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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell activation involved in immune response
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Accession:GO:0002286 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
Synonyms:related_synonym: T cell activation during immune response;   T lymphocyte activation during immune response

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T cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD1C CD1c molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:5,633,807...5,638,528
Ensembl chr20:5,634,457...5,637,860 		JBrowse link
G CD74 CD74 molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr23:53,008,802...53,022,953
Ensembl chr23:53,009,394...53,022,923 		JBrowse link
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISO (PMID:24310610) UniProt PMID:24310610 NCBI chr26:42,966,095...43,072,083
Ensembl chr26:42,962,447...43,072,001 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005 		JBrowse link
G LCP1 lymphocyte cytosolic protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:24,182,086...24,238,746
Ensembl chr 3:24,182,076...24,238,651 		JBrowse link
G MDK midkine involved_in ISO (PMID:28183532) UniProt PMID:28183532 NCBI chr 1:18,945,355...18,948,394
Ensembl chr 1:18,946,378...18,947,134 		JBrowse link
G PSEN1 presenilin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr24:50,394,310...50,476,521
Ensembl chr24:50,405,590...50,472,132 		JBrowse link
G PSEN2 presenilin 2 acts_upstream_of_or_within ISO (PMID:17698590) MGI PMID:17698590 NCBI chr25:2,862,354...2,888,735
Ensembl chr25:2,862,251...2,877,386 		JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EOMES eomesodermin involved_in ISO (PMID:17566017)
(PMID:14605368)		 UniProt PMID:14605368 PMID:17566017 NCBI chr15:72,257,626...72,264,563 JBrowse link
G EOMES eomesodermin involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 Ensembl chr15:72,257,615...72,263,264 JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (PMID:17277142) MGI PMID:17277142 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAB27A RAB27A, member RAS oncogene family acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr26:28,140,972...28,227,847
Ensembl chr26:28,197,464...28,227,963 		JBrowse link
G STX11 syntaxin 11 acts_upstream_of_or_within ISO (PMID:23042080), (PMID:23190531) MGI PMID:23042080 PMID:23190531 NCBI chr13:29,045,674...29,084,602
Ensembl chr13:29,048,119...29,048,982 		JBrowse link
memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TSC1 TSC complex subunit 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:5,195,604...5,249,042
Ensembl chr12:5,195,675...5,244,157 		JBrowse link
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO (PMID:18424730) UniProt PMID:18424730 NCBI chr 6:36,708,368...36,731,729
Ensembl chr 6:36,708,311...36,730,189 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in ISO (PMID:32647003) UniProt PMID:32647003 NCBI chr11:50,611,193...50,658,800 JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 Ensembl chr11:50,611,181...50,647,519 JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGL2 fibrinogen like 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr21:71,735,486...71,741,951
Ensembl chr21:71,735,253...71,742,954 		JBrowse link
G LOC103234663 interferon lambda-1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:33,901,382...33,904,356
Ensembl chr 6:33,901,801...33,903,894 		JBrowse link
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:59,479,794...59,501,532
Ensembl chr23:59,475,826...59,500,836 		JBrowse link
G LGALS3 galectin 3 involved_in ISO (PMID:19706535) BHF-UCL PMID:19706535 NCBI chr24:32,311,343...32,328,335
Ensembl chr24:32,311,271...32,328,339 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:2,075,629...2,080,462
Ensembl chr 1:2,076,851...2,077,432 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:25,019,638...25,069,732
Ensembl chr 5:25,046,701...25,070,015 		JBrowse link
G JAK3 Janus kinase 3 involved_in ISO (PMID:16020505) BHF-UCL PMID:16020505 NCBI chr 6:16,301,760...16,323,343
Ensembl chr 6:16,300,525...16,322,859 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:9670042) BHF-UCL PMID:9670042 NCBI chr25:55,714,291...55,998,009
Ensembl chr25:55,974,691...55,997,374 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:2,075,629...2,080,462
Ensembl chr 1:2,076,851...2,077,432 		JBrowse link
G FOXP3 forkhead box P3 involved_in ISO (PMID:23169781) UniProt PMID:23169781 NCBI chr  X:46,349,890...46,365,133 JBrowse link
