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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell activation involved in immune response
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Accession:GO:0002286 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
Synonyms:related_synonym: T cell activation during immune response;   T lymphocyte activation during immune response

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T cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISO (PMID:24310610) UniProt PMID:24310610 NCBI chrNW_004955416:6,897,897...7,005,602
Ensembl chrNW_004955416:6,897,848...7,009,965 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:19845798) UniProt PMID:19845798 NCBI chrNW_004955425:24,050,901...24,054,039 JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 involved_in ISO (PMID:17294403) UniProt PMID:17294403 NCBI chrNW_004955518:3,815,181...3,863,440
Ensembl chrNW_004955518:3,814,840...3,891,299 		JBrowse link
G Mdk midkine involved_in ISO (PMID:28183532) UniProt PMID:28183532 NCBI chrNW_004955422:1,655,351...1,657,026
Ensembl chrNW_004955422:1,655,358...1,657,044 		JBrowse link
G Psen1 presenilin 1 acts_upstream_of_or_within ISO (PMID:17698590) MGI PMID:17698590 NCBI chrNW_004955523:2,128,529...2,210,737
Ensembl chrNW_004955523:2,128,529...2,210,737 		JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO (PMID:17698590) MGI PMID:17698590 NCBI chrNW_004955406:5,727,367...5,748,798
Ensembl chrNW_004955406:5,727,367...5,752,234 		JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin involved_in ISO (PMID:17566017)
(PMID:14605368)		 UniProt PMID:14605368 PMID:17566017 NCBI chrNW_004955430:19,280,460...19,287,060
Ensembl chrNW_004955430:19,281,602...19,286,867 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (PMID:17277142) MGI PMID:17277142 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab27a RAB27A, member RAS oncogene family acts_upstream_of_or_within ISO (PMID:11266473) MGI PMID:11266473 NCBI chrNW_004955409:588,725...621,874
Ensembl chrNW_004955409:588,254...621,874 		JBrowse link
G Stx11 syntaxin 11 acts_upstream_of_or_within ISO (PMID:23042080), (PMID:23190531) MGI PMID:23042080 PMID:23190531 NCBI chrNW_004955436:16,303,169...16,327,854
Ensembl chrNW_004955436:16,303,189...16,327,854 		JBrowse link
memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tsc1 TSC complex subunit 1 acts_upstream_of_or_within ISO (PMID:25271321) MGI PMID:25271321 NCBI chrNW_004955513:2,197,037...2,244,992
Ensembl chrNW_004955513:2,197,037...2,244,992 		JBrowse link
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO (PMID:18424730) UniProt PMID:18424730 NCBI chrNW_004955555:426,894...446,235 JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISO (PMID:32647003) UniProt PMID:32647003 NCBI chrNW_004955458:1,733,799...1,785,591
Ensembl chrNW_004955458:1,733,883...1,784,182 		JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgl2 fibrinogen like 2 acts_upstream_of_or_within ISO (PMID:29341118) MGI PMID:29341118 NCBI chrNW_004955410:7,899,263...7,903,499
Ensembl chrNW_004955410:7,899,309...7,902,722 		JBrowse link
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:26492563) UniProt PMID:26492563 NCBI chrNW_004955408:11,289,920...11,311,216
Ensembl chrNW_004955408:11,291,937...11,311,320 		JBrowse link
G Lgals3 galectin 3 involved_in ISO (PMID:19706535) BHF-UCL PMID:19706535 NCBI chrNW_004955409:8,448,120...8,452,437
Ensembl chrNW_004955409:8,447,774...8,452,438 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) UniProt PMID:24463518 NCBI chrNW_004955422:14,051,140...14,053,521
Ensembl chrNW_004955422:14,051,140...14,053,521 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (PMID:16020505) BHF-UCL PMID:16020505 NCBI chrNW_004955524:3,399,895...3,412,018
Ensembl chrNW_004955524:3,401,642...3,411,643 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:9670042) BHF-UCL PMID:9670042 NCBI chrNW_004955406:13,477,077...13,493,309
Ensembl chrNW_004955406:13,477,077...13,493,309 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) UniProt PMID:24463518 NCBI chrNW_004955422:14,051,140...14,053,521
