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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell activation involved in immune response
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Accession:GO:0002286 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
Synonyms:related_synonym: T cell activation during immune response;   T lymphocyte activation during immune response

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T cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624774:9,699,876...9,708,871
Ensembl chrNW_004624774:9,700,393...9,709,514 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISO (PMID:24310610) UniProt PMID:24310610 NCBI chrNW_004624804:7,262,195...7,371,506
Ensembl chrNW_004624804:7,262,163...7,376,267 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISS UniProt GO_REF:0000024 NCBI chrNW_004624869:1,326,605...1,337,195 JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 involved_in ISO (PMID:17294403) UniProt PMID:17294403 NCBI chrNW_004624748:8,740,563...8,833,091
Ensembl chrNW_004624748:8,779,395...8,835,500 		JBrowse link
G Mdk midkine involved_in ISO (PMID:28183532) UniProt PMID:28183532 NCBI chrNW_004624767:2,171,096...2,173,436
Ensembl chrNW_004624767:2,171,096...2,173,512 		JBrowse link
G Psen1 presenilin 1 acts_upstream_of_or_within ISO (PMID:17698590) MGI PMID:17698590 NCBI chrNW_004624734:28,200,358...28,272,684
Ensembl chrNW_004624734:28,200,140...28,272,743 		JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO (PMID:17698590) MGI PMID:17698590 NCBI chrNW_004624771:17,183,538...17,205,460
Ensembl chrNW_004624771:17,183,447...17,224,188 		JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624788:5,550,569...5,557,342
Ensembl chrNW_004624788:5,550,445...5,557,321 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (PMID:17277142) MGI PMID:17277142 NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534 		JBrowse link
cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab27a RAB27A, member RAS oncogene family acts_upstream_of_or_within ISO (PMID:11266473) MGI PMID:11266473 NCBI chrNW_004624731:6,315,064...6,355,431
Ensembl chrNW_004624731:6,319,092...6,355,534 		JBrowse link
G Stx11 syntaxin 11 acts_upstream_of_or_within ISO (PMID:23042080), (PMID:23190531) MGI PMID:23042080 PMID:23190531 NCBI chrNW_004624753:10,150,811...10,180,794
Ensembl chrNW_004624753:10,148,416...10,191,153 		JBrowse link
memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tsc1 TSC complex subunit 1 acts_upstream_of_or_within ISO (PMID:25271321) MGI PMID:25271321 NCBI chrNW_004624760:3,479,028...3,536,612
Ensembl chrNW_004624760:3,498,692...3,532,011 		JBrowse link
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nckap1l NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624904:2,508,576...2,575,505
Ensembl chrNW_004624904:2,508,799...2,578,609 		JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgl2 fibrinogen like 2 acts_upstream_of_or_within ISO (PMID:29341118) MGI PMID:29341118 NCBI chrNW_004624739:26,501,149...26,507,305
Ensembl chrNW_004624739:26,503,965...26,507,305 		JBrowse link
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:26492563) UniProt PMID:26492563 NCBI chrNW_004624733:32,521,318...32,527,499 JBrowse link
G Lgals3 galectin 3 involved_in ISO (PMID:19706535) BHF-UCL PMID:19706535 NCBI chrNW_004624731:14,300,138...14,307,843
Ensembl chrNW_004624731:14,298,201...14,304,637 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624767:15,107,157...15,111,696
Ensembl chrNW_004624767:15,107,159...15,109,191 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624782:11,981,781...12,008,362 JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (PMID:16020505) BHF-UCL PMID:16020505 NCBI chrNW_004624908:1,371,595...1,383,879
Ensembl chrNW_004624908:1,371,595...1,383,879 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:9670042) BHF-UCL PMID:9670042 NCBI chrNW_004624771:8,580,489...8,599,735 JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624767:15,107,157...15,111,696
Ensembl chrNW_004624767:15,107,159...15,109,191 		JBrowse link
G Foxp3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679 		JBrowse link
G Il2 interleukin 2 involved_in ISO (PMID:25642768) BHF-UCL PMID:25642768 NCBI chrNW_004624777:2,885,537...2,890,453
