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ONTOLOGY REPORT - ANNOTATIONS

Term:podosome
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Accession:GO:0002102 term browser browse the term
Definition:An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
Comment:Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
Synonyms:xref: Wikipedia:Podosome
 never_in_taxon: NCBITaxon:4751 ! Fungi

GViewer not supported for the selected species.

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podosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin beta ISO RGD PMID:17111031 RGD:11541102 NCBI chrNW_004936765:667,107...670,627
Ensembl chrNW_004936765:667,053...670,672 		JBrowse link
G Actr3 actin related protein 3 ISO RGD PMID:15093736 PMID:17224451 RGD:2306207 RGD:2306209 NCBI chrNW_004936469:55,639,345...55,699,330
Ensembl chrNW_004936469:55,639,068...55,699,640 		JBrowse link
G Adam8 ADAM metallopeptidase domain 8 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936486:19,389,925...19,403,577
Ensembl chrNW_004936486:19,391,324...19,402,332 		JBrowse link
G Afap1l1 actin filament associated protein 1 like 1 located_in IEA UniProt GO_REF:0000044 NCBI chrNW_004936504:5,525,276...5,587,348
Ensembl chrNW_004936504:5,524,739...5,587,366 		JBrowse link
G Amotl2 angiomotin like 2 located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chrNW_004936529:7,454,778...7,471,660
Ensembl chrNW_004936529:7,454,763...7,471,718 		JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:1,953,770...2,016,875
Ensembl chrNW_004936498:1,953,762...2,003,367 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 located_in ISO (PMID:21352810) MGI PMID:21352810 NCBI chrNW_004936580:5,213,323...5,230,861
Ensembl chrNW_004936580:5,214,401...5,245,021 		JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936470:18,340,120...18,640,396
Ensembl chrNW_004936470:18,339,616...18,640,624 		JBrowse link
G Bin2 bridging integrator 2 located_in ISO (PMID:23285027) UniProt PMID:23285027 NCBI chrNW_004936512:8,869,131...8,901,171 JBrowse link
G Ccn5 cellular communication network factor 5 located_in ISO PMID:24488697 UniProt PMID:24488697 RGD:14390054 NCBI chrNW_004936514:7,997,802...8,010,378
Ensembl chrNW_004936514:7,997,697...8,010,396 		JBrowse link
G Cd2ap CD2 associated protein located_in
is_active_in		 IEA
ISO		 (PMID:17606992) Ensembl
MGI		 PMID:17606992 GO_REF:0000107 NCBI chrNW_004936476:12,890,595...12,989,046
Ensembl chrNW_004936476:12,890,468...12,987,843 		JBrowse link
G Cttn cortactin located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:481,234...503,857
Ensembl chrNW_004936599:481,243...501,743 		JBrowse link
G Dbnl drebrin like located_in IEA UniProt
Ensembl		 GO_REF:0000044 GO_REF:0000107 NCBI chrNW_004936478:19,007,630...19,021,068
Ensembl chrNW_004936478:19,007,672...19,020,361 		JBrowse link
G Dock5 dedicator of cytokinesis 5 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936757:1,289,941...1,419,257
Ensembl chrNW_004936757:1,289,954...1,576,984 		JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chrNW_004936606:1,201,420...1,713,894
Ensembl chrNW_004936606:1,201,657...1,708,551 		JBrowse link
G Fermt3 FERM domain containing kindlin 3 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:4,975,435...4,989,225
Ensembl chrNW_004936599:4,973,172...4,989,166 		JBrowse link
G Flii FLII actin remodeling protein located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936741:1,784,802...1,796,176
Ensembl chrNW_004936741:1,783,589...1,796,168 		JBrowse link
G Flna filamin A located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936809:1,097,288...1,123,206
Ensembl chrNW_004936809:1,097,294...1,123,201 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936765:609,894...619,417
Ensembl chrNW_004936765:609,861...619,456 		JBrowse link
G Gsn gelsolin located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:9,749,755...9,802,787
Ensembl chrNW_004936487:9,764,944...9,802,841 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K located_in IEA UniProt GO_REF:0000044 NCBI chrNW_004936828:827,660...839,088
Ensembl chrNW_004936828:828,837...838,720 		JBrowse link
G Kif9 kinesin family member 9 located_in ISO (PMID:21119006) UniProt PMID:21119006 NCBI chrNW_004936596:952,028...1,010,889 JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936857:646,363...726,338
Ensembl chrNW_004936857:646,118...698,035 		JBrowse link
