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ONTOLOGY REPORT - ANNOTATIONS

Term:podosome
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Accession:GO:0002102 term browser browse the term
Definition:An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
Comment:Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
Synonyms:xref: Wikipedia:Podosome
 never_in_taxon: NCBITaxon:4751 ! Fungi

GViewer not supported for the selected species.

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podosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTB actin beta ISO RGD PMID:17111031 RGD:11541102 NCBI chr28:16,195,676...16,197,161
Ensembl chr12:52,426,752...52,427,879 		JBrowse link
G ACTR3 actin related protein 3 ISO RGD PMID:15093736 PMID:17224451 RGD:2306207 RGD:2306209 NCBI chr10:16,296,350...16,369,561
Ensembl chr10:16,297,502...16,369,220 		JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 located_in IEA Ensembl GO_REF:0000107 NCBI chr26:53,114,184...53,129,650
Ensembl chr26:53,114,924...53,126,900 		JBrowse link
G AFAP1L1 actin filament associated protein 1 like 1 located_in IEA UniProt GO_REF:0000044 NCBI chr23:51,893,641...51,959,949
Ensembl chr23:51,920,796...51,963,359 		JBrowse link
G AMOTL2 angiomotin like 2 located_in IEA UniProt
Ensembl		 GO_REF:0000044 GO_REF:0000107 NCBI chr15:56,002,474...56,021,838
Ensembl chr15:56,003,236...56,022,123 		JBrowse link
G ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 1:63,923,241...63,991,221
Ensembl chr 1:63,920,076...63,960,771 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 located_in ISO (PMID:21352810) MGI PMID:21352810 NCBI chr20:7,884,220...7,927,738
Ensembl chr20:7,905,662...7,930,657 		JBrowse link
G ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 located_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:124,515,274...124,912,076
Ensembl chr 8:124,514,210...124,869,668 		JBrowse link
G BIN2 bridging integrator 2 located_in ISO (PMID:23285027) UniProt PMID:23285027 NCBI chr11:47,480,322...47,521,970 JBrowse link
G CCN5 cellular communication network factor 5 located_in ISO PMID:24488697 UniProt PMID:24488697 RGD:14390054 NCBI chr 2:19,089,944...19,103,051
Ensembl chr 2:19,088,597...19,103,136 		JBrowse link
G CD2AP CD2 associated protein located_in
is_active_in		 IEA
ISO		 (PMID:17606992) Ensembl
MGI		 PMID:17606992 GO_REF:0000107 NCBI chr17:24,664,245...24,815,786
Ensembl chr17:24,663,872...24,815,829 		JBrowse link
G CTTN cortactin located_in IEA Ensembl GO_REF:0000107 NCBI chr 1:4,139,045...4,176,962
Ensembl chr 1:4,137,814...4,176,446 		JBrowse link
G DBNL drebrin like located_in IEA UniProt
Ensembl		 GO_REF:0000044 GO_REF:0000107 NCBI chr21:14,610,196...14,627,363
Ensembl chr21:14,608,571...14,627,321 		JBrowse link
G DOCK5 dedicator of cytokinesis 5 located_in IEA Ensembl GO_REF:0000107 NCBI chr 8:23,310,524...23,540,174
Ensembl chr 8:23,310,673...23,540,478 		JBrowse link
G ERC1 ELKS/RAB6-interacting/CAST family member 1 located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chr11:989,376...1,530,470
Ensembl chr11:1,030,294...1,524,817 		JBrowse link
G FERMT3 FERM domain containing kindlin 3 located_in IEA Ensembl GO_REF:0000107 NCBI chr 1:10,012,007...10,031,177
Ensembl chr 1:10,009,626...10,031,209 		JBrowse link
G FLII FLII actin remodeling protein located_in IEA Ensembl GO_REF:0000107 NCBI chr16:17,285,400...17,300,210
Ensembl chr16:17,285,724...17,300,041 		JBrowse link
G FLNA filamin A located_in IEA Ensembl GO_REF:0000107 NCBI chr  X:128,657,580...128,683,812
Ensembl chr  X:128,657,393...128,680,531 		JBrowse link
G FSCN1 fascin actin-bundling protein 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr28:16,127,033...16,142,285
Ensembl chr28:16,127,015...16,142,337 		JBrowse link
G GSN gelsolin located_in IEA Ensembl GO_REF:0000107 NCBI chr12:18,253,079...18,317,285
Ensembl chr12:18,253,324...18,285,938 		JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K located_in IEA UniProt GO_REF:0000044 NCBI chr12:94,768,403...94,789,957
Ensembl chr12:94,768,480...94,789,743 		JBrowse link
G KIF9 kinesin family member 9 located_in IEA Ensembl GO_REF:0000107 NCBI chr22:8,626,636...8,685,473
Ensembl chr22:8,632,849...8,680,002 		JBrowse link
G LCP1 lymphocyte cytosolic protein 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 3:24,182,086...24,238,746
Ensembl chr 3:24,182,076...24,238,651 		JBrowse link
G LOC103218670 heterogeneous nuclear ribonucleoprotein K-like located_in IEA UniProt GO_REF:0000044 NCBI chr11:14,500,971...14,502,440 JBrowse link
