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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell activation involved in immune response
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Accession:GO:0002286 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
Synonyms:related_synonym: T cell activation during immune response;   T lymphocyte activation during immune response


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T cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:54,256,757...54,266,003 JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISO (PMID:24310610) RGD PMID:24310610 NCBI chr 3:105,356,261...105,441,630 JBrowse link
G ENSRNOG00000065554 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G F2rl1 F2R like trypsin receptor 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19845798)		 UniProt
RGD		 PMID:19845798 GO_REF:0000024 NCBI chr 2:26,772,274...26,785,226 JBrowse link
G Ifna1 interferon, alpha 1 acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:19130550)
GO_REF:0000033		 RGD
GO_Central		 PMID:19130550 GO_REF:0000033 NCBI chr 5:103,097,356...103,097,925 JBrowse link
G Ifna4 interferon, alpha 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:103,069,174...103,070,120 JBrowse link
G Ifna4l1 interferon, alpha 4 like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:103,524,733...103,525,302 JBrowse link
G Ifna5 interferon, alpha 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:103,187,852...103,188,430 JBrowse link
G Ifnb1 interferon beta 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:108,066,650...108,067,487 JBrowse link
G Ifnk interferon kappa involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:49,732,073...49,734,281 JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 involved_in ISO (PMID:17294403) RGD PMID:17294403 NCBI chr15:50,443,300...50,544,682 JBrowse link
G LOC120103158 interferon alpha-12-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:103,378,576...103,379,147 JBrowse link
G LOC120103159 interferon alpha-12-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:103,407,135...103,407,884 JBrowse link
G LOC120103160 interferon alpha-12-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:103,426,092...103,427,016 JBrowse link
G LOC120103161 interferon alpha-12-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:103,441,204...103,442,180 JBrowse link
G LOC120103162 interferon alpha-1-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:103,455,380...103,455,934 JBrowse link
G Mdk midkine involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:28183532)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:28183532 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:98,356,789...98,358,960 JBrowse link
G Psen1 presenilin 1 acts_upstream_of_or_within ISO MGI:109284 (PMID:17698590) RGD PMID:17698590 NCBI chr 6:109,054,160...109,106,191 JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO MGI:1202717 (PMID:17698590) RGD PMID:17698590 NCBI chr13:91,967,506...91,993,240 JBrowse link
alpha-beta T cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 acts_upstream_of_or_within ISO MGI:3701255 (PMID:16476767) RGD PMID:16476767 NCBI chr20:1,323,976...1,328,126 JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin involved_in ISO
IBA		 (PMID:17566017)
(PMID:14605368)
GO_REF:0000033		 RGD
GO_Central		 PMID:14605368 PMID:17566017 GO_REF:0000033 NCBI chr 8:118,181,340...118,189,186 JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (PMID:17277142) RGD PMID:17277142 NCBI chr 7:55,789,180...55,793,216 JBrowse link
cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab27a RAB27A, member RAS oncogene family acts_upstream_of_or_within ISO MGI:1856656 (PMID:11266473) RGD PMID:11266473 NCBI chr 8:82,663,373...82,717,267 JBrowse link
G Stx11 syntaxin 11 acts_upstream_of_or_within ISO MGI:5461477 (PMID:23042080), (PMID:23190531) RGD PMID:23042080 PMID:23190531 NCBI chr 1:7,293,427...7,320,060 JBrowse link
memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tsc1 TSC complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2656240 (PMID:25271321)		 Ensembl
RGD		 PMID:25271321 GO_REF:0000107 NCBI chr 3:11,969,547...12,018,591 JBrowse link
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO
ISS		 (PMID:18424730)
GO_REF:0000024		 RGD
UniProt		 PMID:18424730 GO_REF:0000024 NCBI chr 1:90,171,401...90,187,810 JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISO (PMID:32647003) RGD PMID:32647003 NCBI chr 7:134,577,470...134,622,928 JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgl2 fibrinogen-like 2 acts_upstream_of_or_within ISO MGI:3582343 (PMID:29341118) RGD PMID:29341118 NCBI chr 4:13,710,566...13,716,207 JBrowse link
G Ifnl1 interferon, lambda 1 involved_in ISO (PMID:19346497) RGD PMID:19346497 NCBI chr 1:83,798,651...83,800,297 JBrowse link
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:26492563) RGD PMID:26492563 NCBI chr10:31,383,801...31,415,334 JBrowse link
G Lgals3 galectin 3 involved_in ISO (PMID:19706535) RGD PMID:19706535 NCBI chr15:23,099,795...23,111,731 JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) RGD PMID:24463518 NCBI chr 1:198,148,999...198,151,406 JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (PMID:16424184) RGD PMID:16424184 NCBI chr 1:189,545,739...189,570,639 JBrowse link
G Jak3 Janus kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:16020505)		 BHF-UCL
RGD		 PMID:16020505 GO_REF:0000024 NCBI chr16:18,418,807...18,432,515 JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:9670042) RGD PMID:9670042 NCBI chr13:73,723,329...73,746,809 JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) RGD PMID:24463518 NCBI chr 1:198,148,999...198,151,406 JBrowse link
G Foxp3 forkhead box P3 involved_in ISO (PMID:23169781) RGD PMID:23169781 NCBI chr  X:14,908,494...14,924,994 JBrowse link
G Il2 interleukin 2 involved_in ISO RNAcentral:URS000039ED8D_10090 (PMID:25642768) RGD PMID:25642768 NCBI chr 2:120,004,862...120,009,566 JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18792410) RGD PMID:18792410 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Pf4 platelet factor 4 IDA RGD PMID:24986443 RGD:329901907 NCBI chr14:17,298,304...17,299,220 JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr13:73,174,075...73,245,762 JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr 3:21,121,531...21,186,711 JBrowse link
G Smad7 SMAD family member 7 involved_in IEA
ISO		 GO_REF:0000107
(PMID:25642768)		 Ensembl
RGD		 PMID:25642768 GO_REF:0000107 NCBI chr18:68,988,429...69,016,774 JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:21151104) RGD PMID:21151104 NCBI chr10:82,082,322...82,098,831 JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO MGI:3530739 (PMID:23034280) RGD PMID:23034280 NCBI chr 2:174,795,831...174,811,980 JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISS
ISO		 GO_REF:0000024
(PMID:25282160)		 UniProt
RGD		 PMID:25282160 GO_REF:0000024 NCBI chr 5:142,661,193...142,670,051 JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 Cd69 molecule involved_in ISO (PMID:24752896) RGD PMID:24752896 NCBI chr 4:162,725,446...162,733,364 JBrowse link
G Jak3 Janus kinase 3 involved_in ISO
IEA		 (PMID:20696842)
GO_REF:0000107		 RGD
Ensembl		 PMID:20696842 GO_REF:0000107 NCBI chr16:18,418,807...18,432,515 JBrowse link
G Lgals1 galectin 1 involved_in ISO
IEA		 (PMID:24752896)
GO_REF:0000107		 RGD
Ensembl		 PMID:24752896 GO_REF:0000107 NCBI chr 7:110,485,239...110,488,345 JBrowse link
G Loxl3 lysyl oxidase-like 3 involved_in ISO (PMID:28065600) RGD PMID:28065600 NCBI chr 4:115,540,640...115,556,958 JBrowse link
G Stat5a signal transducer and activator of transcription 5A involved_in ISO
IEA		 (PMID:20696842)
GO_REF:0000107		 RGD
Ensembl		 PMID:20696842 GO_REF:0000107 NCBI chr10:85,785,537...85,809,869 JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:21151104) RGD PMID:21151104 NCBI chr10:82,082,322...82,098,831 JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (PMID:24107315) RGD PMID:24107315 NCBI chr13:73,833,478...73,907,249 JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:17008549)		 UniProt
