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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell activation involved in immune response
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Accession:GO:0002286 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
Synonyms:related_synonym: T cell activation during immune response;   T lymphocyte activation during immune response

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T cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1c CD1c molecule involved_in ISO (PMID:21167756) UniProt PMID:21167756 NCBI chrNW_004936740:2,068,558...2,071,531 JBrowse link
G Cd74 CD74 molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936504:4,522,576...4,532,289
Ensembl chrNW_004936504:4,522,751...4,531,750 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISO (PMID:24310610) UniProt PMID:24310610 NCBI chrNW_004936471:3,423,792...3,527,089
Ensembl chrNW_004936471:3,423,813...3,526,913 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936549:142,281...153,575
Ensembl chrNW_004936549:141,512...153,602 		JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936857:646,363...726,338
Ensembl chrNW_004936857:646,118...698,035 		JBrowse link
G Mdk midkine involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936562:2,687,825...2,690,292
Ensembl chrNW_004936562:2,687,825...2,689,484 		JBrowse link
G Psen1 presenilin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936488:2,464,623...2,528,807
Ensembl chrNW_004936488:2,464,527...2,530,065 		JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO (PMID:17698590) MGI PMID:17698590 NCBI chrNW_004936526:3,584,194...3,611,719
Ensembl chrNW_004936526:3,584,188...3,614,074 		JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936473:18,825,969...18,833,179
Ensembl chrNW_004936473:18,825,942...18,833,179 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (PMID:17277142) MGI PMID:17277142 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452 		JBrowse link
cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab27a RAB27A, member RAS oncogene family acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:16,738,204...16,815,561
Ensembl chrNW_004936471:16,738,230...16,815,943 		JBrowse link
memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tsc1 TSC complex subunit 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:19,331,183...19,386,841
Ensembl chrNW_004936487:19,331,194...19,386,892 		JBrowse link
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101954488 CEA cell adhesion molecule 1 involved_in ISO (PMID:18424730) UniProt PMID:18424730 NCBI chrNW_004936706:37,480...53,306 JBrowse link
G Nckap1l NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936512:11,683,330...11,734,423
Ensembl chrNW_004936512:11,683,321...11,734,391 		JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgl2 fibrinogen like 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936479:20,619,955...20,625,416
Ensembl chrNW_004936479:20,619,931...20,652,981 		JBrowse link
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:26492563) UniProt PMID:26492563 NCBI chrNW_004936515:6,001,324...6,015,407 JBrowse link
G Lgals3 galectin 3 involved_in ISO (PMID:19706535) BHF-UCL PMID:19706535 NCBI chrNW_004936697:20,861...38,568
Ensembl chrNW_004936697:27,145...38,586 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936794:567,462...569,195
Ensembl chrNW_004936794:568,567...569,139 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:11,025,590...11,058,807
Ensembl chrNW_004936501:11,025,567...11,058,818 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (PMID:16020505) BHF-UCL PMID:16020505 NCBI chrNW_004936596:3,212,593...3,224,426
Ensembl chrNW_004936596:3,212,593...3,224,048 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:9670042) BHF-UCL PMID:9670042 NCBI chrNW_004936481:14,391,359...14,409,514 JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936794:567,462...569,195
Ensembl chrNW_004936794:568,567...569,139 		JBrowse link
G Foxp3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936721:1,118,376...1,125,282
Ensembl chrNW_004936721:1,118,782...1,132,308 		JBrowse link
G Il2 interleukin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936662:1,594,953...1,599,625
Ensembl chrNW_004936662:1,594,953...1,599,625 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:13,919,006...13,973,868
Ensembl chrNW_004936481:13,919,257...13,966,677 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:11,341,663...11,393,275
Ensembl chrNW_004936487:11,341,700...11,389,859 		JBrowse link
G Smad7 SMAD family member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:13,894,586...13,921,978
Ensembl chrNW_004936497:13,894,580...13,922,065 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,546,405...13,558,635
Ensembl chrNW_004936490:13,546,292...13,558,635 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,546,139...4,560,157