Ensembl chrNW_004624777:2,885,535...2,890,453 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18792410) MGI PMID:18792410 NCBI chrNW_004624733:39,412,800...39,420,079 JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chrNW_004624771:7,837,547...7,948,217 JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624760:12,025,206...12,074,548 JBrowse link
G Smad7 SMAD family member 7 involved_in ISO (PMID:25642768) BHF-UCL PMID:25642768 NCBI chrNW_004624778:12,415,364...12,444,882
Ensembl chrNW_004624778:12,415,282...12,444,835 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:21151104) UniProt PMID:21151104 NCBI chrNW_004624795:4,442,188...4,453,544
Ensembl chrNW_004624795:4,442,188...4,453,143 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO (PMID:23034280) MGI PMID:23034280 NCBI chrNW_004624885:2,474,427...2,489,024
Ensembl chrNW_004624885:2,475,727...2,489,030 		JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624764:20,224,919...20,234,108
Ensembl chrNW_004624764:20,224,906...20,234,629 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 CD69 molecule involved_in ISO (PMID:24752896) UniProt PMID:24752896 NCBI chrNW_004624860:4,345,497...4,364,251
Ensembl chrNW_004624860:4,345,232...4,365,817 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (PMID:20696842) UniProt PMID:20696842 NCBI chrNW_004624908:1,371,595...1,383,879
Ensembl chrNW_004624908:1,371,595...1,383,879 		JBrowse link
G Lgals1 galectin 1 involved_in ISO (PMID:24752896) UniProt PMID:24752896 NCBI chrNW_004624752:10,220,115...10,223,434
Ensembl chrNW_004624752:10,219,872...10,223,317 		JBrowse link
G Loxl3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624749:28,959,682...28,980,428
Ensembl chrNW_004624749:28,960,593...28,980,428 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:21151104) UniProt PMID:21151104 NCBI chrNW_004624795:4,442,188...4,453,544
Ensembl chrNW_004624795:4,442,188...4,453,143 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (PMID:24107315) UniProt PMID:24107315 NCBI chrNW_004624771:8,711,093...8,722,518
Ensembl chrNW_004624771:8,711,017...8,722,539 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISO (PMID:17008549) UniProt PMID:17008549 NCBI chrNW_004624811:765,338...782,203
Ensembl chrNW_004624811:764,940...782,198 		JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624767:15,107,157...15,111,696
Ensembl chrNW_004624767:15,107,159...15,109,191 		JBrowse link
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within ISO (PMID:12594267) MGI PMID:12594267 NCBI chrNW_004624730:69,145,035...69,167,583
Ensembl chrNW_004624730:69,154,080...69,167,689 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624835:4,223,252...4,227,892
Ensembl chrNW_004624835:4,223,511...4,227,979 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624738:28,150,004...28,217,850
Ensembl chrNW_004624738:28,150,664...28,216,389 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO (PMID:15917799) MGI PMID:15917799 NCBI chrNW_004624771:7,837,547...7,948,217 JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chrNW_004624786:478,048...491,086 JBrowse link
positive regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:12540904) UniProt PMID:12540904 NCBI chrNW_004624807:4,040,639...4,074,631 JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624802:11,662,851...11,664,444
Ensembl chrNW_004624802:11,662,753...11,665,418 		JBrowse link
G LOC101706353 HLA class II histocompatibility antigen, DR alpha chain involved_in ISO (PMID:27591323) UniProt PMID:27591323 NCBI chrNW_004624754:24,079,459...24,086,342
Ensembl chrNW_004624754:24,079,366...24,084,512 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 involved_in ISO (PMID:29230018) UniProt PMID:29230018 NCBI chrNW_004624741:23,985,257...23,990,354
Ensembl chrNW_004624741:23,985,675...23,989,790 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:18713990) BHF-UCL PMID:18713990 NCBI chrNW_004624771:8,580,489...8,599,735 JBrowse link
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 CD81 molecule involved_in ISO (PMID:11046035)
(PMID:8766544)		 UniProt PMID:8766544 PMID:11046035 NCBI chrNW_004624767:15,192,446...15,210,923
Ensembl chrNW_004624767:15,192,452...15,210,922 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chrNW_004624786:478,048...491,086 JBrowse link
G LOC101701356 HLA class II histocompatibility antigen, DM beta chain involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624754:23,774,013...23,779,851
Ensembl chrNW_004624754:23,773,934...23,779,952 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISO (PMID:17008549) UniProt PMID:17008549 NCBI chrNW_004624811:765,338...782,203