G FOXP3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr  X:46,346,754...46,356,928 JBrowse link
G IL2 interleukin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969 		JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18792410) MGI PMID:18792410 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G LOC103230557 roquin-1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:55,167,418...55,258,964
Ensembl chr25:55,167,077...55,279,088 		JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:15,230,206...15,283,253
Ensembl chr12:15,238,124...15,280,689 		JBrowse link
G SMAD7 SMAD family member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:31,993,543...32,024,088
Ensembl chr18:31,993,681...32,024,850 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:68,131,258...68,145,579
Ensembl chr16:68,131,536...68,144,415 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr20:8,812,514...8,829,128
Ensembl chr20:8,812,351...8,817,286 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:95,388,469...95,398,305
Ensembl chr20:95,388,477...95,397,960 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD69 CD69 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:9,659,154...9,666,342
Ensembl chr11:9,659,029...9,665,914 		JBrowse link
G JAK3 Janus kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:16,301,760...16,323,343
Ensembl chr 6:16,300,525...16,322,859 		JBrowse link
G LGALS1 galectin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:20,379,144...20,383,303
Ensembl chr19:20,379,003...20,383,464 		JBrowse link
G LOC103243413 signal transducer and activator of transcription 5B involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:63,997,486...64,070,392
Ensembl chr16:63,997,441...64,070,445 		JBrowse link
G LOXL3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:32,722,588...32,745,480
Ensembl chr14:32,725,112...32,745,004 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:63,959,265...63,986,627
Ensembl chr16:63,960,515...63,985,026 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:68,131,258...68,145,579
Ensembl chr16:68,131,536...68,144,415 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (PMID:24107315) UniProt PMID:24107315 NCBI chr25:56,105,757...56,118,249
Ensembl chr25:56,106,584...56,118,758 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:84,207,818...84,226,438
Ensembl chr12:84,207,820...84,226,562 		JBrowse link
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:2,075,629...2,080,462
Ensembl chr 1:2,076,851...2,077,432 		JBrowse link
G BCL6 BCL6 transcription repressor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr15:81,997,659...82,022,059
Ensembl chr15:81,998,545...82,009,946 		JBrowse link
G HLX H2.0 like homeobox acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr25:8,641,386...8,647,485
Ensembl chr25:8,641,752...8,646,563 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:60,330,192...60,335,477
Ensembl chr14:60,431,401...60,433,011
Ensembl chr14:60,431,401...60,433,011 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103230557 roquin-1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr25:55,167,418...55,258,964
Ensembl chr25:55,167,077...55,279,088 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
G LOC103242599 galectin-9 involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chr16:21,421,034...21,439,583 JBrowse link
positive regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD46 CD46 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:21,650,825...21,693,898
Ensembl chr25:21,655,969...21,693,878 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:52,289,486...52,296,735
Ensembl chr11:52,295,106...52,297,244 		JBrowse link
G LOC103221700 HLA class II histocompatibility antigen, DR beta 3 chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,471,058...39,484,265 JBrowse link
G LOC103247148 HLA class II histocompatibility antigen, DRB1 beta chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,556,020...39,564,488 JBrowse link
G LOC119618083 HLA class II histocompatibility antigen, DRB1 beta chain-like involved_in IEA Ensembl GO_REF:0000107
G MHC-DRA major histocompatibility complex, class II, DR alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,623,324...39,628,464
Ensembl chr17:39,622,402...39,629,261 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:6,550,806...6,556,499
Ensembl chr 2:6,549,652...6,556,478 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:18713990) BHF-UCL PMID:18713990 NCBI chr25:55,714,291...55,998,009
Ensembl chr25:55,974,691...55,997,374 		JBrowse link