Ensembl chrNW_004936580:4,551,304...4,560,163 		JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:19,714,145...19,722,512
Ensembl chrNW_004936474:19,714,153...19,722,528 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak3 Janus kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936596:3,212,593...3,224,426
Ensembl chrNW_004936596:3,212,593...3,224,048 		JBrowse link
G Lgals1 galectin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:3,407,704...3,411,197
Ensembl chrNW_004936492:3,407,049...3,411,222 		JBrowse link
G LOC101954799 signal transducer and activator of transcription 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:17,095,047...17,115,945
Ensembl chrNW_004936490:17,095,954...17,114,866 		JBrowse link
G Loxl3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936556:745,798...765,926
Ensembl chrNW_004936556:745,798...765,918 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,546,405...13,558,635
Ensembl chrNW_004936490:13,546,292...13,558,635 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:14,499,495...14,508,074
Ensembl chrNW_004936481:14,499,577...14,508,017 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936503:9,124,314...9,142,372
Ensembl chrNW_004936503:9,124,264...9,142,413 		JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936794:567,462...569,195
Ensembl chrNW_004936794:568,567...569,139 		JBrowse link
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936578:2,371,976...2,395,034
Ensembl chrNW_004936578:2,371,945...2,395,071 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936650:1,416,825...1,422,595
Ensembl chrNW_004936650:1,416,812...1,422,588 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936508:5,531,002...5,588,022
Ensembl chrNW_004936508:5,531,002...5,587,549 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:13,919,006...13,973,868
Ensembl chrNW_004936481:13,919,257...13,966,677 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chrNW_004936538:4,034,467...4,050,240 JBrowse link
positive regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:12540904) UniProt PMID:12540904 NCBI chrNW_004936557:5,136,784...5,175,543 JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936646:743,630...745,998
Ensembl chrNW_004936646:743,688...745,836 		JBrowse link
G LOC101969065 mamu class II histocompatibility antigen, DR alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:540,225...544,968
Ensembl chrNW_004936727:540,217...545,036 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936530:361,872...367,005
Ensembl chrNW_004936530:361,872...367,005 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:18713990) BHF-UCL PMID:18713990 NCBI chrNW_004936481:14,391,359...14,409,514 JBrowse link
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 CD81 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936794:664,089...670,294
Ensembl chrNW_004936794:664,115...669,800 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chrNW_004936538:4,034,467...4,050,240 JBrowse link
G LOC101959667 HLA class II histocompatibility antigen, DM beta chain involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:25,846,653...25,852,006
Ensembl chrNW_004936476:25,846,630...25,851,409 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936503:9,124,314...9,142,372
Ensembl chrNW_004936503:9,124,264...9,142,413 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chrNW_004936524:2,765,271...2,767,259
Ensembl chrNW_004936524:2,765,267...2,767,385 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936650:1,416,825...1,422,595
Ensembl chrNW_004936650:1,416,812...1,422,588 		JBrowse link
G Ripk2 receptor interacting serine/threonine kinase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936544:3,606,925...3,653,248
Ensembl chrNW_004936544:3,606,879...3,655,532 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936508:5,531,002...5,588,022
Ensembl chrNW_004936508:5,531,002...5,587,549 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:5,854,361...5,910,719
Ensembl chrNW_004936497:5,853,870...5,904,266 		JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chrNW_004936570:464,513...471,333
Ensembl chrNW_004936570:463,974...471,344 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936630:1,601,006...1,633,844
Ensembl chrNW_004936630:1,601,010...1,632,745 		JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936864:709,693...732,119
Ensembl chrNW_004936864:709,709...731,718 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:25,807,179...25,818,914
Ensembl chrNW_004936476:25,807,163...25,818,899 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004936596:5,176,682...5,246,102
Ensembl chrNW_004936596:5,177,147...5,246,518 		JBrowse link
G Ep300 E1A binding protein p300 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:696,982...778,132
Ensembl chrNW_004936492:696,960...778,138 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936646:743,630...745,998
Ensembl chrNW_004936646:743,688...745,836 		JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936711:1,027,531...1,113,796