Ensembl chrNW_004955422:14,051,140...14,053,521 		JBrowse link
G Foxp3 forkhead box P3 involved_in ISO (PMID:23169781) UniProt PMID:23169781 NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606 		JBrowse link
G Il2 interleukin 2 involved_in ISO (PMID:25642768) BHF-UCL PMID:25642768 NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18792410) MGI PMID:18792410 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chrNW_004955406:14,053,122...14,123,023
Ensembl chrNW_004955406:14,053,122...14,123,029 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chrNW_004955419:5,054,288...5,103,926
Ensembl chrNW_004955419:5,054,289...5,103,926 		JBrowse link
G Smad7 SMAD family member 7 involved_in ISO (PMID:25642768) BHF-UCL PMID:25642768 NCBI chrNW_004955402:34,028,184...34,058,949
Ensembl chrNW_004955402:34,028,063...34,058,291 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:21151104) UniProt PMID:21151104 NCBI chrNW_004955451:13,315,237...13,317,888
Ensembl chrNW_004955451:13,315,859...13,325,937 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO (PMID:23034280) MGI PMID:23034280 NCBI chrNW_004955545:1,504,656...1,519,954
Ensembl chrNW_004955545:1,503,514...1,521,003 		JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chrNW_004955452:15,306,398...15,314,959
Ensembl chrNW_004955452:15,305,775...15,314,959 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 CD69 molecule involved_in ISO (PMID:24752896) UniProt PMID:24752896 NCBI chrNW_004955413:5,579,037...5,586,238
Ensembl chrNW_004955413:5,579,072...5,587,491 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (PMID:20696842) UniProt PMID:20696842 NCBI chrNW_004955524:3,399,895...3,412,018
Ensembl chrNW_004955524:3,401,642...3,411,643 		JBrowse link
G Lgals1 galectin 1 involved_in ISO (PMID:24752896) UniProt PMID:24752896 NCBI chrNW_004955413:24,072,086...24,075,452
Ensembl chrNW_004955413:24,072,086...24,075,452 		JBrowse link
G Loxl3 lysyl oxidase like 3 involved_in ISO (PMID:28065600) UniProt PMID:28065600 NCBI chrNW_004955424:11,236,415...11,255,801
Ensembl chrNW_004955424:11,236,836...11,259,570 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A involved_in ISO (PMID:20696842) UniProt PMID:20696842 NCBI chrNW_004955451:16,305,363...16,319,219
Ensembl chrNW_004955451:16,305,363...16,318,534 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:21151104) UniProt PMID:21151104 NCBI chrNW_004955451:13,315,237...13,317,888
Ensembl chrNW_004955451:13,315,859...13,325,937 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (PMID:24107315) UniProt PMID:24107315 NCBI chrNW_004955406:13,391,162...13,402,479 JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISO (PMID:17008549) UniProt PMID:17008549 NCBI chrNW_004955512:5,686,508...5,703,645 JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) UniProt PMID:24463518 NCBI chrNW_004955422:14,051,140...14,053,521
Ensembl chrNW_004955422:14,051,140...14,053,521 		JBrowse link
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within ISO (PMID:12594267) MGI PMID:12594267 NCBI chrNW_004955420:19,998,960...20,021,200
Ensembl chrNW_004955420:19,998,742...20,022,259 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004955520:2,937,131...2,941,170
Ensembl chrNW_004955520:2,936,815...2,941,170 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:12242343) UniProt PMID:12242343 NCBI chrNW_004955441:13,593,342...13,657,389
Ensembl chrNW_004955441:13,593,342...13,657,389 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO (PMID:15917799) MGI PMID:15917799 NCBI chrNW_004955406:14,053,122...14,123,023
Ensembl chrNW_004955406:14,053,122...14,123,029 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chrNW_004955481:5,234,125...5,249,564 JBrowse link
positive regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:12540904) UniProt PMID:12540904 NCBI chrNW_004955406:43,002,817...43,034,555 JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (PMID:14688363) BHF-UCL PMID:14688363 NCBI chrNW_004955458:3,946,964...3,949,180
