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ONTOLOGY REPORT - ANNOTATIONS

Term:podosome
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Accession:GO:0002102 term browser browse the term
Definition:An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
Comment:Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
Synonyms:xref: Wikipedia:Podosome
 never_in_taxon: NCBITaxon:4751 ! Fungi

GViewer not supported for the selected species.

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podosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin beta ISO RGD PMID:17111031 RGD:11541102 NCBI chrNW_004624740:28,087,051...28,090,359
Ensembl chrNW_004624740:28,087,736...28,090,512 		JBrowse link
G Actr3 actin related protein 3 ISO RGD PMID:15093736 PMID:17224451 RGD:2306207 RGD:2306209 NCBI chrNW_004624732:31,360,804...31,427,885
Ensembl chrNW_004624732:31,361,147...31,427,811 		JBrowse link
G Adam8 ADAM metallopeptidase domain 8 located_in ISO (PMID:15220135) BHF-UCL PMID:15220135 NCBI chrNW_004624737:13,459,274...13,474,686 JBrowse link
G Afap1l1 actin filament associated protein 1 like 1 located_in IEA UniProt GO_REF:0000044 NCBI chrNW_004624774:8,640,643...8,702,149
Ensembl chrNW_004624774:8,640,684...8,701,107 		JBrowse link
G Amotl2 angiomotin like 2 located_in IEA UniProt GO_REF:0000044 NCBI chrNW_004624730:10,695,648...10,713,188
Ensembl chrNW_004624730:10,695,138...10,713,808 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 located_in ISO (PMID:21352810) MGI PMID:21352810 NCBI chrNW_004624885:1,314,885...1,362,730
Ensembl chrNW_004624885:1,311,512...1,362,730 		JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624735:25,410,002...25,732,847
Ensembl chrNW_004624735:25,409,902...25,732,967 		JBrowse link
G Bin2 bridging integrator 2 located_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624816:941,199...992,157 JBrowse link
G Ccn5 cellular communication network factor 5 located_in ISO PMID:24488697 UniProt PMID:24488697 RGD:14390054 NCBI chrNW_004624790:9,744,127...9,755,685
Ensembl chrNW_004624790:9,744,078...9,755,375 		JBrowse link
G Cd2ap CD2 associated protein is_active_in ISO (PMID:17606992) MGI PMID:17606992 NCBI chrNW_004624754:13,420,594...13,511,672
Ensembl chrNW_004624754:13,420,603...13,511,523 		JBrowse link
G Cttn cortactin located_in ISO (PMID:17893324) MGI PMID:17893324 NCBI chrNW_004624767:16,842,341...16,884,449
Ensembl chrNW_004624767:16,847,459...16,880,183 		JBrowse link
G Dbnl drebrin like located_in IEA UniProt GO_REF:0000044 NCBI chrNW_004624740:7,950,552...7,960,592
Ensembl chrNW_004624740:7,950,556...7,960,568 		JBrowse link
G Dock5 dedicator of cytokinesis 5 located_in ISO (PMID:27505886) MGI PMID:27505886 NCBI chrNW_004624758:20,255,036...20,444,194
Ensembl chrNW_004624758:20,255,062...20,440,370 		JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chrNW_004624735:11,398,603...11,907,553
Ensembl chrNW_004624735:11,400,159...11,841,920 		JBrowse link
G Fermt3 FERM domain containing kindlin 3 located_in ISO (PMID:16876785) MGI PMID:16876785 NCBI chrNW_004624767:22,082,431...22,101,003
Ensembl chrNW_004624767:22,082,436...22,100,969 		JBrowse link
G Flii FLII actin remodeling protein located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chrNW_004624849:3,213,988...3,227,734
Ensembl chrNW_004624849:3,214,042...3,227,476 		JBrowse link
G Flna filamin A located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chrNW_004624946:812,278...836,307
Ensembl chrNW_004624946:812,287...837,273 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 located_in ISO (PMID:20137952) UniProt PMID:20137952 NCBI chrNW_004624740:28,038,216...28,047,252
Ensembl chrNW_004624740:28,036,731...28,047,364 		JBrowse link
G Gsn gelsolin located_in ISO (PMID:24236012) UniProt PMID:24236012 NCBI chrNW_004624760:13,943,680...14,004,660
Ensembl chrNW_004624760:13,943,888...13,969,905 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K located_in IEA UniProt GO_REF:0000044 NCBI chrNW_004624809:7,538,568...7,548,272 JBrowse link
G Kif9 kinesin family member 9 located_in ISO (PMID:21119006) UniProt PMID:21119006 NCBI chrNW_004624730:74,075,530...74,118,164
Ensembl chrNW_004624730:74,075,752...74,118,164 		JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 located_in ISO (PMID:24236012) UniProt PMID:24236012 NCBI chrNW_004624748:8,740,563...8,833,091
