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ONTOLOGY REPORT - ANNOTATIONS

Term:B cell affinity maturation
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Accession:GO:0002344 term browser browse the term
Definition:The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
Synonyms:exact_synonym: B-lymphocyte affinity maturation


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B cell affinity maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btk Bruton agammaglobulinemia tyrosine kinase acts_upstream_of_or_within IMP (PMID:7680896) MGI PMID:7680896 NCBI chr  X:133,443,083...133,484,366
Ensembl chr  X:133,443,085...133,484,319 		JBrowse link
G Ighm immunoglobulin heavy constant mu acts_upstream_of_or_within IMP (PMID:9707605) MGI PMID:9707605 NCBI chr12:113,382,446...113,386,350
Ensembl chr12:113,382,178...113,386,350 		JBrowse link
G Traf3ip2 TRAF3 interacting protein 2 involved_in IMP (PMID:20543113) MGI PMID:20543113 NCBI chr10:39,488,930...39,531,303
Ensembl chr10:39,488,930...39,531,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28640
    immune system process 3186
      B cell selection 5
        peripheral B cell selection 3
          B cell affinity maturation 3
            somatic hypermutation of immunoglobulin genes involved in immune response 0
Path 2
Term Annotations click to browse term
  biological_process 28640
    cellular process 18404
      cellular developmental process 5187
        cell differentiation 5186
          cell development 3530
            hemopoiesis 1182
              leukocyte differentiation 757
                mononuclear cell differentiation 611
                  lymphocyte differentiation 493
                    B cell differentiation 164
                      B cell selection 5
                        peripheral B cell selection 3
                          B cell affinity maturation 3
                            somatic hypermutation of immunoglobulin genes involved in immune response 0
paths to the root