Ensembl chrNW_004955458:3,947,803...3,949,312 		JBrowse link
G LOC102019320 mamu class II histocompatibility antigen, DR alpha chain involved_in ISO (PMID:27591323) UniProt PMID:27591323 NCBI chrNW_004955437:1,109,735...1,114,742
Ensembl chrNW_004955437:1,109,713...1,114,802 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 involved_in ISO (PMID:29230018) UniProt PMID:29230018 NCBI chrNW_004955445:1,909,012...1,914,032
Ensembl chrNW_004955445:1,908,946...1,915,002 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:18713990) BHF-UCL PMID:18713990 NCBI chrNW_004955406:13,477,077...13,493,309
Ensembl chrNW_004955406:13,477,077...13,493,309 		JBrowse link
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 CD81 molecule involved_in ISO (PMID:8766544)
(PMID:11046035)		 UniProt PMID:8766544 PMID:11046035 NCBI chrNW_004955422:14,155,682...14,175,181
Ensembl chrNW_004955422:14,155,682...14,175,181 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chrNW_004955481:5,234,125...5,249,564 JBrowse link
G LOC102023521 HLA class II histocompatibility antigen, DM beta chain involved_in ISO (PMID:8139689) UniProt PMID:8139689 NCBI chrNW_004955437:1,544,906...1,551,412
Ensembl chrNW_004955437:1,541,491...1,551,159 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISO (PMID:17008549) UniProt PMID:17008549 NCBI chrNW_004955512:5,686,508...5,703,645 JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chrNW_004955472:1,444,598...1,446,488
Ensembl chrNW_004955472:1,444,316...1,446,490 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004955520:2,937,131...2,941,170
Ensembl chrNW_004955520:2,936,815...2,941,170 		JBrowse link
G Ripk2 receptor interacting serine/threonine kinase 2 acts_upstream_of_or_within ISO (PMID:11894097) MGI PMID:11894097 NCBI chrNW_004955417:6,669,675...6,698,142
Ensembl chrNW_004955417:6,669,675...6,702,228 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:12242343) UniProt PMID:12242343 NCBI chrNW_004955441:13,593,342...13,657,389
Ensembl chrNW_004955441:13,593,342...13,657,389 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chrNW_004955402:42,919,480...42,968,873
Ensembl chrNW_004955402:42,911,649...42,972,429 		JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chrNW_004955468:2,680,934...2,688,797
Ensembl chrNW_004955468:2,680,806...2,689,155 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chrNW_004955427:3,350,174...3,358,609
Ensembl chrNW_004955427:3,350,174...3,360,379 		JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in ISO (PMID:26098997) UniProt PMID:26098997 NCBI chrNW_004955581:597,952...616,903
Ensembl chrNW_004955581:597,667...617,410 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004955437:1,584,890...1,592,486
Ensembl chrNW_004955437:1,584,479...1,592,826 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004955495:7,959,033...7,989,216
Ensembl chrNW_004955495:7,957,510...7,988,498 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004955413:26,647,553...26,727,875
Ensembl chrNW_004955413:26,648,339...26,727,933 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (PMID:19501566) BHF-UCL PMID:19501566 NCBI chrNW_004955458:3,946,964...3,949,180
Ensembl chrNW_004955458:3,947,803...3,949,312 		JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase involved_in ISO (PMID:36171294) UniProt PMID:36171294 NCBI chrNW_004955420:14,927,490...15,007,082
Ensembl chrNW_004955420:14,923,575...15,007,081 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in ISO (PMID:12829194) BHF-UCL PMID:12829194 NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422 		JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) MGI PMID:12594267 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in ISO (PMID:26098997) UniProt PMID:26098997 NCBI chrNW_004955581:597,952...616,903
Ensembl chrNW_004955581:597,667...617,410 		JBrowse link
G Prkcz protein kinase C zeta involved_in ISO (PMID:15987782) UniProt PMID:15987782 NCBI chrNW_004955486:8,947,579...9,021,702
Ensembl chrNW_004955486:8,947,579...9,021,702 		JBrowse link