Ensembl chrNW_004624748:8,779,395...8,835,500 		JBrowse link
G Lpxn leupaxin located_in ISO (PMID:12674328) UniProt PMID:12674328 NCBI chrNW_004624864:1,815,056...1,852,041
Ensembl chrNW_004624864:1,818,614...1,852,503 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 located_in ISO (PMID:24127566) MGI PMID:24127566 NCBI chrNW_004624928:1,442,216...1,494,275
Ensembl chrNW_004624928:1,439,146...1,494,266 		JBrowse link
G Palld palladin, cytoskeletal associated protein ISO RGD PMID:16868024 RGD:2325783 NCBI chrNW_004624769:150,800...560,163
Ensembl chrNW_004624769:150,738...559,045 		JBrowse link
G Phldb2 pleckstrin homology like domain family B member 2 located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chrNW_004624731:36,596,812...36,871,963
Ensembl chrNW_004624731:36,593,871...36,872,200 		JBrowse link
G Ptpn12 protein tyrosine phosphatase non-receptor type 12 located_in ISO (PMID:12674328) UniProt PMID:12674328 NCBI chrNW_004624739:26,747,830...26,828,535 JBrowse link
G Scin scinderin located_in IEA UniProt GO_REF:0000044 NCBI chrNW_004624739:17,303,805...17,384,105
Ensembl chrNW_004624739:17,304,486...17,384,050 		JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 located_in IEA UniProt GO_REF:0000044 NCBI chrNW_004624828:5,304,887...5,330,440
Ensembl chrNW_004624828:5,305,070...5,330,440 		JBrowse link
G Sh3pxd2a SH3 and PX domains 2A located_in IEA UniProt GO_REF:0000044 NCBI chrNW_004624831:2,779,899...2,973,576
Ensembl chrNW_004624831:2,786,950...2,973,702 		JBrowse link
G Sh3pxd2b SH3 and PX domains 2B located_in IEA UniProt GO_REF:0000044 NCBI chrNW_004624733:17,577,262...17,686,212
Ensembl chrNW_004624733:17,577,336...17,688,155 		JBrowse link
G Spata13 spermatogenesis associated 13 located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chrNW_004624776:13,703,451...13,852,924 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase located_in ISO (PMID:17893324) MGI PMID:17893324 NCBI chrNW_004624842:2,212,561...2,260,514
Ensembl chrNW_004624842:2,211,020...2,230,132 		JBrowse link
G Tns3 tensin 3 located_in ISO (PMID:27505886) MGI PMID:27505886 NCBI chrNW_004624740:5,776,883...5,928,434
Ensembl chrNW_004624740:5,824,510...5,930,478 		JBrowse link
G Tpm3 tropomyosin 3 located_in ISO (PMID:16765662) MGI PMID:16765662 NCBI chrNW_004624885:3,109,360...3,139,664
Ensembl chrNW_004624885:3,109,436...3,139,789 		JBrowse link
G Tpm4 tropomyosin 4 located_in ISO (PMID:16765662) MGI PMID:16765662 NCBI chrNW_004624908:1,135,240...1,155,175
Ensembl chrNW_004624908:1,132,215...1,152,319 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 located_in ISO (PMID:15220135) BHF-UCL PMID:15220135 NCBI chrNW_004624857:3,606,573...3,625,991
Ensembl chrNW_004624857:3,606,431...3,627,063 		JBrowse link
G Vcl vinculin located_in IEA UniProt GO_REF:0000044 NCBI chrNW_004624754:7,484,759...7,590,108
Ensembl chrNW_004624754:7,484,773...7,590,108 		JBrowse link
podosome core term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 ISO RGD PMID:23158496 RGD:11530035 NCBI chrNW_004624762:8,282,415...8,339,818
Ensembl chrNW_004624762:8,281,433...8,339,830 		JBrowse link
G Actr3 actin related protein 3 ISO RGD PMID:24290759 RGD:11530018 NCBI chrNW_004624732:31,360,804...31,427,885
Ensembl chrNW_004624732:31,361,147...31,427,811 		JBrowse link
G Arpc2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chrNW_004624823:6,774,855...6,804,219 JBrowse link
podosome ring term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chrNW_004624823:6,774,855...6,804,219 JBrowse link
G Vcl vinculin located_in ISO (PMID:27505886) MGI PMID:27505886 NCBI chrNW_004624754:7,484,759...7,590,108
Ensembl chrNW_004624754:7,484,773...7,590,108 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 18619
    cellular anatomical structure 18486
      intracellular anatomical structure 14267
        intracellular organelle 12714
          intracellular membraneless organelle 4799
            podosome 40
              podosome core 3
              podosome ring 2
Path 2
Term Annotations click to browse term
  cellular_component 18619
    cellular anatomical structure 18486
      organelle 13115
        membraneless organelle 4799
          intracellular membraneless organelle 4799
            cytoskeleton 2227
              actin cytoskeleton 522
                podosome 40
                  podosome core 3
                  podosome ring 2
paths to the root