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ONTOLOGY REPORT - ANNOTATIONS


Term:somatic diversification of immune receptors
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Accession:GO:0002200 term browser browse the term
Definition:The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.
Comment:Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification.


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immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POLB DNA polymerase beta acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:24388753) MGI
Ensembl
PMID:24388753 GO_REF:0000107 NCBI chr 8:40,332,165...40,368,065
Ensembl chr 8:40,332,208...40,372,582
JBrowse link
G YY1 YY1 transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:78,199,172...78,243,081
Ensembl chr24:78,199,039...78,237,165
JBrowse link
immunoglobulin V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYREN cell cycle regulator of NHEJ involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:103,838,218...103,843,151
Ensembl chr21:103,838,988...103,842,620
JBrowse link
G FOXP1 forkhead box P1 acts_upstream_of_or_within ISO (PMID:16819554) MGI PMID:16819554 NCBI chr22:31,907,941...32,538,294
Ensembl chr22:31,912,460...32,154,502
JBrowse link
G LIG4 DNA ligase 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:9823897) MGI
Ensembl
TreeGrafter
PMID:9823897 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:86,576,200...86,587,097
Ensembl chr 3:86,577,304...86,580,039
JBrowse link
G NHEJ1 non-homologous end joining factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:104,981,313...105,071,828
Ensembl chr10:104,982,380...105,068,999
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9768755) Ensembl
TreeGrafter
MGI
PMID:9768755 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:43,915,226...44,119,547
Ensembl chr 8:43,914,636...44,119,541
JBrowse link
G TCF3 transcription factor 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:16428437) MGI
TreeGrafter
Ensembl
PMID:16428437 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:1,393,147...1,440,515
Ensembl chr 6:1,393,107...1,440,479
JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:9875844) MGI
TreeGrafter
PMID:9875844 GO_REF:0000118 NCBI chr 4:77,182,569...77,468,786
Ensembl chr 4:77,182,793...77,468,775
JBrowse link
isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase acts_upstream_of_or_within
involved_in
ISO (PMID:17713479)
(PMID:21518874)
MGI
UniProt
PMID:17713479 PMID:21518874 NCBI chr11:8,426,920...8,438,331
Ensembl chr11:8,428,922...8,431,641
JBrowse link
G ATAD5 ATPase family AAA domain containing 5 involved_in
acts_upstream_of
IEA
ISO
(PMID:25404367) Ensembl
MGI
PMID:25404367 GO_REF:0000107 NCBI chr16:25,536,911...25,597,911
Ensembl chr16:25,538,131...25,597,695
JBrowse link
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:52,761,569...52,785,999
Ensembl chr24:52,761,651...52,785,978
JBrowse link
G CD40LG CD40 ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:111,655,301...111,667,602
Ensembl chr  X:111,655,397...111,666,639
JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15280420) Ensembl
MGI
PMID:15280420 GO_REF:0000107 NCBI chr 6:38,857,067...38,900,177
Ensembl chr 6:38,854,803...38,872,967
JBrowse link
G EXO1 exonuclease 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:14716311) MGI
Ensembl
PMID:14716311 GO_REF:0000107 NCBI chr25:78,934,337...78,976,346
Ensembl chr25:78,934,459...78,976,219
JBrowse link
G EXOSC3 exosome component 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:42,798,609...42,819,431
Ensembl chr12:42,799,067...42,803,471
JBrowse link
G EXOSC6 exosome component 6 involved_in ISO (PMID:21255825) UniProt PMID:21255825 NCBI chr 5:53,397,973...53,399,526 JBrowse link
G LIG4 DNA ligase 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:17713479) MGI
Ensembl
PMID:17713479 GO_REF:0000107 NCBI chr 3:86,576,200...86,587,097
Ensembl chr 3:86,577,304...86,580,039
JBrowse link
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12743174) Ensembl
MGI
PMID:12743174 GO_REF:0000107 NCBI chr15:2,364,537...2,418,379
Ensembl chr15:2,364,738...2,418,393
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12743174)
(PMID:10430621)
Ensembl
MGI
PMID:10430621 PMID:12743174 GO_REF:0000107 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819
JBrowse link
G MSH6 mutS homolog 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16618598)
(PMID:17015724)
Ensembl
MGI
PMID:16618598 PMID:17015724 GO_REF:0000107 NCBI chr14:59,375,602...59,400,252
Ensembl chr14:59,375,691...59,400,174
JBrowse link