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD81 CD81 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:2,190,896...2,211,838
Ensembl chr 1:2,190,845...2,211,389 		JBrowse link
G LOC103242599 galectin-9 involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chr16:21,421,034...21,439,583 JBrowse link
G MHC-DMB major histocompatibility complex, class II, DM beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,153,744...39,161,029
Ensembl chr17:39,154,850...39,161,090 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:84,207,818...84,226,438
Ensembl chr12:84,207,820...84,226,562 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr12:45,928,212...45,930,897
Ensembl chr12:45,929,071...45,930,904 		JBrowse link
G HLX H2.0 like homeobox acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr25:8,641,386...8,647,485
Ensembl chr25:8,641,752...8,646,563 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:84,843,391...84,881,087
Ensembl chr 8:84,843,471...84,881,303 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:60,330,192...60,335,477
Ensembl chr14:60,431,401...60,433,011
Ensembl chr14:60,431,401...60,433,011 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MALT1 MALT1 paracaspase involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:20,984,985...21,064,198
Ensembl chr18:20,985,819...21,054,554 		JBrowse link
G NFKBID NFKB inhibitor delta involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chr 6:30,800,122...30,812,991
Ensembl chr 6:30,799,204...30,811,141 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:79,044,624...79,077,736
Ensembl chr22:79,044,619...79,055,776 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 involved_in ISO (PMID:26098997) UniProt PMID:26098997 NCBI chr25:84,431,436...84,463,387
Ensembl chr25:84,434,527...84,463,249 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD2 bromodomain containing 2 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chr17:39,113,519...39,126,267 JBrowse link
G BRD2 bromodomain containing 2 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr17:39,114,700...39,122,051 JBrowse link
G BRD4 bromodomain containing 4 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chr 6:13,836,332...13,883,459
Ensembl chr 6:13,836,324...13,873,877 		JBrowse link
G EP300 E1A binding protein p300 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:23,634,132...23,726,095
Ensembl chr19:23,634,571...23,724,979 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:52,289,486...52,296,735
Ensembl chr11:52,295,106...52,297,244 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:87,679,656...87,778,767
Ensembl chr15:87,679,077...87,779,102 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL18 interleukin 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:25,019,638...25,069,732
Ensembl chr 5:25,046,701...25,070,015 		JBrowse link
G IL6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) MGI PMID:12594267 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 involved_in ISO (PMID:26098997) UniProt PMID:26098997 NCBI chr25:84,431,436...84,463,387
Ensembl chr25:84,434,527...84,463,249 		JBrowse link
G PRKCZ protein kinase C zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:129,367,309...129,502,681
Ensembl chr20:129,365,679...129,485,818 		JBrowse link
G RARA retinoic acid receptor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:65,817,849...65,866,862
Ensembl chr16:65,817,757...65,866,878 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:18354165) BHF-UCL PMID:18354165 NCBI chr25:55,714,291...55,998,009
Ensembl chr25:55,974,691...55,997,374 		JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SHB SH2 domain containing adaptor protein B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:42,520,803...42,669,892
Ensembl chr12:42,520,905...42,669,211 		JBrowse link
regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr15:81,997,659...82,022,059
Ensembl chr15:81,998,545...82,009,946 		JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL27 interleukin 27 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:26,348,559...26,358,028
Ensembl chr 5:26,348,848...26,356,360 		JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL20 C-C motif chemokine ligand 20 NOT|involved_in ISO (PMID:19050256) UniProt PMID:19050256 NCBI chr10:113,815,099...113,836,562
Ensembl chr10:113,832,573...113,835,736 		JBrowse link
G CCR6 C-C motif chemokine receptor 6 NOT|involved_in ISO (PMID:19050256) UniProt PMID:19050256 NCBI chr13:94,865,480...94,894,331
Ensembl chr13:94,865,936...94,894,315 		JBrowse link
regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA3 GATA binding protein 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:8,101,404...8,122,762
Ensembl chr 9:8,101,432...8,123,064 		JBrowse link
G LOC103221700 HLA class II histocompatibility antigen, DR beta 3 chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,471,058...39,484,265 JBrowse link
G LOC103247148 HLA class II histocompatibility antigen, DRB1 beta chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,556,020...39,564,488 JBrowse link
G LOC119618083 HLA class II histocompatibility antigen, DRB1 beta chain-like involved_in IEA Ensembl GO_REF:0000107
G MHC-DRA major histocompatibility complex, class II, DR alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,623,324...39,628,464
Ensembl chr17:39,622,402...39,629,261 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr20:8,812,514...8,829,128
Ensembl chr20:8,812,351...8,817,286 		JBrowse link
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APBB1IP amyloid beta precursor protein binding family B member 1 interacting protein acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:26,163,881...26,289,713
Ensembl chr 9:26,122,428...26,289,708 		JBrowse link
G FGL2 fibrinogen like 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr21:71,735,486...71,741,951
Ensembl chr21:71,735,253...71,742,954 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:9,320,991...9,338,125
Ensembl chr 6:9,322,550...9,338,263 		JBrowse link
G ITGAL integrin subunit alpha L involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:27,157,866...27,206,802
Ensembl chr 5:27,157,878...27,206,714 		JBrowse link
G PLXNA1 plexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:53,949,566...54,005,626
Ensembl chr22:53,951,119...53,999,812 		JBrowse link
G SEMA6D semaphorin 6D involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:35,511,593...36,095,816
Ensembl chr26:35,511,594...35,526,130 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:16715077) UniProt PMID:16715077 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:30,816,675...30,820,816
Ensembl chr 6:30,816,678...30,820,597 		JBrowse link
T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLEC4D C-type lectin domain family 4 member D acts_upstream_of_or_within ISO (PMID:23602766) MGI PMID:23602766 NCBI chr11:8,294,999...8,303,866 JBrowse link
G CLEC4D C-type lectin domain family 4 member D acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr11:8,297,155...8,302,780 JBrowse link
G CLEC4E C-type lectin domain family 4 member E acts_upstream_of_or_within ISO (PMID:23602766) MGI PMID:23602766 NCBI chr11:8,315,888...8,322,240
Ensembl chr11:8,316,049...8,321,274 		JBrowse link
G FCER1G Fc fragment of IgE receptor Ig involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:2,763,412...2,767,774
Ensembl chr20:2,763,417...2,767,248 		JBrowse link
G SEMA4A semaphorin 4A involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:7,684,107...7,716,866
Ensembl chr20:7,683,994...7,708,741 		JBrowse link
T cell proliferation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD86 CD86 molecule ISO RGD PMID:20500684 RGD:4892204 NCBI chr22:58,741,534...58,805,417
Ensembl chr22:58,741,525...58,805,366 		JBrowse link
G RPS6 ribosomal protein S6 acts_upstream_of_or_within ISO (PMID:16357222) MGI PMID:16357222 NCBI chr12:60,353,800...60,357,797
Ensembl chr12:60,353,817...60,357,759 		JBrowse link
G SLC11A1 solute carrier family 11 member 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:104,276,553...104,288,466 JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr25:56,105,757...56,118,249
Ensembl chr25:56,106,584...56,118,758 		JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223 		JBrowse link
T follicular helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:2,075,629...2,080,462
Ensembl chr 1:2,076,851...2,077,432 		JBrowse link
G FOXP1 forkhead box P1 involved_in ISO (PMID:24859450) UniProt PMID:24859450 NCBI chr22:31,907,941...32,538,294
Ensembl chr22:31,912,460...32,154,502 		JBrowse link
G GPR183 G protein-coupled receptor 183 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:77,952,689...77,966,317
Ensembl chr 3:77,953,212...77,954,297 		JBrowse link
G ICOS inducible T cell costimulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:89,706,755...89,732,600
Ensembl chr10:89,726,489...89,732,944 		JBrowse link
G ICOSLG inducible T cell costimulator ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:87,974,651...87,986,867
Ensembl chr 2:87,973,786...87,986,639 		JBrowse link
