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ONTOLOGY REPORT - ANNOTATIONS

Term:podosome
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Accession:GO:0002102 term browser browse the term
Definition:An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
Comment:Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
Synonyms:xref: Wikipedia:Podosome
 never_in_taxon: NCBITaxon:4751 ! Fungi


show annotations for term's descendants           Sort by:
podosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTB actin beta ISO RGD PMID:17111031 RGD:11541102 NCBI chr 7:5,527,148...5,530,601
Ensembl chr 7:5,526,409...5,563,902 		JBrowse link
G ACTR3 actin related protein 3 ISO RGD PMID:15093736 PMID:17224451 RGD:2306207 RGD:2306209 NCBI chr 2:113,889,934...113,962,596
Ensembl chr 2:113,890,063...113,962,596 		JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 located_in IDA (PMID:15220135) BHF-UCL PMID:15220135 NCBI chr10:133,262,423...133,276,868
Ensembl chr10:133,262,420...133,276,868 		JBrowse link
G AFAP1L1 actin filament associated protein 1 like 1 located_in IEA UniProt GO_REF:0000044 NCBI chr 5:149,271,859...149,343,637
Ensembl chr 5:149,271,859...149,343,637 		JBrowse link
G AMOTL2 angiomotin like 2 located_in IDA
IEA		 (PMID:23525008) UniProt PMID:23525008 GO_REF:0000044 NCBI chr 3:134,355,345...134,375,417
Ensembl chr 3:134,355,347...134,375,479 		JBrowse link
G ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 located_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr11:72,685,069...72,752,408
Ensembl chr11:72,685,069...72,793,599 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 located_in ISO (PMID:21352810) MGI PMID:21352810 NCBI chr 1:155,946,854...155,979,617
Ensembl chr 1:155,946,851...156,007,070 		JBrowse link
G ARHGEF5 Rho guanine nucleotide exchange factor 5 located_in IEA UniProt GO_REF:0000044 NCBI chr 7:144,355,402...144,380,632
Ensembl chr 7:144,355,288...144,380,632 		JBrowse link
G ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 located_in
is_active_in		 IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:130,052,104...130,443,674
Ensembl chr 8:130,052,104...130,443,674 		JBrowse link
G BIN2 bridging integrator 2 located_in
is_active_in		 IDA
IBA		 (PMID:23285027) UniProt
GO_Central		 PMID:23285027 GO_REF:0000033 NCBI chr12:51,281,038...51,324,668
Ensembl chr12:51,281,038...51,324,668 		JBrowse link
G CCN5 cellular communication network factor 5 located_in ISO PMID:24488697 UniProt PMID:24488697 RGD:14390054 NCBI chr20:44,714,861...44,727,811
Ensembl chr20:44,714,844...44,728,509 		JBrowse link
G CD2AP CD2 associated protein located_in
is_active_in		 IEA
ISO		 (PMID:17606992) Ensembl
MGI		 PMID:17606992 GO_REF:0000107 NCBI chr 6:47,477,789...47,627,263
Ensembl chr 6:47,477,789...47,627,263 		JBrowse link
G CTTN cortactin located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr11:70,398,529...70,436,575
Ensembl chr11:70,398,404...70,436,584 		JBrowse link
G DBNL drebrin like located_in IEA
ISS		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000044 GO_REF:0000107 NCBI chr 7:44,044,702...44,069,456
Ensembl chr 7:44,044,640...44,069,456 		JBrowse link
G DNM2 dynamin 2 located_in IEA UniProt GO_REF:0000044 NCBI chr19:10,718,079...10,831,903
Ensembl chr19:10,718,055...10,833,488 		JBrowse link
G DOCK5 dedicator of cytokinesis 5 located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr 8:25,184,689...25,415,711
Ensembl chr 8:25,184,689...25,418,082 		JBrowse link
G ERC1 ELKS/RAB6-interacting/CAST family member 1 located_in ISS