G Rara retinoic acid receptor alpha involved_in ISO (PMID:18416830) BHF-UCL PMID:18416830 NCBI chrNW_004955451:14,876,663...14,917,134
Ensembl chrNW_004955451:14,897,726...14,917,134 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:18354165) BHF-UCL PMID:18354165 NCBI chrNW_004955406:13,477,077...13,493,309
Ensembl chrNW_004955406:13,477,077...13,493,309 		JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within ISO (PMID:24645804) MGI PMID:24645804 NCBI chrNW_004955419:28,423,354...28,555,948
Ensembl chrNW_004955419:28,421,354...28,558,823 		JBrowse link
regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within ISO (PMID:15240675) MGI PMID:15240675 NCBI chrNW_004955420:19,998,960...20,021,200
Ensembl chrNW_004955420:19,998,742...20,022,259 		JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il27 interleukin 27 involved_in ISO (PMID:12734330) UniProt PMID:12734330 NCBI chrNW_004955493:6,712,005...6,717,417
Ensembl chrNW_004955493:6,712,005...6,717,417 		JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 NOT|involved_in ISO (PMID:19050256) UniProt PMID:19050256 NCBI chrNW_004955453:6,846,625...6,850,007
Ensembl chrNW_004955453:6,846,549...6,850,031 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 NOT|involved_in ISO (PMID:19050256) UniProt PMID:19050256 NCBI chrNW_004955439:14,921,524...14,949,493
Ensembl chrNW_004955439:14,920,601...14,924,191 		JBrowse link
regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO (PMID:18776904) MGI PMID:18776904 NCBI chrNW_004955421:24,448,446...24,477,885
Ensembl chrNW_004955421:24,457,496...24,478,744 		JBrowse link
G LOC102019320 mamu class II histocompatibility antigen, DR alpha chain involved_in ISO (PMID:15322540) UniProt PMID:15322540 NCBI chrNW_004955437:1,109,735...1,114,742
Ensembl chrNW_004955437:1,109,713...1,114,802 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO (PMID:18776904) MGI PMID:18776904 NCBI chrNW_004955545:1,504,656...1,519,954
Ensembl chrNW_004955545:1,503,514...1,521,003 		JBrowse link
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein acts_upstream_of_or_within ISO (PMID:17403904) MGI PMID:17403904 NCBI chrNW_004955429:2,874,783...2,973,321
Ensembl chrNW_004955429:2,871,943...2,930,213 		JBrowse link
G Fgl2 fibrinogen like 2 acts_upstream_of_or_within ISO (PMID:29341118) MGI PMID:29341118 NCBI chrNW_004955410:7,899,263...7,903,499
Ensembl chrNW_004955410:7,899,309...7,902,722 		JBrowse link
G Icam1 intercellular adhesion molecule 1 involved_in ISO (PMID:2477710) BHF-UCL PMID:2477710 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755 		JBrowse link
G Itgal integrin subunit alpha L involved_in ISO (PMID:2477710) BHF-UCL PMID:2477710 NCBI chrNW_004955493:7,397,813...7,435,420
Ensembl chrNW_004955493:7,397,991...7,439,070 		JBrowse link
G Plxna1 plexin A1 involved_in ISO (PMID:16715077) UniProt PMID:16715077 NCBI chrNW_004955429:16,482,821...16,522,978
Ensembl chrNW_004955429:16,482,725...16,522,973 		JBrowse link
G Sema6d semaphorin 6D involved_in ISO (PMID:16715077) UniProt PMID:16715077 NCBI chrNW_004955409:6,086,178...6,143,702
Ensembl chrNW_004955409:6,086,113...6,143,713 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:16715077) UniProt PMID:16715077 NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor TYROBP involved_in ISO (PMID:16715077) UniProt PMID:16715077 NCBI chrNW_004955468:2,673,657...2,677,633
Ensembl chrNW_004955468:2,673,980...2,677,321 		JBrowse link
T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec4d C-type lectin domain family 4 member D acts_upstream_of_or_within ISO (PMID:23602766) MGI PMID:23602766 NCBI chrNW_004955413:5,267,548...5,276,969
Ensembl chrNW_004955413:5,267,161...5,277,090 		JBrowse link
G Clec4e C-type lectin domain family 4 member E acts_upstream_of_or_within ISO (PMID:23602766) MGI PMID:23602766 NCBI chrNW_004955413:5,256,523...5,261,385
Ensembl chrNW_004955413:5,256,440...5,262,938 		JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig acts_upstream_of_or_within ISO (PMID:23602766) MGI PMID:23602766 NCBI chrNW_004955468:12,971,931...12,975,206
