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ONTOLOGY REPORT - ANNOTATIONS

Term:B cell affinity maturation
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Accession:GO:0002344 term browser browse the term
Definition:The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
Synonyms:exact_synonym: B-lymphocyte affinity maturation

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B cell affinity maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btk Bruton tyrosine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936813:429,400...467,481
Ensembl chrNW_004936813:429,224...463,441 		JBrowse link
G LOC101968779 HLA class II histocompatibility antigen, DQ beta 1 chain-like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:361,446...368,507
Ensembl chrNW_004936727:361,398...368,532 		JBrowse link
G Traf3ip2 TRAF3 interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936679:308,508...348,561
Ensembl chrNW_004936679:316,277...336,557 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17417
    immune system process 2307
      B cell selection 5
        peripheral B cell selection 3
          B cell affinity maturation 3
            somatic hypermutation of immunoglobulin genes involved in immune response 0
Path 2
Term Annotations click to browse term
  biological_process 17417
    cellular process 17021
      cellular developmental process 4354
        cell differentiation 4353
          cell development 3128
            hemopoiesis 989
              leukocyte differentiation 633
                mononuclear cell differentiation 511
                  lymphocyte differentiation 416
                    B cell differentiation 146
                      B cell selection 5
                        peripheral B cell selection 3
                          B cell affinity maturation 3
                            somatic hypermutation of immunoglobulin genes involved in immune response 0
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