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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
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Accession:GO:0002291 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response.
Synonyms:exact_synonym: T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell


show annotations for term's descendants           Sort by:
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein acts_upstream_of_or_within ISO (PMID:17403904) RGD PMID:17403904 NCBI chr17:89,849,474...89,941,099
Ensembl chr17:84,982,243...85,033,010 		JBrowse link
G Fgl2 fibrinogen-like 2 acts_upstream_of_or_within ISO MGI:3582343 (PMID:29341118) RGD PMID:29341118 NCBI chr 4:14,602,762...14,608,405
Ensembl chr 4:13,710,575...13,716,207 		JBrowse link
G Icam1 intercellular adhesion molecule 1 involved_in ISO (PMID:2477710) RGD PMID:2477710 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Itgal integrin subunit alpha L involved_in ISO (PMID:2477710) RGD PMID:2477710 NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:181,918,183...181,955,732 		JBrowse link
G Plxna1 plexin A1 involved_in ISO (PMID:16715077) RGD PMID:16715077 NCBI chr 4:123,295,165...123,340,132
Ensembl chr 4:121,737,945...122,024,196 		JBrowse link
G Sema6d semaphorin 6D involved_in ISO (PMID:16715077) RGD PMID:16715077 NCBI chr 3:131,801,680...132,394,578
Ensembl chr 3:111,883,872...111,941,094 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:16715077) RGD PMID:16715077 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in ISS
ISO		 GO_REF:0000024
(PMID:16715077)		 UniProt
RGD		 PMID:16715077 GO_REF:0000024 NCBI chr 1:94,800,372...94,804,307
Ensembl chr 1:85,672,994...85,676,848 		JBrowse link
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:26492563) RGD PMID:26492563 NCBI chr10:31,383,801...31,415,334
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Lgals3 galectin 3 involved_in ISO (PMID:19706535) RGD PMID:19706535 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:11046035)
GO_REF:0000107
(PMID:8766544)		 UniProt
RGD
Ensembl		 PMID:8766544 PMID:11046035 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:207,665,274...207,681,094
Ensembl chr 1:198,241,484...198,251,660 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16116184) RGD PMID:16116184 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G RT1-DMb RT1 class II, locus DMb involved_in ISO (PMID:8139689) RGD PMID:8139689 NCBI chr20:4,695,009...4,702,560
Ensembl chr20:4,693,103...4,700,340 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20546
    immune system process 3119
      leukocyte activation 1075
        leukocyte activation involved in immune response 336
          lymphocyte activation involved in immune response 236
            T cell activation involved in immune response 136
              T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 13
                negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 2
                positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 3
                regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 5
Path 2
Term Annotations click to browse term
  biological_process 20546
    cellular process 19536
      cell activation 1231
        cell activation involved in immune response 340
          leukocyte activation involved in immune response 336
            lymphocyte activation involved in immune response 236
              T cell activation involved in immune response 136
                T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 13
                  negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 2
                  positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 3
                  regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 5
paths to the root