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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell activation involved in immune response
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Accession:GO:0002286 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
Synonyms:related_synonym: T cell activation during immune response;   T lymphocyte activation during immune response


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T cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD1C CD1c molecule involved_in ISO (PMID:21167756) UniProt PMID:21167756 NCBI chr38:23,328,183...23,331,270
Ensembl chr38:23,295,128...23,331,613 		JBrowse link
G CD74 CD74 molecule involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:58,689,745...58,698,421
Ensembl chr 4:58,689,752...58,698,151 		JBrowse link
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISO (PMID:24310610) UniProt PMID:24310610 NCBI chr30:7,144,727...7,248,014
Ensembl chr30:7,144,570...7,248,000 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:29,801,119...29,810,006
Ensembl chr 3:29,800,211...29,810,180 		JBrowse link
G IFNA5 interferon, alpha 5 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:40,726,568...40,727,131
Ensembl chr11:40,726,568...40,727,131 		JBrowse link
G IFNA7 interferon, alpha 7 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:40,862,587...40,863,150
Ensembl chr11:40,862,587...40,863,150 		JBrowse link
G IFNB1 interferon beta 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:40,668,295...40,668,855
Ensembl chr11:40,668,295...40,668,855 		JBrowse link
G IFNK interferon kappa involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:45,641,627...45,642,256
Ensembl chr11:45,641,627...45,642,256 		JBrowse link
G LCP1 lymphocyte cytosolic protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:4,955,453...5,059,654
Ensembl chr22:4,992,347...5,059,636 		JBrowse link
G LOC100682977 interferon alpha-1/2 involved_in IBA GO_Central GO_REF:0000033
G LOC100683045 interferon alpha-1/2 involved_in IBA GO_Central GO_REF:0000033
G LOC100683567 interferon alpha-1/2-like involved_in IBA GO_Central GO_REF:0000033
G LOC100685213 interferon alpha-1/2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:40,816,731...40,817,513 JBrowse link
G LOC100686162 interferon alpha-2-like involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:40,697,253...40,697,786 JBrowse link
G LOC100688005 interferon alpha-1/2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:40,762,074...40,762,872 JBrowse link
G LOC100688084 interferon alpha-1/2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:40,765,515...40,766,521 JBrowse link
G LOC119873921 interferon alpha-1/2 involved_in IBA GO_Central GO_REF:0000033
G LOC119876805 interferon alpha-1/2 involved_in IBA GO_Central GO_REF:0000033
G LOC119876806 interferon alpha-1/2 involved_in IBA GO_Central GO_REF:0000033
G LOC119876807 interferon alpha-1/2 involved_in IBA GO_Central GO_REF:0000033
G LOC119876808 interferon alpha-1/2 involved_in IBA GO_Central GO_REF:0000033
G LOC119876809 interferon alpha-1/2 involved_in IBA GO_Central GO_REF:0000033
G LOC119876810 interferon alpha-1/2 involved_in IBA GO_Central GO_REF:0000033
G LOC119876811 interferon alpha-1/2 involved_in IBA GO_Central GO_REF:0000033
G LOC491316 midkine involved_in ISO (PMID:28183532) UniProt PMID:28183532 NCBI chr 9:55,100,491...55,101,081 JBrowse link
G LOC611406 interferon alpha-1/2-like involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:40,820,163...40,821,002 JBrowse link
G PSEN1 presenilin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:46,495,551...46,569,532
Ensembl chr 8:46,495,624...46,569,532 		JBrowse link
G PSEN2 presenilin 2 acts_upstream_of_or_within ISO (PMID:17698590) MGI PMID:17698590 NCBI chr 7:38,147,157...38,163,023
Ensembl chr 7:38,147,173...38,166,722 		JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EOMES eomesodermin involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr23:16,476,498...16,512,406
Ensembl chr23:16,506,032...16,511,527 		JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (PMID:17277142) MGI PMID:17277142 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAB27A RAB27A, member RAS oncogene family acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr30:20,633,576...20,706,240
Ensembl chr30:20,635,400...20,690,521 		JBrowse link
G STX11 syntaxin 11 acts_upstream_of_or_within ISO (PMID:23042080), (PMID:23190531) MGI PMID:23042080 PMID:23190531 NCBI chr 1:35,600,440...35,645,421
Ensembl chr 1:35,601,133...35,644,819 		JBrowse link
memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TSC1 TSC complex subunit 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:51,409,307...51,459,546
