Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of heart rate
go back to main search page
Accession:GO:0002027 term browser browse the term
Definition:Any process that modulates the frequency or rate of heart contraction.
Synonyms:exact_synonym: cardiac chronotropy;   regulation of heart contraction rate;   regulation of rate of heart contraction


show annotations for term's descendants           Sort by:
regulation of heart rate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IDA RGD PMID:11897768 RGD:70484 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ank2 ankyrin 2 involved_in ISO (PMID:18832177) RGD PMID:18832177 NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E acts_upstream_of_or_within ISO MGI:3526823 (PMID:14976402) RGD PMID:14976402 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2182962 (PMID:16690884)		 Ensembl
RGD		 PMID:16690884 GO_REF:0000107 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752 		JBrowse link
G Calm1 calmodulin 1 involved_in ISO (PMID:23040497) RGD PMID:23040497 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Calm2 calmodulin 2 involved_in ISO (PMID:23040497) RGD PMID:23040497 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287 		JBrowse link
G Calm3 calmodulin 3 involved_in ISO (PMID:23040497) RGD PMID:23040497 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207 		JBrowse link
G Casq2 calsequestrin 2 involved_in ISO
IEA		 (PMID:15485681), (PMID:16601229), (PMID:16908766)
(PMID:16932808)
GO_REF:0000107		 RGD
Ensembl		 PMID:15485681 PMID:16601229 PMID:16908766 PMID:16932808 GO_REF:0000107 NCBI chr 2:189,526,003...189,582,276
Ensembl chr 2:189,525,960...189,582,267 		JBrowse link
G Cav3 caveolin 3 involved_in ISO (PMID:17060380) RGD PMID:17060380 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
G Dmd dystrophin involved_in ISO (PMID:19027585)
(PMID:20080623)		 RGD PMID:19027585 PMID:20080623 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207 		JBrowse link
G Drd2 dopamine receptor D2 acts_upstream_of_or_within ISO MGI:1857875 (PMID:11566895) RGD PMID:11566895 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Ednra endothelin receptor type A involved_in IEA
ISO		 GO_REF:0000107
MGI:102720 (PMID:16399858)		 Ensembl
RGD		 PMID:16399858 GO_REF:0000107 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Ednrb endothelin receptor type B involved_in ISO MGI:105923 (PMID:16399858) RGD PMID:16399858 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Epas1 endothelial PAS domain protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1861921 (PMID:9808618)		 Ensembl
RGD		 PMID:9808618 GO_REF:0000107 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B acts_upstream_of_or_within ISO MGI:3623214 (PMID:16672364) RGD PMID:16672364 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653 		JBrowse link
G Gpd1l glycerol-3-phosphate dehydrogenase 1 like involved_in ISO (PMID:17967977), (PMID:19666841) RGD PMID:17967977 PMID:19666841 NCBI chr 8:114,591,103...114,620,771
Ensembl chr 8:114,588,487...114,620,723 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 involved_in ISO
ISS		 (PMID:16407510)
GO_REF:0000024		 RGD
UniProt		 PMID:16407510 GO_REF:0000024 NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639 		JBrowse link
G Hrc histidine rich calcium binding protein involved_in ISO (PMID:18617481) RGD PMID:18617481 NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984 		JBrowse link
G Irx5 iroquois homeobox 5 acts_upstream_of_or_within ISO MGI:3610374 (PMID:16239150) RGD PMID:16239150 NCBI chr19:14,639,052...14,643,911
Ensembl chr19:14,624,225...14,642,318 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 acts_upstream_of_or_within ISO MGI:6358100 (PMID:29666184) RGD PMID:29666184 NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO MGI:3056651 (PMID:20368164) RGD PMID:20368164 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Mc3r melanocortin 3 receptor IMP RGD PMID:21091037 RGD:6484594 NCBI chr 3:161,016,347...161,017,444
Ensembl chr 3:161,016,347...161,017,444 		JBrowse link