G IL21 interleukin 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:69,859,793...69,872,237
Ensembl chr 7:69,863,535...69,872,025 		JBrowse link
G IL6 interleukin 6 involved_in ISO (PMID:23045607) UniProt PMID:23045607 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G LOC103230557 roquin-1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr25:55,167,418...55,258,964
Ensembl chr25:55,167,077...55,279,088 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:64,321,296...64,406,188
Ensembl chr 4:64,321,078...64,406,519 		JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:15,230,206...15,283,253
Ensembl chr12:15,238,124...15,280,689 		JBrowse link
G TBK1 TANK binding kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:60,136,162...60,182,354
Ensembl chr11:60,136,232...60,182,344 		JBrowse link
T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRACR2A calcium release activated channel regulator 2A involved_in ISO (PMID:29987160) UniProt PMID:29987160 NCBI chr11:3,659,745...3,815,742
Ensembl chr11:3,667,647...3,743,026 		JBrowse link
G HLX H2.0 like homeobox acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr25:8,641,386...8,647,485
Ensembl chr25:8,641,752...8,646,563 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:15944249) UniProt PMID:15944249 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G IL18R1 interleukin 18 receptor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:6,026,683...6,067,808
Ensembl chr14:6,026,443...6,066,884 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 5:25,019,638...25,069,732
Ensembl chr 5:25,046,701...25,070,015 		JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:55,974,770...56,096,214
Ensembl chr 7:55,990,621...56,094,110 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:79,044,624...79,077,736
Ensembl chr22:79,044,619...79,055,776 		JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit acts_upstream_of_or_within ISO (PMID:16081776) MGI PMID:16081776 NCBI chr 6:38,463,414...38,500,487 JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr 6:38,464,860...38,500,591 JBrowse link
G SEMA4A semaphorin 4A involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:7,684,107...7,716,866
Ensembl chr20:7,683,994...7,708,741 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:76,553,626...76,708,540
Ensembl chr10:76,553,606...76,674,928 		JBrowse link
G TMEM98 transmembrane protein 98 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:26,468,148...26,481,681
Ensembl chr16:26,468,419...26,481,025 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G MTOR mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:120,522,667...120,678,988
Ensembl chr20:120,525,737...120,679,020 		JBrowse link
G SPN sialophorin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:26,987,810...26,990,214 JBrowse link
G STAT6 signal transducer and activator of transcription 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:53,005,378...53,020,899
Ensembl chr11:53,006,145...53,021,203 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:68,131,258...68,145,579
Ensembl chr16:68,131,536...68,144,415 		JBrowse link
T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:52,761,569...52,785,999
Ensembl chr24:52,761,651...52,785,978 		JBrowse link
G ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:92,722,960...92,769,563
Ensembl chr 9:92,723,015...92,768,558 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:79,044,624...79,077,736
Ensembl chr22:79,044,619...79,055,776 		JBrowse link
G RORA RAR related orphan receptor A involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:22,263,889...23,002,224
Ensembl chr26:22,812,445...22,993,021 		JBrowse link
G RORC RAR related orphan receptor C involved_in
acts_upstream_of_or_within		 ISO (PMID:20383124)
(PMID:18792410)
(PMID:16990136), (PMID:18164222)		 MGI
UniProt		 PMID:16990136 PMID:18164222 PMID:18792410 PMID:20383124 NCBI chr20:11,854,911...11,880,221
Ensembl chr20:11,855,005...11,879,717 		JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:52,761,569...52,785,999
Ensembl chr24:52,761,651...52,785,978 		JBrowse link
G IL6 interleukin 6 involved_in ISO (PMID:27893700)
(PMID:16990136)		 UniProt PMID:16990136 PMID:27893700 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G IL6R interleukin 6 receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:9,345,723...9,418,963
Ensembl chr20:9,361,152...9,396,610 		JBrowse link
G IRF4 interferon regulatory factor 4 involved_in ISO (PMID:22983707) UniProt PMID:22983707 NCBI chr17:71,739,920...71,758,811 JBrowse link