Ensembl chr 9:51,425,937...51,454,677 		JBrowse link
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO (PMID:18424730) UniProt PMID:18424730 NCBI chr 1:111,902,429...111,919,191
Ensembl chr 1:111,745,413...111,917,830 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:805,274...858,901
Ensembl chr27:805,310...843,439 		JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGL2 fibrinogen like 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr18:17,328,794...17,335,429
Ensembl chr18:17,331,780...17,335,401 		JBrowse link
G IL29L interleukin 29-like involved_in ISO (PMID:19346497) UniProt PMID:19346497 NCBI chr24:36,440,445...36,441,017
Ensembl chr24:36,440,445...36,441,017 		JBrowse link
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:53,018,990...53,032,035
Ensembl chr 4:53,012,234...53,033,393 		JBrowse link
G LGALS3 galectin 3 involved_in ISO (PMID:19706535) BHF-UCL PMID:19706535 NCBI chr 8:30,977,438...30,994,711
Ensembl chr 8:30,983,633...30,994,705 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:46,394,034...46,396,723
Ensembl chr18:46,395,391...46,395,975 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 6:19,254,183...19,280,973
Ensembl chr 6:19,254,487...19,389,291 		JBrowse link
G JAK3 Janus kinase 3 involved_in ISO (PMID:16020505) BHF-UCL PMID:16020505 NCBI chr20:45,051,135...45,068,445
Ensembl chr20:45,050,526...45,072,805 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:9670042) BHF-UCL PMID:9670042 NCBI chr 7:25,883,297...25,909,608
Ensembl chr 7:25,883,251...25,906,892 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:46,394,034...46,396,723
Ensembl chr18:46,395,391...46,395,975 		JBrowse link
G FOXP3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758 		JBrowse link
G IL2 interleukin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394 		JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18792410) MGI PMID:18792410 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:25,265,836...25,312,417
Ensembl chr 7:25,233,235...25,305,174 		JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:59,881,889...59,943,271
Ensembl chr 9:59,881,966...59,929,341 		JBrowse link
G SMAD7 SMAD family member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:79,706,485...79,734,673
Ensembl chr 7:79,706,705...79,734,749 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:24,077,752...24,086,560
Ensembl chr 9:24,077,761...24,086,261 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:42,468,376...42,482,219
Ensembl chr 7:42,468,247...42,483,436 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:4,972,369...4,984,218
Ensembl chr15:4,972,956...4,980,371 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD69 CD69 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:36,197,202...36,205,045
Ensembl chr27:36,197,175...36,204,597 		JBrowse link
G JAK3 Janus kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:45,051,135...45,068,445
Ensembl chr20:45,050,526...45,072,805 		JBrowse link
G LGALS1 galectin 1 involved_in ISO (PMID:24752896) UniProt PMID:24752896 NCBI chr10:26,932,351...26,935,580
Ensembl chr10:26,932,301...26,935,646 		JBrowse link
G LOXL3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:48,590,996...48,610,264
Ensembl chr17:48,591,768...48,610,392 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:20,616,041...20,638,523
Ensembl chr 9:20,617,151...20,638,103 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:24,077,752...24,086,560
Ensembl chr 9:24,077,761...24,086,261 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (PMID:24107315) UniProt PMID:24107315 NCBI chr 7:25,983,064...25,994,605
Ensembl chr 7:25,963,719...25,992,801 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011 		JBrowse link
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:46,394,034...46,396,723
Ensembl chr18:46,395,391...46,395,975 		JBrowse link
G BCL6 BCL6 transcription repressor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704 		JBrowse link
G HLX H2.0 like homeobox acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr38:15,538,744...15,543,686
Ensembl chr38:15,539,029...15,542,152 		JBrowse link
G LOC111089966 zinc finger protein 271 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:54,714,912...54,727,638 JBrowse link
G RTP2 receptor transporter protein 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr34:20,087,395...20,091,248
Ensembl chr34:20,087,226...20,115,428 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:48,916,446...48,977,183
Ensembl chr10:48,972,842...48,974,452 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RC3H1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:25,265,836...25,312,417
