Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:humoral immune response mediated by circulating immunoglobulin
go back to main search page
Accession:GO:0002455 term browser browse the term
Definition:An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
Synonyms:exact_synonym: circulating antibody mediated immune response;   circulating immunoglobulin mediated immune response;   humoral immune response mediated by circulating antibody
 related_synonym: humoral defence mechanism


show annotations for term's descendants           Sort by:
humoral immune response mediated by circulating immunoglobulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl3 BCL3, transcription coactivator acts_upstream_of_or_within ISO MGI:1861796 (PMID:9009202) RGD PMID:9009202 NCBI chr 1:88,599,321...88,613,555
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Cd81 Cd81 molecule involved_in ISO
ISS		 (PMID:20237408)
GO_REF:0000024		 RGD
UniProt		 PMID:20237408 GO_REF:0000024 NCBI chr 1:207,665,274...207,681,094
Ensembl chr 1:198,241,484...198,251,660 		JBrowse link
G Exo1 exonuclease 1 acts_upstream_of_or_within ISO
IEA		 MGI:2653925 (PMID:14716311)
GO_REF:0000107		 RGD
Ensembl		 PMID:14716311 GO_REF:0000107 NCBI chr13:90,341,947...90,366,861
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Fcmr Fc mu receptor involved_in ISS
ISO		 GO_REF:0000024
(PMID:22988094)		 UniProt
RGD		 PMID:22988094 GO_REF:0000024 NCBI chr13:44,889,628...44,903,926
Ensembl chr13:42,337,414...42,351,653 		JBrowse link
G Ighg1 immunoglobulin heavy constant gamma 1 acts_upstream_of_or_within ISO (PMID:11057672), (PMID:14988498), (PMID:15692051), (PMID:16492738), (PMID:8041705), (PMID:8566034), (PMID:9834074) RGD PMID:8041705 PMID:8566034 PMID:9834074 PMID:11057672 PMID:14988498 More... Ensembl chr 6:132,389,370...132,393,397 JBrowse link
G Zp2 zona pellucida glycoprotein 2 involved_in ISO (PMID:12052239) RGD PMID:12052239 NCBI chr 1:183,944,840...183,956,619
Ensembl chr 1:174,513,511...174,525,288 		JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:20382503)
(PMID:12052239)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:12052239 PMID:20382503 GO_REF:0000024 GO_REF:0000107 NCBI chr12:26,327,161...26,334,126
Ensembl chr12:20,690,547...20,697,513 		JBrowse link
complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07006691.1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr 1:228,016,498...228,043,066 JBrowse link
G C1qa complement C1q A chain involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:29449492)
GO_REF:0000043
MGI:2158701 (PMID:11901193)
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:11901193 PMID:29449492 GO_REF:0000043 GO_REF:0000107 NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qb complement C1q B chain involved_in ISO
IEA		 (PMID:29449492)
GO_REF:0000043		 RGD
UniProt		 PMID:29449492 GO_REF:0000043 NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G C1qbp complement C1q binding protein involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:56,198,534...56,203,185
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G C1qc complement C1q C chain involved_in ISO
IEA		 (PMID:29449492)
GO_REF:0000043
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:29449492 GO_REF:0000043 GO_REF:0000107 NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G C1r complement C1r involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:157,412,692...157,423,484 		JBrowse link
G C1rl complement C1r subcomponent like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:159,080,495...159,097,066
Ensembl chr 4:157,394,200...157,410,134 		JBrowse link
G C1s complement C1s involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:157,430,117...157,442,303 		JBrowse link
G C2 complement C2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:3,944,722...3,975,006
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G C3 complement C3 involved_in TAS
IEA		 GO_REF:0000043 UniProt
RGD		 PMID:16996480 GO_REF:0000043, RGD:1600605 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C4a complement C4A involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:4,010,306...4,024,707
Ensembl chr20:4,005,731...4,020,080 		JBrowse link
G C4b complement C4B involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G C4bpa complement component 4 binding protein, alpha involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:44,627,959...44,663,552
Ensembl chr13:42,075,717...42,111,205 		JBrowse link
G C4bpb complement component 4 binding protein, beta involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:44,673,064...44,683,781
Ensembl chr13:42,120,798...42,131,817 		JBrowse link
G C5 complement C5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C5l1 complement C5 like 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:38,799,165...38,818,443
Ensembl chr 3:18,404,899...18,420,054 		JBrowse link
G C6 complement C6 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
G C8a complement C8 alpha chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:124,812,131...124,866,631
Ensembl chr 5:119,583,174...119,637,754 		JBrowse link
G C8b complement C8 beta chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:124,763,974...124,801,522
Ensembl chr 5:119,535,146...119,572,565 		JBrowse link
G C9 complement C9 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:57,300,510...57,348,759
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cfb complement factor B involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfi complement factor I involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:221,062,206...221,104,790
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Crp C-reactive protein IMP RGD PMID:16367929 RGD:1580273 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G ENSRNOG00000065917 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 6:132,469,837...132,473,735 JBrowse link
G ENSRNOG00000070986 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 6:132,341,443...132,343,215 JBrowse link