G NBN nibrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:85,017,807...85,069,219
Ensembl chr 8:85,015,752...85,069,028
JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:79,044,624...79,077,736
Ensembl chr22:79,044,619...79,055,776
JBrowse link
G PCYT1A phosphate cytidylyltransferase 1A, choline involved_in ISO (PMID:19139091) UniProt PMID:19139091 NCBI chr15:90,905,691...90,944,485 JBrowse link
G RNF168 ring finger protein 168 involved_in ISO (PMID:20080757) UniProt PMID:20080757 NCBI chr15:90,702,740...90,735,279
Ensembl chr15:90,702,765...90,737,687
JBrowse link
G RNF8 ring finger protein 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:34,754,186...34,787,676
Ensembl chr17:34,751,945...34,787,632
JBrowse link
G SANBR SANT and BTB domain regulator of CSR involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:45,865,697...45,920,403
Ensembl chr14:45,864,838...45,920,782
JBrowse link
G SWAP70 switching B cell complex subunit SWAP70 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:9642267) MGI
Ensembl
PMID:9642267 GO_REF:0000107 NCBI chr 1:55,074,255...55,156,632
Ensembl chr 1:55,074,209...55,156,599
JBrowse link
G UNG uracil DNA glycosylase acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:17015724) MGI
Ensembl
PMID:17015724 GO_REF:0000107 NCBI chr11:104,302,507...104,325,160 JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:17713479) MGI PMID:17713479 NCBI chr 4:77,182,569...77,468,786
Ensembl chr 4:77,182,793...77,468,775
JBrowse link
isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR6 C-C motif chemokine receptor 6 involved_in ISO (PMID:27174992) UniProt PMID:27174992 NCBI chr13:94,865,480...94,894,331
Ensembl chr13:94,865,936...94,894,315
JBrowse link
isotype switching to IgD isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FDCSP follicular dendritic cell secreted protein acts_upstream_of_positive_effect ISO (PMID:17548624) MGI PMID:17548624 NCBI chr 7:18,711,145...18,721,926
Ensembl chr 7:18,716,973...18,721,350
JBrowse link
isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of
IEA
ISO
(PMID:10490661) Ensembl
MGI
PMID:10490661 GO_REF:0000107 NCBI chr15:81,997,659...82,022,059
Ensembl chr15:81,998,545...82,009,946
JBrowse link
G FDCSP follicular dendritic cell secreted protein acts_upstream_of_or_within_negative_effect ISO (PMID:17548624) MGI PMID:17548624 NCBI chr 7:18,711,145...18,721,926
Ensembl chr 7:18,716,973...18,721,350
JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of ISO (PMID:16275384) MGI PMID:16275384 NCBI chr  X:46,349,890...46,365,133 JBrowse link
G FOXP3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr  X:46,346,754...46,356,928 JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258
JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of
IEA
ISO
(PMID:10490661) Ensembl
MGI
PMID:10490661 GO_REF:0000107 NCBI chr11:53,005,378...53,020,899
Ensembl chr11:53,006,145...53,021,203
JBrowse link
isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FDCSP follicular dendritic cell secreted protein acts_upstream_of_or_within_negative_effect ISO (PMID:17548624) MGI PMID:17548624 NCBI chr 7:18,711,145...18,721,926
Ensembl chr 7:18,716,973...18,721,350
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:83,003,266...83,017,397
Ensembl chr10:83,003,717...83,017,363
JBrowse link
G IL4 interleukin 4 acts_upstream_of ISO (PMID:14988498) MGI PMID:14988498 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258
JBrowse link
G LOC103238722 60 kDa heat shock protein, mitochondrial-like involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:66,923,204...66,925,397 JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARP3 poly(ADP-ribose) polymerase family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:13,310,885...13,316,807
Ensembl chr22:13,310,938...13,320,680
JBrowse link
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FDCSP follicular dendritic cell secreted protein involved_in ISO (PMID:24399151) MGI PMID:24399151 NCBI chr 7:18,711,145...18,721,926
Ensembl chr 7:18,716,973...18,721,350
JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10490661) Ensembl
MGI
PMID:10490661 GO_REF:0000107 NCBI chr15:81,997,659...82,022,059
Ensembl chr15:81,998,545...82,009,946
JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:16275384) MGI PMID:16275384 NCBI chr  X:46,349,890...46,365,133 JBrowse link
G FOXP3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr  X:46,346,754...46,356,928 JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17137798) Ensembl
MGI
PMID:17137798 GO_REF:0000107 NCBI chr23:44,737,432...44,783,409
Ensembl chr23:44,737,422...44,775,657
JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:12496423) BHF-UCL PMID:12496423 NCBI chr25:55,714,291...55,998,009
Ensembl chr25:55,974,691...55,997,374
JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EXOSC3 exosome component 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:21255825) MGI
Ensembl
PMID:21255825 GO_REF:0000107 NCBI chr12:42,798,609...42,819,431
Ensembl chr12:42,799,067...42,803,471
JBrowse link
G EXOSC6 exosome component 6 acts_upstream_of_or_within ISO (PMID:21255825) MGI PMID:21255825 NCBI chr 5:53,397,973...53,399,526 JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:51,759,776...51,785,902
Ensembl chr22:51,759,715...51,785,987
JBrowse link
G KMT5B lysine methyltransferase 5B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:6,308,565...6,367,272
Ensembl chr 1:6,308,742...6,367,393
JBrowse link
G KMT5C lysine methyltransferase 5C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:47,942,100...47,950,364
Ensembl chr 6:47,944,197...47,949,693
JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:120,099,928...120,115,954
Ensembl chr20:120,110,269...120,116,083
JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:123,095,968...123,156,157
Ensembl chr21:123,095,966...123,155,800
JBrowse link
G RIF1 replication timing regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:36,845,751...36,937,040
Ensembl chr10:36,845,777...36,907,015
JBrowse link
G SHLD1 shieldin complex subunit 1 involved_in IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chr 2:32,265,882...32,381,411
Ensembl chr 2:32,265,788...32,381,395
JBrowse link
G SHLD2 shieldin complex subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:44,565,105...44,652,926
Ensembl chr 9:44,564,792...44,605,562
JBrowse link
G SHLD3 shieldin complex subunit 3 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chr 4:61,817,386...61,823,423 JBrowse link
G TFRC transferrin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:91,102,153...91,134,994
Ensembl chr15:91,102,817...91,135,584
JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:39,489,925...39,595,096
Ensembl chr26:39,508,600...39,594,927
JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103242307 TNF superfamily member 13 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:14988498) MGI
TreeGrafter
PMID:14988498 GO_REF:0000118 NCBI chr16:6,935,073...6,938,792
Ensembl chr16:6,926,584...6,938,019
JBrowse link
G LOC103246803 mismatch repair endonuclease PMS2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:15,174,359...15,209,962
Ensembl chr28:15,172,100...15,209,852
JBrowse link
G MLH1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:2,364,537...2,418,379
Ensembl chr15:2,364,738...2,418,393
JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819
JBrowse link
G NSD2 nuclear receptor binding SET domain protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23241889) Ensembl
MGI
PMID:23241889 GO_REF:0000107 NCBI chr27:46,787,325...46,896,898
Ensembl chr27:46,787,154...46,867,792
JBrowse link
G TGFB1 transforming growth factor beta 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:14988498) MGI
Ensembl
PMID:14988498 GO_REF:0000107 NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365
JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCF1 cardiotrophin like cytokine factor 1 involved_in ISO (PMID:12023368) BHF-UCL PMID:12023368 NCBI chr 1:6,890,751...6,900,370 JBrowse link
G CLCF1 cardiotrophin like cytokine factor 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 1:6,896,591...6,899,396 JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:14988498) MGI PMID:14988498 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258
JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10490661) Ensembl
MGI
PMID:10490661 GO_REF:0000107 NCBI chr11:53,005,378...53,020,899
Ensembl chr11:53,006,145...53,021,203
JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAD5 ATPase family AAA domain containing 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:25404367) Ensembl
MGI
PMID:25404367 GO_REF:0000107 NCBI chr16:25,536,911...25,597,911
Ensembl chr16:25,538,131...25,597,695
JBrowse link
G CD28 CD28 molecule acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:7688139) MGI
Ensembl
PMID:7688139 GO_REF:0000107 NCBI chr10:89,471,710...89,505,152
Ensembl chr10:89,471,730...89,500,387
JBrowse link
G CD40 CD40 molecule involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12882831) Ensembl
MGI
PMID:12882831 GO_REF:0000107 NCBI chr 2:17,753,713...17,765,134
Ensembl chr 2:17,753,394...17,764,566
JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473
JBrowse link
G IL2 interleukin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:1830926) Ensembl