Ensembl
RGD		 PMID:17008549 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:227,287,713...227,306,739 JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) RGD PMID:24463518 NCBI chr 1:198,148,999...198,151,406 JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:96559 (PMID:12594267) RGD PMID:12594267 NCBI chr11:76,854,090...76,877,389 JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO MGI:105367|MGI:2182089 (PMID:16424184) RGD PMID:16424184 NCBI chr13:96,280,335...96,285,750 JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:12242343) RGD PMID:12242343 NCBI chr 6:7,481,039...7,512,644 JBrowse link
G Zfp35 zinc finger protein 35 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr18:15,268,852...15,284,334 JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO MGI:3581675 (PMID:15917799) RGD PMID:15917799 NCBI chr13:73,174,075...73,245,762 JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr10:63,907,018...63,930,224 JBrowse link
positive regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:12540904) RGD PMID:12540904 NCBI chr13:109,104,122...109,134,903 JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (PMID:14688363) RGD PMID:14688363 NCBI chr 7:721,809...723,923 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:29230018)		 UniProt
RGD		 PMID:29230018 GO_REF:0000024 NCBI chr 3:161,930,256...161,936,205 JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO (PMID:27591323) RGD PMID:27591323 NCBI chr20:4,515,393...4,520,387 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:27591323) RGD PMID:27591323 NCBI chr20:4,550,594...4,560,182 JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:18713990) RGD PMID:18713990 NCBI chr13:73,723,329...73,746,809 JBrowse link
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:11046035)
GO_REF:0000107
(PMID:8766544)		 UniProt
RGD
Ensembl		 PMID:8766544 PMID:11046035 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:198,235,861...198,251,660 JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16116184) RGD PMID:16116184 NCBI chr10:63,907,018...63,930,224 JBrowse link
G RT1-DMb RT1 class II, locus DMb involved_in ISO (PMID:8139689) RGD PMID:8139689 NCBI chr20:4,693,102...4,700,340 JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:17008549)		 UniProt
Ensembl
RGD		 PMID:17008549 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:227,287,713...227,306,739 JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) RGD PMID:15845453 NCBI chr 5:56,963,364...56,965,308 JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO MGI:105367|MGI:2182089 (PMID:16424184) RGD PMID:16424184 NCBI chr13:96,280,335...96,285,750 JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2446070 (PMID:11894097) RGD PMID:11894097 NCBI chr 5:29,630,806...29,662,804 JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:12242343) RGD PMID:12242343 NCBI chr 6:7,481,039...7,512,644 JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr18:58,942,282...58,996,318 JBrowse link
G Mir326 microRNA 326 acts_upstream_of_or_within ISO (PMID:19838199) RGD PMID:19838199 NCBI chr 1:153,854,029...153,854,123 JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr 1:85,679,353...85,690,415 JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr11:44,782,676...44,810,722 JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (PMID:26098997) RGD PMID:26098997 NCBI chr10:44,826,299...44,853,373 JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:28262505)		 UniProt
RGD		 PMID:28262505 GO_REF:0000024 NCBI chr20:4,727,078...4,735,389 JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:11,216,446...11,296,029 JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:113,108,476...113,178,529 JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IBA
ISO		 GO_REF:0000033
(PMID:19501566)		 GO_Central
