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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell activation involved in immune response
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Accession:GO:0002286 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
Synonyms:related_synonym: T cell activation during immune response;   T lymphocyte activation during immune response


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T cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD1C CD1c molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:133,647,482...133,651,575
Ensembl chr 1:137,437,235...137,441,075 		JBrowse link
G CD74 CD74 molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:145,825,635...145,836,916
Ensembl chr 5:151,830,311...151,841,334 		JBrowse link
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISO (PMID:24310610) UniProt PMID:24310610 NCBI chr15:18,871,867...18,973,380
Ensembl chr15:37,120,044...37,229,211 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 5:39,006,331...39,024,265 JBrowse link
G LCP1 lymphocyte cytosolic protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:26,820,846...26,906,916 JBrowse link
G MDK midkine involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:46,339,365...46,342,388
Ensembl chr11:46,891,540...46,893,254 		JBrowse link
G PSEN1 presenilin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17698590) Ensembl
MGI		 PMID:17698590 GO_REF:0000107 NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876 		JBrowse link
G PSEN2 presenilin 2 acts_upstream_of_or_within ISO (PMID:17698590) MGI PMID:17698590 NCBI chr 1:202,328,987...202,354,440
Ensembl chr 1:207,320,937...207,346,295 		JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EOMES eomesodermin involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:27,601,829...27,608,701
Ensembl chr 3:27,925,086...27,930,274 		JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (PMID:17277142) MGI PMID:17277142 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAB27A RAB27A, member RAS oncogene family involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11266473) Ensembl
MGI		 PMID:11266473 GO_REF:0000107 NCBI chr15:34,174,491...34,263,045
Ensembl chr15:52,498,202...52,529,984 		JBrowse link
G STX11 syntaxin 11 acts_upstream_of_or_within ISO (PMID:23042080), (PMID:23190531) MGI PMID:23042080 PMID:23190531 NCBI chr 6:141,924,656...141,974,579
Ensembl chr 6:146,688,670...146,689,533 		JBrowse link
memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TSC1 TSC complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25271321) Ensembl
MGI		 PMID:25271321 GO_REF:0000107 NCBI chr 9:104,007,708...104,060,938
Ensembl chr 9:132,638,003...132,675,759 		JBrowse link
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEACAM1 CEA cell adhesion molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:39,395,550...39,417,063
Ensembl chr19:47,989,430...48,008,739 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:34,200,102...34,249,873
Ensembl chr12:34,932,470...34,977,881 		JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGL2 fibrinogen like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29341118) Ensembl
MGI		 PMID:29341118 GO_REF:0000107 NCBI chr 7:69,114,082...69,120,575
Ensembl chr 7:82,926,266...82,932,550 		JBrowse link
G LOC100976419 interferon lambda-1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:36,394,462...36,397,363
Ensembl chr19:44,942,186...44,944,519 		JBrowse link
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:152,486,125...152,514,004
Ensembl chr 5:159,108,915...159,131,007 		JBrowse link
G LGALS3 galectin 3 involved_in ISO (PMID:19706535) BHF-UCL PMID:19706535 NCBI chr14:35,715,850...35,732,263
Ensembl chr14:53,990,023...54,006,412 		JBrowse link
G LOC103783591 leukocyte immunoglobulin-like receptor subfamily B member 1 involved_in ISO (PMID:18094328) UniProt PMID:18094328 NCBI chr19:51,561,376...51,578,564 JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) UniProt PMID:24463518 NCBI chr11:2,305,497...2,308,080 JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 Ensembl chr16:27,642,702...27,737,445 JBrowse link
G JAK3 Janus kinase 3 involved_in ISO (PMID:16020505) BHF-UCL PMID:16020505 NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:9670042) BHF-UCL PMID:9670042 NCBI chr 1:148,684,689...148,989,775
Ensembl chr 1:152,391,450...152,415,845
Ensembl chr 1:152,391,450...152,415,845 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) UniProt PMID:24463518 NCBI chr11:2,305,497...2,308,080 JBrowse link
