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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell differentiation involved in immune response
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Accession:GO:0002292 term browser browse the term
Definition:The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: T cell development involved in immune response;   T cell differentiation during immune response;   T-lymphocyte differentiation during immune response


show annotations for term's descendants           Sort by:
T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec4d C-type lectin domain family 4, member D acts_upstream_of_or_within ISO (PMID:23602766) RGD PMID:23602766 NCBI chr 4:158,275,287...158,286,978
Ensembl chr 4:158,275,341...158,287,055 		JBrowse link
G Clec4e C-type lectin domain family 4, member E acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:5013826 (PMID:23602766) 		Ensembl
RGD		 PMID:23602766 GO_REF:0000107 NCBI chr 4:158,292,624...158,298,607
Ensembl chr 4:158,293,311...158,298,467 		JBrowse link
G Fcer1g Fc epsilon receptor Ig involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
MGI:2384004 (PMID:23602766) 		GO_Central
RGD		 PMID:23602766 GO_REF:0000033 NCBI chr13:86,181,908...86,186,766
Ensembl chr13:86,181,908...86,186,859 		JBrowse link
G Sema4a semaphorin 4A involved_in IEA
ISO 		GO_REF:0000107
(PMID:15780988) 		Ensembl
RGD		 PMID:15780988 GO_REF:0000107 NCBI chr 2:176,194,248...176,215,752
Ensembl chr 2:176,194,255...176,212,258 		JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin involved_in ISO
IEA
IBA 		(PMID:17566017)
(PMID:14605368)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:14605368 PMID:17566017 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:127,059,215...127,067,070
Ensembl chr 8:127,059,215...127,067,070 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (PMID:17277142) RGD PMID:17277142 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgb6 integrin subunit beta 6 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 3:65,454,964...65,579,179
Ensembl chr 3:65,456,713...65,530,333 		JBrowse link
G Tsc1 TSC complex subunit 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2656240 (PMID:25271321) 		Ensembl
RGD		 PMID:25271321 GO_REF:0000107 NCBI chr 3:32,367,434...32,416,565
Ensembl chr 3:32,367,670...32,416,568 		JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgl2 fibrinogen-like 2 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3582343 (PMID:29341118) 		Ensembl
RGD		 PMID:29341118 GO_REF:0000107 NCBI chr 4:14,602,762...14,608,405
Ensembl chr 4:14,602,771...14,608,405 		JBrowse link
G Ifnl1 interferon, lambda 1 involved_in ISO (PMID:19346497) RGD PMID:19346497 NCBI chr 1:92,926,184...92,927,830 JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:24463518) 		Ensembl
RGD		 PMID:24463518 GO_REF:0000107 NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:207,578,449...207,580,856 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISS
ISO 		GO_REF:0000024
(PMID:16020505) 		BHF-UCL
RGD		 PMID:16020505 GO_REF:0000024 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,420,415...18,433,222 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in IEA
ISO 		GO_REF:0000107
(PMID:9670042) 		Ensembl
RGD		 PMID:9670042 GO_REF:0000107 NCBI chr13:76,256,654...76,280,133
Ensembl chr13:76,256,654...76,280,133 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:24463518) 		Ensembl
RGD		 PMID:24463518 GO_REF:0000107 NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:207,578,449...207,580,856 		JBrowse link
G Foxp3 forkhead box P3 involved_in ISO
IEA 		(PMID:23169781)
GO_REF:0000107 		RGD
Ensembl		 PMID:23169781 GO_REF:0000107 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:17,580,380...17,595,894 		JBrowse link
G Il2 interleukin 2 involved_in ISO RNAcentral:URS000039ED8D_10090 (PMID:25642768) RGD PMID:25642768 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18792410) RGD PMID:18792410 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Pf4 platelet factor 4 IDA RGD PMID:24986443 RGD:329901907 NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:25282160)
GO_REF:0000117 		Ensembl
RGD
UniProt		 PMID:25282160 GO_REF:0000107 GO_REF:0000117 NCBI chr13:75,707,098...75,779,114
Ensembl chr13:75,707,338...75,772,816 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in IEA
ISO 		GO_REF:0000117
