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ONTOLOGY REPORT - ANNOTATIONS

Term:B cell affinity maturation
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Accession:GO:0002344 term browser browse the term
Definition:The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
Synonyms:exact_synonym: B-lymphocyte affinity maturation

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B cell affinity maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btk Bruton tyrosine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624902:1,173,101...1,216,662
Ensembl chrNW_004624902:1,182,682...1,216,171 		JBrowse link
G Traf3ip2 TRAF3 interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624933:507,879...558,357
Ensembl chrNW_004624933:506,254...554,015 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17650
    immune system process 2287
      B cell selection 4
        peripheral B cell selection 2
          B cell affinity maturation 2
            somatic hypermutation of immunoglobulin genes involved in immune response 0
Path 2
Term Annotations click to browse term
  biological_process 17650
    cellular process 17226
      cellular developmental process 4324
        cell differentiation 4323
          cell development 3073
            hemopoiesis 949
              leukocyte differentiation 611
                mononuclear cell differentiation 495
                  lymphocyte differentiation 403
                    B cell differentiation 138
                      B cell selection 4
                        peripheral B cell selection 2
                          B cell affinity maturation 2
                            somatic hypermutation of immunoglobulin genes involved in immune response 0
paths to the root