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ONTOLOGY REPORT - ANNOTATIONS

Term:germinal center formation
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Accession:GO:0002467 term browser browse the term
Definition:The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.


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germinal center formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of ISO
IEA		 MGI:1857117|MGI:2683027 (PMID:14607964)
GO_REF:0000107		 RGD
Ensembl		 PMID:14607964 GO_REF:0000107 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 involved_in ISO
IEA		 (PMID:17371977)
GO_REF:0000107		 RGD
Ensembl		 PMID:17371977 GO_REF:0000107 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Bcl3 BCL3, transcription coactivator acts_upstream_of_or_within ISO MGI:1861796|MGI:2158443 (PMID:10586052), (PMID:9009202), (PMID:9133427) RGD PMID:9009202 PMID:9133427 PMID:10586052 NCBI chr 1:88,599,321...88,613,555
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO
IEA		 MGI:2158436|MGI:2158438|MGI:2158439 (PMID:12354385), (PMID:9110977), (PMID:9171827), (PMID:9236196)
GO_REF:0000107		 RGD
Ensembl		 PMID:9110977 PMID:9171827 PMID:9236196 PMID:12354385 GO_REF:0000107 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Klhl6 kelch-like family member 6 involved_in ISO
IEA		 (PMID:16166635)
GO_REF:0000002
GO_REF:0000107		 RGD
InterPro
Ensembl		 PMID:16166635 GO_REF:0000002 GO_REF:0000107 NCBI chr11:94,475,262...94,514,653
Ensembl chr11:80,970,917...81,009,677 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO		 GO_REF:0000024
(PMID:18955699)		 UniProt
RGD		 PMID:18955699 GO_REF:0000024 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 acts_upstream_of_or_within ISO
IEA		 MGI:2179705 (PMID:10586052)
GO_REF:0000107		 RGD
Ensembl		 PMID:10586052 GO_REF:0000107 NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C acts_upstream_of ISO MGI:2389403 (PMID:14557413) RGD PMID:14557413 NCBI chr 7:115,616,139...115,618,647
Ensembl chr 7:113,736,055...113,738,517 		JBrowse link
G Tnfsf13 TNF superfamily member 13 acts_upstream_of ISO MGI:3038886 (PMID:14988498) RGD PMID:14988498 NCBI chr10:54,898,805...54,901,815
Ensembl chr10:54,400,065...54,403,042 		JBrowse link
G Tnfsf13b TNF superfamily member 13b acts_upstream_of ISO
IEA		 MGI:2387426 (PMID:14557413)
GO_REF:0000107		 RGD
Ensembl		 PMID:14557413 GO_REF:0000107 NCBI chr16:86,164,377...86,195,072
Ensembl chr16:79,462,402...79,492,693 		JBrowse link
G Unc13d unc-13 homolog D acts_upstream_of_or_within ISO MGI:3628822 (PMID:17420270) RGD PMID:17420270 NCBI chr10:101,795,652...101,810,409
Ensembl chr10:101,296,776...101,311,687 		JBrowse link
negative regulation of germinal center formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxj1 forkhead box J1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:16002694)		 Ensembl
RGD		 PMID:16002694 GO_REF:0000107 NCBI chr10:102,065,163...102,069,945
Ensembl chr10:101,566,304...101,570,237 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO
IEA		 (PMID:18172933)
GO_REF:0000107		 RGD
Ensembl		 PMID:18172933 GO_REF:0000107 NCBI chr13:75,707,098...75,779,114
Ensembl chr13:73,173,946...73,238,839 		JBrowse link
positive regulation of germinal center formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within ISO
IEA		 MGI:1857117|MGI:2683027 (PMID:14607964)
GO_REF:0000107		 RGD
Ensembl		 PMID:14607964 GO_REF:0000107 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G RT1-DMa RT1 class II, locus DMa involved_in ISO (PMID:11714799) RGD PMID:11714799 NCBI chr20:4,708,932...4,712,335
Ensembl chr20:4,707,028...4,710,432 		JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C acts_upstream_of_or_within ISO MGI:2389403 (PMID:14557413) RGD PMID:14557413 NCBI chr 7:115,616,139...115,618,647
Ensembl chr 7:113,736,055...113,738,517 		JBrowse link
G Tnfsf13 TNF superfamily member 13 acts_upstream_of_or_within ISO MGI:3038886 (PMID:14988498) RGD PMID:14988498 NCBI chr10:54,898,805...54,901,815
Ensembl chr10:54,400,065...54,403,042 		JBrowse link
G Tnfsf13b TNF superfamily member 13b acts_upstream_of_or_within ISO
IEA		 MGI:2387426 (PMID:14557413)
GO_REF:0000107		 RGD
Ensembl		 PMID:14557413 GO_REF:0000107 NCBI chr16:86,164,377...86,195,072
Ensembl chr16:79,462,402...79,492,693 		JBrowse link
regulation of germinal center formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO		 GO_REF:0000024
(PMID:18438409)		 UniProt
RGD		 PMID:18438409 GO_REF:0000024 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Pkn1 protein kinase N1 acts_upstream_of_or_within ISO
IEA		 MGI:5475202 (PMID:23223530)
GO_REF:0000107		 RGD
Ensembl		 PMID:23223530 GO_REF:0000107 NCBI chr19:41,346,855...41,374,832
Ensembl chr19:24,442,122...24,470,107 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO
IEA		 (PMID:15917799), (PMID:19217324)
GO_REF:0000107		 RGD
Ensembl		 PMID:15917799 PMID:19217324 GO_REF:0000107 NCBI chr13:75,707,098...75,779,114
Ensembl chr13:73,173,946...73,238,839 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO
IEA		 (PMID:21088135)
GO_REF:0000107		 RGD
Ensembl		 PMID:21088135 GO_REF:0000107 NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20567
    developmental process 7160
      anatomical structure formation involved in morphogenesis 1383
        germinal center formation 16
          negative regulation of germinal center formation 2
          positive regulation of germinal center formation 5
          regulation of germinal center formation + 10
Path 2
Term Annotations click to browse term
  biological_process 20567
    immune system process 3132
      immune response 2238
        adaptive immune response 668
          adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 474
            germinal center formation 16
              negative regulation of germinal center formation 2
              positive regulation of germinal center formation 5
              regulation of germinal center formation + 10
paths to the root