G LOC101957084 plectin located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:8,194,124...8,252,139
Ensembl chrNW_004936470:8,216,205...8,250,978 		JBrowse link
G Lpxn leupaxin located_in IEA UniProt
Ensembl		 GO_REF:0000044 GO_REF:0000107 NCBI chrNW_004936581:3,750,819...3,784,488
Ensembl chrNW_004936581:3,751,277...3,784,503 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 located_in ISO (PMID:24127566) MGI PMID:24127566 NCBI chrNW_004936728:1,775,746...1,893,895
Ensembl chrNW_004936728:1,775,641...1,893,907 		JBrowse link
G Palld palladin, cytoskeletal associated protein ISO RGD PMID:16868024 RGD:2325783 NCBI chrNW_004936516:786,358...1,151,910
Ensembl chrNW_004936516:802,484...1,151,801 		JBrowse link
G Phldb2 pleckstrin homology like domain family B member 2 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936834:592,688...791,533
Ensembl chrNW_004936834:592,584...793,386 		JBrowse link
G Ptpn12 protein tyrosine phosphatase non-receptor type 12 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936479:20,909,557...21,016,562
Ensembl chrNW_004936479:20,909,551...21,016,606 		JBrowse link
G Scin scinderin located_in IEA UniProt GO_REF:0000044 NCBI chrNW_004936795:418,874...495,990
Ensembl chrNW_004936795:418,436...495,936 		JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 located_in IEA UniProt GO_REF:0000044 NCBI chrNW_004936588:2,504,372...2,535,993
Ensembl chrNW_004936588:2,504,374...2,536,011 		JBrowse link
G Sh3pxd2a SH3 and PX domains 2A located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chrNW_004936600:2,343,709...2,513,497
Ensembl chrNW_004936600:2,343,658...2,509,612 		JBrowse link
G Sh3pxd2b SH3 and PX domains 2B located_in IEA UniProt GO_REF:0000044 NCBI chrNW_004936609:2,934,814...2,975,111
Ensembl chrNW_004936609:2,926,771...2,978,914 		JBrowse link
G Spata13 spermatogenesis associated 13 located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chrNW_004936688:1,433,231...1,569,954 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936561:3,826,802...3,844,406
Ensembl chrNW_004936561:3,825,787...3,844,483 		JBrowse link
G Tns3 tensin 3 located_in ISO (PMID:27505886) MGI PMID:27505886 NCBI chrNW_004936478:21,784,486...21,924,240
Ensembl chrNW_004936478:21,786,120...21,924,221 		JBrowse link
G Tpm3 tropomyosin 3 located_in ISO (PMID:16765662) MGI PMID:16765662 NCBI chrNW_004936580:3,860,185...3,893,251
Ensembl chrNW_004936580:3,860,190...3,889,978 		JBrowse link
G Tpm4 tropomyosin 4 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936596:4,406,301...4,423,775
Ensembl chrNW_004936596:4,406,283...4,418,932 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936748:785,491...802,791
Ensembl chrNW_004936748:785,455...803,048 		JBrowse link
G Vcl vinculin located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chrNW_004936521:5,051,077...5,163,036
Ensembl chrNW_004936521:5,050,900...5,163,086 		JBrowse link
podosome core term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 ISO RGD PMID:23158496 RGD:11530035 NCBI chrNW_004936491:9,980,228...10,021,417
Ensembl chrNW_004936491:9,979,427...10,022,043 		JBrowse link
G Actr3 actin related protein 3 ISO RGD PMID:24290759 RGD:11530018 NCBI chrNW_004936469:55,639,345...55,699,330
Ensembl chrNW_004936469:55,639,068...55,699,640 		JBrowse link
G Arpc2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chrNW_004936569:758,358...786,995
Ensembl chrNW_004936569:758,199...786,760 		JBrowse link
podosome ring term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chrNW_004936569:758,358...786,995
Ensembl chrNW_004936569:758,199...786,760 		JBrowse link
G Vcl vinculin located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936521:5,051,077...5,163,036
Ensembl chrNW_004936521:5,050,900...5,163,086 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 16782
    cellular anatomical structure 16690
      intracellular anatomical structure 13071
        intracellular organelle 11659
          intracellular membraneless organelle 4524
            podosome 42
              podosome core 3
              podosome ring 2
Path 2
Term Annotations click to browse term
  cellular_component 16782
    cellular anatomical structure 16690
      organelle 12061
        membraneless organelle 4524
          intracellular membraneless organelle 4524
            cytoskeleton 2212
              actin cytoskeleton 521
                podosome 42
                  podosome core 3
                  podosome ring 2
paths to the root