G LOC103226102 tensin-3 located_in ISO (PMID:27505886) MGI PMID:27505886 NCBI chr21:11,248,003...11,554,903
Ensembl chr21:11,292,788...11,554,933 		JBrowse link
G LOC103230439 heterogeneous nuclear ribonucleoprotein K-like located_in IEA UniProt GO_REF:0000044 NCBI chr25:44,517,612...44,519,703 JBrowse link
G LPXN leupaxin located_in IEA UniProt
Ensembl		 GO_REF:0000044 GO_REF:0000107 NCBI chr 1:14,776,434...14,827,095
Ensembl chr 1:14,779,606...14,827,301 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 located_in ISO (PMID:24127566) MGI PMID:24127566 NCBI chr 9:43,356,603...43,489,066
Ensembl chr 9:43,356,308...43,393,425 		JBrowse link
G PALLD palladin, cytoskeletal associated protein ISO RGD PMID:16868024 RGD:2325783 NCBI chr 7:114,758,017...115,173,240 JBrowse link
G PHLDB2 pleckstrin homology like domain family B member 2 located_in IEA Ensembl GO_REF:0000107 NCBI chr22:68,821,958...69,059,087
Ensembl chr22:68,821,742...69,059,087 		JBrowse link
G PLEC plectin located_in IEA Ensembl GO_REF:0000107 NCBI chr 8:138,125,471...138,187,209
Ensembl chr 8:138,125,280...138,149,364 		JBrowse link
G PTPN12 protein tyrosine phosphatase non-receptor type 12 located_in IEA Ensembl GO_REF:0000107 NCBI chr21:71,285,917...71,389,645
Ensembl chr21:71,285,736...71,389,926 		JBrowse link
G SCIN scinderin located_in IEA UniProt GO_REF:0000044 NCBI chr21:45,453,034...45,537,733
Ensembl chr21:45,452,659...45,537,323 		JBrowse link
G SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 located_in IEA UniProt GO_REF:0000044 NCBI chr 6:4,090,800...4,130,566
Ensembl chr 6:4,091,359...4,130,578 		JBrowse link
G SH3PXD2A SH3 and PX domains 2A located_in IEA Ensembl GO_REF:0000107 NCBI chr 9:96,645,955...96,898,749 JBrowse link
G SH3PXD2B SH3 and PX domains 2B located_in IEA UniProt GO_REF:0000044 NCBI chr23:74,498,389...74,613,296
Ensembl chr23:74,498,381...74,613,123 		JBrowse link
G SPATA13 spermatogenesis associated 13 located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chr 3:3,767,078...4,085,379
Ensembl chr 3:3,932,482...4,085,375 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase located_in IEA Ensembl GO_REF:0000107 NCBI chr 2:26,344,480...26,367,448
Ensembl chr 2:26,343,450...26,367,776 		JBrowse link
G TPM3 tropomyosin 3 located_in ISO (PMID:16765662) MGI PMID:16765662 NCBI chr20:9,630,056...9,669,819
Ensembl chr20:9,638,678...9,653,039 		JBrowse link
G TPM4 tropomyosin 4 located_in ISO (PMID:16765662) MGI PMID:16765662 NCBI chr 6:14,566,958...14,604,754
Ensembl chr 6:14,566,869...14,598,934 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr20:32,616,425...32,635,903
Ensembl chr20:32,615,333...32,635,862 		JBrowse link
G VCL vinculin located_in IEA UniProt
Ensembl		 GO_REF:0000044 GO_REF:0000107 NCBI chr 9:57,253,219...57,375,947
Ensembl chr 9:57,255,166...57,376,028 		JBrowse link
podosome core term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTR2 actin related protein 2 ISO RGD PMID:23158496 RGD:11530035 NCBI chr14:41,740,432...41,780,045
Ensembl chr14:41,739,968...41,779,964 		JBrowse link
G ACTR3 actin related protein 3 ISO RGD PMID:24290759 RGD:11530018 NCBI chr10:16,296,350...16,369,561
Ensembl chr10:16,297,502...16,369,220 		JBrowse link
G ARPC2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chr10:104,098,275...104,144,043
Ensembl chr10:104,098,402...104,135,791 		JBrowse link
podosome ring term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARPC2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chr10:104,098,275...104,144,043
Ensembl chr10:104,098,402...104,135,791 		JBrowse link
G VCL vinculin located_in IEA Ensembl GO_REF:0000107 NCBI chr 9:57,253,219...57,375,947
Ensembl chr 9:57,255,166...57,376,028 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 17932
    cellular anatomical structure 17824
      intracellular anatomical structure 14332
        intracellular organelle 12802
          intracellular membraneless organelle 4967
            podosome 44
              podosome core 3
              podosome ring 2
Path 2
Term Annotations click to browse term
  cellular_component 17932
    cellular anatomical structure 17824
      organelle 13228
        membraneless organelle 4967
          intracellular membraneless organelle 4967
            cytoskeleton 2343
              actin cytoskeleton 555
                podosome 44
                  podosome core 3
                  podosome ring 2
paths to the root