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ONTOLOGY REPORT - ANNOTATIONS


Term:mature B cell differentiation
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Accession:GO:0002335 term browser browse the term
Definition:The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: mature B lymphocyte differentiation
 related_synonym: mature cell development



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mature B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of ISO MGI:5544783 (PMID:23918385) RGD PMID:23918385 NCBI chr  X:66,395,330...66,399,026 JBrowse link
G Pou2f2 POU class 2 homeobox 2 acts_upstream_of_or_within ISO MGI:3028896 (PMID:8096198) RGD PMID:8096198 NCBI chr 1:80,682,330...80,769,756 JBrowse link
B-1 B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd19 CD19 molecule involved_in ISO (PMID:7543183) RGD PMID:7543183 NCBI chr 1:180,987,286...180,993,920 JBrowse link
G Malt1 MALT1 paracaspase acts_upstream_of_or_within ISO MGI:3639305 (PMID:14614861) RGD PMID:14614861 NCBI chr18:58,942,282...58,996,318 JBrowse link
B-1 B cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slamf8 SLAM family member 8 involved_in ISO (PMID:11313408) RGD PMID:11313408 NCBI chr13:87,580,081...87,589,941 JBrowse link
B-1a B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cmtm7 CKLF-like MARVEL transmembrane domain containing 7 acts_upstream_of_or_within ISO (PMID:24080084) RGD PMID:24080084 NCBI chr 8:114,448,037...114,474,958 JBrowse link
G Dpp4 dipeptidylpeptidase 4 IMP RGD PMID:19327106 RGD:41408336 NCBI chr 3:46,962,233...47,043,870 JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 acts_upstream_of_or_within ISO MGI:2181762 (PMID:14595020) RGD PMID:14595020 NCBI chr18:74,046,422...74,156,041 JBrowse link
G Plcl2 phospholipase C-like 2 acts_upstream_of_or_within ISO MGI:2679632 (PMID:14517301) RGD PMID:14517301 NCBI chr 9:3,292,564...3,477,009 JBrowse link
follicular B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf8 interferon regulatory factor 8 involved_in ISO UniProtKB:P17433 (PMID:31000603) RGD PMID:31000603 NCBI chr19:65,699,284...65,721,066 JBrowse link
G Muc19 mucin 19, oligomeric acts_upstream_of_or_within ISO (PMID:37475871) RGD PMID:37475871 NCBI chr 7:123,017,896...123,139,053 JBrowse link
G Plcg2 phospholipase C, gamma 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386100 (PMID:12928432)
Ensembl
RGD
PMID:12928432 GO_REF:0000107 NCBI chr19:45,547,416...45,683,930 JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO UniProtKB:P23611 (PMID:31000603) RGD PMID:31000603 NCBI chr 3:77,059,744...77,093,730 JBrowse link
germinal center B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857117|MGI:2683027 (PMID:14607964)
Ensembl
RGD
PMID:14607964 GO_REF:0000107 NCBI chr 3:152,398,745...152,422,854 JBrowse link
G Cdh17 cadherin 17 involved_in ISO (PMID:15688343) RGD PMID:15688343 NCBI chr 5:25,262,820...25,314,884 JBrowse link
G Il21 interleukin 21 involved_in ISS
ISO
GO_REF:0000024
(PMID:23045607)
UniProt
RGD
PMID:23045607 GO_REF:0000024 NCBI chr 2:122,045,240...122,055,142 JBrowse link
G Il6 interleukin 6 involved_in ISS
ISO
GO_REF:0000024
(PMID:23045607)
UniProt
RGD
PMID:23045607 GO_REF:0000024 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Irf8 interferon regulatory factor 8 involved_in ISO UniProtKB:P17433 (PMID:31000603) RGD PMID:31000603 NCBI chr19:65,699,284...65,721,066 JBrowse link
G Itfg2 integrin alpha FG-GAP repeat containing 2 acts_upstream_of_or_within ISO MGI:4235940 (PMID:23997217) RGD PMID:23997217 NCBI chr 4:161,684,249...161,698,315 JBrowse link
G Phf14 PHD finger protein 14 involved_in ISO (PMID:33035772) RGD PMID:33035772 NCBI chr 4:40,009,691...40,195,877 JBrowse link
G Pou2af1 POU class 2 homeobox associating factor 1 involved_in ISO (PMID:23045607) RGD PMID:23045607 NCBI chr 8:60,418,173...60,445,176 JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO UniProtKB:P23611 (PMID:31000603) RGD PMID:31000603 NCBI chr 3:77,059,744...77,093,730 JBrowse link
marginal zone B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl3 BCL3, transcription coactivator acts_upstream_of_or_within ISO MGI:1861796 (PMID:9009202) RGD PMID:9009202 NCBI chr 1:79,471,368...79,485,908 JBrowse link
G Cdh17 cadherin 17 involved_in ISO (PMID:15688343) RGD PMID:15688343 NCBI chr 5:25,262,820...25,314,884 JBrowse link
G Dll1 delta like canonical Notch ligand 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:15146182), (PMID:19217325)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:15146182 PMID:19217325 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:64,985,161...64,993,274 JBrowse link