MGI
PMID:1830926 GO_REF:0000107 NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969
JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:12882831), (PMID:14988498) MGI PMID:12882831 PMID:14988498 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258
JBrowse link
G LOC103246803 mismatch repair endonuclease PMS2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:15,174,359...15,209,962
Ensembl chr28:15,172,100...15,209,852
JBrowse link
G MLH1 mutL homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:2,364,537...2,418,379
Ensembl chr15:2,364,738...2,418,393
JBrowse link
G MSH2 mutS homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819
JBrowse link
G PAGR1 PAXIP1 associated glutamate rich protein 1 involved_in ISO (PMID:26744420) UniProt PMID:26744420 NCBI chr 5:26,833,333...26,837,655
Ensembl chr 5:26,833,675...26,837,640
JBrowse link
G PAXIP1 PAX interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:123,095,968...123,156,157
Ensembl chr21:123,095,966...123,155,800
JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9015183) Ensembl
MGI
PMID:9015183 GO_REF:0000107 NCBI chr25:30,655,014...30,777,367
Ensembl chr25:30,653,044...30,777,303
JBrowse link
G TBX21 T-box transcription factor 21 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12882831) Ensembl
MGI
PMID:12882831 GO_REF:0000107 NCBI chr16:68,131,258...68,145,579
Ensembl chr16:68,131,536...68,144,415
JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLF aprataxin and PNKP like factor acts_upstream_of_or_within ISO (PMID:21211721) MGI PMID:21211721 NCBI chr14:38,539,398...38,636,666
Ensembl chr14:38,540,084...38,636,569
JBrowse link
G SUPT6H SPT6 homolog, histone chaperone and transcription elongation factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:22,444,864...22,470,248 JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:16275384) MGI PMID:16275384 NCBI chr  X:46,349,890...46,365,133 JBrowse link
G FOXP3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr  X:46,346,754...46,356,928 JBrowse link
G IL27RA interleukin 27 receptor subunit alpha acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:11057672) MGI
Ensembl
PMID:11057672 GO_REF:0000107 NCBI chr 6:12,679,270...12,699,254
Ensembl chr 6:12,686,838...12,701,867
JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17137798) Ensembl
MGI
PMID:17137798 GO_REF:0000107 NCBI chr23:44,737,432...44,783,409
Ensembl chr23:44,737,422...44,775,657
JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:124,170,785...124,204,358
Ensembl chr11:124,169,732...124,204,200
JBrowse link
somatic diversification of immune receptors via somatic mutation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAR adenosine deaminase RNA specific involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23209284) Ensembl
MGI
PMID:23209284 GO_REF:0000107 NCBI chr20:9,194,611...9,241,102
Ensembl chr20:9,219,937...9,241,329
JBrowse link
somatic diversification of immunoglobulins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:8,426,920...8,438,331
Ensembl chr11:8,428,922...8,431,641
JBrowse link
G CTNNBL1 catenin beta like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:25,877,750...26,055,283
Ensembl chr 2:25,877,700...26,055,209
JBrowse link
G POLB DNA polymerase beta acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:24388753) MGI
Ensembl
PMID:24388753 GO_REF:0000107 NCBI chr 8:40,332,165...40,368,065
Ensembl chr 8:40,332,208...40,372,582
JBrowse link
somatic hypermutation of immunoglobulin genes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AICDA activation induced cytidine deaminase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:8,426,920...8,438,331
Ensembl chr11:8,428,922...8,431,641
JBrowse link
G EXO1 exonuclease 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:14716311) MGI
Ensembl
PMID:14716311 GO_REF:0000107 NCBI chr25:78,934,337...78,976,346
Ensembl chr25:78,934,459...78,976,219
JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:51,759,776...51,785,902
Ensembl chr22:51,759,715...51,785,987
JBrowse link
G LOC103246803 mismatch repair endonuclease PMS2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:10429667) MGI
Ensembl
TreeGrafter
PMID:10429667 GO_REF:0000107 GO_REF:0000118 NCBI chr28:15,174,359...15,209,962
Ensembl chr28:15,172,100...15,209,852
JBrowse link
G MCM3AP minichromosome maintenance complex component 3 associated protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:89,852,450...89,900,002
Ensembl chr 2:89,852,447...89,890,054
JBrowse link
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10092760), (PMID:10429667) Ensembl
TreeGrafter
MGI