RGD		 PMID:19501566 GO_REF:0000033 NCBI chr 7:721,809...723,923 JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:36171294)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:36171294 GO_REF:0000024 GO_REF:0000107 NCBI chr11:71,108,100...71,185,170 JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IEA
ISO		 GO_REF:0000107
(PMID:12829194)		 Ensembl
RGD		 PMID:12829194 GO_REF:0000107 NCBI chr 8:59,802,072...59,829,275 JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (PMID:16424184) RGD PMID:16424184 NCBI chr 1:189,545,739...189,570,639 JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) RGD PMID:12594267 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (PMID:26098997) RGD PMID:26098997 NCBI chr10:44,826,299...44,853,373 JBrowse link
G Prkcz protein kinase C, zeta involved_in ISS
ISO		 GO_REF:0000024
(PMID:15987782)		 UniProt
RGD		 PMID:15987782 GO_REF:0000024 NCBI chr 5:165,817,786...165,930,386 JBrowse link
G Rara retinoic acid receptor, alpha involved_in ISO (PMID:18416830) RGD PMID:18416830 NCBI chr10:84,379,780...84,424,371 JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:18354165) RGD PMID:18354165 NCBI chr13:73,723,329...73,746,809 JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within ISO MGI:3721903 (PMID:24645804) RGD PMID:24645804 NCBI chr 5:59,678,066...59,785,443 JBrowse link
regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:2158436 (PMID:15240675) RGD PMID:15240675 NCBI chr11:76,854,090...76,877,389 JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il27 interleukin 27 involved_in ISO
IBA		 (PMID:12734330)
GO_REF:0000033		 RGD
GO_Central		 PMID:12734330 GO_REF:0000033 NCBI chr 1:190,603,684...190,609,292 JBrowse link
regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 NOT|involved_in ISO (PMID:19050256) RGD PMID:19050256 NCBI chr 9:91,837,139...91,839,736 JBrowse link
G Ccr6 C-C motif chemokine receptor 6 NOT|involved_in ISO (PMID:19050256) RGD PMID:19050256 NCBI chr 1:52,474,477...52,508,301 JBrowse link
G Mir301a microRNA 301a acts_upstream_of_or_within ISO (PMID:22517757) RGD PMID:22517757 NCBI chr10:71,925,336...71,925,435 JBrowse link
regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO MGI:3487291 (PMID:18776904) RGD PMID:18776904 NCBI chr17:68,643,760...68,666,000 JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 NAS RGD PMID:10651948 RGD:1331512 NCBI chr 4:96,426,396...96,515,251 JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO (PMID:15322540) RGD PMID:15322540 NCBI chr20:4,515,393...4,520,387 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:15322540) RGD PMID:15322540 NCBI chr20:4,550,594...4,560,182 JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO MGI:3817628 (PMID:18776904) RGD PMID:18776904 NCBI chr 2:174,795,831...174,811,980 JBrowse link
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein acts_upstream_of_or_within ISO (PMID:17403904) RGD PMID:17403904 NCBI chr17:84,941,404...85,033,020 JBrowse link
G Fgl2 fibrinogen-like 2 acts_upstream_of_or_within ISO MGI:3582343 (PMID:29341118) RGD PMID:29341118 NCBI chr 4:13,710,566...13,716,207 JBrowse link
G Icam1 intercellular adhesion molecule 1 involved_in ISO (PMID:2477710) RGD PMID:2477710 NCBI chr 8:27,829,688...27,841,618 JBrowse link
G Itgal integrin subunit alpha L involved_in ISO (PMID:2477710) RGD PMID:2477710 NCBI chr 1:181,918,183...181,955,735 JBrowse link
G Plxna1 plexin A1 involved_in ISO (PMID:16715077) RGD PMID:16715077 NCBI chr 4:121,737,934...121,782,901 JBrowse link
G Sema6d semaphorin 6D involved_in ISO (PMID:16715077) RGD PMID:16715077 NCBI chr 3:111,883,415...111,941,100 JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:16715077) RGD PMID:16715077 NCBI chr 9:20,145,215...20,151,797 JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in ISS
ISO		 GO_REF:0000024
(PMID:16715077)		 UniProt
RGD		 PMID:16715077 GO_REF:0000024 NCBI chr 1:85,672,931...85,676,856 JBrowse link
T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec4d C-type lectin domain family 4, member D involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:23602766)		 Ensembl