G FOXP3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029 		JBrowse link
G IL2 interleukin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18792410) MGI PMID:18792410 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G PF4 platelet factor 4 ISO RGD PMID:24986443 RGD:329901907 NCBI chr 4:50,208,806...50,210,570
Ensembl chr 4:56,041,833...56,043,750 		JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:149,454,748...149,539,566
Ensembl chr 1:153,160,661...153,213,402 		JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:93,975,164...94,031,516
Ensembl chr 9:122,313,791...122,365,102 		JBrowse link
G SMAD7 SMAD family member 7 involved_in ISO (PMID:25642768) BHF-UCL PMID:25642768 NCBI chr18:42,306,324...42,337,214 JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:9,791,008...9,803,894
Ensembl chr17:9,973,920...9,985,660 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23034280) Ensembl
MGI		 PMID:23034280 GO_REF:0000107 NCBI chr 1:130,350,798...130,366,690
Ensembl chr 1:133,959,847...133,975,729 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:36,743,341...36,753,261
Ensembl chr 1:38,093,917...38,103,556 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD69 CD69 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:9,800,446...9,808,874
Ensembl chr12:10,049,668...10,058,094 		JBrowse link
G JAK3 Janus kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964 		JBrowse link
G LGALS1 galectin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:18,593,154...18,597,432
Ensembl chr22:36,426,228...36,430,356 		JBrowse link
G LOC100988550 signal transducer and activator of transcription 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:15,005,025...15,029,110
Ensembl chr17:15,228,465...15,251,783 		JBrowse link
G LOXL3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:74,598,870...74,622,502
Ensembl chr2A:76,105,957...76,128,495 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:9,791,008...9,803,894
Ensembl chr17:9,973,920...9,985,660 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (PMID:24107315) UniProt PMID:24107315
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) UniProt PMID:24463518 NCBI chr11:2,305,497...2,308,080 JBrowse link
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12594267) Ensembl
MGI		 PMID:12594267 GO_REF:0000107 NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124 		JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr 1:196,465,704...196,471,803
Ensembl chr 1:201,500,470...201,506,222 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in ISO (PMID:12242343) UniProt PMID:12242343 NCBI chr2A:46,813,589...46,878,102
Ensembl chr2A:47,804,431...47,806,041 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RC3H1 ring finger and CCCH-type domains 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15917799) Ensembl
MGI		 PMID:15917799 GO_REF:0000107 NCBI chr 1:149,454,748...149,539,566
Ensembl chr 1:153,160,661...153,213,402 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G LOC100977210 galectin-9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:29,125,460...29,145,028
Ensembl chr17:29,623,398...29,642,959 		JBrowse link
G LOC117976679 galectin-9B involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:35,781,679...35,790,573 JBrowse link
G LOC129394382 galectin-9B-like involved_in IEA Ensembl GO_REF:0000107
positive regulation of gamma-delta T cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103783591 leukocyte immunoglobulin-like receptor subfamily B member 1 involved_in ISO (PMID:21233315) UniProt PMID:21233315 NCBI chr19:51,561,376...51,578,564 JBrowse link
positive regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD46 CD46 molecule involved_in ISO (PMID:12540904) UniProt PMID:12540904 NCBI chr 1:183,330,423...183,373,916
Ensembl chr 1:188,031,758...188,182,046 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:32,575,321...32,576,856
Ensembl chr12:32,828,902...32,830,617 		JBrowse link
G LOC100987081 HLA class II histocompatibility antigen, DR alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:32,105,421...32,110,579
Ensembl chr 6:32,982,228...32,987,417 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:53,901,738...53,907,090
Ensembl chr20:55,179,429...55,184,920 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:18713990) BHF-UCL PMID:18713990 NCBI chr 1:148,684,689...148,989,775
Ensembl chr 1:152,391,450...152,415,845
Ensembl chr 1:152,391,450...152,415,845 		JBrowse link
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD81 CD81 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:2,400,503...2,421,132