Ensembl chrNW_004936711:1,032,935...1,106,847 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:11,025,590...11,058,807
Ensembl chrNW_004936501:11,025,567...11,058,818 		JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) MGI PMID:12594267 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936864:709,693...732,119
Ensembl chrNW_004936864:709,709...731,718 		JBrowse link
G Prkcz protein kinase C zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936737:1,303,502...1,383,135
Ensembl chrNW_004936737:1,303,887...1,321,944 		JBrowse link
G Rara retinoic acid receptor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:15,376,217...15,420,638
Ensembl chrNW_004936490:15,376,205...15,421,611 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:18354165) BHF-UCL PMID:18354165 NCBI chrNW_004936481:14,391,359...14,409,514 JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936524:5,698,101...5,832,801
Ensembl chrNW_004936524:5,701,566...5,834,539 		JBrowse link
regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936578:2,371,976...2,395,034
Ensembl chrNW_004936578:2,371,945...2,395,071 		JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il27 interleukin 27 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936501:11,972,715...11,978,152
Ensembl chrNW_004936501:11,973,385...11,976,583 		JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 NOT|involved_in ISO (PMID:19050256) UniProt PMID:19050256 NCBI chrNW_004936525:8,238,128...8,240,974
Ensembl chrNW_004936525:8,237,831...8,240,974 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 NOT|involved_in ISO (PMID:19050256) UniProt PMID:19050256 NCBI chrNW_004936489:16,669,297...16,689,451
Ensembl chrNW_004936489:16,669,297...16,689,451 		JBrowse link
regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936484:6,780,692...6,800,883
Ensembl chrNW_004936484:6,780,692...6,800,966 		JBrowse link
G LOC101969065 mamu class II histocompatibility antigen, DR alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:540,225...544,968
Ensembl chrNW_004936727:540,217...545,036 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,546,139...4,560,157
Ensembl chrNW_004936580:4,551,304...4,560,163 		JBrowse link
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936484:1,909,547...2,009,596
Ensembl chrNW_004936484:1,950,017...2,009,575 		JBrowse link
G Fgl2 fibrinogen like 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936479:20,619,955...20,625,416
Ensembl chrNW_004936479:20,619,931...20,652,981 		JBrowse link
G Icam1 intercellular adhesion molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936659:616,570...627,172
Ensembl chrNW_004936659:616,752...627,174 		JBrowse link
G Itgal integrin subunit alpha L involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:12,921,509...12,966,791
Ensembl chrNW_004936501:12,922,642...12,966,663 		JBrowse link
G Plxna1 plexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936798:951,138...989,955
Ensembl chrNW_004936798:952,428...989,894 		JBrowse link
G Sema6d semaphorin 6D involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:10,036,279...10,091,699
Ensembl chrNW_004936471:10,077,222...10,089,286 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:16715077) UniProt PMID:16715077 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor TYROBP involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936570:457,993...460,735
Ensembl chrNW_004936570:458,054...460,579 		JBrowse link
T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec4d C-type lectin domain family 4 member D acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936858:303,639...312,092
Ensembl chrNW_004936858:303,639...312,083 		JBrowse link
G Clec4e C-type lectin domain family 4 member E acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936858:316,954...321,668
Ensembl chrNW_004936858:316,954...321,668 		JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936903:514,278...517,975
Ensembl chrNW_004936903:514,761...517,948 		JBrowse link
G Sema4a semaphorin 4A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:5,404,380...5,431,183
Ensembl chrNW_004936580:5,406,194...5,431,185 		JBrowse link
T cell proliferation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule ISO RGD PMID:20500684 RGD:4892204 NCBI chrNW_004936536:8,414,491...8,481,712 JBrowse link
G Rps6 ribosomal protein S6 acts_upstream_of_or_within ISO (PMID:16357222) MGI PMID:16357222 NCBI chrNW_004936652:1,252,986...1,255,987
Ensembl chrNW_004936652:1,253,025...1,255,906 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936569:888,309...895,991
Ensembl chrNW_004936569:887,742...895,977 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936481:14,499,495...14,508,074
Ensembl chrNW_004936481:14,499,577...14,508,017 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425 		JBrowse link
T follicular helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936794:567,462...569,195
