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ONTOLOGY REPORT - ANNOTATIONS

Term:podosome
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Accession:GO:0002102 term browser browse the term
Definition:An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.
Comment:Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
Synonyms:xref: Wikipedia:Podosome
 never_in_taxon: NCBITaxon:4751 ! Fungi


show annotations for term's descendants           Sort by:
podosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta IDA RGD PMID:17111031 RGD:11541102 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Actr3 actin related protein 3 IDA RGD PMID:17224451 PMID:15093736 RGD:2306207, RGD:2306209 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124 		JBrowse link
G Adam8 ADAM metallopeptidase domain 8 located_in ISO (PMID:15220135) RGD PMID:15220135 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801 		JBrowse link
G Afap1l1 actin filament associated protein 1-like 1 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr18:55,183,786...55,244,174
Ensembl chr18:55,183,786...55,244,146 		JBrowse link
G Amotl2 angiomotin like 2 located_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000044
(PMID:23525008)		 UniProt
RGD		 PMID:23525008 GO_REF:0000024 GO_REF:0000044 NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 located_in ISO (PMID:21352810) RGD PMID:21352810 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355 		JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 located_in
is_active_in		 IEA
ISO
IBA		 GO_REF:0000107
(PMID:21352810)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:21352810 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:95,786,130...96,093,111
Ensembl chr 7:95,787,818...96,092,754 		JBrowse link
G Bin2 bridging integrator 2 located_in
is_active_in		 ISO
IBA
IEA
ISS		 (PMID:23285027)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:23285027 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:131,742,001...131,768,208
Ensembl chr 7:131,742,002...131,786,285 		JBrowse link
G Ccn5 cellular communication network factor 5 located_in IDA PMID:24488697 UniProt PMID:24488697 RGD:14390054 NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636 		JBrowse link
G Cd2ap CD2-associated protein located_in
is_active_in		 IEA
ISO		 GO_REF:0000107
(PMID:17606992)		 Ensembl
RGD		 PMID:17606992 GO_REF:0000107 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199 		JBrowse link
G Cela1 chymotrypsin like elastase 1 located_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 7:131,773,161...131,786,300
Ensembl chr 7:131,742,002...131,786,285 		JBrowse link
G Cttn cortactin located_in IEA
ISO		 GO_REF:0000107
(PMID:17893324)		 Ensembl
RGD		 PMID:17893324 GO_REF:0000107 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164 		JBrowse link
G Dbnl drebrin-like located_in ISS
ISO		 GO_REF:0000024
(PMID:22303001)		 UniProt
RGD		 PMID:22303001 GO_REF:0000024 NCBI chr14:80,666,115...80,681,155
Ensembl chr14:80,666,124...80,681,155 		JBrowse link
G Dnm2 dynamin 2 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157 		JBrowse link
G Dock5 dedicator of cytokinesis 5 located_in ISO (PMID:27505886) RGD PMID:27505886 NCBI chr15:41,979,728...42,158,733
Ensembl chr15:41,979,729...42,158,649 		JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 located_in ISS
ISO		 GO_REF:0000024
(PMID:23525008)		 UniProt
RGD		 PMID:23525008 GO_REF:0000024 NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639 		JBrowse link
G Fermt3 FERM domain containing kindlin 3 located_in ISO (PMID:16876785) RGD PMID:16876785 NCBI chr 1:204,189,483...204,207,683
Ensembl chr 1:204,189,484...204,207,587 		JBrowse link
G Flii FLII, actin remodeling protein located_in IEA
ISO		 GO_REF:0000107
(PMID:23525008)		 Ensembl
RGD		 PMID:23525008 GO_REF:0000107 NCBI chr10:45,394,032...45,408,051
Ensembl chr10:45,394,032...45,407,970 		JBrowse link
G Flna filamin A located_in IEA
ISO		 GO_REF:0000107
(PMID:23525008)		 Ensembl
RGD		 PMID:23525008 GO_REF:0000107 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 located_in ISO
IEA
ISS		 (PMID:20137952)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:20137952 GO_REF:0000024 GO_REF:0000107 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211 		JBrowse link
G Gsn gelsolin located_in ISO
IEA		 (PMID:24236012)
GO_REF:0000107		 RGD
Ensembl		 PMID:24236012 GO_REF:0000107 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Hnrnpk-ps1 heterogeneous nuclear ribonucleoprotein K, pseudogene 1 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr14:91,756,628...91,758,358
Ensembl chr14:91,756,837...91,758,227 		JBrowse link
G Kif9 kinesin family member 9 located_in ISO (PMID:21119006) RGD PMID:21119006 NCBI chr 8:110,459,467...110,504,492
Ensembl chr 8:110,459,383...110,505,252 		JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 located_in ISO (PMID:24236012) RGD PMID:24236012 NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680 		JBrowse link
