl chr 3:72,258,456...72,498,173 		JBrowse link
G LIG4 DNA ligase 4 involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr13:89,336,434...89,347,418
Ensembl chr13:108,475,820...108,478,555 		JBrowse link
G NHEJ1 non-homologous end joining factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:106,326,596...106,419,928
Ensembl chr2B:224,926,183...225,008,788 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:44,201,391...44,386,803
Ensembl chr 8:41,593,029...41,778,299 		JBrowse link
G TCF3 transcription factor 3 involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 Ensembl chr19:1,582,297...1,622,025 JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9875844) MGI
TreeGrafter		 PMID:9875844 GO_REF:0000118 NCBI chr 5:31,927,463...32,202,394
Ensembl chr 5:32,246,320...32,521,490 		JBrowse link
isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase acts_upstream_of_or_within
involved_in		 ISO (PMID:17713479)
(PMID:21518874)		 MGI
UniProt		 PMID:17713479 PMID:21518874 NCBI chr12:8,688,392...8,699,008
Ensembl chr12:8,904,273...8,913,917 		JBrowse link
G ATAD5 ATPase family AAA domain containing 5 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr17:25,944,259...26,009,317
Ensembl chr17:25,436,195...25,496,242 		JBrowse link
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:56,075,768...56,100,749
Ensembl chr14:74,919,115...74,943,652 		JBrowse link
G CD40LG CD40 ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:125,776,138...125,788,820
Ensembl chr  X:136,042,849...136,058,202 		JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr19:42,356,039...42,427,754
Ensembl chr19:50,951,674...50,968,430 		JBrowse link
G EXO1 exonuclease 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:217,410,175...217,451,982
Ensembl chr 1:222,389,684...222,431,556 		JBrowse link
G EXOSC3 exosome component 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:37,611,173...37,634,869
Ensembl chr 9:38,552,659...38,558,078 		JBrowse link
G LIG4 DNA ligase 4 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr13:89,336,434...89,347,418
Ensembl chr13:108,475,820...108,478,555 		JBrowse link
G LOC100970806 exosome complex component MTR3 involved_in ISO (PMID:21255825) UniProt PMID:21255825 NCBI chr 7:140,163,275...140,176,732 JBrowse link
G MLH1 mutL homolog 1 acts_upstream_of_or_within ISO (PMID:12743174) MGI PMID:12743174 NCBI chr 3:36,899,828...36,957,076
Ensembl chr 3:37,189,439...37,245,801 		JBrowse link
G MSH2 mutS homolog 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr2A:47,524,468...47,602,376
Ensembl chr2A:48,447,207...48,554,461 		JBrowse link
G MSH6 mutS homolog 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr2A:47,901,591...47,926,662
Ensembl chr2A:48,824,350...48,849,779 		JBrowse link
G NBN nibrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:86,622,797...86,674,202
Ensembl chr 8:88,575,198...88,626,307 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:98,914,957...98,948,467
Ensembl chr 3:105,616,645...105,628,300 		JBrowse link
G PCYT1A phosphate cytidylyltransferase 1A, choline involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:193,574,603...193,633,601
Ensembl chr 3:203,517,951...203,576,854 		JBrowse link
G RNF168 ring finger protein 168 involved_in ISO (PMID:20080757) UniProt PMID:20080757 NCBI chr 3:193,814,785...193,848,620
Ensembl chr 3:203,756,589...203,790,687 		JBrowse link
G RNF8 ring finger protein 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:36,918,705...36,955,380
Ensembl chr 6:38,108,414...38,145,949 		JBrowse link
G SANBR SANT and BTB domain regulator of CSR involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:61,157,551...61,229,955
Ensembl chr2A:62,299,121...62,369,817 		JBrowse link
G SWAP70 switching B cell complex subunit SWAP70 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:9,797,024...9,883,400
Ensembl chr11:9,526,752...9,614,422 		JBrowse link
G UNG uracil DNA glycosylase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:106,674,073...106,687,054
Ensembl chr12:110,067,879...110,080,891 		JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:17713479) MGI PMID:17713479 NCBI chr 5:31,927,463...32,202,394
Ensembl chr 5:32,246,320...32,521,490 		JBrowse link
isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR6 C-C motif chemokine receptor 6 involved_in ISO (PMID:27174992) UniProt PMID:27174992 NCBI chr 6:165,094,563...165,109,774