Ensembl chr 7:25,233,235...25,305,174 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G LGALS9 galectin 9 involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chr 9:42,154,613...42,170,423
Ensembl chr 9:42,154,702...42,170,391 		JBrowse link
positive regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DLA-DRA MHC class II DR alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,133,026...2,137,825
Ensembl chr12:2,132,499...2,168,975 		JBrowse link
G DLA-DRB1 MHC class II DLA DRB1 beta chain involved_in ISO (PMID:27591323) UniProt PMID:27591323 NCBI chr12:2,151,409...2,164,564 JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:635,384...640,715
Ensembl chr10:638,719...640,359 		JBrowse link
G LOC609365 CD46 molecule, complement regulatory protein-like involved_in ISO (PMID:12540904) UniProt PMID:12540904 NCBI chr 7:6,602,762...6,646,561 JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:42,538,858...42,544,200
Ensembl chr24:42,538,882...42,544,198 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:18713990) BHF-UCL PMID:18713990 NCBI chr 7:25,883,297...25,909,608
Ensembl chr 7:25,883,251...25,906,892 		JBrowse link
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD81 CD81 molecule involved_in ISO (PMID:8766544)
(PMID:11046035)		 UniProt PMID:8766544 PMID:11046035 NCBI chr18:46,466,484...46,474,236
Ensembl chr18:46,466,499...46,473,868 		JBrowse link
G DLA-DMB major histocompatibility complex, class II, DM beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,503,325...2,508,380
Ensembl chr12:2,503,325...2,533,990 		JBrowse link
G LGALS9 galectin 9 involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chr 9:42,154,613...42,170,423
Ensembl chr 9:42,154,702...42,170,391 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr11:51,357,706...51,359,207
Ensembl chr11:51,340,530...51,359,365 		JBrowse link
G HLX H2.0 like homeobox acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr38:15,538,744...15,543,686
Ensembl chr38:15,539,029...15,542,152 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr29:35,283,209...35,311,608
Ensembl chr29:35,282,072...35,311,333 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:48,916,446...48,977,183
Ensembl chr10:48,972,842...48,974,452 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MALT1 MALT1 paracaspase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:17,351,458...17,412,591
Ensembl chr 1:17,354,926...17,403,927 		JBrowse link
G MIR326 microRNA mir-326 acts_upstream_of_or_within ISO (PMID:19838199) MGI PMID:19838199 NCBI chr21:23,240,463...23,240,553
Ensembl chr21:23,240,463...23,240,553 		JBrowse link
G NFKBID NFKB inhibitor delta involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chr 1:116,763,371...116,770,683
Ensembl chr 1:116,757,289...116,772,325 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:8,147,160...8,154,401
Ensembl chr33:8,073,840...8,154,561 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 involved_in ISO (PMID:26098997) UniProt PMID:26098997 NCBI chr 8:251,776...313,290
Ensembl chr 8:253,407...313,059 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD2 bromodomain containing 2 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:2,534,034...2,546,029
Ensembl chr12:2,534,034...2,546,029 		JBrowse link
G BRD4 bromodomain containing 4 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chr20:46,844,795...46,927,620
Ensembl chr20:46,891,514...46,927,608 		JBrowse link
G EP300 E1A binding protein p300 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:24,076,538...24,156,708
Ensembl chr10:24,077,971...24,156,396 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr10:635,384...640,715
Ensembl chr10:638,719...640,359 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase involved_in ISO (PMID:36171294) UniProt PMID:36171294 NCBI chr23:52,068,123...52,154,410
Ensembl chr23:52,068,118...52,151,593 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL18 interleukin 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 6:19,254,183...19,280,973
Ensembl chr 6:19,254,487...19,389,291 		JBrowse link
G IL6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) MGI PMID:12594267 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 involved_in ISO (PMID:26098997) UniProt PMID:26098997 NCBI chr 8:251,776...313,290
Ensembl chr 8:253,407...313,059 		JBrowse link
G PRKCZ protein kinase C zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G RARA retinoic acid receptor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:22,254,803...22,298,614
Ensembl chr 9:22,254,806...22,289,459 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:18354165) BHF-UCL PMID:18354165 NCBI chr 7:25,883,297...25,909,608