Ensembl chrNW_004955468:12,971,931...12,975,206 		JBrowse link
G Sema4a semaphorin 4A involved_in ISO (PMID:15780988) UniProt PMID:15780988 NCBI chrNW_004955545:2,316,402...2,341,873
Ensembl chrNW_004955545:2,316,390...2,342,233 		JBrowse link
T cell proliferation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule ISO RGD PMID:20500684 RGD:4892204 NCBI chrNW_004955427:21,375,820...21,436,767
Ensembl chrNW_004955427:21,375,794...21,435,874 		JBrowse link
G Rps6 ribosomal protein S6 acts_upstream_of_or_within ISO (PMID:16357222) MGI PMID:16357222 NCBI chrNW_004955434:21,744,045...21,745,646
Ensembl chrNW_004955434:21,744,082...21,746,626 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 acts_upstream_of_or_within ISO (PMID:9176118) MGI PMID:9176118 NCBI chrNW_004955453:14,980,562...14,995,118
Ensembl chrNW_004955453:14,980,562...14,995,608 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (PMID:14608036) UniProt PMID:14608036 NCBI chrNW_004955406:13,391,162...13,402,479 JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO (PMID:16357222) MGI PMID:16357222 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928 		JBrowse link
T follicular helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) UniProt PMID:24463518 NCBI chrNW_004955422:14,051,140...14,053,521
Ensembl chrNW_004955422:14,051,140...14,053,521 		JBrowse link
G Foxp1 forkhead box P1 involved_in ISO (PMID:24859450) UniProt PMID:24859450 NCBI chrNW_004955421:16,595,445...17,075,923
Ensembl chrNW_004955421:16,595,471...17,075,923 		JBrowse link
G Gpr183 G protein-coupled receptor 183 involved_in ISO (PMID:27147029) UniProt PMID:27147029 NCBI chrNW_004955404:11,264,954...11,277,531
Ensembl chrNW_004955404:11,264,954...11,277,531 		JBrowse link
G Icos inducible T cell costimulator involved_in ISO (PMID:27135603) UniProt PMID:27135603 NCBI chrNW_004955457:10,934,390...10,952,318
Ensembl chrNW_004955457:10,934,341...10,952,404 		JBrowse link
G Icoslg inducible T cell costimulator ligand involved_in ISO (PMID:24411167) UniProt PMID:24411167 NCBI chrNW_004955407:41,190,875...41,197,521
Ensembl chrNW_004955407:41,189,974...41,198,254 		JBrowse link
G Il21 interleukin 21 involved_in ISO (PMID:23045607) UniProt PMID:23045607 NCBI chrNW_004955428:18,057,096...18,065,492
Ensembl chrNW_004955428:18,057,096...18,065,492 		JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:23045607) UniProt PMID:23045607 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO (PMID:30523347) UniProt PMID:30523347 NCBI chrNW_004955446:1,020,707...1,098,327
Ensembl chrNW_004955446:1,020,043...1,098,820 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO (PMID:23583643) MGI PMID:23583643 NCBI chrNW_004955406:14,053,122...14,123,023
Ensembl chrNW_004955406:14,053,122...14,123,029 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within ISO (PMID:23583643) MGI PMID:23583643 NCBI chrNW_004955419:5,054,288...5,103,926
Ensembl chrNW_004955419:5,054,289...5,103,926 		JBrowse link
G Tbk1 TANK binding kinase 1 involved_in ISO (PMID:27135603) UniProt PMID:27135603 NCBI chrNW_004955458:11,210,120...11,263,632
Ensembl chrNW_004955458:11,211,398...11,263,867 		JBrowse link
T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cracr2a calcium release activated channel regulator 2A involved_in ISO (PMID:29987160) UniProt PMID:29987160 NCBI chrNW_004955413:1,425,165...1,544,226
Ensembl chrNW_004955413:1,429,021...1,543,662 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004955520:2,937,131...2,941,170
Ensembl chrNW_004955520:2,936,815...2,941,170 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:15944249) UniProt PMID:15944249 NCBI chrNW_004955431:15,373,207...15,377,339
Ensembl chrNW_004955431:15,373,207...15,377,339 		JBrowse link
G Il18r1 interleukin 18 receptor 1 acts_upstream_of_or_within ISO (PMID:10227969) MGI PMID:10227969 NCBI chrNW_004955470:7,854,995...7,887,810
Ensembl chrNW_004955470:7,854,988...7,887,883 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in ISO (PMID:18579517) UniProt PMID:18579517 NCBI chrNW_004955496:1,728,840...1,827,749