(PMID:25282160) 		UniProt
RGD		 PMID:25282160 GO_REF:0000117 NCBI chr 3:41,531,319...41,596,496
Ensembl chr 3:41,531,617...41,589,715 		JBrowse link
G Smad7 SMAD family member 7 involved_in IEA
ISO 		GO_REF:0000107
(PMID:25642768) 		Ensembl
RGD		 PMID:25642768 GO_REF:0000107 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA
ISO 		GO_REF:0000107
(PMID:21151104) 		Ensembl
RGD		 PMID:21151104 GO_REF:0000107 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,578,751...82,595,253 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3530739 (PMID:23034280) 		Ensembl
RGD		 PMID:23034280 GO_REF:0000107 NCBI chr 2:177,093,569...177,111,894
Ensembl chr 2:177,095,185...177,109,031 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:25282160)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:25282160 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:142,661,193...142,670,051
Ensembl chr 5:142,661,199...142,669,985 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 Cd69 molecule involved_in ISO (PMID:24752896) RGD PMID:24752896 NCBI chr 4:164,411,485...164,419,403
Ensembl chr 4:164,411,485...164,419,509 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (PMID:20696842) RGD PMID:20696842 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,420,415...18,433,222 		JBrowse link
G Lgals1 galectin 1 involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:24752896)
GO_REF:0000107 		RGD
Ensembl		 PMID:24752896 GO_REF:0000107 NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:112,361,850...112,368,800 		JBrowse link
G Loxl3 lysyl oxidase-like 3 involved_in ISO
IEA 		(PMID:28065600)
GO_REF:0000117 		RGD
UniProt		 PMID:28065600 GO_REF:0000117 NCBI chr 4:117,098,358...117,114,673
Ensembl chr 4:117,099,635...117,115,046 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A involved_in ISO
IEA 		(PMID:20696842)
GO_REF:0000107 		RGD
Ensembl		 PMID:20696842 GO_REF:0000107 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA
ISO 		GO_REF:0000107
(PMID:21151104) 		Ensembl
RGD		 PMID:21151104 GO_REF:0000107 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,578,751...82,595,253 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (PMID:24107315) RGD PMID:24107315 NCBI chr13:76,366,790...76,440,673
Ensembl chr13:76,366,771...76,376,608 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:17008549)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:17008549 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831 		JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:24463518) 		Ensembl
RGD		 PMID:24463518 GO_REF:0000107 NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:207,578,449...207,580,856 		JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:96559 (PMID:12594267) 		Ensembl
RGD		 PMID:12594267 GO_REF:0000107 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047 		JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:105367|MGI:2182089 (PMID:16424184) 		Ensembl
RGD		 PMID:16424184 GO_REF:0000107 NCBI chr13:98,811,852...98,817,264
Ensembl chr13:98,811,856...98,817,264 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:12242343) RGD PMID:12242343 NCBI chr 6:13,235,157...13,266,161
Ensembl chr 6:13,234,062...13,273,883 		JBrowse link
G Zfp35 zinc finger protein 35 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr18:15,543,604...15,559,084
Ensembl chr18:15,543,516...15,559,837 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3581675 (PMID:15917799) 		Ensembl
RGD		 PMID:15917799 GO_REF:0000107 NCBI chr13:75,707,098...75,779,114
Ensembl chr13:75,707,338...75,772,816 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:64,405,044...64,428,070 		JBrowse link
positive regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:12540904) RGD PMID:12540904 NCBI chr13:109,104,122...109,134,903 JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IEA
ISO 		GO_REF:0000107
(PMID:14688363) 		Ensembl
RGD		 PMID:14688363 GO_REF:0000107 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:29230018)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:29230018 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561 		JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO
IEA 		(PMID:27591323)
GO_REF:0000107 		RGD