Ensembl chr 7:25,883,251...25,906,892 		JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SHB SH2 domain containing adaptor protein B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:54,189,580...54,329,004
Ensembl chr11:54,189,843...54,329,325 		JBrowse link
regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704 		JBrowse link
G RTP2 receptor transporter protein 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr34:20,087,395...20,091,248
Ensembl chr34:20,087,226...20,115,428 		JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL27 interleukin 27 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:18,243,988...18,248,369
Ensembl chr 6:18,244,040...18,247,635 		JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL20 C-C motif chemokine ligand 20 NOT|involved_in ISO (PMID:19050256) UniProt PMID:19050256 NCBI chr25:40,506,385...40,509,903
Ensembl chr25:40,506,753...40,509,709 		JBrowse link
G CCR6 C-C motif chemokine receptor 6 NOT|involved_in ISO (PMID:19050256) UniProt PMID:19050256 NCBI chr 1:54,932,798...54,960,646
Ensembl chr 1:54,932,690...54,959,740 		JBrowse link
G MIR301A microRNA mir-301a acts_upstream_of_or_within ISO (PMID:22517757) MGI PMID:22517757 NCBI chr 9:33,724,572...33,724,655
Ensembl chr 9:33,724,571...33,724,655 		JBrowse link
regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DLA-DRA MHC class II DR alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,133,026...2,137,825
Ensembl chr12:2,132,499...2,168,975 		JBrowse link
G DLA-DRB1 MHC class II DLA DRB1 beta chain involved_in ISO (PMID:15322540) UniProt PMID:15322540 NCBI chr12:2,151,409...2,164,564 JBrowse link
G GATA3 GATA binding protein 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:28,068,143...28,098,445
Ensembl chr 2:28,069,051...28,087,760 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:42,468,376...42,482,219
Ensembl chr 7:42,468,247...42,483,436 		JBrowse link
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APBB1IP amyloid beta precursor protein binding family B member 1 interacting protein acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:7,151,443...7,250,412
Ensembl chr 2:7,151,443...7,212,200 		JBrowse link
G FGL2 fibrinogen like 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr18:17,328,794...17,335,429
Ensembl chr18:17,331,780...17,335,401 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914 		JBrowse link
G ITGAL integrin subunit alpha L involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:17,605,611...17,645,134
Ensembl chr 6:17,605,760...17,644,986 		JBrowse link
G PLXNA1 plexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:1,143,072...1,186,623
Ensembl chr20:870,870...1,184,321 		JBrowse link
G SEMA6D semaphorin 6D involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:13,489,896...14,059,623
Ensembl chr30:14,005,124...14,057,202 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in ISO (PMID:16715077) UniProt PMID:16715077 NCBI chr 1:116,757,271...116,760,453
Ensembl chr 1:116,757,289...116,772,325 		JBrowse link
T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FCER1G Fc epsilon receptor Ig involved_in
acts_upstream_of_or_within		 IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr38:21,267,841...21,271,036
Ensembl chr38:21,268,001...21,270,940 		JBrowse link
G LOC611536 C-type lectin domain family 4 member D acts_upstream_of_or_within ISO (PMID:23602766) MGI PMID:23602766 NCBI chr27:37,520,289...37,559,920
Ensembl chr27:37,551,064...37,558,847 		JBrowse link
G LOC611538 C-type lectin domain family 4 member E acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr27:37,561,445...37,568,652
Ensembl chr27:37,563,038...37,568,463 		JBrowse link
G SEMA4A semaphorin 4A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:41,670,814...41,695,349
Ensembl chr 7:41,672,120...41,692,460 		JBrowse link
T cell proliferation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD86 CD86 molecule ISO RGD PMID:20500684 RGD:4892204 NCBI chr33:25,256,267...25,318,855
Ensembl chr33:25,256,267...25,318,087 		JBrowse link
G RPS6 ribosomal protein S6 acts_upstream_of_or_within ISO (PMID:16357222) MGI PMID:16357222 NCBI chr11:39,161,422...39,165,148
Ensembl chr11:39,161,422...39,165,148 		JBrowse link
G SLC11A1 solute carrier family 11 member 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr37:25,039,203...25,047,461
Ensembl chr37:25,038,360...25,047,282 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 7:25,983,064...25,994,605
Ensembl chr 7:25,963,719...25,992,801 		JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109 		JBrowse link
T follicular helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:46,394,034...46,396,723