IEA		 UniProt GO_REF:0000024 GO_REF:0000044 NCBI chr12:989,959...1,495,933
Ensembl chr12:990,509...1,495,933 		JBrowse link
G FERMT3 FERM domain containing kindlin 3 located_in IEA
ISS		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000044 GO_REF:0000107 NCBI chr11:64,205,920...64,223,891
Ensembl chr11:64,205,926...64,223,896 		JBrowse link
G FLII FLII actin remodeling protein located_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000044 GO_REF:0000107 NCBI chr17:18,244,815...18,259,022
Ensembl chr17:18,244,815...18,258,738 		JBrowse link
G FLNA filamin A located_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000044 GO_REF:0000107 NCBI chr  X:154,348,531...154,374,634
Ensembl chr  X:154,348,524...154,374,634 		JBrowse link
G FSCN1 fascin actin-bundling protein 1 located_in IDA (PMID:20137952) UniProt PMID:20137952 NCBI chr 7:5,592,816...5,606,655
Ensembl chr 7:5,592,816...5,606,655 		JBrowse link
G GSN gelsolin located_in IDA (PMID:24236012) UniProt PMID:24236012 NCBI chr 9:121,201,483...121,332,842
Ensembl chr 9:121,207,794...121,332,843 		JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K located_in IEA UniProt GO_REF:0000044 NCBI chr 9:83,968,083...83,980,615
Ensembl chr 9:83,968,083...83,980,631 		JBrowse link
G KIF9 kinesin family member 9 located_in IDA (PMID:21119006) UniProt PMID:21119006 NCBI chr 3:47,227,998...47,282,799
Ensembl chr 3:47,227,998...47,283,451 		JBrowse link
G LCP1 lymphocyte cytosolic protein 1 located_in IDA (PMID:24236012) UniProt PMID:24236012 NCBI chr13:46,125,923...46,182,177
Ensembl chr13:46,125,920...46,211,871 		JBrowse link
G LPXN leupaxin located_in IDA
IEA		 (PMID:12674328) UniProt
Ensembl		 PMID:12674328 GO_REF:0000044 GO_REF:0000107 NCBI chr11:58,526,871...58,578,891
Ensembl chr11:58,526,871...58,578,220 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 located_in ISO (PMID:24127566) MGI PMID:24127566 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G NOS1AP nitric oxide synthase 1 adaptor protein located_in IEA UniProt GO_REF:0000044 NCBI chr 1:162,069,691...162,370,475
Ensembl chr 1:162,069,691...162,370,475 		JBrowse link
G PALLD palladin, cytoskeletal associated protein located_in ISO
IEA		 RGD
UniProt		 PMID:16868024 GO_REF:0000044 RGD:2325783 NCBI chr 4:168,497,052...168,928,441
Ensembl chr 4:168,497,052...168,928,457 		JBrowse link
G PHLDB2 pleckstrin homology like domain family B member 2 located_in IDA
IEA		 (PMID:23525008) UniProt PMID:23525008 GO_REF:0000044 NCBI chr 3:111,732,496...111,976,517
Ensembl chr 3:111,732,497...111,976,517 		JBrowse link
G PLEC plectin located_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000044 GO_REF:0000107 NCBI chr 8:143,915,153...143,976,745
Ensembl chr 8:143,915,153...143,976,734 		JBrowse link
G PTPN12 protein tyrosine phosphatase non-receptor type 12 located_in IEA UniProt
Ensembl		 GO_REF:0000044 GO_REF:0000107 NCBI chr 7:77,537,295...77,640,069
Ensembl chr 7:77,537,295...77,640,069 		JBrowse link
G RHOU ras homolog family member U located_in IEA UniProt GO_REF:0000044 NCBI chr 1:228,644,647...228,746,669
Ensembl chr 1:228,735,479...228,746,664 		JBrowse link
G SCIN scinderin located_in IEA UniProt GO_REF:0000044 NCBI chr 7:12,570,720...12,660,182
Ensembl chr 7:12,570,577...12,660,182 		JBrowse link
G SCN8A sodium voltage-gated channel alpha subunit 8 located_in IEA UniProt GO_REF:0000044 NCBI chr12:51,591,233...51,812,864
Ensembl chr12:51,590,266...51,812,864 		JBrowse link
G SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 located_in IEA UniProt GO_REF:0000044 NCBI chr19:4,360,370...4,400,547