Ensembl		 PMID:27591323 GO_REF:0000107 NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,513,908...4,520,383 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:27591323) RGD PMID:27591323 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,550,596...4,560,165 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in IEA
ISO 		GO_REF:0000107
(PMID:18713990) 		Ensembl
RGD		 PMID:18713990 GO_REF:0000107 NCBI chr13:76,256,654...76,280,133
Ensembl chr13:76,256,654...76,280,133 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:17008549) 		UniProt
Ensembl
RGD		 PMID:17008549 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) RGD PMID:15845453 NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:61,759,220...61,772,022 		JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:105367|MGI:2182089 (PMID:16424184) 		Ensembl
RGD		 PMID:16424184 GO_REF:0000107 NCBI chr13:98,811,852...98,817,264
Ensembl chr13:98,811,856...98,817,264 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2446070 (PMID:11894097) 		Ensembl
RGD		 PMID:11894097 GO_REF:0000107 NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:12242343) RGD PMID:12242343 NCBI chr 6:13,235,157...13,266,161
Ensembl chr 6:13,234,062...13,273,883 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in IEA
ISO 		GO_REF:0000107
(PMID:25282160) 		Ensembl
RGD		 PMID:25282160 GO_REF:0000107 NCBI chr18:61,212,290...61,266,272
Ensembl chr18:61,212,317...61,266,272 		JBrowse link
G Mir326 microRNA 326 acts_upstream_of_or_within ISO (PMID:19838199) RGD PMID:19838199 NCBI chr 1:163,266,165...163,266,259
Ensembl chr 1:163,266,165...163,266,259 		JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr 1:94,808,459...94,824,726
Ensembl chr 1:94,808,453...94,817,861 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr11:58,251,720...58,279,767
Ensembl chr11:58,251,721...58,279,767 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in IEA
ISO 		GO_REF:0000107
(PMID:26098997) 		Ensembl
RGD		 PMID:26098997 GO_REF:0000107 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:28262505)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:28262505 GO_REF:0000024 GO_REF:0000107 NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,951...4,737,290 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,866,997...11,946,923 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
(PMID:19501566) 		GO_Central
Ensembl
RGD		 PMID:19501566 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:36171294) 		UniProt
Ensembl
RGD		 PMID:36171294 GO_REF:0000024 GO_REF:0000107 NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IEA
ISO 		GO_REF:0000107
(PMID:12829194) 		Ensembl
RGD		 PMID:12829194 GO_REF:0000107 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) RGD PMID:12594267 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in IEA
ISO 		GO_REF:0000107
(PMID:26098997) 		Ensembl
RGD		 PMID:26098997 GO_REF:0000107 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Prkcz protein kinase C, zeta involved_in ISS
ISO 		GO_REF:0000024
(PMID:15987782) 		UniProt
RGD		 PMID:15987782 GO_REF:0000024 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674 		JBrowse link
G Rara retinoic acid receptor, alpha involved_in ISO
IEA 		(PMID:18416830)
GO_REF:0000107 		RGD
Ensembl		 PMID:18416830 GO_REF:0000107 NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in IEA
ISO 		GO_REF:0000107
(PMID:18354165) 		Ensembl
RGD		 PMID:18354165 GO_REF:0000107 NCBI chr13:76,256,654...76,280,133
Ensembl chr13:76,256,654...76,280,133 		JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr65 G-protein coupled receptor 65 involved_in ISO (PMID:35668320) RGD PMID:35668320 NCBI chr 6:123,245,534...123,262,758
Ensembl chr 6:123,219,633...123,266,285 		JBrowse link
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:3721903 (PMID:24645804) 		Ensembl
RGD		 PMID:24645804 GO_REF:0000107 NCBI chr 5:64,473,694...64,581,072
Ensembl chr 5:64,473,694...64,581,072 		JBrowse link
regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2158436 (PMID:15240675) 		Ensembl
RGD		 PMID:15240675 GO_REF:0000107 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047 		JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il27 interleukin 27 involved_in ISO
IEA
IBA 		(PMID:12734330)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:12734330 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:190,603,522...190,609,258 		JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 NOT|involved_in ISO (PMID:19050256) RGD PMID:19050256 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 NOT|involved_in ISO (PMID:19050256) RGD PMID:19050256 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:55,021,833...55,046,059 		JBrowse link