Ensembl chrNW_004955496:1,728,840...1,828,698 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:31182790) MGI PMID:31182790 NCBI chrNW_004955427:3,350,174...3,358,609
Ensembl chrNW_004955427:3,350,174...3,360,379 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit acts_upstream_of_or_within ISO (PMID:16081776) MGI PMID:16081776 NCBI chrNW_004955555:2,060,533...2,086,229
Ensembl chrNW_004955555:2,060,533...2,086,229 		JBrowse link
G Sema4a semaphorin 4A involved_in ISO (PMID:15780988) UniProt PMID:15780988 NCBI chrNW_004955545:2,316,402...2,341,873
Ensembl chrNW_004955545:2,316,390...2,342,233 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 involved_in ISO (PMID:14688310) UniProt PMID:14688310 NCBI chrNW_004955403:8,061,471...8,144,252
Ensembl chrNW_004955403:8,061,471...8,144,276 		JBrowse link
G Tmem98 transmembrane protein 98 involved_in ISO (PMID:25946230) UniProt PMID:25946230 NCBI chrNW_004955481:7,788,066...7,797,433
Ensembl chrNW_004955481:7,785,967...7,798,575 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO (PMID:26410627) MGI PMID:26410627 NCBI chrNW_004955486:2,487,642...2,599,694
Ensembl chrNW_004955486:2,487,642...2,599,694 		JBrowse link
G Spn sialophorin involved_in ISO (PMID:18036228) UniProt PMID:18036228 NCBI chrNW_004955493:7,256,505...7,258,607 JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chrNW_004955458:4,833,417...4,847,956
Ensembl chrNW_004955458:4,833,515...4,843,273 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:10761931) UniProt PMID:10761931 NCBI chrNW_004955451:13,315,237...13,317,888
Ensembl chrNW_004955451:13,315,859...13,325,937 		JBrowse link
T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISO (PMID:20421391), (PMID:21572431) UniProt PMID:20421391 PMID:21572431 NCBI chrNW_004955523:42,365...66,103
Ensembl chrNW_004955523:42,218...66,103 		JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 involved_in ISO (PMID:23241884) UniProt PMID:23241884 NCBI chrNW_004955507:5,552,788...5,594,911
Ensembl chrNW_004955507:5,552,764...5,594,911 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:20383124) MGI PMID:20383124 NCBI chrNW_004955427:3,350,174...3,358,609
Ensembl chrNW_004955427:3,350,174...3,360,379 		JBrowse link
G Rora RAR related orphan receptor A involved_in ISO (PMID:18164222) GO_Central PMID:18164222 NCBI chrNW_004955450:14,262,199...14,434,611
Ensembl chrNW_004955450:14,262,190...14,425,233 		JBrowse link
G Rorc RAR related orphan receptor C acts_upstream_of_or_within
involved_in		 ISO (PMID:18792410)
(PMID:16990136), (PMID:18164222)
(PMID:20383124)		 MGI
UniProt		 PMID:16990136 PMID:18164222 PMID:18792410 PMID:20383124 NCBI chrNW_004955589:590,653...616,784
Ensembl chrNW_004955589:590,743...616,694 		JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISO (PMID:19578362), (PMID:22983707) UniProt PMID:19578362 PMID:22983707 NCBI chrNW_004955523:42,365...66,103
Ensembl chrNW_004955523:42,218...66,103 		JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:16990136)
(PMID:27893700)		 UniProt PMID:16990136 PMID:27893700 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Il6r interleukin 6 receptor involved_in ISO (PMID:27893700) UniProt PMID:27893700 NCBI chrNW_004955545:932,814...979,359
Ensembl chrNW_004955545:950,765...981,762 		JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO (PMID:22983707) UniProt PMID:22983707 NCBI chrNW_004955465:12,497,534...12,512,529
Ensembl chrNW_004955465:12,497,462...12,513,106 		JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (PMID:25470037) MGI PMID:25470037 NCBI chrNW_004955543:452,172...484,564
Ensembl chrNW_004955543:452,121...484,560 		JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:22184727) UniProt PMID:22184727 NCBI chrNW_004955468:12,233,629...12,264,502 JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISO (PMID:28065600) UniProt PMID:28065600 NCBI chrNW_004955451:16,320,326...16,348,505
Ensembl chrNW_004955451:16,319,904...16,357,687 		JBrowse link
T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISO (PMID:20421391), (PMID:21572431) UniProt PMID:20421391 PMID:21572431 NCBI chrNW_004955523:42,365...66,103