G Mdm2 MDM2 proto-oncogene acts_upstream_of_or_within ISO MGI:107934 (PMID:22821713) RGD PMID:22821713 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mdm4 MDM4 regulator of p53 acts_upstream_of_or_within ISO MGI:96952 (PMID:22821713) RGD PMID:22821713 NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226 		JBrowse link
G Mybpc3 myosin binding protein C3 acts_upstream_of_or_within ISO (PMID:10532952) RGD PMID:10532952 NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405 		JBrowse link
G Myh6 myosin heavy chain 6 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:15621050)
MGI:2182704 (PMID:9541509)
GO_REF:0000107		 RGD
Ensembl		 PMID:9541509 PMID:15621050 GO_REF:0000107 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 involved_in ISO
IEA		 (PMID:15621050)
GO_REF:0000107		 RGD
Ensembl		 PMID:15621050 GO_REF:0000107 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide IDA RGD PMID:3668162 RGD:2304216 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490 		JBrowse link
G Pde4d phosphodiesterase 4D involved_in ISO (PMID:16213210) RGD PMID:16213210 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Pmch pro-melanin-concentrating hormone IDA RGD PMID:17045349 RGD:1642492 NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250 		JBrowse link
G Popdc1 popeye domain cAMP effector 1 acts_upstream_of_or_within ISO MGI:2385915 (PMID:22354168) RGD PMID:22354168 NCBI chr20:48,819,241...48,860,282
Ensembl chr20:48,822,308...48,857,472 		JBrowse link
G Popdc2 popeye domain cAMP effector 2 acts_upstream_of_or_within ISO MGI:3773727 (PMID:22354168) RGD PMID:22354168 NCBI chr11:62,351,843...62,398,688
Ensembl chr11:62,374,759...62,390,756 		JBrowse link
G Ryr2 ryanodine receptor 2 involved_in ISO (PMID:11159936), (PMID:12919952), (PMID:15197150)
(PMID:17872467)		 RGD PMID:11159936 PMID:12919952 PMID:15197150 PMID:17872467 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in ISO
IBA		 (PMID:20062061), (PMID:21041692)
GO_REF:0000033		 RGD
GO_Central		 PMID:20062061 PMID:21041692 GO_REF:0000033 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:10471492), (PMID:18065446), (PMID:18616619), (PMID:21895525), (PMID:22529811), (PMID:23085483), (PMID:26279430), (PMID:26392562)		 BHF-UCL
GO_Central
RGD		 PMID:10471492 PMID:18065446 PMID:18616619 PMID:21895525 PMID:22529811 More... GO_REF:0000024 GO_REF:0000033 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Sema3a semaphorin 3A acts_upstream_of_or_within ISO MGI:2158944 (PMID:17417650) RGD PMID:17417650 NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432 		JBrowse link
G Shox2 SHOX homeobox 2 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
(PMID:19166829)		 Ensembl
RGD		 PMID:19166829 GO_REF:0000107 NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 involved_in ISO MGI:2655190 (PMID:23361868) RGD PMID:23361868 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 involved_in ISO (PMID:10967099) RGD PMID:10967099 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
G Snta1 syntrophin, alpha 1 involved_in ISO (PMID:18591664) RGD PMID:18591664 NCBI chr 3:142,876,285...142,906,737
Ensembl chr 3:142,876,296...142,906,709 		JBrowse link
G Tmem161b transmembrane protein 161B involved_in ISO (PMID:33597309) RGD PMID:33597309 NCBI chr 2:14,714,451...14,793,809
Ensembl chr 2:14,715,701...14,793,803 		JBrowse link
G Tnni3k TNNI3 interacting kinase involved_in ISO
IEA
ISS		 UniProtKB:Q5GIG6 (PMID:23236294), (PMID:24925317)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
BHF-UCL		 PMID:23236294 PMID:24925317 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:243,737,346...244,005,319
Ensembl chr 2:243,710,950...244,005,268 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 NOT|involved_in IMP PMID:23136043 UniProt PMID:23136043 RGD:10400856 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517 		JBrowse link
negative regulation of heart rate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor, type 2 involved_in ISO (PMID:9449684) RGD PMID:9449684 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B involved_in ISO (PMID:12837242) RGD PMID:12837242 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653 		JBrowse link