Ensembl chrNW_004624811:764,940...782,198 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chrNW_004624736:39,088,741...39,090,745
Ensembl chrNW_004624736:39,088,921...39,090,394 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624835:4,223,252...4,227,892
Ensembl chrNW_004624835:4,223,511...4,227,979 		JBrowse link
G Ripk2 receptor interacting serine/threonine kinase 2 acts_upstream_of_or_within ISO (PMID:11894097) MGI PMID:11894097 NCBI chrNW_004624744:2,194,339...2,227,498
Ensembl chrNW_004624744:2,201,319...2,226,890 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624738:28,150,004...28,217,850
Ensembl chrNW_004624738:28,150,664...28,216,389 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chrNW_004624792:4,148,258...4,223,431
Ensembl chrNW_004624792:4,148,453...4,217,548 		JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chrNW_004624794:10,172,789...10,180,693
Ensembl chrNW_004624794:10,168,792...10,179,510 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chrNW_004624789:15,612,311...15,623,878
Ensembl chrNW_004624789:15,612,335...15,624,152 		JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in ISO (PMID:26098997) UniProt PMID:26098997 NCBI chrNW_004624937:564,191...584,470 JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004624754:23,742,506...23,750,668
Ensembl chrNW_004624754:23,742,509...23,750,062 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004624901:2,348,218...2,434,429
Ensembl chrNW_004624901:2,346,734...2,380,852 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624802:11,662,851...11,664,444
Ensembl chrNW_004624802:11,662,753...11,665,418 		JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase involved_in ISO (PMID:36171294) UniProt PMID:36171294 NCBI chrNW_004624730:63,911,066...63,994,886
Ensembl chrNW_004624730:63,911,066...63,995,596 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624784:7,294,286...7,312,959
Ensembl chrNW_004624784:7,294,183...7,304,687 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624782:11,981,781...12,008,362 JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) MGI PMID:12594267 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318 		JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in ISO (PMID:26098997) UniProt PMID:26098997 NCBI chrNW_004624937:564,191...584,470 JBrowse link
G Prkcz protein kinase C zeta involved_in ISO (PMID:15987782) UniProt PMID:15987782 NCBI chrNW_004624818:7,758,192...7,846,950
Ensembl chrNW_004624818:7,759,770...7,847,208 		JBrowse link
G Rara retinoic acid receptor alpha involved_in ISO (PMID:18416830) BHF-UCL PMID:18416830 NCBI chrNW_004624795:2,935,432...2,975,226
Ensembl chrNW_004624795:2,934,731...2,967,232 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:18354165) BHF-UCL PMID:18354165 NCBI chrNW_004624771:8,580,489...8,599,735 JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within ISO (PMID:24645804) MGI PMID:24645804 NCBI chrNW_004624825:3,846,604...3,972,780
Ensembl chrNW_004624825:3,845,092...3,973,636 		JBrowse link
regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within ISO (PMID:15240675) MGI PMID:15240675 NCBI chrNW_004624730:69,145,035...69,167,583
Ensembl chrNW_004624730:69,154,080...69,167,689 		JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il27 interleukin 27 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624782:13,009,450...13,015,548
Ensembl chrNW_004624782:13,009,564...13,015,440 		JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 NOT|involved_in ISO (PMID:19050256) UniProt PMID:19050256 NCBI chrNW_004624843:2,017,738...2,021,153 JBrowse link
G Ccr6 C-C motif chemokine receptor 6 NOT|involved_in ISO (PMID:19050256) UniProt PMID:19050256 NCBI chrNW_004624785:12,190,802...12,203,924 JBrowse link
regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624775:2,985,077...3,014,567
Ensembl chrNW_004624775:2,994,164...3,015,392 		JBrowse link
G LOC101706353 HLA class II histocompatibility antigen, DR alpha chain involved_in ISO (PMID:15322540) UniProt PMID:15322540 NCBI chrNW_004624754:24,079,459...24,086,342
Ensembl chrNW_004624754:24,079,366...24,084,512 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO (PMID:18776904) MGI PMID:18776904 NCBI chrNW_004624885:2,474,427...2,489,024
Ensembl chrNW_004624885:2,475,727...2,489,030 		JBrowse link
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein acts_upstream_of_or_within ISO (PMID:17403904) MGI PMID:17403904 NCBI chrNW_004624796:2,512,292...2,621,505