Ensembl chr11:2,437,991...2,449,308 		JBrowse link
G LOC100977210 galectin-9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:29,125,460...29,145,028
Ensembl chr17:29,623,398...29,642,959 		JBrowse link
G LOC117976679 galectin-9B involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:35,781,679...35,790,573 JBrowse link
G LOC129394382 galectin-9B-like involved_in IEA Ensembl GO_REF:0000107
G MHC-DMB HLA class II histocompatibility antigen, DM beta chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:32,504,074...32,510,669
Ensembl chr 6:33,619,870...33,625,685 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr 9:34,525,820...34,527,628
Ensembl chr 9:35,334,353...35,336,108 		JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr 1:196,465,704...196,471,803
Ensembl chr 1:201,500,470...201,506,222 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894097) Ensembl
MGI		 PMID:11894097 GO_REF:0000107 NCBI chr 8:86,447,216...86,480,511
Ensembl chr 8:88,398,468...88,456,268 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in ISO (PMID:12242343) UniProt PMID:12242343 NCBI chr2A:46,813,589...46,878,102
Ensembl chr2A:47,804,431...47,806,041 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MALT1 MALT1 paracaspase involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chr18:52,060,878...52,141,985
Ensembl chr18:55,395,462...55,473,574 		JBrowse link
G NFKBID NFKB inhibitor delta involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chr19:32,805,772...32,817,778
Ensembl chr19:41,553,727...41,568,555 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:98,914,957...98,948,467
Ensembl chr 3:105,616,645...105,628,300 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 involved_in ISO (PMID:26098997) UniProt PMID:26098997 NCBI chr 1:223,052,307...223,084,736
Ensembl chr 1:228,505,147...228,537,216 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD2 bromodomain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:32,538,130...32,550,823
Ensembl chr 6:33,657,648...33,666,031 		JBrowse link
G BRD4 bromodomain containing 4 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chr19:14,768,239...14,805,770
Ensembl chr19:15,754,930...15,789,600 		JBrowse link
G EP300 E1A binding protein p300 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:32,575,321...32,576,856
Ensembl chr12:32,828,902...32,830,617 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:190,890,242...190,995,133
Ensembl chr 3:201,207,607...201,312,358 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL18 interleukin 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 Ensembl chr16:27,642,702...27,737,445 JBrowse link
G IL6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) MGI PMID:12594267 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G NLRP3 NLR family pyrin domain containing 3 involved_in ISO (PMID:26098997) UniProt PMID:26098997 NCBI chr 1:223,052,307...223,084,736
Ensembl chr 1:228,505,147...228,537,216 		JBrowse link
G PRKCZ protein kinase C zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:763,942...901,531
Ensembl chr 1:1,920,219...2,045,855 		JBrowse link
G RARA retinoic acid receptor alpha involved_in ISO (PMID:18416830) BHF-UCL PMID:18416830 NCBI chr17:16,932,485...16,980,958 JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:18354165) BHF-UCL PMID:18354165 NCBI chr 1:148,684,689...148,989,775
Ensembl chr 1:152,391,450...152,415,845
Ensembl chr 1:152,391,450...152,415,845 		JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SHB SH2 domain containing adaptor protein B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24645804) Ensembl
MGI		 PMID:24645804 GO_REF:0000107 NCBI chr 9:37,768,566...37,921,897 JBrowse link
regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15240675) Ensembl
MGI		 PMID:15240675 GO_REF:0000107 NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124 		JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL27 interleukin 27 involved_in ISO (PMID:12734330) UniProt PMID:12734330
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL20 C-C motif chemokine ligand 20 NOT|involved_in ISO (PMID:19050256) UniProt PMID:19050256 NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225 		JBrowse link
G CCR6 C-C motif chemokine receptor 6 NOT|involved_in ISO (PMID:19050256) UniProt PMID:19050256 NCBI chr 6:165,094,563...165,109,774
Ensembl chr 6:170,069,689...170,084,779 		JBrowse link
regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA3 GATA binding protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18776904) Ensembl