Ensembl chr 6:170,069,689...170,084,779 		JBrowse link
isotype switching to IgD isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FDCSP follicular dendritic cell secreted protein acts_upstream_of_positive_effect ISO (PMID:17548624) MGI PMID:17548624 NCBI chr 4:53,988,378...53,998,028
Ensembl chr 4:60,331,243...60,341,647 		JBrowse link
isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124 		JBrowse link
G FDCSP follicular dendritic cell secreted protein acts_upstream_of_or_within_negative_effect ISO (PMID:17548624) MGI PMID:17548624 NCBI chr 4:53,988,378...53,998,028
Ensembl chr 4:60,331,243...60,341,647 		JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029 		JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 acts_upstream_of IEA Ensembl GO_REF:0000107 Ensembl chr12:32,068,679...32,085,099 JBrowse link
isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FDCSP follicular dendritic cell secreted protein acts_upstream_of_or_within_negative_effect ISO (PMID:17548624) MGI PMID:17548624 NCBI chr 4:53,988,378...53,998,028
Ensembl chr 4:60,331,243...60,341,647 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:84,729,615...84,743,352
Ensembl chr2B:202,623,497...202,636,959 		JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARP3 poly(ADP-ribose) polymerase family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:51,883,695...51,890,266
Ensembl chr 3:53,112,494...53,119,053 		JBrowse link
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FDCSP follicular dendritic cell secreted protein involved_in ISO (PMID:24399151) MGI PMID:24399151 NCBI chr 4:53,988,378...53,998,028
Ensembl chr 4:60,331,243...60,341,647 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124 		JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:137,467,161...137,511,569
Ensembl chr 5:143,600,789...143,622,913 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:12496423) BHF-UCL PMID:12496423 NCBI chr 1:148,684,689...148,989,775
Ensembl chr 1:152,391,450...152,415,845
Ensembl chr 1:152,391,450...152,415,845 		JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EXOSC3 exosome component 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:37,611,173...37,634,869
Ensembl chr 9:38,552,659...38,558,078 		JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific involved_in ISO (PMID:31806351) UniProt PMID:31806351 NCBI chr 3:126,339,758...126,367,166
Ensembl chr 3:133,694,676...133,721,519 		JBrowse link
G KMT5B lysine methyltransferase 5B involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:63,239,796...63,297,113
Ensembl chr11:66,549,230...66,581,475 		JBrowse link
G KMT5C lysine methyltransferase 5C involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:52,381,963...52,390,507
Ensembl chr19:61,073,396...61,078,717 		JBrowse link
G LOC100970806 exosome complex component MTR3 acts_upstream_of_or_within ISO (PMID:21255825) MGI PMID:21255825 NCBI chr 7:140,163,275...140,176,732 JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:10,436,532...10,454,023
Ensembl chr 1:11,654,963...11,661,526 		JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:146,546,658...146,605,912
Ensembl chr 7:158,276,798...158,330,911 		JBrowse link
G RIF1 replication timing regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:38,721,658...38,818,488
Ensembl chr2B:155,985,960...156,052,926 		JBrowse link
G SHLD1 shieldin complex subunit 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:5,753,262...5,858,728
Ensembl chr20:5,537,488...5,642,107 		JBrowse link
G SHLD2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chr10:83,639,020...83,643,420 JBrowse link
G SHLD3 shieldin complex subunit 3 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chr 5:48,376,338...48,382,052 JBrowse link
G TFRC transferrin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:193,384,817...193,417,532
Ensembl chr 3:203,333,953...203,373,998 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:22,364,696...22,472,499
Ensembl chr15:40,519,012...40,626,741 		JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 involved_in ISO (PMID:10430621) CAFA PMID:10430621 NCBI chr 3:36,899,828...36,957,076
Ensembl chr 3:37,189,439...37,245,801 		JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:47,524,468...47,602,376
Ensembl chr2A:48,447,207...48,554,461 		JBrowse link
