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ONTOLOGY REPORT - ANNOTATIONS

Term:podosome
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Accession:GO:0002102 term browser browse the term
Definition:An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
Comment:Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
Synonyms:xref: Wikipedia:Podosome
 never_in_taxon: NCBITaxon:4751 ! Fungi


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podosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTB actin beta ISO RGD PMID:17111031 RGD:11541102 NCBI chr 3:4,084,275...4,090,383
Ensembl chr 3:4,082,216...4,090,356 		JBrowse link
G ACTR3 actin related protein 3 ISO RGD PMID:15093736 PMID:17224451 RGD:2306207 RGD:2306209 NCBI chr15:20,104,808...20,171,721
Ensembl chr15:20,104,812...20,167,421 		JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 located_in IEA Ensembl GO_REF:0000107 NCBI chr14:141,221,177...141,233,728
Ensembl chr14:141,221,198...141,232,306 		JBrowse link
G AFAP1L1 actin filament associated protein 1 like 1 located_in IEA UniProt GO_REF:0000044 NCBI chr 2:150,445,146...150,507,577
Ensembl chr 2:150,445,126...150,510,002 		JBrowse link
G AMOTL2 angiomotin like 2 located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr13:75,490,936...75,507,360
Ensembl chr13:75,490,942...75,509,420 		JBrowse link
G ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 9:7,238,043...7,301,085
Ensembl chr 9:7,238,049...7,301,086 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 located_in ISO (PMID:21352810) MGI PMID:21352810 NCBI chr 4:94,026,391...94,082,206
Ensembl chr 4:94,026,386...94,080,420 		JBrowse link
G ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 located_in
is_active_in		 IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:10,103,860...10,451,928
Ensembl chr 4:10,179,758...10,451,929 		JBrowse link
G BIN2 bridging integrator 2 located_in
is_active_in		 IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107
G CCN5 cellular communication network factor 5 located_in ISO PMID:24488697 UniProt PMID:24488697 RGD:14390054 NCBI chr17:47,131,236...47,146,455
Ensembl chr17:47,131,501...47,146,449 		JBrowse link
G CD2AP CD2 associated protein located_in
is_active_in		 IEA
ISO		 (PMID:17606992) Ensembl
MGI		 PMID:17606992 GO_REF:0000107 NCBI chr 7:42,218,016...42,332,523
Ensembl chr 7:42,218,290...42,332,518 		JBrowse link
G CTTN cortactin located_in IEA Ensembl GO_REF:0000107 NCBI chr 2:3,031,103...3,060,796
Ensembl chr 2:3,031,103...3,060,813 		JBrowse link
G DBNL drebrin like located_in IEA UniProt
Ensembl		 GO_REF:0000044 GO_REF:0000107 NCBI chr18:48,713,335...48,725,692
Ensembl chr18:48,713,340...48,725,697 		JBrowse link
G DOCK5 dedicator of cytokinesis 5 located_in IEA Ensembl GO_REF:0000107 NCBI chr14:9,197,280...9,438,715
Ensembl chr14:9,197,293...9,436,249 		JBrowse link
G ERC1 ELKS/RAB6-interacting/CAST family member 1 located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chr 5:68,223,722...68,608,705
Ensembl chr 5:68,223,729...68,608,703 		JBrowse link
G FERMT3 FERM domain containing kindlin 3 located_in IEA Ensembl GO_REF:0000107 NCBI chr 2:7,886,781...7,909,892
Ensembl chr 2:7,886,790...7,909,158 		JBrowse link
G FLII FLII actin remodeling protein located_in IEA Ensembl GO_REF:0000107 NCBI chr12:60,475,722...60,487,376
Ensembl chr12:60,475,733...60,487,408 		JBrowse link
G FLNA filamin A located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chr  X:124,889,934...124,915,000
Ensembl chr  X:124,890,162...124,914,992 		JBrowse link
G FSCN1 fascin actin-bundling protein 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 3:4,134,173...4,143,275
Ensembl chr 3:4,134,177...4,143,286 		JBrowse link
G GSN gelsolin located_in IEA Ensembl GO_REF:0000107 NCBI chr 1:261,295,711...261,372,848
Ensembl chr 1:261,307,008...261,372,848 		JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K located_in IEA UniProt GO_REF:0000044 NCBI chr10:30,975,639...30,987,955
Ensembl chr10:30,975,702...30,987,956 		JBrowse link
G KIF9 kinesin family member 9 located_in IEA Ensembl GO_REF:0000107 NCBI chr13:30,014,468...30,062,871
Ensembl chr13:30,014,991...30,063,073 		JBrowse link
G LCP1 lymphocyte cytosolic protein 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr11:21,126,504...21,223,543
Ensembl chr11:21,126,539...21,223,550 		JBrowse link
G LPXN leupaxin located_in IEA UniProt