MGI		 PMID:18776904 GO_REF:0000107 NCBI chr10:8,075,951...8,105,573
Ensembl chr10:8,064,207...8,086,272 		JBrowse link
G LOC100987081 HLA class II histocompatibility antigen, DR alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:32,105,421...32,110,579
Ensembl chr 6:32,982,228...32,987,417 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18776904) Ensembl
MGI		 PMID:18776904 GO_REF:0000107 NCBI chr 1:130,350,798...130,366,690
Ensembl chr 1:133,959,847...133,975,729 		JBrowse link
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APBB1IP amyloid beta precursor protein binding family B member 1 interacting protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17403904) Ensembl
MGI		 PMID:17403904 GO_REF:0000107 NCBI chr10:26,613,897...26,740,670
Ensembl chr10:27,030,218...27,104,483 		JBrowse link
G FGL2 fibrinogen like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29341118) Ensembl
MGI		 PMID:29341118 GO_REF:0000107 NCBI chr 7:69,114,082...69,120,575
Ensembl chr 7:82,926,266...82,932,550 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G ITGAL integrin subunit alpha L involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:24,445,966...24,496,037
Ensembl chr16:30,843,747...30,892,597 		JBrowse link
G PLXNA1 plexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:124,026,069...124,080,241
Ensembl chr 3:131,340,584...131,393,561 		JBrowse link
G SEMA6D semaphorin 6D involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:26,135,344...26,725,571
Ensembl chr15:44,994,073...45,050,169 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:40,735,483...40,740,208
Ensembl chr 6:42,043,900...42,048,578 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in ISO (PMID:16715077) UniProt PMID:16715077 NCBI chr19:32,821,279...32,825,488
Ensembl chr19:41,570,683...41,575,226 		JBrowse link
T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLEC4D C-type lectin domain family 4 member D acts_upstream_of_or_within ISO (PMID:23602766) MGI PMID:23602766 NCBI chr12:8,599,654...8,608,494
Ensembl chr12:8,814,680...8,823,484 		JBrowse link
G CLEC4E C-type lectin domain family 4 member E acts_upstream_of_or_within ISO (PMID:23602766) MGI PMID:23602766 NCBI chr12:8,620,618...8,627,610 JBrowse link
G FCER1G Fc epsilon receptor Ig acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23602766) MGI
TreeGrafter		 PMID:23602766 GO_REF:0000118 NCBI chr 1:136,627,672...136,631,696
Ensembl chr 1:140,539,555...140,544,810 		JBrowse link
G SEMA4A semaphorin 4A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:131,489,446...131,519,864
Ensembl chr 1:135,321,288...135,350,724 		JBrowse link
T cell proliferation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD86 CD86 molecule ISO RGD PMID:20500684 RGD:4892204 NCBI chr 3:119,151,884...119,217,641
Ensembl chr 3:126,059,008...126,124,339 		JBrowse link
G LOC103783591 leukocyte immunoglobulin-like receptor subfamily B member 1 involved_in ISO (PMID:18094328) UniProt PMID:18094328 NCBI chr19:51,561,376...51,578,564 JBrowse link
G RPS6 ribosomal protein S6 acts_upstream_of_or_within ISO (PMID:16357222) MGI PMID:16357222 NCBI chr 9:19,185,455...19,189,504
Ensembl chr 9:19,674,380...19,677,722 		JBrowse link
G SLC11A1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9176118) Ensembl
MGI		 PMID:9176118 GO_REF:0000107 NCBI chr2B:105,640,613...105,655,524
Ensembl chr2B:224,238,284...224,252,941 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (PMID:14608036) UniProt PMID:14608036
G TNFSF4 TNF superfamily member 4 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:148,684,689...148,989,775
Ensembl chr 1:152,391,450...152,415,845
Ensembl chr 1:152,391,450...152,415,845 		JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16357222) Ensembl
MGI		 PMID:16357222 GO_REF:0000107 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120 		JBrowse link
T follicular helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) UniProt PMID:24463518 NCBI chr11:2,305,497...2,308,080 JBrowse link
G FOXP1 forkhead box P1 involved_in ISO (PMID:24859450) UniProt PMID:24859450 NCBI chr 3:70,893,933...71,523,892
Ensembl chr 3:72,258,456...72,498,173 		JBrowse link
G GPR183 G protein-coupled receptor 183 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:80,461,908...80,475,046
Ensembl chr13:99,601,220...99,602,305 		JBrowse link
G ICOS inducible T cell costimulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:91,168,998...91,193,808
Ensembl chr2B:209,307,938...209,332,734 		JBrowse link