Ensembl chrNW_004936794:568,567...569,139 		JBrowse link
G Foxp1 forkhead box P1 involved_in ISO (PMID:24859450) UniProt PMID:24859450 NCBI chrNW_004936603:2,631,781...3,146,104
Ensembl chrNW_004936603:2,632,274...2,830,324 		JBrowse link
G Gpr183 G protein-coupled receptor 183 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936472:11,196,567...11,198,890
Ensembl chrNW_004936472:11,186,267...11,198,832 		JBrowse link
G Icos inducible T cell costimulator involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936631:562,650...572,263
Ensembl chrNW_004936631:551,394...570,804 		JBrowse link
G Icoslg inducible T cell costimulator ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936500:164,659...173,144
Ensembl chrNW_004936500:164,603...173,155 		JBrowse link
G Il21 interleukin 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936662:1,689,879...1,696,883
Ensembl chrNW_004936662:1,689,879...1,696,883 		JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:23045607) UniProt PMID:23045607 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936480:1,188,408...1,273,210
Ensembl chrNW_004936480:1,188,183...1,273,537 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:13,919,006...13,973,868
Ensembl chrNW_004936481:13,919,257...13,966,677 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:11,341,663...11,393,275
Ensembl chrNW_004936487:11,341,700...11,389,859 		JBrowse link
G Tbk1 TANK binding kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936545:2,763,755...2,809,229
Ensembl chrNW_004936545:2,763,596...2,809,709 		JBrowse link
T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cracr2a calcium release activated channel regulator 2A involved_in ISO (PMID:29987160) UniProt PMID:29987160 NCBI chrNW_004936606:3,880,214...3,970,278
Ensembl chrNW_004936606:3,882,276...3,955,765 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936650:1,416,825...1,422,595
Ensembl chrNW_004936650:1,416,812...1,422,588 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:15944249) UniProt PMID:15944249 NCBI chrNW_004936472:25,236,728...25,246,585
Ensembl chrNW_004936472:25,236,728...25,246,580 		JBrowse link
G Il18r1 interleukin 18 receptor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936713:1,038,985...1,075,770
Ensembl chrNW_004936713:1,038,877...1,075,811 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:11,025,590...11,058,807
Ensembl chrNW_004936501:11,025,567...11,058,818 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936818:453,635...569,194
Ensembl chrNW_004936818:453,635...567,469 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936630:1,601,006...1,633,844
Ensembl chrNW_004936630:1,601,010...1,632,745 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:1,569,603...1,596,831
Ensembl chrNW_004936706:1,569,756...1,596,456 		JBrowse link
G Sema4a semaphorin 4A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:5,404,380...5,431,183
Ensembl chrNW_004936580:5,406,194...5,431,185 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936506:7,091,982...7,185,938
Ensembl chrNW_004936506:7,095,009...7,184,689 		JBrowse link
G Tmem98 transmembrane protein 98 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:2,065,663...2,074,678
Ensembl chrNW_004936538:2,064,696...2,074,730 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtor mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:158,376...282,310
Ensembl chrNW_004936474:157,590...282,342 		JBrowse link
G Spn sialophorin involved_in ISO (PMID:18036228) UniProt PMID:18036228 NCBI chrNW_004936501:12,773,967...12,776,642 JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936646:1,297,530...1,312,508
Ensembl chrNW_004936646:1,296,290...1,312,157 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,546,405...13,558,635
Ensembl chrNW_004936490:13,546,292...13,558,635 		JBrowse link
T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936488:4,607,716...4,631,237
Ensembl chrNW_004936488:4,607,716...4,631,283 		JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936636:406,389...446,167
Ensembl chrNW_004936636:407,186...446,125 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936630:1,601,006...1,633,844
Ensembl chrNW_004936630:1,601,010...1,632,745 		JBrowse link
G Rora RAR related orphan receptor A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:21,402,056...21,567,908
Ensembl chrNW_004936471:21,400,589...22,069,643 		JBrowse link
G Rorc RAR related orphan receptor C acts_upstream_of_or_within
involved_in		 ISO (PMID:18792410)
(PMID:16990136), (PMID:18164222)
(PMID:20383124)		 MGI
UniProt		 PMID:16990136 PMID:18164222 PMID:18792410 PMID:20383124 NCBI chrNW_004936580:1,997,640...2,020,649
Ensembl chrNW_004936580:1,997,640...2,020,649 		JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936488:4,607,716...4,631,237
Ensembl chrNW_004936488:4,607,716...4,631,283 		JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:16990136)
