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ONTOLOGY REPORT - ANNOTATIONS

Term:immature B cell differentiation
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Accession:GO:0002327 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of an immature B cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: immature B lymphocyte differentiation
 related_synonym: immature B cell development


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immature B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fnip1 folliculin interacting protein 1 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:5437714 (PMID:22608497)		 UniProt
RGD		 PMID:22608497 GO_REF:0000024 NCBI chr10:39,068,432...39,151,552
Ensembl chr10:38,567,729...38,650,824 		JBrowse link
G Irf2bp2 interferon regulatory factor 2 binding protein 2 involved_in ISO (PMID:27016798) RGD PMID:27016798 NCBI chr19:71,456,689...71,462,368
Ensembl chr19:54,560,128...54,566,642 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase involved_in ISO (PMID:15067126) RGD PMID:15067126 NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO MGI:2383951 (PMID:9768755) RGD PMID:9768755 NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO UniProtKB:O35906 (PMID:28062693) RGD PMID:28062693 NCBI chr 3:97,529,509...97,548,204
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
G Spib Spi-B transcription factor involved_in ISO UniProtKB:P17433 (PMID:28062693) RGD PMID:28062693 NCBI chr 1:104,155,456...104,161,311
Ensembl chr 1:95,018,947...95,024,780 		JBrowse link
G Syvn1 synoviolin 1 involved_in ISO (PMID:29907570) RGD PMID:29907570 NCBI chr 1:212,766,736...212,775,426
Ensembl chr 1:203,339,619...203,346,152 		JBrowse link
negative regulation of pre-B cell receptor expression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (PMID:22949502) RGD PMID:22949502 NCBI chr 5:148,371,880...148,393,927
Ensembl chr 5:143,087,759...143,109,807 		JBrowse link
pre-B cell allelic exclusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase involved_in ISO (PMID:19448632) RGD PMID:19448632 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Rag1 recombination activating 1 involved_in IBA
ISO		 GO_REF:0000033
(PMID:19448632)		 GO_Central
RGD		 PMID:19448632 GO_REF:0000033 NCBI chr 3:108,372,087...108,383,184
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rag2 recombination activating 2 involved_in ISO (PMID:19448632) RGD PMID:19448632 NCBI chr 3:108,357,399...108,367,186
Ensembl chr 3:87,902,238...87,911,066 		JBrowse link
pre-B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp11c ATPase phospholipid transporting 11C involved_in ISO (PMID:21423173) RGD PMID:21423173 NCBI chr  X:143,600,763...143,788,407
Ensembl chr  X:138,565,836...138,751,204 		JBrowse link
G Cd24 CD24 molecule acts_upstream_of_or_within ISO MGI:2179996 (PMID:7795661), (PMID:9028339) RGD PMID:7795661 PMID:9028339 NCBI chr20:48,655,549...48,661,786
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Foxp1 forkhead box P1 acts_upstream_of_or_within ISO MGI:3711150 (PMID:16819554) RGD PMID:16819554 NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Lrrc8a leucine rich repeat containing 8 VRAC subunit A involved_in ISS
ISO		 GO_REF:0000024
(PMID:14660746)		 UniProt
RGD		 PMID:14660746 GO_REF:0000024 NCBI chr 3:33,902,299...33,934,989
Ensembl chr 3:13,510,513...13,536,202 		JBrowse link
G Mir17 microRNA 17 acts_upstream_of_or_within ISO MGI:2676844|MGI:2676872|MGI:3618743|MGI:3629917|MGI:3629918 (PMID:18329372) RGD PMID:18329372 NCBI chr15:98,587,848...98,587,931
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir18a microRNA 18a acts_upstream_of_or_within ISO MGI:2676872|MGI:3618743|MGI:3619065|MGI:3629917|MGI:3629918 (PMID:18329372) RGD PMID:18329372 NCBI chr15:98,587,984...98,588,079
Ensembl chr15:92,180,765...92,180,860 		JBrowse link
G Mir19a microRNA 19a acts_upstream_of_or_within ISO MGI:2676844|MGI:2676872|MGI:3619065|MGI:3629917|MGI:3629918 (PMID:18329372) RGD PMID:18329372 NCBI chr15:98,588,131...98,588,212
Ensembl chr15:92,180,912...92,180,993 		JBrowse link
G Mir19b1 microRNA 19b-1 acts_upstream_of_or_within ISO MGI:2676844|MGI:2676872|MGI:3618743|MGI:3619065|MGI:3629918 (PMID:18329372) RGD PMID:18329372 NCBI chr15:98,588,433...98,588,519
Ensembl chr15:92,181,214...92,181,300 		JBrowse link
G Mir20a microRNA 20a acts_upstream_of_or_within ISO MGI:2676844|MGI:3618743|MGI:3619065|MGI:3629917|MGI:3629918 (PMID:18329372) RGD PMID:18329372 NCBI chr15:98,588,303...98,588,387
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir92a1 microRNA 92a-1 acts_upstream_of_or_within ISO MGI:2676844|MGI:2676872|MGI:3618743|MGI:3619065|MGI:3629917 (PMID:18329372) RGD PMID:18329372 NCBI chr15:98,588,555...98,588,632
Ensembl chr15:92,181,336...92,181,413 		JBrowse link
transitional one stage B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:2153718 (PMID:19228876) RGD PMID:19228876 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Tnfsf13b TNF superfamily member 13b acts_upstream_of_or_within ISO (PMID:17581616) RGD PMID:17581616 NCBI chr16:86,164,377...86,195,072
Ensembl chr16:79,462,402...79,492,693 		JBrowse link
transitional two stage B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Traf3ip2 Traf3 interacting protein 2 involved_in ISO MGI:3510784 (PMID:20543113) RGD PMID:20543113 NCBI chr20:44,565,992...44,609,240
Ensembl chr20:43,011,450...43,054,667 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    immune system process 3112
      leukocyte activation 1069
        lymphocyte activation 866
          lymphocyte differentiation 446
            B cell differentiation 154
              immature B cell differentiation 24
                pre-B cell differentiation + 14
                transitional stage B cell differentiation + 3
Path 2
Term Annotations click to browse term
  biological_process 20536
    developmental process 7109
      cellular developmental process 4812
        cell differentiation 4811
          cell development 3339
            hemopoiesis 1079
              leukocyte differentiation 685
                mononuclear cell differentiation 549
                  lymphocyte differentiation 446
                    B cell differentiation 154
                      immature B cell differentiation 24
                        pre-B cell differentiation + 14
                        transitional stage B cell differentiation + 3
paths to the root