RGD		 PMID:23602766 GO_REF:0000107 NCBI chr 4:156,589,591...156,599,279 JBrowse link
G Clec4e C-type lectin domain family 4, member E involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5013826 (PMID:23602766)		 Ensembl
RGD		 PMID:23602766 GO_REF:0000107 NCBI chr 4:156,606,927...156,612,911 JBrowse link
G Fcer1g Fc epsilon receptor Ig involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:2384004 (PMID:23602766)		 GO_Central
RGD		 PMID:23602766 GO_REF:0000033 NCBI chr13:83,649,447...83,654,248 JBrowse link
G Sema4a semaphorin 4A involved_in ISO (PMID:15780988) RGD PMID:15780988 NCBI chr 2:173,896,432...173,917,903 JBrowse link
T cell proliferation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule IEP RGD PMID:20500684 RGD:4892204 NCBI chr11:77,647,565...77,706,178 JBrowse link
G Rps6 ribosomal protein S6 acts_upstream_of_or_within ISO MGI:2387471|MGI:98834 (PMID:16357222) RGD PMID:16357222 NCBI chr 5:101,371,716...101,374,576 JBrowse link
G Slc11a1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857755 (PMID:9176118)		 Ensembl
RGD		 PMID:9176118 GO_REF:0000107 NCBI chr 9:83,406,327...83,417,252 JBrowse link
G Slfn2 schlafen family member 2 involved_in ISO (PMID:20190759) RGD PMID:20190759 NCBI chr10:67,953,322...67,959,659 JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in IBA
ISO		 GO_REF:0000033
(PMID:14608036)		 GO_Central
RGD		 PMID:14608036 GO_REF:0000033 NCBI chr13:73,833,478...73,907,249 JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:98159 (PMID:16357222)		 Ensembl
RGD		 PMID:16357222 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300 JBrowse link
T follicular helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) RGD PMID:24463518 NCBI chr 1:198,148,999...198,151,406 JBrowse link
G Foxp1 forkhead box P1 involved_in ISO (PMID:24859450) RGD PMID:24859450 NCBI chr 4:131,559,599...132,155,092 JBrowse link
G Gpr183 G protein-coupled receptor 183 involved_in ISS
ISO		 GO_REF:0000024
(PMID:27147029)		 UniProt
RGD		 PMID:27147029 GO_REF:0000024 NCBI chr15:99,037,764...99,050,550 JBrowse link
G Icos inducible T-cell co-stimulator involved_in ISO
IEA		 (PMID:27135603)
GO_REF:0000107		 RGD
Ensembl		 PMID:27135603 GO_REF:0000107 NCBI chr 9:62,368,075...62,406,900 JBrowse link
G Icoslg inducible T-cell co-stimulator ligand involved_in ISO (PMID:24411167) RGD PMID:24411167 NCBI chr20:10,600,420...10,610,718 JBrowse link
G Il21 interleukin 21 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23045607)		 UniProt
RGD		 PMID:23045607 GO_REF:0000024 NCBI chr 2:122,045,240...122,055,142 JBrowse link
G Il6 interleukin 6 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23045607)		 UniProt
RGD		 PMID:23045607 GO_REF:0000024 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO
IEA		 (PMID:30523347)
GO_REF:0000107		 RGD
Ensembl		 PMID:30523347 GO_REF:0000107 NCBI chr 2:32,878,942...32,963,668 JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO MGI:2442789 (PMID:23583643) RGD PMID:23583643 NCBI chr13:73,174,075...73,245,762 JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within ISO MGI:2685397 (PMID:23583643) RGD PMID:23583643 NCBI chr 3:21,121,531...21,186,711 JBrowse link
G Tbk1 TANK-binding kinase 1 involved_in ISO (PMID:27135603) RGD PMID:27135603 NCBI chr 7:57,077,830...57,110,868 JBrowse link
T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cracr2a calcium release activated channel regulator 2A involved_in ISO (PMID:29987160) RGD PMID:29987160 NCBI chr 4:160,428,987...160,517,427 JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of ISO MGI:105367|MGI:2182089 (PMID:16424184) RGD PMID:16424184 NCBI chr13:96,280,335...96,285,750 JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:15944249) RGD PMID:15944249 NCBI chr12:5,972,950...5,979,658 JBrowse link