G IRF4 interferon regulatory factor 4 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr17:71,751,770...71,757,496 JBrowse link
G LY9 lymphocyte antigen 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:3,140,059...3,145,818 JBrowse link
G OTUD5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (PMID:25470037) MGI PMID:25470037 NCBI chr  X:46,041,348...46,077,195 JBrowse link
G SLAMF6 SLAM family member 6 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:3,426,868...3,465,553
Ensembl chr20:3,453,370...3,463,901 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:63,877,884...63,957,894
Ensembl chr16:63,922,862...63,957,984 		JBrowse link
T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:52,761,569...52,785,999
Ensembl chr24:52,761,651...52,785,978 		JBrowse link
G BCL3 BCL3 transcription coactivator acts_upstream_of_or_within ISO (PMID:16081776) MGI PMID:16081776 NCBI chr 6:38,228,137...38,243,767 JBrowse link
G BCL3 BCL3 transcription coactivator acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr 6:38,229,459...38,244,150 JBrowse link
G BCL6 BCL6 transcription repressor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr15:81,997,659...82,022,059
Ensembl chr15:81,998,545...82,009,946 		JBrowse link
G GATA3 GATA binding protein 3 involved_in
acts_upstream_of_or_within		 IEA Ensembl GO_REF:0000107 NCBI chr 9:8,101,404...8,122,762
Ensembl chr 9:8,101,432...8,123,064 		JBrowse link
G HLX H2.0 like homeobox acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr25:8,641,386...8,647,485
Ensembl chr25:8,641,752...8,646,563 		JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 5:25,019,638...25,069,732
Ensembl chr 5:25,046,701...25,070,015 		JBrowse link
G IL6 interleukin 6 acts_upstream_of ISO (PMID:12594267) MGI PMID:12594267 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G KMT2A lysine methyltransferase 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:109,819,748...109,912,763
Ensembl chr 1:109,853,758...109,908,113 		JBrowse link
G MEN1 menin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:9,423,885...9,431,123
Ensembl chr 1:9,423,917...9,431,104 		JBrowse link
G MYB MYB proto-oncogene, transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:38,203,923...38,242,148
Ensembl chr13:38,203,731...38,241,864 		JBrowse link
T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:66,843,519...66,985,655
Ensembl chr  X:66,843,558...66,985,709 		JBrowse link
G IL12B interleukin 12B involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:61,714,293...61,731,835 JBrowse link
G PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:52,575,280...52,583,614
Ensembl chr 5:52,580,423...52,582,009 		JBrowse link
G PTGER4 prostaglandin E receptor 4 involved_in ISO (PMID:19465928) UniProt PMID:19465928 NCBI chr 4:39,440,697...39,453,983
Ensembl chr 4:39,440,276...39,454,004 		JBrowse link
G RORC RAR related orphan receptor C involved_in ISO (PMID:14691482) UniProt PMID:14691482 NCBI chr20:11,854,911...11,880,221
Ensembl chr20:11,855,005...11,879,717 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19829
    immune system process 2687
      leukocyte activation 1043
        leukocyte activation involved in immune response 327
          lymphocyte activation involved in immune response 234
            T cell activation involved in immune response 129
              T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 13
              T cell differentiation involved in immune response + 101
              T cell proliferation involved in immune response + 5
              alpha-beta T cell activation involved in immune response + 92
              cytotoxic T cell degranulation + 5
              gamma-delta T cell activation involved in immune response + 0
Path 2
Term Annotations click to browse term
  biological_process 19829
    cellular process 19347
      cell activation 1226
        cell activation involved in immune response 331
          leukocyte activation involved in immune response 327
            lymphocyte activation involved in immune response 234
              T cell activation involved in immune response 129
                T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 13
                T cell differentiation involved in immune response + 101
                T cell proliferation involved in immune response + 5
                alpha-beta T cell activation involved in immune response + 92
                cytotoxic T cell degranulation + 5
                gamma-delta T cell activation involved in immune response + 0
paths to the root