Ensembl		 GO_REF:0000044 GO_REF:0000107 NCBI chr 2:12,534,780...12,582,756
Ensembl chr 2:12,540,098...12,582,752 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 located_in ISO (PMID:24127566) MGI PMID:24127566 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874 		JBrowse link
G PALLD palladin, cytoskeletal associated protein ISO RGD PMID:16868024 RGD:2325783 NCBI chr14:20,678,456...21,020,125
Ensembl chr14:20,678,452...21,020,125 		JBrowse link
G PHLDB2 pleckstrin homology like domain family B member 2 located_in IEA Ensembl GO_REF:0000107 NCBI chr13:147,778,420...148,025,943
Ensembl chr13:147,778,370...147,879,794 		JBrowse link
G PHLDB2 pleckstrin homology like domain family B member 2 located_in IEA Ensembl GO_REF:0000107 NCBI chr13:148,033,712...148,087,766
Ensembl chr13:148,033,704...148,087,744 		JBrowse link
G PLEC plectin located_in IEA Ensembl GO_REF:0000107 NCBI chr 4:696,355...753,859
Ensembl chr 4:689,034...753,696 		JBrowse link
G PTPN12 protein tyrosine phosphatase non-receptor type 12 located_in IEA Ensembl GO_REF:0000107 NCBI chr 9:102,480,914...102,563,969
Ensembl chr 9:102,480,924...102,563,751 		JBrowse link
G SCIN scinderin located_in IEA UniProt GO_REF:0000044 NCBI chr 9:82,103,271...82,185,254
Ensembl chr 9:82,103,087...82,185,283 		JBrowse link
G SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 located_in IEA UniProt GO_REF:0000044 NCBI chr 2:74,414,453...74,445,450
Ensembl chr 2:74,414,466...74,445,447 		JBrowse link
G SH3PXD2A SH3 and PX domains 2A located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr14:114,515,459...114,777,251
Ensembl chr14:114,519,928...114,777,238 		JBrowse link
G SH3PXD2B SH3 and PX domains 2B located_in IEA UniProt GO_REF:0000044 NCBI chr16:51,733,170...51,858,774
Ensembl chr16:51,733,135...51,858,772 		JBrowse link
G SPATA13 spermatogenesis associated 13 located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chr11:2,806,674...3,161,372 JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase located_in IEA Ensembl GO_REF:0000107 NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860 		JBrowse link
G TNS3 tensin 3 located_in ISO (PMID:27505886) MGI PMID:27505886 NCBI chr18:48,960,938...49,192,434
Ensembl chr18:48,997,217...49,192,433 		JBrowse link
G TPM3 tropomyosin 3 located_in ISO (PMID:16765662) MGI PMID:16765662 NCBI chr 4:95,542,329...95,572,946
Ensembl chr 4:95,542,473...95,572,938 		JBrowse link
G TPM4 tropomyosin 4 located_in IEA Ensembl GO_REF:0000107 NCBI chr 2:61,453,721...61,476,781
Ensembl chr 2:61,453,725...61,476,781 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222 		JBrowse link
G VCL vinculin located_in IEA UniProt
Ensembl		 GO_REF:0000044 GO_REF:0000107 NCBI chr14:76,700,143...76,811,875
Ensembl chr14:76,700,173...76,811,869 		JBrowse link
podosome core term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTR2 actin related protein 2 ISO RGD PMID:23158496 RGD:11530035 NCBI chr 3:76,691,275...76,729,269
Ensembl chr 3:76,691,280...76,729,252 		JBrowse link
G ACTR3 actin related protein 3 ISO RGD PMID:24290759 RGD:11530018 NCBI chr15:20,104,808...20,171,721
Ensembl chr15:20,104,812...20,167,421 		JBrowse link
G ARPC2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chr15:120,297,122...120,328,795
Ensembl chr15:120,297,025...120,328,542 		JBrowse link
podosome ring term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARPC2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chr15:120,297,122...120,328,795
Ensembl chr15:120,297,025...120,328,542 		JBrowse link
G VCL vinculin located_in IEA Ensembl GO_REF:0000107 NCBI chr14:76,700,143...76,811,875
Ensembl chr14:76,700,173...76,811,869 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18691
    cellular anatomical structure 18472
      intracellular anatomical structure 13544
        intracellular organelle 12082
          intracellular membraneless organelle 4652
            podosome 43
              podosome core 3
              podosome ring 2
Path 2
Term Annotations click to browse term
  cellular_component 18691
    cellular anatomical structure 18472
      organelle 12493
        membraneless organelle 4652
          intracellular membraneless organelle 4652
            cytoskeleton 2292
              actin cytoskeleton 532
                podosome 43
                  podosome core 3
                  podosome ring 2
paths to the root