Ensembl chrNW_004624796:2,510,878...2,568,532 		JBrowse link
G Fgl2 fibrinogen like 2 acts_upstream_of_or_within ISO (PMID:29341118) MGI PMID:29341118 NCBI chrNW_004624739:26,501,149...26,507,305
Ensembl chrNW_004624739:26,503,965...26,507,305 		JBrowse link
G Icam1 intercellular adhesion molecule 1 involved_in ISO (PMID:2477710) BHF-UCL PMID:2477710 NCBI chrNW_004624828:2,432,584...2,451,997
Ensembl chrNW_004624828:2,432,550...2,453,071 		JBrowse link
G Itgal integrin subunit alpha L involved_in ISO (PMID:2477710) BHF-UCL PMID:2477710 NCBI chrNW_004624782:13,635,217...13,671,401
Ensembl chrNW_004624782:13,640,996...13,669,541 		JBrowse link
G Plxna1 plexin A1 involved_in ISO (PMID:16715077) UniProt PMID:16715077 NCBI chrNW_004624900:2,779,008...2,825,263
Ensembl chrNW_004624900:2,784,106...2,825,360 		JBrowse link
G Sema6d semaphorin 6D involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624731:11,914,530...12,269,463
Ensembl chrNW_004624731:11,914,422...11,970,138 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:16715077) UniProt PMID:16715077 NCBI chrNW_004624754:17,643,397...17,649,255
Ensembl chrNW_004624754:17,643,363...17,648,231 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor TYROBP involved_in ISO (PMID:16715077) UniProt PMID:16715077 NCBI chrNW_004624794:10,183,934...10,187,180
Ensembl chrNW_004624794:10,183,515...10,187,244 		JBrowse link
T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec4e C-type lectin domain family 4 member E acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624860:4,108,782...4,113,693
Ensembl chrNW_004624860:4,108,640...4,113,839 		JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig acts_upstream_of_or_within ISO (PMID:23602766) MGI PMID:23602766 NCBI chrNW_004624794:168,564...172,433
Ensembl chrNW_004624794:168,564...172,034 		JBrowse link
G Sema4a semaphorin 4A involved_in ISO (PMID:15780988) UniProt PMID:15780988 NCBI chrNW_004624885:1,470,666...1,493,634
Ensembl chrNW_004624885:1,470,525...1,495,369 		JBrowse link
T cell proliferation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule ISO RGD PMID:20500684 RGD:4892204 NCBI chrNW_004624912:350,201...432,410
Ensembl chrNW_004624912:350,157...426,712 		JBrowse link
G Rps6 ribosomal protein S6 acts_upstream_of_or_within ISO (PMID:16357222) MGI PMID:16357222 NCBI chrNW_004624736:23,332,556...23,336,234
Ensembl chrNW_004624736:23,328,002...23,336,140 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624823:6,612,452...6,625,047
Ensembl chrNW_004624823:6,612,452...6,625,300 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624771:8,711,093...8,722,518
Ensembl chrNW_004624771:8,711,017...8,722,539 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO (PMID:16357222) MGI PMID:16357222 NCBI chrNW_004624786:10,266,316...10,282,664
Ensembl chrNW_004624786:10,263,518...10,271,218 		JBrowse link
T follicular helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624767:15,107,157...15,111,696
Ensembl chrNW_004624767:15,107,159...15,109,191 		JBrowse link
G Foxp1 forkhead box P1 involved_in ISO (PMID:24859450) UniProt PMID:24859450 NCBI chrNW_004624773:5,543,529...6,076,522
Ensembl chrNW_004624773:5,543,536...5,883,131 		JBrowse link
G Icos inducible T cell costimulator involved_in ISO (PMID:27135603) UniProt PMID:27135603 NCBI chrNW_004624765:12,351,695...12,417,847
Ensembl chrNW_004624765:12,352,042...12,372,861 		JBrowse link
G Icoslg inducible T cell costimulator ligand involved_in ISO (PMID:24411167) UniProt PMID:24411167 NCBI chrNW_004624745:29,880,943...29,888,635
Ensembl chrNW_004624745:29,880,992...29,888,717 		JBrowse link
G Il21 interleukin 21 involved_in ISO (PMID:23045607) UniProt PMID:23045607 NCBI chrNW_004624777:3,054,368...3,061,304
Ensembl chrNW_004624777:3,054,368...3,061,304 		JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:23045607) UniProt PMID:23045607 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO (PMID:30523347) UniProt PMID:30523347 NCBI chrNW_004624815:1,290,106...1,376,961
Ensembl chrNW_004624815:1,289,997...1,369,610 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO (PMID:23583643) MGI PMID:23583643 NCBI chrNW_004624771:7,837,547...7,948,217 JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624760:12,025,206...12,074,548 JBrowse link
G Tbk1 TANK binding kinase 1 involved_in ISO (PMID:27135603) UniProt PMID:27135603 NCBI chrNW_004624802:3,861,821...3,914,061