G Mir301a microRNA 301a acts_upstream_of_or_within ISO (PMID:22517757) RGD PMID:22517757 NCBI chr10:72,422,599...72,422,698
Ensembl chr10:72,422,599...72,422,698 		JBrowse link
regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr17:73,544,234...73,575,670
Ensembl chr17:73,553,548...73,575,670 		JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 NAS RGD PMID:10651948 RGD:1331512 NCBI chr 4:97,756,089...97,844,937
Ensembl chr 4:97,756,089...97,844,937 		JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO
IEA 		(PMID:15322540)
GO_REF:0000107 		RGD
Ensembl		 PMID:15322540 GO_REF:0000107 NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,513,908...4,520,383 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:15322540) RGD PMID:15322540 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,550,596...4,560,165 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:177,093,569...177,111,894
Ensembl chr 2:177,095,185...177,109,031 		JBrowse link
T follicular helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:24463518) 		Ensembl
RGD		 PMID:24463518 GO_REF:0000107 NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:207,578,449...207,580,856 		JBrowse link
G Foxp1 forkhead box P1 involved_in ISO (PMID:24859450) RGD PMID:24859450 NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:133,122,055...133,500,272 		JBrowse link
G Gpr183 G protein-coupled receptor 183 involved_in ISS
ISO 		GO_REF:0000024
(PMID:27147029) 		UniProt
RGD		 PMID:27147029 GO_REF:0000024 NCBI chr15:105,445,129...105,457,192
Ensembl chr15:105,437,561...105,466,977 		JBrowse link
G Icos inducible T-cell co-stimulator involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:27135603)
GO_REF:0000107 		RGD
Ensembl		 PMID:27135603 GO_REF:0000107 NCBI chr 9:69,862,042...69,900,864
Ensembl chr 9:69,877,785...69,900,960 		JBrowse link
G Icoslg inducible T-cell co-stimulator ligand involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:24411167)
GO_REF:0000107 		RGD
Ensembl		 PMID:24411167 GO_REF:0000107 NCBI chr20:10,600,078...10,610,385
Ensembl chr20:10,600,078...10,610,365 		JBrowse link
G Il21 interleukin 21 involved_in ISS
ISO 		GO_REF:0000024
(PMID:23045607) 		UniProt
RGD		 PMID:23045607 GO_REF:0000024 NCBI chr 2:122,045,240...122,055,142
Ensembl chr 2:122,045,240...122,055,142 		JBrowse link
G Il6 interleukin 6 involved_in ISS
ISO 		GO_REF:0000024
(PMID:23045607) 		UniProt
RGD		 PMID:23045607 GO_REF:0000024 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO (PMID:30523347) RGD PMID:30523347 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within
involved_in 		IEA
ISO 		GO_REF:0000107
MGI:2442789 (PMID:23583643)
GO_REF:0000117 		Ensembl
RGD
UniProt		 PMID:23583643 GO_REF:0000107 GO_REF:0000117 NCBI chr13:75,707,098...75,779,114
Ensembl chr13:75,707,338...75,772,816 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in
acts_upstream_of_or_within 		IEA
ISO 		GO_REF:0000117
MGI:2685397 (PMID:23583643) 		UniProt
RGD		 PMID:23583643 GO_REF:0000117 NCBI chr 3:41,531,319...41,596,496
Ensembl chr 3:41,531,617...41,589,715 		JBrowse link
G Tbk1 TANK-binding kinase 1 involved_in ISO
IEA 		(PMID:27135603)
GO_REF:0000107 		RGD
Ensembl		 PMID:27135603 GO_REF:0000107 NCBI chr 7:58,963,319...58,996,357
Ensembl chr 7:58,963,325...58,996,357 		JBrowse link
T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cracr2a calcium release activated channel regulator 2A involved_in ISO (PMID:29987160) RGD PMID:29987160 NCBI chr 4:162,094,247...162,207,926
Ensembl chr 4:162,110,929...162,221,529 		JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr13:98,811,852...98,817,264
Ensembl chr13:98,811,856...98,817,264 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:15944249) RGD PMID:15944249 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Il12a interleukin 12A acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997 		JBrowse link
G Il12b interleukin 12B acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:97,756,089...97,844,937
Ensembl chr 4:97,756,089...97,844,937 		JBrowse link
G Il18r1 interleukin 18 receptor 1 acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2136765 (PMID:10227969) 		Ensembl
RGD		 PMID:10227969 GO_REF:0000107 NCBI chr 9:50,223,274...50,257,370