Ensembl chrNW_004955523:42,218...66,103 		JBrowse link
G Bcl3 BCL3 transcription coactivator acts_upstream_of_or_within ISO (PMID:16081776) MGI PMID:16081776 NCBI chrNW_004955555:1,898,280...1,911,466
Ensembl chrNW_004955555:1,856,250...1,911,466 		JBrowse link
G Bcl6 BCL6 transcription repressor acts_upstream_of ISO (PMID:12594267) MGI PMID:12594267 NCBI chrNW_004955420:19,998,960...20,021,200
Ensembl chrNW_004955420:19,998,742...20,022,259 		JBrowse link
G Gata3 GATA binding protein 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:20484083)
(PMID:20706986)		 UniProt
MGI		 PMID:20484083 PMID:20706986 NCBI chrNW_004955421:24,448,446...24,477,885
Ensembl chrNW_004955421:24,457,496...24,478,744 		JBrowse link
G Hlx H2.0 like homeobox acts_upstream_of ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004955520:2,937,131...2,941,170
Ensembl chrNW_004955520:2,936,815...2,941,170 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of ISO (PMID:16424184) MGI PMID:16424184 NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422 		JBrowse link
G Il6 interleukin 6 acts_upstream_of ISO (PMID:12594267) MGI PMID:12594267 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Kmt2a lysine methyltransferase 2A involved_in ISO (PMID:20484083) UniProt PMID:20484083 NCBI chrNW_004955412:19,586,435...19,670,149
Ensembl chrNW_004955412:19,586,141...19,665,527 		JBrowse link
G Men1 menin 1 involved_in ISO (PMID:20484083) UniProt PMID:20484083 NCBI chrNW_004955422:20,356,491...20,363,374
Ensembl chrNW_004955422:20,356,491...20,363,575 		JBrowse link
G Myb MYB proto-oncogene, transcription factor involved_in ISO (PMID:20484083) UniProt PMID:20484083 NCBI chrNW_004955439:1,523,516...1,560,185
Ensembl chrNW_004955439:1,521,292...1,560,220 		JBrowse link
T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO (PMID:8434133) MGI PMID:8434133 NCBI chrNW_004955557:1,355,471...1,515,725
Ensembl chrNW_004955557:1,355,397...1,515,393 		JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:1673147) UniProt PMID:1673147 NCBI chrNW_004955408:13,302,506...13,316,300
Ensembl chrNW_004955408:13,304,219...13,312,620 		JBrowse link
G Ptger4 prostaglandin E receptor 4 involved_in ISO (PMID:19465928) UniProt PMID:19465928 NCBI chrNW_004955426:24,997,811...25,010,822
Ensembl chrNW_004955426:24,997,811...25,010,822 		JBrowse link
G Rorc RAR related orphan receptor C involved_in ISO (PMID:14691482) UniProt PMID:14691482 NCBI chrNW_004955589:590,653...616,784
Ensembl chrNW_004955589:590,743...616,694 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12619
    immune system process 2046
      leukocyte activation 916
        leukocyte activation involved in immune response 283
          lymphocyte activation involved in immune response 202
            T cell activation involved in immune response 112
              T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 13
              T cell differentiation involved in immune response + 87
              T cell proliferation involved in immune response + 5
              alpha-beta T cell activation involved in immune response + 80
              cytotoxic T cell degranulation + 4
              gamma-delta T cell activation involved in immune response + 0
Path 2
Term Annotations click to browse term
  biological_process 12619
    cellular process 12054
      cell activation 1052
        cell activation involved in immune response 287
          leukocyte activation involved in immune response 283
            lymphocyte activation involved in immune response 202
              T cell activation involved in immune response 112
                T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 13
                T cell differentiation involved in immune response + 87
                T cell proliferation involved in immune response + 5
                alpha-beta T cell activation involved in immune response + 80
                cytotoxic T cell degranulation + 4
                gamma-delta T cell activation involved in immune response + 0
paths to the root