G Igg-2a gamma-2a immunoglobulin heavy chain involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Igh-6 immunoglobulin heavy chain 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Ighg1 immunoglobulin heavy constant gamma 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:6952213)		 GO_Central
RGD		 PMID:6952213 GO_REF:0000033 Ensembl chr 6:132,389,370...132,393,397 JBrowse link
G Masp2 MBL associated serine protease 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:164,319,017...164,332,686
Ensembl chr 5:159,035,911...159,049,580 		JBrowse link
G Mbl1 mannose binding lectin 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr16:17,063,232...17,069,271
Ensembl chr16:17,029,118...17,035,174 		JBrowse link
G Mbl2 mannose binding lectin 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:237,429,873...237,465,567 JBrowse link
G Serping1 serpin family G member 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4bpa complement component 4 binding protein, alpha involved_in ISO
IEA
IBA		 (PMID:22333221)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:22333221 GO_REF:0000033 GO_REF:0000107 NCBI chr13:44,627,959...44,663,552
Ensembl chr13:42,075,717...42,111,205 		JBrowse link
G C4bpb complement component 4 binding protein, beta involved_in ISO
IEA		 (PMID:22333221)
GO_REF:0000107		 RGD
Ensembl		 PMID:22333221 GO_REF:0000107 NCBI chr13:44,673,064...44,683,781
Ensembl chr13:42,120,798...42,131,817 		JBrowse link
G Cd46 CD46 molecule involved_in ISO
IBA		 (PMID:9029106)
GO_REF:0000033		 RGD
GO_Central		 PMID:9029106 GO_REF:0000033 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cd46l1 CD46 molecule like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:34,538,996...34,539,997
Ensembl chr20:33,996,224...33,997,432 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cr2 complement C3d receptor 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:109,207,034...109,244,980
Ensembl chr13:106,685,413...106,716,235 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) RGD PMID:23482636 NCBI chr13:96,982,867...97,109,419
Ensembl chr13:94,455,165...94,577,750 		JBrowse link
G Zp3r zona pellucida 3 receptor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:44,572,283...44,617,101
Ensembl chr13:42,020,018...42,064,812 		JBrowse link
negative regulation of humoral immune response mediated by circulating immunoglobulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcgr2b Fc gamma receptor 2B acts_upstream_of_or_within ISO MGI:1857166 (PMID:12385742) RGD PMID:12385742 NCBI chr13:85,725,897...85,740,517
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Foxj1 forkhead box J1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:16002694)		 Ensembl
RGD		 PMID:16002694 GO_REF:0000107 NCBI chr10:102,065,163...102,069,945
Ensembl chr10:101,566,304...101,570,237 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 acts_upstream_of_or_within ISO
IEA		 MGI:1856074 (PMID:9254656)
GO_REF:0000107		 RGD
Ensembl		 PMID:9254656 GO_REF:0000107 NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
positive regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:30548312) RGD PMID:30548312 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
positive regulation of humoral immune response mediated by circulating immunoglobulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcer2 Fc epsilon receptor II acts_upstream_of_or_within ISO MGI:3583003 (PMID:8041705) RGD PMID:8041705 NCBI chr12:6,540,697...6,552,364
Ensembl chr12:1,742,815...1,754,476 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:11934565 RGD:2303774 NCBI chr 4:79,025,151...79,031,917
Ensembl chr 4:77,687,564...77,703,086 		JBrowse link
G Hpx hemopexin acts_upstream_of_or_within ISO
IEA		 MGI:2447193 (PMID:18641331)
GO_REF:0000107		 RGD
Ensembl		 PMID:18641331 GO_REF:0000107 NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:159,932,755...159,940,328 		JBrowse link
G Lta lymphotoxin alpha acts_upstream_of_or_within ISO
IEA		 MGI:104798 (PMID:9834074)
GO_REF:0000107		 RGD
Ensembl		 PMID:9834074 GO_REF:0000107 NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within ISO MGI:3529594 (PMID:15692051) RGD PMID:15692051 NCBI chr19:34,555,832...34,596,281
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:2181288 (PMID:8566034) RGD PMID:8566034 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Tnf tumor necrosis factor acts_upstream_of_or_within ISO MGI:104797 (PMID:9834074) RGD PMID:9834074 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO MGI:2387405 (PMID:9892684) RGD PMID:9892684 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
regulation of humoral immune response mediated by circulating immunoglobulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:2181288 (PMID:9015183) RGD PMID:9015183 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    response to stimulus 11067
      immune response 2236
        humoral immune response 272
          humoral immune response mediated by circulating immunoglobulin 56
            complement activation, classical pathway + 40
            negative regulation of humoral immune response mediated by circulating immunoglobulin + 11
            positive regulation of humoral immune response mediated by circulating immunoglobulin + 8
            regulation of humoral immune response mediated by circulating immunoglobulin + 20
Path 2
Term Annotations click to browse term
  biological_process 20558
    immune system process 3130
      immune effector process 844
        leukocyte mediated immunity 580
          lymphocyte mediated immunity 465
            B cell mediated immunity 253
              immunoglobulin mediated immune response 249
                humoral immune response mediated by circulating immunoglobulin 56
                  complement activation, classical pathway + 40
                  negative regulation of humoral immune response mediated by circulating immunoglobulin + 11
                  positive regulation of humoral immune response mediated by circulating immunoglobulin + 8
                  regulation of humoral immune response mediated by circulating immunoglobulin + 20
paths to the root