Ensembl chr 9:50,223,200...50,257,367 		JBrowse link
G Jak2 Janus kinase 2 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:18579517) 		Ensembl
RGD		 PMID:18579517 GO_REF:0000107 NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO MGI:3046930 (PMID:31182790) RGD PMID:31182790 NCBI chr11:58,251,720...58,279,767
Ensembl chr11:58,251,721...58,279,767 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit acts_upstream_of_or_within IEA
ISO 		GO_REF:0000107
MGI:2179545 (PMID:16081776) 		Ensembl
RGD		 PMID:16081776 GO_REF:0000107 NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:88,385,717...88,413,420 		JBrowse link
G Sema4a semaphorin 4A involved_in IEA
ISO 		GO_REF:0000107
(PMID:15780988) 		Ensembl
RGD		 PMID:15780988 GO_REF:0000107 NCBI chr 2:176,194,248...176,215,752
Ensembl chr 2:176,194,255...176,212,258 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 involved_in ISO (PMID:14688310) RGD PMID:14688310 NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Tmem98 transmembrane protein 98 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:25946230)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:25946230 GO_REF:0000024 GO_REF:0000107 NCBI chr10:66,293,895...66,304,806
Ensembl chr10:66,293,867...66,304,803 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 acts_upstream_of_or_within ISO MGI:103034 (PMID:20706986) RGD PMID:20706986 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in IEA
ISO 		GO_REF:0000107
(PMID:26410627) 		Ensembl
RGD		 PMID:26410627 GO_REF:0000107 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Spn sialophorin involved_in ISO
ISS 		(PMID:18036228)
GO_REF:0000024 		RGD
UniProt		 PMID:18036228 GO_REF:0000024 NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:191,178,096...191,187,852 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO MGI:96556 (PMID:20706986) RGD PMID:20706986 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA
ISO 		GO_REF:0000107
(PMID:10761931) 		Ensembl
RGD		 PMID:10761931 GO_REF:0000107 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,578,751...82,595,253 		JBrowse link
T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:20421391), (PMID:21572431)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:20421391 PMID:21572431 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:111,084,717...111,107,052
Ensembl chr 6:111,084,717...111,107,052 		JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 involved_in IEA
ISO 		GO_REF:0000107
(PMID:23241884) 		Ensembl
RGD		 PMID:23241884 GO_REF:0000107 NCBI chr 1:252,508,594...252,550,269
Ensembl chr 1:252,508,594...252,550,269 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO MGI:3046930 (PMID:20383124) RGD PMID:20383124 NCBI chr11:58,251,720...58,279,767
Ensembl chr11:58,251,721...58,279,767 		JBrowse link
G Rora RAR-related orphan receptor A involved_in ISO (PMID:18164222) RGD PMID:18164222 NCBI chr 8:78,182,710...78,915,730
Ensembl chr 8:78,182,620...78,915,730 		JBrowse link
G Rorc RAR-related orphan receptor C involved_in
acts_upstream_of_or_within 		ISO (PMID:31776512)
(PMID:16990136), (PMID:18164222)
(PMID:18792410)
MGI:2386114 (PMID:20383124) 		RGD PMID:16990136 PMID:18164222 PMID:18792410 PMID:20383124 PMID:31776512 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566 		JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:19578362), (PMID:22983707)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:19578362 PMID:22983707 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:111,084,717...111,107,052
Ensembl chr 6:111,084,717...111,107,052 		JBrowse link
G Il6 interleukin 6 involved_in ISS
ISO 		GO_REF:0000024
(PMID:16990136), (PMID:27893700)
(PMID:27893700) 		UniProt
RGD		 PMID:16990136 PMID:27893700 GO_REF:0000024 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Il6r interleukin 6 receptor involved_in ISS
ISO 		GO_REF:0000024
(PMID:27893700) 		UniProt
RGD		 PMID:27893700 GO_REF:0000024 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221 		JBrowse link
G Irf4 interferon regulatory factor 4 involved_in IEA
ISO 		GO_REF:0000107
(PMID:22983707) 		Ensembl
RGD		 PMID:22983707 GO_REF:0000107 NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,930,471...33,948,730 		JBrowse link
G Ly9 lymphocyte antigen 9 involved_in ISO
IEA 		(PMID:22184727)
GO_REF:0000107 		RGD
Ensembl		 PMID:22184727 GO_REF:0000107 NCBI chr13:86,610,762...86,633,314
