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ONTOLOGY REPORT - ANNOTATIONS

Term:podosome
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Accession:GO:0002102 term browser browse the term
Definition:An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
Comment:Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
Synonyms:xref: Wikipedia:Podosome
 never_in_taxon: NCBITaxon:4751 ! Fungi


show annotations for term's descendants           Sort by:
podosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTB actin beta ISO RGD PMID:17111031 RGD:11541102
G ACTR3 actin related protein 3 ISO RGD PMID:15093736 PMID:17224451 RGD:2306207 RGD:2306209 NCBI chr2B:827,184...900,424
Ensembl chr2B:114,373,392...114,445,729 		JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 located_in IEA Ensembl GO_REF:0000107 Ensembl chr10:134,172,724...134,186,227 JBrowse link
G AFAP1L1 actin filament associated protein 1 like 1 located_in IEA UniProt GO_REF:0000044 NCBI chr 5:144,698,397...144,767,606
Ensembl chr 5:150,708,786...150,778,670 		JBrowse link
G AMOTL2 angiomotin like 2 located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr 3:131,402,375...131,421,030
Ensembl chr 3:138,874,309...138,892,913 		JBrowse link
G ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr11:67,763,944...67,831,728
Ensembl chr11:70,985,926...71,028,342 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 located_in ISO (PMID:21352810) MGI PMID:21352810 NCBI chr 1:131,282,514...131,326,535
Ensembl chr 1:135,112,040...135,159,299 		JBrowse link
G ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:126,688,608...127,080,662
Ensembl chr 8:129,418,796...130,021,261 		JBrowse link
G BIN2 bridging integrator 2 located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:37,430,061...37,473,182
Ensembl chr12:38,314,126...38,357,264 		JBrowse link
G CCN5 cellular communication network factor 5 located_in ISO PMID:24488697 UniProt PMID:24488697 RGD:14390054 NCBI chr20:41,045,205...41,058,137
Ensembl chr20:42,139,551...42,152,563 		JBrowse link
G CD2AP CD2 associated protein located_in
is_active_in		 IEA
ISO		 (PMID:17606992) Ensembl
MGI		 PMID:17606992 GO_REF:0000107 NCBI chr 6:47,065,284...47,210,746
Ensembl chr 6:48,328,863...48,474,163 		JBrowse link
G CTTN cortactin located_in IEA Ensembl GO_REF:0000107 NCBI chr11:65,500,074...65,539,158
Ensembl chr11:68,794,162...68,823,857 		JBrowse link
G DBNL drebrin like located_in IEA UniProt GO_REF:0000044 NCBI chr 7:44,753,062...44,775,717
Ensembl chr 7:44,824,608...44,845,891 		JBrowse link
G DOCK5 dedicator of cytokinesis 5 located_in IEA Ensembl GO_REF:0000107 NCBI chr 8:24,463,582...24,696,736
Ensembl chr 8:21,372,756...21,605,877 		JBrowse link
G ERC1 ELKS/RAB6-interacting/CAST family member 1 located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chr12:1,066,034...1,597,562
Ensembl chr12:1,027,967...1,545,431 		JBrowse link
G FERMT3 FERM domain containing kindlin 3 located_in IEA Ensembl GO_REF:0000107 NCBI chr11:59,562,861...59,581,054
Ensembl chr11:62,909,030...62,928,191 		JBrowse link
G FLII FLII actin remodeling protein located_in IEA Ensembl GO_REF:0000107 NCBI chr17:32,789,717...32,803,661
Ensembl chr17:37,949,994...37,965,414 		JBrowse link
G FLNA filamin A located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chr  X:143,799,088...143,825,282 JBrowse link
G FSCN1 fascin actin-bundling protein 1 located_in ISO (PMID:20137952) UniProt PMID:20137952 NCBI chr 7:5,848,902...5,862,756 JBrowse link
G GSN gelsolin located_in IEA Ensembl GO_REF:0000107 NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831 		JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K located_in IEA UniProt GO_REF:0000044 NCBI chr 9:40,898,593...40,911,159
Ensembl chr 9:83,324,238...83,336,756 		JBrowse link
G KIF9 kinesin family member 9 located_in IEA Ensembl GO_REF:0000107 NCBI chr 3:47,130,047...47,183,636
Ensembl chr 3:48,229,703...48,283,002 		JBrowse link
G LCP1 lymphocyte cytosolic protein 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr13:26,820,846...26,906,916 JBrowse link
G LOC100977130 tropomyosin alpha-3 chain located_in ISO (PMID:16765662) MGI PMID:16765662 NCBI chr 1:129,511,914...129,538,703
