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ONTOLOGY REPORT - ANNOTATIONS

Term:B cell affinity maturation
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Accession:GO:0002344 term browser browse the term
Definition:The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
Synonyms:exact_synonym: B-lymphocyte affinity maturation


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B cell affinity maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btk Bruton tyrosine kinase acts_upstream_of_or_within ISO
IEA 		MGI:1856317 (PMID:7680896)
GO_REF:0000107 		RGD
Ensembl		 PMID:7680896 GO_REF:0000107 NCBI chr  X:102,016,070...102,055,448
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G RT1-Bb RT1 class II, locus Bb involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G Traf3ip2 Traf3 interacting protein 2 involved_in ISO MGI:3510784 (PMID:20543113) RGD PMID:20543113 NCBI chr20:44,565,992...44,609,240
Ensembl chr20:43,011,450...43,054,667 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    immune system process 3133
      B cell selection 5
        peripheral B cell selection 3
          B cell affinity maturation 3
            somatic hypermutation of immunoglobulin genes involved in immune response 0
Path 2
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      cellular developmental process 4838
        cell differentiation 4837
          cell development 3352
            hemopoiesis 1084
              leukocyte differentiation 690
                mononuclear cell differentiation 556
                  lymphocyte differentiation 455
                    B cell differentiation 158
                      B cell selection 5
                        peripheral B cell selection 3
                          B cell affinity maturation 3
                            somatic hypermutation of immunoglobulin genes involved in immune response 0
paths to the root