PMID:10092760 PMID:10429667 GO_REF:0000107 GO_REF:0000118 NCBI chr15:2,364,537...2,418,379
Ensembl chr15:2,364,738...2,418,393
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
NOT|acts_upstream_of_or_within
IEA
ISO
(PMID:9697842), (PMID:9697843)
(PMID:9607916)
(PMID:15494304)
(PMID:9607915)
(PMID:14568978)
Ensembl
MGI
PMID:9607915 PMID:9607916 PMID:9697842 PMID:9697843 PMID:14568978 More... GO_REF:0000107 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819
JBrowse link
G MSH3 mutS homolog 3 NOT|acts_upstream_of_or_within ISO (PMID:10662804) MGI PMID:10662804 NCBI chr 4:74,811,181...75,032,067
Ensembl chr 4:74,811,198...75,032,005
JBrowse link
G MSH6 mutS homolog 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10662804), (PMID:15238604), (PMID:17015724)
(PMID:16618598)
Ensembl
MGI
PMID:10662804 PMID:15238604 PMID:16618598 PMID:17015724 GO_REF:0000107 NCBI chr14:59,375,602...59,400,252
Ensembl chr14:59,375,691...59,400,174
JBrowse link
G NUGGC nuclear GTPase, germinal center associated acts_upstream_of_or_within ISO (PMID:22833677) MGI PMID:22833677 NCBI chr 8:26,129,593...26,190,881 JBrowse link
G POLB DNA polymerase beta acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:24388753) MGI
Ensembl
PMID:24388753 GO_REF:0000107 NCBI chr 8:40,332,165...40,368,065
Ensembl chr 8:40,332,208...40,372,582
JBrowse link
G POLM DNA polymerase mu acts_upstream_of_or_within ISO (PMID:15789338) MGI PMID:15789338 NCBI chr21:14,585,912...14,596,127
Ensembl chr21:14,586,164...14,599,248
JBrowse link
G POLQ DNA polymerase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:59,336,506...59,448,609
Ensembl chr22:59,336,842...59,448,604
JBrowse link
G SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in ISO (PMID:29669924) UniProt PMID:29669924 NCBI chr 2:57,641,634...57,699,685
Ensembl chr 2:57,639,046...57,699,525
JBrowse link
G UNG uracil DNA glycosylase acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:15494304)
(PMID:17015724)
MGI
Ensembl
PMID:15494304 PMID:17015724 GO_REF:0000107 NCBI chr11:104,302,507...104,325,160 JBrowse link
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103246803 mismatch repair endonuclease PMS2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:11828012) MGI
Ensembl
PMID:11828012 GO_REF:0000107 NCBI chr28:15,174,359...15,209,962
Ensembl chr28:15,172,100...15,209,852
JBrowse link
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:11828012) Ensembl
MGI
PMID:11828012 GO_REF:0000107 NCBI chr15:2,364,537...2,418,379
Ensembl chr15:2,364,738...2,418,393
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14563316), (PMID:15955838)
(PMID:11828012)
(PMID:15494304)
(PMID:14568978)
Ensembl
MGI
PMID:11828012 PMID:14563316 PMID:14568978 PMID:15494304 PMID:15955838 GO_REF:0000107 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819
JBrowse link
G MSH3 mutS homolog 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:15238604) MGI
TreeGrafter
PMID:15238604 GO_REF:0000118 NCBI chr 4:74,811,181...75,032,067
Ensembl chr 4:74,811,198...75,032,005
JBrowse link
G MSH6 mutS homolog 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15238604) Ensembl
MGI
PMID:15238604 GO_REF:0000107 NCBI chr14:59,375,602...59,400,252
Ensembl chr14:59,375,691...59,400,174
JBrowse link
G UNG uracil DNA glycosylase acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:15494304) MGI
Ensembl
PMID:15494304 GO_REF:0000107 NCBI chr11:104,302,507...104,325,160 JBrowse link
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12743174) Ensembl
MGI
PMID:12743174 GO_REF:0000107 NCBI chr15:2,364,537...2,418,379
Ensembl chr15:2,364,738...2,418,393
JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12743174) Ensembl
TreeGrafter
MGI
PMID:12743174 GO_REF:0000107 GO_REF:0000118 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819
JBrowse link
T cell receptor V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL11B BCL11 transcription factor B acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:12717433) MGI
Ensembl
PMID:12717433 GO_REF:0000107 NCBI chr24:77,122,591...77,222,562
Ensembl chr24:77,122,689...77,221,454
JBrowse link
G LEF1 lymphoid enhancer binding factor 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:9462507) MGI
Ensembl
PMID:9462507 GO_REF:0000107 NCBI chr 7:55,974,770...56,096,214
Ensembl chr 7:55,990,621...56,094,110
JBrowse link
G LIG4 DNA ligase 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:10911993) MGI
Ensembl
PMID:10911993 GO_REF:0000107 NCBI chr 3:86,576,200...86,587,097
Ensembl chr 3:86,577,304...86,580,039
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9768755) Ensembl
MGI