G ICOSLG inducible T cell costimulator ligand involved_in ISO (PMID:24411167) UniProt PMID:24411167 NCBI chr21:30,474,655...30,499,302 JBrowse link
G IL21 interleukin 21 involved_in ISO (PMID:23045607) UniProt PMID:23045607 NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915 		JBrowse link
G IL6 interleukin 6 involved_in ISO (PMID:23045607) UniProt PMID:23045607 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:45,701,219...45,786,652
Ensembl chr 5:47,267,286...47,350,960 		JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23583643) Ensembl
MGI		 PMID:23583643 GO_REF:0000107 NCBI chr 1:149,454,748...149,539,566
Ensembl chr 1:153,160,661...153,213,402 		JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23583643) Ensembl
MGI		 PMID:23583643 GO_REF:0000107 NCBI chr 9:93,975,164...94,031,516
Ensembl chr 9:122,313,791...122,365,102 		JBrowse link
G TBK1 TANK binding kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:24,419,271...24,469,164
Ensembl chr12:24,917,246...24,968,587 		JBrowse link
T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRACR2A calcium release activated channel regulator 2A involved_in ISO (PMID:29987160) UniProt PMID:29987160 NCBI chr12:3,729,241...3,875,715
Ensembl chr12:3,655,031...3,737,592 		JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr 1:196,465,704...196,471,803
Ensembl chr 1:201,500,470...201,506,222 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:15944249) UniProt PMID:15944249 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527 		JBrowse link
G IL18R1 interleukin 18 receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10227969) Ensembl
MGI		 PMID:10227969 GO_REF:0000107 NCBI chr2A:99,419,686...99,462,650 JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of ISO (PMID:16424184) MGI PMID:16424184 Ensembl chr16:27,642,702...27,737,445 JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:100,552,959...100,674,156
Ensembl chr 4:111,125,312...111,245,980 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:98,914,957...98,948,467
Ensembl chr 3:105,616,645...105,628,300 		JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16081776) Ensembl
MGI		 PMID:16081776 GO_REF:0000107 NCBI chr19:41,948,559...41,987,121
Ensembl chr19:50,554,864...50,590,223 		JBrowse link
G SEMA4A semaphorin 4A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:131,489,446...131,519,864
Ensembl chr 1:135,321,288...135,350,724 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:78,331,402...78,549,231
Ensembl chr2B:196,247,881...196,366,011 		JBrowse link
G TMEM98 transmembrane protein 98 involved_in ISO (PMID:25946230) UniProt PMID:25946230 NCBI chr17:23,844,747...23,858,390
Ensembl chr17:24,133,357...24,146,912 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G MTOR mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841 		JBrowse link
G SPN sialophorin involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:30,035,243...30,036,445 JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20706986) Ensembl
MGI		 PMID:20706986 GO_REF:0000107 Ensembl chr12:32,068,679...32,085,099 JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:9,791,008...9,803,894
Ensembl chr17:9,973,920...9,985,660 		JBrowse link
T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:56,075,768...56,100,749
Ensembl chr14:74,919,115...74,943,652 		JBrowse link
G ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:96,276,454...96,323,287
Ensembl chr10:99,768,566...99,813,568 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:98,914,957...98,948,467
Ensembl chr 3:105,616,645...105,628,300 		JBrowse link
G RORA RAR related orphan receptor A involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:39,461,553...40,200,118
Ensembl chr15:57,771,735...57,980,460 		JBrowse link
G RORC RAR related orphan receptor C acts_upstream_of_or_within
involved_in		 ISO (PMID:18792410)
(PMID:16990136), (PMID:18164222)
(PMID:20383124)		 MGI
UniProt		 PMID:16990136 PMID:18164222 PMID:18792410 PMID:20383124 NCBI chr 1:127,164,725...127,190,479
Ensembl chr 1:130,808,705...130,834,490 		JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:56,075,768...56,100,749
Ensembl chr14:74,919,115...74,943,652 		JBrowse link
G IL6 interleukin 6 involved_in ISO (PMID:27893700)
(PMID:16990136)		 UniProt PMID:16990136 PMID:27893700 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IL6R interleukin 6 receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:129,761,914...129,824,386
Ensembl chr 1:133,374,078...133,433,089 		JBrowse link
G IRF4 interferon regulatory factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:206,282...226,487