Ensembl chr 1:133,126,641...133,161,894 		JBrowse link
G LPXN leupaxin located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr11:53,781,270...53,832,785
Ensembl chr11:57,243,028...57,293,442 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 located_in ISO (PMID:24127566) MGI PMID:24127566 NCBI chr10:45,806,748...45,936,362 JBrowse link
G PALLD palladin, cytoskeletal associated protein ISO RGD PMID:16868024 RGD:2325783 NCBI chr 4:160,718,475...161,140,436 JBrowse link
G PHLDB2 pleckstrin homology like domain family B member 2 located_in IEA Ensembl GO_REF:0000107 NCBI chr 3:108,878,798...109,120,501
Ensembl chr 3:115,745,634...116,044,586 		JBrowse link
G PLEC plectin located_in IEA Ensembl GO_REF:0000107 NCBI chr 8:140,681,252...140,742,753
Ensembl chr 8:143,674,696...143,712,433 		JBrowse link
G PTPN12 protein tyrosine phosphatase non-receptor type 12 located_in IEA Ensembl GO_REF:0000107 NCBI chr 7:69,457,158...69,560,111
Ensembl chr 7:83,268,834...83,371,120 		JBrowse link
G SCIN scinderin located_in IEA UniProt GO_REF:0000044 NCBI chr 7:13,269,361...13,351,854
Ensembl chr 7:12,613,996...12,696,244 		JBrowse link
G SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 located_in IEA UniProt GO_REF:0000044 NCBI chr19:3,383,267...3,423,165
Ensembl chr19:4,329,750...4,340,121 		JBrowse link
G SH3PXD2A SH3 and PX domains 2A located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr10:100,193,961...100,455,200
Ensembl chr10:103,663,163...103,861,437 		JBrowse link
G SH3PXD2B SH3 and PX domains 2B located_in IEA UniProt GO_REF:0000044 NCBI chr 5:167,678,633...167,807,960
Ensembl chr 5:174,591,759...174,719,957 		JBrowse link
G SPATA13 spermatogenesis associated 13 located_in ISO (PMID:23525008) UniProt PMID:23525008 NCBI chr13:5,298,466...5,626,162
Ensembl chr13:23,837,412...23,921,025 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase located_in IEA Ensembl GO_REF:0000107 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634 		JBrowse link
G TNS3 tensin 3 located_in ISO (PMID:27505886) MGI PMID:27505886 NCBI chr 7:47,915,668...48,223,267
Ensembl chr 7:48,025,720...48,221,437 		JBrowse link
G TPM4 tropomyosin 4 located_in ISO (PMID:16765662) MGI PMID:16765662 NCBI chr19:15,557,683...15,593,143
Ensembl chr19:16,540,805...16,575,312 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 1:103,377,815...103,395,118
Ensembl chr 1:102,091,336...102,107,732 		JBrowse link
G VCL vinculin located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr10:70,521,259...70,641,917
Ensembl chr10:73,191,375...73,311,296 		JBrowse link
podosome core term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTR2 actin related protein 2 ISO RGD PMID:23158496 RGD:11530035 NCBI chr2A:65,289,675...65,333,219
Ensembl chr2A:66,413,011...66,456,857 		JBrowse link
G ACTR3 actin related protein 3 ISO RGD PMID:24290759 RGD:11530018 NCBI chr2B:827,184...900,424
Ensembl chr2B:114,373,392...114,445,729 		JBrowse link
G ARPC2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chr2B:105,478,035...105,513,665
Ensembl chr2B:224,076,356...224,111,643 		JBrowse link
podosome ring term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARPC2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chr2B:105,478,035...105,513,665
Ensembl chr2B:224,076,356...224,111,643 		JBrowse link
G VCL vinculin located_in IEA Ensembl GO_REF:0000107 NCBI chr10:70,521,259...70,641,917
Ensembl chr10:73,191,375...73,311,296 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 17427
    cellular anatomical structure 17201
      intracellular anatomical structure 13807
        intracellular organelle 12344
          intracellular membraneless organelle 4803
            podosome 42
              podosome core 3
              podosome ring 2
Path 2
Term Annotations click to browse term
  cellular_component 17427
    cellular anatomical structure 17201
      organelle 12755
        membraneless organelle 4803
          intracellular membraneless organelle 4803
            cytoskeleton 2260
              actin cytoskeleton 525
                podosome 42
                  podosome core 3
                  podosome ring 2
paths to the root