PMID:9768755 GO_REF:0000107 NCBI chr 8:43,915,226...44,119,547
Ensembl chr 8:43,914,636...44,119,541
JBrowse link
G TCF7 transcription factor 7 acts_upstream_of_or_within ISO (PMID:9462507) MGI PMID:9462507 NCBI chr23:36,919,648...36,953,088
Ensembl chr23:36,919,745...36,951,192
JBrowse link
V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:23836881) MGI
Ensembl
PMID:23836881 GO_REF:0000107 NCBI chr 1:99,653,208...99,786,889
Ensembl chr 1:99,653,139...99,791,520
JBrowse link
G DCAF1 DDB1 and CUL4 associated factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:12,736,784...12,843,762
Ensembl chr22:12,739,665...12,823,363
JBrowse link
G DCLRE1C DNA cross-link repair 1C involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23836881) Ensembl
MGI
PMID:23836881 GO_REF:0000107 NCBI chr 9:14,929,221...14,974,791
Ensembl chr 9:14,929,317...14,965,443
JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:9166431) UniProt PMID:9166431 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G LIG1 DNA ligase 1 NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chr 6:41,354,701...41,405,417
Ensembl chr 6:41,351,389...41,403,421
JBrowse link
G LIG3 DNA ligase 3 NOT|involved_in ISO (PMID:9809069) UniProt PMID:9809069 NCBI chr16:28,487,953...28,511,945
Ensembl chr16:28,490,434...28,511,130
JBrowse link
G LIG4 DNA ligase 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:10716994)
(PMID:15194694)
MGI
Ensembl
PMID:10716994 PMID:15194694 GO_REF:0000107 NCBI chr 3:86,576,200...86,587,097
Ensembl chr 3:86,577,304...86,580,039
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23836881) Ensembl
MGI
PMID:23836881 GO_REF:0000107 NCBI chr 8:43,915,226...44,119,547
Ensembl chr 8:43,914,636...44,119,541
JBrowse link
G RAG1 recombination activating 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:2360047) Ensembl
TreeGrafter
MGI
UniProt
InterPro
PMID:2360047 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:28,667,996...28,701,002 JBrowse link
G RAG2 recombination activating 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:2360047) MGI
Ensembl
TreeGrafter
PMID:2360047 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:28,645,175...28,653,823
Ensembl chr 1:28,649,930...28,651,513
JBrowse link
G XRCC4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO (PMID:10716994) MGI PMID:10716994 NCBI chr 4:77,182,569...77,468,786
Ensembl chr 4:77,182,793...77,468,775
JBrowse link
G XRCC6 X-ray repair cross complementing 6 acts_upstream_of_or_within ISO (PMID:10716994) MGI PMID:10716994 NCBI chr19:24,160,459...24,204,237
Ensembl chr19:24,160,483...24,206,320
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19829
    immune system process 2676
      somatic diversification of immune receptors 88
        somatic diversification of DSCAM-based immune receptors 0
        somatic diversification of FREP-based immune receptors 0
        somatic diversification of T cell receptor genes + 5
        somatic diversification of immune receptors by N region addition + 0
        somatic diversification of immune receptors via alternate splicing + 0
        somatic diversification of immune receptors via gene conversion + 0
        somatic diversification of immune receptors via germline recombination within a single locus + 81
        somatic diversification of immune receptors via somatic mutation + 16
        somatic diversification of immunoglobulins + 75
        somatic diversification of variable lymphocyte receptors of jawless fish 0
Path 2
Term Annotations click to browse term
  biological_process 19829
    developmental process 6858
      anatomical structure development 6432
        multicellular organism development 5173
          system development 4482
            immune system development 241
              somatic diversification of immune receptors 88
                somatic diversification of DSCAM-based immune receptors 0
                somatic diversification of FREP-based immune receptors 0
                somatic diversification of T cell receptor genes + 5
                somatic diversification of immune receptors by N region addition + 0
                somatic diversification of immune receptors via alternate splicing + 0
                somatic diversification of immune receptors via gene conversion + 0
                somatic diversification of immune receptors via germline recombination within a single locus + 81
                somatic diversification of immune receptors via somatic mutation + 16
                somatic diversification of immunoglobulins + 75
                somatic diversification of variable lymphocyte receptors of jawless fish 0
paths to the root