Ensembl chr 6:342,718...356,654 		JBrowse link
G LY9 lymphocyte antigen 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:136,151,608...136,185,365
Ensembl chr 1:140,075,646...140,107,784 		JBrowse link
G OTUD5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (PMID:25470037) MGI PMID:25470037 NCBI chr  X:41,219,536...41,256,219 JBrowse link
G SLAMF6 SLAM family member 6 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:135,838,862...135,878,207
Ensembl chr 1:139,761,121...139,799,348 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067 		JBrowse link
T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:56,075,768...56,100,749
Ensembl chr14:74,919,115...74,943,652 		JBrowse link
G BCL3 BCL3 transcription coactivator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16081776) Ensembl
MGI		 PMID:16081776 GO_REF:0000107 NCBI chr19:41,696,162...41,708,485
Ensembl chr19:50,304,171...50,313,005 		JBrowse link
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of		 IEA
ISO		 (PMID:12594267) Ensembl
MGI		 PMID:12594267 GO_REF:0000107 NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124 		JBrowse link
G GATA3 GATA binding protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20706986) Ensembl
MGI		 PMID:20706986 GO_REF:0000107 NCBI chr10:8,075,951...8,105,573
Ensembl chr10:8,064,207...8,086,272 		JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr 1:196,465,704...196,471,803
Ensembl chr 1:201,500,470...201,506,222 		JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of ISO (PMID:16424184) MGI PMID:16424184 Ensembl chr16:27,642,702...27,737,445 JBrowse link
G IL6 interleukin 6 acts_upstream_of ISO (PMID:12594267) MGI PMID:12594267 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G KMT2A lysine methyltransferase 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:113,273,198...113,364,404
Ensembl chr11:117,204,820...117,290,100 		JBrowse link
G MEN1 menin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:60,159,009...60,166,222
Ensembl chr11:63,499,962...63,507,164 		JBrowse link
G MYB MYB proto-oncogene, transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:132,952,728...132,990,560
Ensembl chr 6:137,048,812...137,086,194 		JBrowse link
T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within ISO (PMID:8434133) MGI PMID:8434133 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756 		JBrowse link
G IL12B interleukin 12B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:154,706,467...154,722,231
Ensembl chr 5:161,325,303...161,335,381 		JBrowse link
G PDP2 pyruvate dehydrogenase phosphatase catalytic subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:47,195,850...47,205,214
Ensembl chr16:66,301,453...66,303,042 		JBrowse link
G PTGER4 prostaglandin E receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148 		JBrowse link
G RORC RAR related orphan receptor C involved_in ISO (PMID:14691482) UniProt PMID:14691482 NCBI chr 1:127,164,725...127,190,479
Ensembl chr 1:130,808,705...130,834,490 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19312
    immune system process 2508
      leukocyte activation 998
        leukocyte activation involved in immune response 310
          lymphocyte activation involved in immune response 219
            T cell activation involved in immune response 121
              T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 16
              T cell differentiation involved in immune response + 93
              T cell proliferation involved in immune response + 7
              alpha-beta T cell activation involved in immune response + 85
              cytotoxic T cell degranulation + 4
              gamma-delta T cell activation involved in immune response + 1
Path 2
Term Annotations click to browse term
  biological_process 19312
    cellular process 18866
      cell activation 1157
        cell activation involved in immune response 314
          leukocyte activation involved in immune response 310
            lymphocyte activation involved in immune response 219
              T cell activation involved in immune response 121
                T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 16
                T cell differentiation involved in immune response + 93
                T cell proliferation involved in immune response + 7
                alpha-beta T cell activation involved in immune response + 85
                cytotoxic T cell degranulation + 4
                gamma-delta T cell activation involved in immune response + 1
paths to the root