G LOC100359916 heterogeneous nuclear ribonucleoprotein K-like located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 5:58,668,326...58,670,222
Ensembl chr 5:58,668,327...58,670,220 		JBrowse link
G Lpxn leupaxin located_in ISO (PMID:12674328) RGD PMID:12674328 NCBI chr 1:209,928,297...209,963,085
Ensembl chr 1:209,929,202...209,963,084 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 located_in ISO (PMID:24127566) RGD PMID:24127566 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nos1ap nitric oxide synthase 1 adaptor protein located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr13:82,547,799...82,820,999
Ensembl chr13:82,530,577...82,820,949 		JBrowse link
G Palld palladin, cytoskeletal associated protein IDA RGD PMID:16868024 RGD:2325783 NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337 		JBrowse link
G Phldb2 pleckstrin homology-like domain, family B, member 2 located_in ISO (PMID:23525008) RGD PMID:23525008 NCBI chr11:54,859,173...55,078,212
Ensembl chr11:54,859,135...55,078,467 		JBrowse link
G Plec plectin located_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:23525008)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23525008 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467 		JBrowse link
G Ptpn12 protein tyrosine phosphatase, non-receptor type 12 located_in ISO (PMID:12674328) RGD PMID:12674328 NCBI chr 4:14,020,997...14,092,931
Ensembl chr 4:14,021,052...14,092,927 		JBrowse link
G Scin scinderin located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 6:57,109,500...57,188,123
Ensembl chr 6:57,109,403...57,188,242 		JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 9:842,285...869,753
Ensembl chr 9:842,288...869,716 		JBrowse link
G Sh3pxd2a SH3 and PX domains 2A located_in ISO (PMID:18417249)
(PMID:12615925)		 RGD PMID:12615925 PMID:18417249 NCBI chr 1:246,153,660...246,359,806
Ensembl chr 1:246,160,502...246,360,166 		JBrowse link
G Sh3pxd2b SH3 and PX domains 2B located_in ISO (PMID:19144821), (PMID:19669234) RGD PMID:19144821 PMID:19669234 NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170 		JBrowse link
G Spata13 spermatogenesis associated 13 located_in ISO (PMID:23525008) RGD PMID:23525008 NCBI chr15:34,778,479...34,907,645
Ensembl chr15:34,778,473...34,905,114 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase located_in ISO (PMID:17893324) RGD PMID:17893324 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tns3 tensin 3 located_in ISO (PMID:27505886) RGD PMID:27505886 NCBI chr14:83,173,649...83,405,671
Ensembl chr14:83,173,649...83,405,998 		JBrowse link
G Tpm3 tropomyosin 3 located_in ISO (PMID:16765662) RGD PMID:16765662 NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013 		JBrowse link
G Tpm4 tropomyosin 4 located_in IEA
ISO		 GO_REF:0000107
(PMID:16765662)		 Ensembl
RGD		 PMID:16765662 GO_REF:0000107 NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 located_in ISO (PMID:15220135) RGD PMID:15220135 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vcl vinculin located_in IEA
ISO		 GO_REF:0000044
(PMID:17893324)		 UniProt
RGD		 PMID:17893324 GO_REF:0000044 NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606 		JBrowse link
G Wdr1 WD repeat domain 1 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr14:72,258,032...72,291,768
Ensembl chr14:72,257,956...72,291,766 		JBrowse link
podosome core term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 IDA RGD PMID:23158496 RGD:11530035 NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524 		JBrowse link
G Actr3 actin related protein 3 IDA RGD PMID:24290759 RGD:11530018 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124 		JBrowse link
G Arpc2 actin related protein 2/3 complex, subunit 2 IDA RGD PMID:17224451 RGD:2306207 NCBI chr 9:75,820,782...75,851,471
Ensembl chr 9:75,820,770...75,851,471 		JBrowse link
podosome ring term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc2 actin related protein 2/3 complex, subunit 2 IDA RGD PMID:17224451 RGD:2306207 NCBI chr 9:75,820,782...75,851,471
Ensembl chr 9:75,820,770...75,851,471 		JBrowse link
G Vcl vinculin located_in IEA
ISO		 GO_REF:0000107
(PMID:27505886)		 Ensembl
RGD		 PMID:27505886 GO_REF:0000107 NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20833
    cellular anatomical structure 20633
      intracellular anatomical structure 15189
        intracellular organelle 13569
          intracellular membraneless organelle 5268
            podosome 47
              podosome core 3
              podosome ring 2
Path 2
Term Annotations click to browse term
  cellular_component 20833
    cellular anatomical structure 20633
      organelle 13975
        membraneless organelle 5268
          intracellular membraneless organelle 5268
            cytoskeleton 2384
              actin cytoskeleton 548
                podosome 47
                  podosome core 3
                  podosome ring 2
paths to the root