G Dock10 dedicator of cytokinesis 10 involved_in ISO (PMID:25729399) RGD PMID:25729399 NCBI chr 9:81,843,599...82,101,540 JBrowse link
G Dock11 dedicator of cytokinesis 11 involved_in ISO (PMID:25729399) RGD PMID:25729399 NCBI chr  X:115,131,720...115,314,854 JBrowse link
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:19217325)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:19217325 GO_REF:0000024 GO_REF:0000107 NCBI chr12:14,030,551...14,038,996 JBrowse link
G Mfng MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase involved_in ISO (PMID:19217325) RGD PMID:19217325 NCBI chr 7:110,310,810...110,328,653 JBrowse link
G Notch2 notch receptor 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:19217325)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:19217325 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:185,610,594...185,744,088 JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISS
ISO
GO_REF:0000024
(PMID:10881171)
UniProt
RGD
PMID:10881171 GO_REF:0000024 NCBI chr15:40,360,722...40,481,235 JBrowse link
mature B cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C10h17orf99 similar to human chromosome 17 open reading frame 99 involved_in ISO (PMID:28978694) RGD PMID:28978694 NCBI chr10:103,015,371...103,027,407 JBrowse link
G Gpr183 G protein-coupled receptor 183 involved_in ISO (PMID:19597478) RGD PMID:19597478 NCBI chr15:99,037,764...99,050,550 JBrowse link
G Rag2 recombination activating 2 IMP RGD PMID:30206106 RGD:38508903 NCBI chr 3:108,357,399...108,367,186 JBrowse link
memory B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 involved_in ISO (PMID:10755614) RGD PMID:10755614 NCBI chr 7:98,845,270...98,913,409 JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:2158439 (PMID:15240705) RGD PMID:15240705 NCBI chr11:76,854,090...76,877,389 JBrowse link
plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of ISO MGI:2158439 (PMID:15240705) RGD PMID:15240705 NCBI chr11:76,854,090...76,877,389 JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO MGI:2385534 (PMID:29259245) RGD PMID:29259245 NCBI chr 1:22,518,051...22,583,044 JBrowse link
G Itm2a integral membrane protein 2A acts_upstream_of_or_within ISO MGI:5645968 (PMID:24831988) RGD PMID:24831988 NCBI chr  X:72,486,383...72,492,344 JBrowse link
G Lgals1 galectin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:21753146)
Ensembl
RGD
PMID:21753146 GO_REF:0000107 NCBI chr 7:110,485,239...110,488,345 JBrowse link
G Lgals8 galectin 8 acts_upstream_of_or_within ISO (PMID:21753146) RGD PMID:21753146 NCBI chr17:58,024,652...58,052,764 JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO MGI:5501251 (PMID:25124037) RGD PMID:25124037 NCBI chr11:44,782,676...44,810,722 JBrowse link
G Nkx2-3 NK2 homeobox 3 acts_upstream_of_or_within ISO MGI:2448069 (PMID:10926756) RGD PMID:10926756 NCBI chr 1:242,478,130...242,481,083 JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:30842412) RGD PMID:30842412 NCBI chr 3:117,861,916...117,882,680 JBrowse link
G Il10 interleukin 10 acts_upstream_of ISO UniProtKB:P60568 (PMID:22962438) RGD PMID:22962438 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Il2 interleukin 2 acts_upstream_of ISO UniProtKB:P22301 (PMID:22962438) RGD PMID:22962438 NCBI chr 2:120,004,862...120,009,566 JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
ISS
IEA
(PMID:11460154)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:11460154 GO_REF:0000024 GO_REF:0000107 NCBI chr14:84,604,623...84,609,707 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    immune system process 3112
      leukocyte activation 1069
        lymphocyte activation 866
          lymphocyte differentiation 446
            B cell differentiation 154
              mature B cell differentiation 43
                B-1 B cell differentiation + 7
                mature B cell differentiation involved in immune response + 34
Path 2
Term Annotations click to browse term
  biological_process 20536
    developmental process 7109
      cellular developmental process 4812
        cell differentiation 4811
          cell development 3339
            hemopoiesis 1079
              leukocyte differentiation 685
                mononuclear cell differentiation 549
                  lymphocyte differentiation 446
                    B cell differentiation 154
                      mature B cell differentiation 43
                        B-1 B cell differentiation + 7
                        mature B cell differentiation involved in immune response + 34
paths to the root