G NSD2 nuclear receptor binding SET domain protein 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:2,009,276...2,119,182
Ensembl chr 4:1,945,307...2,027,425 		JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:7,433,031...7,459,560
Ensembl chr 7:6,167,403...6,202,984 		JBrowse link
G TGFB1 transforming growth factor beta 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973 		JBrowse link
G TNFSF13 TNF superfamily member 13 involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:7,589,931...7,593,527
Ensembl chr17:7,576,465...7,579,834 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCF1 cardiotrophin like cytokine factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:62,722,611...62,734,279 JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:14988498) MGI PMID:14988498 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr12:32,068,679...32,085,099 JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAD5 ATPase family AAA domain containing 5 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:25,944,259...26,009,317
Ensembl chr17:25,436,195...25,496,242 		JBrowse link
G CD28 CD28 molecule acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr2B:90,938,795...90,971,438
Ensembl chr2B:209,076,388...209,111,213 		JBrowse link
G CD40 CD40 molecule acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994 		JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IL2 interleukin 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:12882831), (PMID:14988498) MGI PMID:12882831 PMID:14988498 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G MLH1 mutL homolog 1 involved_in ISO (PMID:10430621) CAFA PMID:10430621 NCBI chr 3:36,899,828...36,957,076
Ensembl chr 3:37,189,439...37,245,801 		JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:47,524,468...47,602,376
Ensembl chr2A:48,447,207...48,554,461 		JBrowse link
G PAGR1 PAXIP1 associated glutamate rich protein 1 involved_in ISO (PMID:26744420) UniProt PMID:26744420 Ensembl chr16:30,186,326...30,190,654 JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:146,546,658...146,605,912
Ensembl chr 7:158,276,798...158,330,911 		JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:7,433,031...7,459,560
Ensembl chr 7:6,167,403...6,202,984 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:174,246,389...174,364,893
Ensembl chr 1:178,556,104...178,672,994 		JBrowse link
G TBX21 T-box transcription factor 21 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:9,791,008...9,803,894
Ensembl chr17:9,973,920...9,985,660 		JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLF aprataxin and PNKP like factor acts_upstream_of_or_within ISO (PMID:21211721) MGI PMID:21211721 NCBI chr2A:68,509,314...68,629,192
Ensembl chr2A:69,632,459...69,744,611 		JBrowse link
G SUPT6H SPT6 homolog, histone chaperone and transcription elongation factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:28,073,288...28,113,041
Ensembl chr17:28,578,199...28,617,292 		JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029 		JBrowse link
G IL27RA interleukin 27 receptor subunit alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr19:14,323,618...14,343,627 JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:137,467,161...137,511,569
Ensembl chr 5:143,600,789...143,622,913 		JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in ISO (PMID:25310967) UniProt PMID:25310967 NCBI chr12:126,418,071...126,448,917 JBrowse link
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 acts_upstream_of_or_within ISO (PMID:11828012) MGI PMID:11828012 NCBI chr 3:36,899,828...36,957,076
Ensembl chr 3:37,189,439...37,245,801 		JBrowse link
G MSH2 mutS homolog 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr2A:47,524,468...47,602,376
Ensembl chr2A:48,447,207...48,554,461 		JBrowse link
G MSH3 mutS homolog 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15238604) MGI
TreeGrafter		 PMID:15238604 GO_REF:0000118 NCBI chr 5:34,408,469...34,663,483
Ensembl chr 5:34,719,322...34,938,469 		JBrowse link
G MSH6 mutS homolog 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr2A:47,901,591...47,926,662
Ensembl chr2A:48,824,350...48,849,779 		JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:7,433,031...7,459,560
Ensembl chr 7:6,167,403...6,202,984 		JBrowse link
G UNG uracil DNA glycosylase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:106,674,073...106,687,054