G Il18r1 interleukin 18 receptor 1 acts_upstream_of_or_within ISO MGI:2136765 (PMID:10227969) RGD PMID:10227969 NCBI chr 9:50,223,274...50,257,370 JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of ISO MGI:96109 (PMID:16424184) RGD PMID:16424184 NCBI chr 1:189,545,739...189,570,639 JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:18579517)		 Ensembl
RGD		 PMID:18579517 GO_REF:0000107 NCBI chr 2:219,666,549...219,779,815 JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO MGI:3046930 (PMID:31182790) RGD PMID:31182790 NCBI chr11:44,782,676...44,810,722 JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit acts_upstream_of_or_within ISO MGI:2179545 (PMID:16081776) RGD PMID:16081776 NCBI chr 1:79,257,738...79,285,490 JBrowse link
G Sema4a semaphorin 4A involved_in ISO (PMID:15780988) RGD PMID:15780988 NCBI chr 2:173,896,432...173,917,903 JBrowse link
G Stat4 signal transducer and activator of transcription 4 involved_in ISO (PMID:14688310) RGD PMID:14688310 NCBI chr 9:56,964,617...57,080,523 JBrowse link
G Tmem98 transmembrane protein 98 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:25946230)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:25946230 GO_REF:0000024 GO_REF:0000107 NCBI chr10:65,796,173...65,807,082 JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 acts_upstream_of_or_within ISO MGI:103034 (PMID:20706986) RGD PMID:20706986 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in IEA
ISO		 GO_REF:0000107
(PMID:26410627)		 Ensembl
RGD		 PMID:26410627 GO_REF:0000107 NCBI chr 5:158,884,856...158,994,311 JBrowse link
G Spn sialophorin involved_in ISO
ISS		 (PMID:18036228)
GO_REF:0000024		 RGD
UniProt		 PMID:18036228 GO_REF:0000024 NCBI chr 1:181,746,937...181,759,564 JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO MGI:96556 (PMID:20706986) RGD PMID:20706986 NCBI chr 7:63,480,229...63,497,551 JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:10761931) RGD PMID:10761931 NCBI chr10:82,082,322...82,098,831 JBrowse link
T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO		 GO_REF:0000024
(PMID:20421391), (PMID:21572431)		 UniProt
RGD		 PMID:20421391 PMID:21572431 GO_REF:0000024 NCBI chr 6:105,353,715...105,376,051 JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 involved_in ISO (PMID:23241884) RGD PMID:23241884 NCBI chr 1:242,559,365...242,601,044 JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO MGI:3046930 (PMID:20383124) RGD PMID:20383124 NCBI chr11:44,782,676...44,810,722 JBrowse link
G Rora RAR-related orphan receptor A involved_in ISO (PMID:18164222) RGD PMID:18164222 NCBI chr 8:69,301,635...70,034,741 JBrowse link
G Rorc RAR-related orphan receptor C acts_upstream_of_or_within
involved_in		 ISO (PMID:18792410)
(PMID:16990136), (PMID:18164222)
MGI:2386114 (PMID:20383124)		 RGD PMID:16990136 PMID:18164222 PMID:18792410 PMID:20383124 NCBI chr 2:182,009,707...182,034,910 JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO		 GO_REF:0000024
(PMID:19578362), (PMID:22983707)		 UniProt
RGD		 PMID:19578362 PMID:22983707 GO_REF:0000024 NCBI chr 6:105,353,715...105,376,051 JBrowse link
G Il6 interleukin 6 involved_in ISS
ISO		 GO_REF:0000024
(PMID:16990136), (PMID:27893700)		 UniProt
RGD		 PMID:16990136 PMID:27893700 GO_REF:0000024 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Il6r interleukin 6 receptor involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:27893700)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:27893700 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:175,289,157...175,347,719 JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO (PMID:22983707) RGD PMID:22983707 NCBI chr17:33,721,800...33,742,570 JBrowse link
G Ly9 lymphocyte antigen 9 involved_in ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:84,079,345...84,100,783 JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO MGI:2386448|MGI:5752247 (PMID:25470037) RGD PMID:25470037 NCBI chr  X:14,626,173...14,659,331 JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:22184727) RGD PMID:22184727 NCBI chr13:84,384,561...84,405,300 JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:28065600)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:28065600 GO_REF:0000024 GO_REF:0000107 NCBI chr10:86,311,528...86,363,513 JBrowse link