Ensembl chr13:86,611,784...86,657,293 		JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO MGI:2386448|MGI:5752247 (PMID:25470037) RGD PMID:25470037 NCBI chr  X:17,296,750...17,331,257
Ensembl chr  X:17,298,029...17,331,054 		JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:86,916,956...86,937,697
Ensembl chr13:86,916,122...86,938,354 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:28065600)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:28065600 GO_REF:0000024 GO_REF:0000107 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:20421391), (PMID:21572431)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:20421391 PMID:21572431 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:111,084,717...111,107,052
Ensembl chr 6:111,084,717...111,107,052 		JBrowse link
G Bcl3 BCL3, transcription coactivator acts_upstream_of_or_within ISO MGI:2158443 (PMID:16081776) RGD PMID:16081776 NCBI chr 1:88,599,321...88,613,555
Ensembl chr 1:88,599,321...88,614,368 		JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047 		JBrowse link
G Gata3 GATA binding protein 3 involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:20484083)
(PMID:20706986)
GO_REF:0000107 		RGD
Ensembl		 PMID:20484083 PMID:20706986 GO_REF:0000107 NCBI chr17:73,544,234...73,575,670
Ensembl chr17:73,553,548...73,575,670 		JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr13:98,811,852...98,817,264
Ensembl chr13:98,811,856...98,817,264 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) RGD PMID:20706986 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Kmt2a lysine methyltransferase 2A involved_in ISO
IEA 		(PMID:20484083)
GO_REF:0000107 		RGD
Ensembl		 PMID:20484083 GO_REF:0000107 NCBI chr 8:54,013,547...54,089,219
Ensembl chr 8:54,013,547...54,089,317 		JBrowse link
G Men1 menin 1 involved_in ISO
IEA 		(PMID:20484083)
GO_REF:0000107 		RGD
Ensembl		 PMID:20484083 GO_REF:0000107 NCBI chr 1:213,068,166...213,074,132
Ensembl chr 1:213,068,166...213,074,120 		JBrowse link
G Myb MYB proto-oncogene, transcription factor involved_in ISO
IEA 		(PMID:20484083)
GO_REF:0000107 		RGD
Ensembl		 PMID:20484083 GO_REF:0000107 NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:17,759,309...17,792,547 		JBrowse link
T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856466 (PMID:8434133) RGD PMID:8434133 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:75,159,782...75,267,093 		JBrowse link
G Il12b interleukin 12B involved_in ISO
IEA 		(PMID:1673147)
GO_REF:0000107 		RGD
Ensembl		 PMID:1673147 GO_REF:0000107 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 involved_in ISS
ISO 		GO_REF:0000024
(PMID:30150402) 		UniProt
RGD		 PMID:30150402 GO_REF:0000024 NCBI chr19:392,858...400,529
Ensembl chr19:392,183...400,902 		JBrowse link
G Ptger4 prostaglandin E receptor 4 involved_in ISS
ISO 		GO_REF:0000024
(PMID:19465928) 		UniProt
RGD		 PMID:19465928 GO_REF:0000024 NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:56,062,890...56,074,135 		JBrowse link
G Rorc RAR-related orphan receptor C involved_in ISO (PMID:14691482) RGD PMID:14691482 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    immune system process 2920
      leukocyte activation 1068
        lymphocyte activation 867
          lymphocyte differentiation 454
            T cell differentiation 337
              T cell differentiation involved in immune response 99
                alpha-beta T cell differentiation involved in immune response + 90
                gamma-delta T cell differentiation involved in immune response 0
                memory T cell differentiation + 11
Path 2
Term Annotations click to browse term
  biological_process 19315
    developmental process 7255
      cellular developmental process 4933
        cell differentiation 4932
          cell development 3418
            hemopoiesis 1096
              leukocyte differentiation 699
                mononuclear cell differentiation 559
                  lymphocyte differentiation 454
                    T cell differentiation 337
                      T cell differentiation involved in immune response 99
                        alpha-beta T cell differentiation involved in immune response + 90
                        gamma-delta T cell differentiation involved in immune response 0
                        memory T cell differentiation + 11
paths to the root