Ensembl chr18:46,395,391...46,395,975 		JBrowse link
G FOXP1 forkhead box P1 involved_in ISO (PMID:24859450) UniProt PMID:24859450 NCBI chr20:20,438,631...21,020,516
Ensembl chr20:20,788,433...21,016,397 		JBrowse link
G GPR183 G protein-coupled receptor 183 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:49,332,665...49,347,721
Ensembl chr22:49,333,188...49,347,593 		JBrowse link
G ICOS inducible T cell costimulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:12,663,839...12,735,266
Ensembl chr37:12,670,999...12,733,458 		JBrowse link
G ICOSLG inducible T cell costimulator ligand involved_in ISO (PMID:24411167) UniProt PMID:24411167 NCBI chr31:38,084,861...38,094,743 JBrowse link
G IL21 interleukin 21 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr19:17,641,833...17,651,275
Ensembl chr19:17,641,833...17,651,266 		JBrowse link
G IL6 interleukin 6 involved_in ISO (PMID:23045607) UniProt PMID:23045607 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970 		JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:25,265,836...25,312,417
Ensembl chr 7:25,233,235...25,305,174 		JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:59,881,889...59,943,271
Ensembl chr 9:59,881,966...59,929,341 		JBrowse link
G TBK1 TANK binding kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:7,169,664...7,208,890
Ensembl chr10:7,168,007...7,208,899 		JBrowse link
T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRACR2A calcium release activated channel regulator 2A involved_in ISO (PMID:29987160) UniProt PMID:29987160 NCBI chr27:41,090,906...41,228,677
Ensembl chr27:41,094,009...41,217,919 		JBrowse link
G HLX H2.0 like homeobox acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr38:15,538,744...15,543,686
Ensembl chr38:15,539,029...15,542,152 		JBrowse link
G HMGB1 high mobility group box 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:9,431,223...9,558,167
Ensembl chr25:9,431,218...9,558,165 		JBrowse link
G IL18R1 interleukin 18 receptor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:40,614,336...40,653,300
Ensembl chr10:40,615,312...40,653,454 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 6:19,254,183...19,280,973
Ensembl chr 6:19,254,487...19,389,291 		JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr32:28,516,002...28,633,759
Ensembl chr32:28,517,108...28,634,019 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:8,147,160...8,154,401
Ensembl chr33:8,073,840...8,154,561 		JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:110,436,677...110,466,709
Ensembl chr 1:110,436,662...110,466,809 		JBrowse link
G SEMA4A semaphorin 4A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:41,670,814...41,695,349
Ensembl chr 7:41,672,120...41,692,460 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:1,566,563...1,685,378
Ensembl chr37:1,566,585...1,829,894 		JBrowse link
G TMEM98 transmembrane protein 98 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:40,130,421...40,144,120
Ensembl chr 9:40,128,885...40,144,181 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G MTOR mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114 		JBrowse link
G SPN sialophorin involved_in ISO (PMID:18036228) UniProt PMID:18036228 NCBI chr 6:17,770,303...17,774,946 JBrowse link
G STAT6 signal transducer and activator of transcription 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:1,232,515...1,247,011
Ensembl chr10:1,233,691...1,247,075 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:24,077,752...24,086,560
Ensembl chr 9:24,077,761...24,086,261 		JBrowse link
T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:48,537,036...48,561,154 JBrowse link
G ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:12,565,173...12,601,152
Ensembl chr28:12,564,727...12,600,240 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:8,147,160...8,154,401
Ensembl chr33:8,073,840...8,154,561 		JBrowse link
G RORA RAR related orphan receptor A involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:25,315,974...26,026,708
Ensembl chr30:25,325,275...26,026,623 		JBrowse link
G RORC RAR related orphan receptor C involved_in
acts_upstream_of_or_within		 ISO (PMID:20383124)
(PMID:16990136), (PMID:18164222)
(PMID:18792410)		 MGI
UniProt		 PMID:16990136 PMID:18164222 PMID:18792410 PMID:20383124 NCBI chr17:60,821,498...60,842,485
Ensembl chr17:60,821,981...60,842,453 		JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:48,537,036...48,561,154 JBrowse link
G IL6 interleukin 6 involved_in ISS UniProt GO_REF:0000024 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G IL6R interleukin 6 receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:42,877,731...42,920,149
Ensembl chr 7:42,880,885...42,920,090 		JBrowse link