T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO		 GO_REF:0000024
(PMID:20421391), (PMID:21572431)		 UniProt
RGD		 PMID:20421391 PMID:21572431 GO_REF:0000024 NCBI chr 6:105,353,715...105,376,051 JBrowse link
G Bcl3 BCL3, transcription coactivator acts_upstream_of_or_within ISO MGI:2158443 (PMID:16081776) RGD PMID:16081776 NCBI chr 1:79,471,368...79,485,908 JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of ISO MGI:96559 (PMID:12594267) RGD PMID:12594267 NCBI chr11:76,854,090...76,877,389 JBrowse link
G Gata3 GATA binding protein 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:20484083)
(PMID:20706986)		 RGD PMID:20484083 PMID:20706986 NCBI chr17:68,643,760...68,666,000 JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of ISO MGI:105367|MGI:2182089 (PMID:16424184) RGD PMID:16424184 NCBI chr13:96,280,335...96,285,750 JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) RGD PMID:20706986 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of ISO MGI:96109 (PMID:16424184) RGD PMID:16424184 NCBI chr 1:189,545,739...189,570,639 JBrowse link
G Il6 interleukin 6 acts_upstream_of ISO (PMID:12594267) RGD PMID:12594267 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Kmt2a lysine methyltransferase 2A involved_in ISO (PMID:20484083) RGD PMID:20484083 NCBI chr 8:45,116,763...45,193,320 JBrowse link
G Men1 menin 1 involved_in ISO
IEA		 (PMID:20484083)
GO_REF:0000107		 RGD
Ensembl		 PMID:20484083 GO_REF:0000107 NCBI chr 1:203,638,905...203,644,871 JBrowse link
G Myb MYB proto-oncogene, transcription factor involved_in ISO (PMID:20484083) RGD PMID:20484083 NCBI chr 1:15,939,771...15,973,367 JBrowse link
T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856466 (PMID:8434133) RGD PMID:8434133 NCBI chr  X:71,094,144...71,201,550 JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:1673147) RGD PMID:1673147 NCBI chr10:29,390,300...29,405,194 JBrowse link
G Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr19:386,408...394,068 JBrowse link
G Ptger4 prostaglandin E receptor 4 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:19465928)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:19465928 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:54,330,563...54,347,451 JBrowse link
G Rorc RAR-related orphan receptor C involved_in ISO (PMID:14691482) RGD PMID:14691482 NCBI chr 2:182,009,707...182,034,910 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    immune system process 3112
      leukocyte activation 1069
        leukocyte activation involved in immune response 335
          lymphocyte activation involved in immune response 235
            T cell activation involved in immune response 136
              T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 13
              T cell differentiation involved in immune response + 96
              T cell proliferation involved in immune response + 6
              alpha-beta T cell activation involved in immune response + 89
              cytotoxic T cell degranulation + 4
              gamma-delta T cell activation involved in immune response + 0
Path 2
Term Annotations click to browse term
  biological_process 20536
    cellular process 19525
      cell activation 1225
        cell activation involved in immune response 339
          leukocyte activation involved in immune response 335
            lymphocyte activation involved in immune response 235
              T cell activation involved in immune response 136
                T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + 13
                T cell differentiation involved in immune response + 96
                T cell proliferation involved in immune response + 6
                alpha-beta T cell activation involved in immune response + 89
                cytotoxic T cell degranulation + 4
                gamma-delta T cell activation involved in immune response + 0
paths to the root