Ensembl chrNW_004624802:3,862,709...3,914,028 		JBrowse link
T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cracr2a calcium release activated channel regulator 2A involved_in ISO (PMID:29987160) UniProt PMID:29987160 NCBI chrNW_004624860:846,420...959,600
Ensembl chrNW_004624860:849,278...959,584 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624835:4,223,252...4,227,892
Ensembl chrNW_004624835:4,223,511...4,227,979 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:15944249) UniProt PMID:15944249 NCBI chrNW_004624776:7,858,400...7,862,716
Ensembl chrNW_004624776:7,793,259...7,863,184 		JBrowse link
G Il18r1 interleukin 18 receptor 1 acts_upstream_of_or_within ISO (PMID:10227969) MGI PMID:10227969 NCBI chrNW_004624749:6,875,934...6,909,702
Ensembl chrNW_004624749:6,875,750...6,909,734 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624782:11,981,781...12,008,362 JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in ISO (PMID:18579517) UniProt PMID:18579517 NCBI chrNW_004624830:1,320,034...1,422,774
Ensembl chrNW_004624830:1,321,387...1,424,389 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:31182790) MGI PMID:31182790 NCBI chrNW_004624789:15,612,311...15,623,878
Ensembl chrNW_004624789:15,612,335...15,624,152 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit acts_upstream_of_or_within ISO (PMID:16081776) MGI PMID:16081776 NCBI chrNW_004624907:1,806,784...1,829,686
Ensembl chrNW_004624907:1,806,874...1,829,417 		JBrowse link
G Sema4a semaphorin 4A involved_in ISO (PMID:15780988) UniProt PMID:15780988 NCBI chrNW_004624885:1,470,666...1,493,634
Ensembl chrNW_004624885:1,470,525...1,495,369 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 involved_in ISO (PMID:14688310) UniProt PMID:14688310 NCBI chrNW_004624854:4,975,724...5,056,940
Ensembl chrNW_004624854:4,976,507...5,057,391 		JBrowse link
G Tmem98 transmembrane protein 98 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624875:909,040...920,826
Ensembl chrNW_004624875:909,017...920,823 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chrNW_004624733:39,412,800...39,420,079 JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO (PMID:26410627) MGI PMID:26410627 NCBI chrNW_004624818:1,570,155...1,698,264
Ensembl chrNW_004624818:1,570,276...1,698,259 		JBrowse link
G Spn sialophorin involved_in ISO (PMID:18036228) UniProt PMID:18036228 NCBI chrNW_004624782:13,471,083...13,483,712 JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chrNW_004624802:10,809,234...10,847,762
Ensembl chrNW_004624802:10,809,252...10,846,693 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:10761931) UniProt PMID:10761931 NCBI chrNW_004624795:4,442,188...4,453,544
Ensembl chrNW_004624795:4,442,188...4,453,143 		JBrowse link
T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:26,118,840...26,139,328
Ensembl chrNW_004624734:26,118,754...26,139,468 		JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 involved_in ISO (PMID:23241884) UniProt PMID:23241884 NCBI chrNW_004624737:11,361,248...11,430,476
Ensembl chrNW_004624737:11,361,737...11,428,288 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:20383124) MGI PMID:20383124 NCBI chrNW_004624789:15,612,311...15,623,878
Ensembl chrNW_004624789:15,612,335...15,624,152 		JBrowse link
G Rora RAR related orphan receptor A involved_in ISO (PMID:18164222) GO_Central PMID:18164222 NCBI chrNW_004624781:11,014,185...11,688,558
Ensembl chrNW_004624781:11,014,286...11,679,678 		JBrowse link
G Rorc RAR related orphan receptor C involved_in
acts_upstream_of_or_within		 ISO (PMID:20383124)
(PMID:16990136), (PMID:18164222)
(PMID:18792410)		 MGI
UniProt		 PMID:16990136 PMID:18164222 PMID:18792410 PMID:20383124 NCBI chrNW_004624772:19,478,403...19,501,184
Ensembl chrNW_004624772:19,477,093...19,501,169 		JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:26,118,840...26,139,328
Ensembl chrNW_004624734:26,118,754...26,139,468 		JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:27893700)
(PMID:16990136)		 UniProt PMID:16990136 PMID:27893700 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318 		JBrowse link
G Il6r interleukin 6 receptor involved_in ISO (PMID:27893700) UniProt PMID:27893700 NCBI chrNW_004624885:2,910,367...2,946,916
Ensembl chrNW_004624885:2,910,112...2,946,886 		JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO (PMID:22983707) UniProt PMID:22983707 NCBI chrNW_004624756:23,917,111...23,931,482