G IRF4 interferon regulatory factor 4 involved_in ISO (PMID:22983707) UniProt PMID:22983707 NCBI chr35:760,367...782,314
Ensembl chr35:767,011...781,339 		JBrowse link
G LY9 lymphocyte antigen 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:21,522,898...21,554,652
Ensembl chr38:21,523,637...21,554,579 		JBrowse link
G OTUD5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (PMID:25470037) MGI PMID:25470037 NCBI chr  X:42,079,396...42,109,129
Ensembl chr  X:42,081,561...42,108,612 		JBrowse link
G SLAMF6 SLAM family member 6 involved_in ISO (PMID:22184727) UniProt PMID:22184727 NCBI chr38:21,742,228...21,769,521
Ensembl chr38:21,742,301...21,764,494 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672 		JBrowse link
T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:48,537,036...48,561,154 JBrowse link
G BCL3 BCL3 transcription coactivator acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:110,620,850...110,628,830
Ensembl chr 1:110,620,827...110,654,771 		JBrowse link
G BCL6 BCL6 transcription repressor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704 		JBrowse link
G GATA3 GATA binding protein 3 acts_upstream_of_or_within
involved_in		 IEA Ensembl GO_REF:0000107 NCBI chr 2:28,068,143...28,098,445
Ensembl chr 2:28,069,051...28,087,760 		JBrowse link
G HLX H2.0 like homeobox acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr38:15,538,744...15,543,686
Ensembl chr38:15,539,029...15,542,152 		JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 6:19,254,183...19,280,973
Ensembl chr 6:19,254,487...19,389,291 		JBrowse link
G IL6 interleukin 6 acts_upstream_of ISO (PMID:12594267) MGI PMID:12594267 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G KMT2A lysine methyltransferase 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:15,212,559...15,302,825
Ensembl chr 5:15,217,348...15,270,971 		JBrowse link
G MEN1 menin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:52,346,747...52,352,884
Ensembl chr18:52,346,933...52,353,340 		JBrowse link
G MYB MYB proto-oncogene, transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:27,908,309...27,991,984
Ensembl chr 1:27,908,364...27,991,969 		JBrowse link
G RTP2 receptor transporter protein 2 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr34:20,087,395...20,091,248
Ensembl chr34:20,087,226...20,115,428 		JBrowse link
T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:60,203,336...60,356,525
Ensembl chr  X:60,203,270...60,352,869 		JBrowse link
G IL12B interleukin 12B involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:51,178,637...51,194,606
Ensembl chr 4:51,183,568...51,193,228 		JBrowse link
G PDP2 pyruvate dehydrogenase phosphatase catalytic subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:82,421,531...82,428,600
Ensembl chr 5:82,424,978...82,426,573 		JBrowse link
G PTGER4 prostaglandin E receptor 4 involved_in ISO (PMID:19465928) UniProt PMID:19465928 NCBI chr 4:68,663,362...68,676,241
Ensembl chr 4:68,663,364...68,676,358 		JBrowse link
G RORC RAR related orphan receptor C involved_in ISO (PMID:14691482) UniProt PMID:14691482 NCBI chr17:60,821,498...60,842,485
Ensembl chr17:60,821,981...60,842,453 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22141
    immune system process 2645
      leukocyte activation 1053
        leukocyte activation involved in immune response 333
          lymphocyte activation involved in immune response 240
            T cell activation involved in immune response 141
              T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 12
              T cell differentiation involved in immune response + 95
              T cell proliferation involved in immune response + 5
              alpha-beta T cell activation involved in immune response + 87
              cytotoxic T cell degranulation + 4
              gamma-delta T cell activation involved in immune response + 0
Path 2
Term Annotations click to browse term
  biological_process 22141
    cellular process 21672
      cell activation 1202
        cell activation involved in immune response 337
          leukocyte activation involved in immune response 333
            lymphocyte activation involved in immune response 240
              T cell activation involved in immune response 141
                T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 12
                T cell differentiation involved in immune response + 95
                T cell proliferation involved in immune response + 5
                alpha-beta T cell activation involved in immune response + 87
                cytotoxic T cell degranulation + 4
                gamma-delta T cell activation involved in immune response + 0
paths to the root