Ensembl chr19:4,360,370...4,400,547 		JBrowse link
G SH3PXD2A SH3 and PX domains 2A located_in IDA
IEA		 (PMID:18417249) UniProt
Ensembl		 PMID:18417249 GO_REF:0000044 GO_REF:0000107 NCBI chr10:103,594,027...103,855,576
Ensembl chr10:103,594,027...103,855,584 		JBrowse link
G SH3PXD2B SH3 and PX domains 2B located_in ISS
IEA		 UniProt GO_REF:0000024 GO_REF:0000044 NCBI chr 5:172,325,181...172,454,525
Ensembl chr 5:172,325,000...172,454,525 		JBrowse link
G SPATA13 spermatogenesis associated 13 located_in ISS
IEA		 UniProt GO_REF:0000024 GO_REF:0000044 NCBI chr13:23,979,802...24,307,069
Ensembl chr13:23,979,805...24,307,074
Ensembl chr13:23,979,805...24,307,074 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase located_in IEA Ensembl GO_REF:0000107 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G SVIL supervillin located_in IEA UniProt GO_REF:0000044 NCBI chr10:29,457,338...29,736,936
Ensembl chr10:29,457,338...29,736,959 		JBrowse link
G TJP1 tight junction protein 1 located_in IEA UniProt GO_REF:0000044 NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,915 		JBrowse link
G TNS3 tensin 3 located_in IEA UniProt GO_REF:0000044 NCBI chr 7:47,275,154...47,582,586
Ensembl chr 7:47,275,154...47,582,558 		JBrowse link
G TPM3 tropomyosin 3 located_in ISO (PMID:16765662) MGI PMID:16765662 NCBI chr 1:154,155,308...154,192,100
Ensembl chr 1:154,155,308...154,194,648 		JBrowse link
G TPM4 tropomyosin 4 located_in IEA Ensembl GO_REF:0000107 NCBI chr19:16,067,538...16,103,002
Ensembl chr19:16,067,021...16,103,005 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 located_in IDA (PMID:15220135) BHF-UCL PMID:15220135 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VCL vinculin located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr10:73,998,116...74,121,363
Ensembl chr10:73,995,193...74,121,363 		JBrowse link
G WDR1 WD repeat domain 1 located_in IEA UniProt GO_REF:0000044 NCBI chr 4:10,074,339...10,116,799
Ensembl chr 4:10,068,089...10,116,972 		JBrowse link
podosome core term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTR2 actin related protein 2 ISO RGD PMID:23158496 RGD:11530035 NCBI chr 2:65,227,831...65,271,253
Ensembl chr 2:65,227,788...65,271,253 		JBrowse link
G ACTR3 actin related protein 3 ISO RGD PMID:24290759 RGD:11530018 NCBI chr 2:113,889,934...113,962,596
Ensembl chr 2:113,890,063...113,962,596 		JBrowse link
G ARPC2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chr 2:218,217,189...218,254,348
Ensembl chr 2:218,217,141...218,254,356 		JBrowse link
podosome ring term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARPC2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chr 2:218,217,189...218,254,348
Ensembl chr 2:218,217,141...218,254,356 		JBrowse link
G VCL vinculin located_in IEA Ensembl GO_REF:0000107 NCBI chr10:73,998,116...74,121,363
Ensembl chr10:73,995,193...74,121,363 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21533
    cellular anatomical structure 21181
      intracellular anatomical structure 17092
        intracellular organelle 15359
          intracellular membraneless organelle 6793
            podosome 50
              podosome core 3
              podosome ring 2
Path 2
Term Annotations click to browse term
  cellular_component 21533
    cellular anatomical structure 21181
      organelle 16328
        membraneless organelle 6793
          intracellular membraneless organelle 6793
            cytoskeleton 2638
              actin cytoskeleton 582
                podosome 50
                  podosome core 3
                  podosome ring 2
paths to the root