Ensembl chr12:110,067,879...110,080,891 		JBrowse link
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 acts_upstream_of_or_within ISO (PMID:12743174) MGI PMID:12743174 NCBI chr 3:36,899,828...36,957,076
Ensembl chr 3:37,189,439...37,245,801 		JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr2A:47,524,468...47,602,376
Ensembl chr2A:48,447,207...48,554,461 		JBrowse link
T cell receptor V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL11B BCL11 transcription factor B acts_upstream_of_or_within ISO (PMID:12717433) MGI PMID:12717433 NCBI chr14:79,795,262...79,898,472 JBrowse link
G LEF1 lymphoid enhancer binding factor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:100,552,959...100,674,156
Ensembl chr 4:111,125,312...111,245,980 		JBrowse link
G LIG4 DNA ligase 4 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr13:89,336,434...89,347,418
Ensembl chr13:108,475,820...108,478,555 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:44,201,391...44,386,803
Ensembl chr 8:41,593,029...41,778,299 		JBrowse link
G TCF7 transcription factor 7 acts_upstream_of_or_within ISO (PMID:9462507) MGI PMID:9462507 NCBI chr 5:129,518,134...129,549,972
Ensembl chr 5:135,671,095...135,702,734 		JBrowse link
V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041 		JBrowse link
G DCAF1 DDB1 and CUL4 associated factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:51,326,589...51,430,217
Ensembl chr 3:52,560,427...52,663,807 		JBrowse link
G DCLRE1C DNA cross-link repair 1C acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:14,901,335...14,956,947
Ensembl chr10:15,236,558...15,269,043 		JBrowse link
G HMGB1 high mobility group box 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527 		JBrowse link
G LIG1 DNA ligase 1 NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chr19:45,056,737...45,110,867
Ensembl chr19:53,706,778...53,761,088 		JBrowse link
G LIG3 DNA ligase 3 NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chr17:21,776,483...21,805,706
Ensembl chr17:22,074,046...22,095,220 		JBrowse link
G LIG4 DNA ligase 4 acts_upstream_of_or_within
involved_in		 IEA Ensembl GO_REF:0000107 NCBI chr13:89,336,434...89,347,418
Ensembl chr13:108,475,820...108,478,555 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:44,201,391...44,386,803
Ensembl chr 8:41,593,029...41,778,299 		JBrowse link
G RAG1 recombination activating 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:2360047) Ensembl
TreeGrafter
MGI
UniProt
InterPro		 PMID:2360047 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr11:36,483,697...36,546,242
Ensembl chr11:36,412,420...36,422,904 		JBrowse link
G RAG2 recombination activating 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:2360047) Ensembl
TreeGrafter
MGI		 PMID:2360047 GO_REF:0000107 GO_REF:0000118 NCBI chr11:36,558,419...36,564,997
Ensembl chr11:36,431,703...36,433,286 		JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:10716994) MGI PMID:10716994 NCBI chr 5:31,927,463...32,202,394
Ensembl chr 5:32,246,320...32,521,490 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 acts_upstream_of_or_within ISO (PMID:10716994) MGI PMID:10716994 NCBI chr22:22,516,281...22,557,379
Ensembl chr22:40,603,038...40,643,314 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    immune system process 2521
      somatic diversification of immune receptors 85
        somatic diversification of immune receptors via germline recombination within a single locus 78
          V(D)J recombination + 21
          somatic recombination of T cell receptor gene segments + 5
          somatic recombination of immunoglobulin gene segments + 66
Path 2
Term Annotations click to browse term
  biological_process 19315
    cellular process 18871
      metabolic process 12799
        primary metabolic process 11199
          nucleobase-containing compound metabolic process 7087
            nucleic acid metabolic process 6570
              DNA metabolic process 902
                DNA recombination 313
                  somatic cell DNA recombination 78
                    somatic diversification of immune receptors via germline recombination within a single locus 78
                      V(D)J recombination + 21
                      somatic recombination of T cell receptor gene segments + 5
                      somatic recombination of immunoglobulin gene segments + 66
paths to the root