(PMID:27893700)		 UniProt PMID:16990136 PMID:27893700 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Il6r interleukin 6 receptor involved_in ISO (PMID:27893700) UniProt PMID:27893700 NCBI chrNW_004936580:4,055,438...4,081,876
Ensembl chrNW_004936580:4,057,771...4,081,885 		JBrowse link
G Irf4 interferon regulatory factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936633:1,565,293...1,580,859
Ensembl chrNW_004936633:1,564,637...1,580,859 		JBrowse link
G LOC101968708 T-lymphocyte surface antigen Ly-9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936903:53,648...143,272
Ensembl chrNW_004936903:111,986...143,081 		JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (PMID:25470037) MGI PMID:25470037 NCBI chrNW_004936721:847,360...876,912
Ensembl chrNW_004936721:848,324...877,068 		JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:22184727) UniProt PMID:22184727 NCBI chrNW_004936740:155,268...165,536 JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:17,119,189...17,178,402
Ensembl chrNW_004936490:17,117,290...17,178,402 		JBrowse link
T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936488:4,607,716...4,631,237
Ensembl chrNW_004936488:4,607,716...4,631,283 		JBrowse link
G Bcl3 BCL3 transcription coactivator acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:1,410,848...1,427,822
Ensembl chrNW_004936706:1,416,249...1,427,407 		JBrowse link
G Bcl6 BCL6 transcription repressor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936578:2,371,976...2,395,034
Ensembl chrNW_004936578:2,371,945...2,395,071 		JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within
involved_in		 IEA Ensembl GO_REF:0000107 NCBI chrNW_004936484:6,780,692...6,800,883
Ensembl chrNW_004936484:6,780,692...6,800,966 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936650:1,416,825...1,422,595
Ensembl chrNW_004936650:1,416,812...1,422,588 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:11,025,590...11,058,807
Ensembl chrNW_004936501:11,025,567...11,058,818 		JBrowse link
G Il6 interleukin 6 acts_upstream_of ISO (PMID:12594267) MGI PMID:12594267 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Kmt2a lysine methyltransferase 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:3,480,071...3,566,823
Ensembl chrNW_004936542:3,391,774...3,562,147 		JBrowse link
G Men1 menin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:4,504,489...4,510,085
Ensembl chrNW_004936599:4,504,397...4,510,555 		JBrowse link
G Myb MYB proto-oncogene, transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936560:2,797,943...2,828,813
Ensembl chrNW_004936560:2,796,697...2,829,650 		JBrowse link
T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936683:2,874,022...2,936,214
Ensembl chrNW_004936683:2,874,042...2,935,040 		JBrowse link
G Il12b interleukin 12B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936515:4,056,214...4,066,121
Ensembl chrNW_004936515:4,056,214...4,065,076 		JBrowse link
G Pdp2 pyruvate dehyrogenase phosphatase catalytic subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:17,139,135...17,146,021
Ensembl chrNW_004936475:17,139,521...17,143,304 		JBrowse link
G Ptger4 prostaglandin E receptor 4 involved_in ISO (PMID:19465928) UniProt PMID:19465928 NCBI chrNW_004936518:1,903,636...1,916,746
Ensembl chrNW_004936518:1,903,725...1,916,746 		JBrowse link
G Rorc RAR related orphan receptor C involved_in ISO (PMID:14691482) UniProt PMID:14691482 NCBI chrNW_004936580:1,997,640...2,020,649
Ensembl chrNW_004936580:1,997,640...2,020,649 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17417
    immune system process 2307
      leukocyte activation 950
        leukocyte activation involved in immune response 295
          lymphocyte activation involved in immune response 209
            T cell activation involved in immune response 113
              T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 13
              T cell differentiation involved in immune response + 87
              T cell proliferation involved in immune response + 5
              alpha-beta T cell activation involved in immune response + 80
              cytotoxic T cell degranulation + 3
              gamma-delta T cell activation involved in immune response + 0
Path 2
Term Annotations click to browse term
  biological_process 17417
    cellular process 17021
      cell activation 1096
        cell activation involved in immune response 299
          leukocyte activation involved in immune response 295
            lymphocyte activation involved in immune response 209
              T cell activation involved in immune response 113
                T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 13
                T cell differentiation involved in immune response + 87
                T cell proliferation involved in immune response + 5
                alpha-beta T cell activation involved in immune response + 80
                cytotoxic T cell degranulation + 3
                gamma-delta T cell activation involved in immune response + 0
paths to the root