Ensembl chrNW_004624756:23,918,323...23,931,501 		JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (PMID:25470037) MGI PMID:25470037 NCBI chrNW_004624893:702,895...736,623 JBrowse link
G Slamf6 SLAM family member 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624794:754,530...796,732 JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISO (PMID:28065600) UniProt PMID:28065600 NCBI chrNW_004624795:1,648,235...1,680,788
Ensembl chrNW_004624795:1,648,080...1,681,200 		JBrowse link
T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:26,118,840...26,139,328
Ensembl chrNW_004624734:26,118,754...26,139,468 		JBrowse link
G Bcl3 BCL3 transcription coactivator acts_upstream_of_or_within ISO (PMID:16081776) MGI PMID:16081776 NCBI chrNW_004624907:1,656,803...1,666,774
Ensembl chrNW_004624907:1,656,783...1,667,575 		JBrowse link
G Bcl6 BCL6 transcription repressor acts_upstream_of ISO (PMID:12594267) MGI PMID:12594267 NCBI chrNW_004624730:69,145,035...69,167,583
Ensembl chrNW_004624730:69,154,080...69,167,689 		JBrowse link
G Gata3 GATA binding protein 3 involved_in
acts_upstream_of_or_within		 IEA Ensembl GO_REF:0000107 NCBI chrNW_004624775:2,985,077...3,014,567
Ensembl chrNW_004624775:2,994,164...3,015,392 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624835:4,223,252...4,227,892
Ensembl chrNW_004624835:4,223,511...4,227,979 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chrNW_004624733:39,412,800...39,420,079 JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004624782:11,981,781...12,008,362 JBrowse link
G Il6 interleukin 6 acts_upstream_of ISO (PMID:12594267) MGI PMID:12594267 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318 		JBrowse link
G Kmt2a lysine methyltransferase 2A involved_in ISO (PMID:20484083) UniProt PMID:20484083 NCBI chrNW_004624784:13,824,507...13,912,672
Ensembl chrNW_004624784:13,824,541...13,908,077 		JBrowse link
G Men1 menin 1 involved_in ISO (PMID:20484083) UniProt PMID:20484083 NCBI chrNW_004624767:21,579,084...21,585,380
Ensembl chrNW_004624767:21,579,103...21,585,373 		JBrowse link
G Myb MYB proto-oncogene, transcription factor involved_in ISO (PMID:20484083) UniProt PMID:20484083 NCBI chrNW_004624886:2,455,704...2,489,593 JBrowse link
T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624836:2,804,349...3,058,125
Ensembl chrNW_004624836:2,808,681...2,993,452 		JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:1673147) UniProt PMID:1673147 NCBI chrNW_004624733:30,146,050...30,156,144
Ensembl chrNW_004624733:30,146,050...30,154,589 		JBrowse link
G Ptger4 prostaglandin E receptor 4 involved_in ISO (PMID:19465928) UniProt PMID:19465928 NCBI chrNW_004624759:14,243,887...14,259,090
Ensembl chrNW_004624759:14,244,899...14,258,445 		JBrowse link
G Rorc RAR related orphan receptor C involved_in ISO (PMID:14691482) UniProt PMID:14691482 NCBI chrNW_004624772:19,478,403...19,501,184
Ensembl chrNW_004624772:19,477,093...19,501,169 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17650
    immune system process 2287
      leukocyte activation 929
        leukocyte activation involved in immune response 288
          lymphocyte activation involved in immune response 200
            T cell activation involved in immune response 108
              T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 13
              T cell differentiation involved in immune response + 83
              T cell proliferation involved in immune response + 5
              alpha-beta T cell activation involved in immune response + 77
              cytotoxic T cell degranulation + 3
              gamma-delta T cell activation involved in immune response + 0
Path 2
Term Annotations click to browse term
  biological_process 17650
    cellular process 17226
      cell activation 1080
        cell activation involved in immune response 292
          leukocyte activation involved in immune response 288
            lymphocyte activation involved in immune response 200
              T cell activation involved in immune response 108
                T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 13
                T cell differentiation involved in immune response + 83
                T cell proliferation involved in immune response + 5
                alpha-beta T cell activation involved in immune response + 77
                cytotoxic T cell degranulation + 3
                gamma-delta T cell activation involved in immune response + 0
paths to the root