G Gjd3 gap junction protein, delta 3 involved_in ISO (PMID:16571663) RGD PMID:16571663 NCBI chr10:83,933,694...83,935,759
Ensembl chr10:83,934,135...83,934,971 		JBrowse link
G Npff neuropeptide FF-amide peptide precursor IDA RGD PMID:8680863 RGD:2316573 NCBI chr 7:133,654,530...133,655,319 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IMP RGD PMID:19015400 RGD:4108483 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pln phospholamban involved_in ISO
IBA		 (PMID:16432188)
GO_REF:0000033		 RGD
GO_Central		 PMID:16432188 GO_REF:0000033 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Rnls renalase, FAD-dependent amine oxidase involved_in ISO (PMID:15841207) RGD PMID:15841207 NCBI chr 1:231,037,481...231,309,855
Ensembl chr 1:231,037,486...231,309,823 		JBrowse link
G Sptbn4 spectrin, beta, non-erythrocytic 4 acts_upstream_of_or_within ISO MGI:1856134 (PMID:20877009) RGD PMID:20877009 NCBI chr 1:82,650,750...82,738,345
Ensembl chr 1:82,650,751...82,737,228 		JBrowse link
G Spx spexin hormone involved_in IDA PMID:22038051 UniProt PMID:22038051 RGD:8693358 NCBI chr 4:175,356,044...175,362,082
Ensembl chr 4:175,356,247...175,362,082 		JBrowse link
G Sri sorcin involved_in ISO (PMID:12754254) RGD PMID:12754254 NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077 		JBrowse link
G Tac1 tachykinin, precursor 1 IDA RGD PMID:2471579 RGD:2305984 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tnf tumor necrosis factor IMP RGD PMID:7875478 RGD:14975128 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:27335281 RGD:13792700 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Uts2 urotensin 2 IDA RGD PMID:12217424 RGD:2306871 NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237 		JBrowse link
negative regulation of heart rate by acetylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm3 cholinergic receptor, muscarinic 3 IMP RGD PMID:9316844 RGD:2303391 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2387663 (PMID:12093905)		 Ensembl
RGD		 PMID:12093905 GO_REF:0000107 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
positive regulation of heart rate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857117|MGI:2681791 (PMID:16626672)		 Ensembl
RGD		 PMID:16626672 GO_REF:0000107 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adm adrenomedullin involved_in IDA
ISO
IBA		 (PMID:18434369)
GO_REF:0000033		 RGD
GO_Central		 PMID:18434369 PMID:19520650 GO_REF:0000033, RGD:2325635 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Adm2 adrenomedullin 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:120,393,179...120,394,965
Ensembl chr 7:120,393,179...120,396,331 		JBrowse link
G Adra1a adrenoceptor alpha 1A IMP RGD PMID:22040923 RGD:5688308 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:9089896 RGD:5129112 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Apln apelin IDA RGD PMID:12798955 RGD:1626237 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391 		JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 IDA RGD PMID:12686462 RGD:13800918 NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A IMP RGD PMID:18339407 RGD:2300339 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:20060787 RGD:5130949 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Edn1 endothelin 1 involved_in ISO (PMID:2649896) RGD PMID:2649896 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Edn2 endothelin 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:2649896)		 Ensembl
RGD		 PMID:2649896 GO_REF:0000107 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814 		JBrowse link
G Edn3 endothelin 3 involved_in ISO (PMID:2649896) RGD PMID:2649896 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093 		JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in ISO (PMID:25557619) RGD PMID:25557619 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO MGI:3574394 (PMID:15297376) RGD PMID:15297376 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Hrc histidine rich calcium binding protein involved_in ISO UniProtKB:B9EIW1 (PMID:24125847) RGD PMID:24125847 NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO
IEA		 (PMID:19646991)
GO_REF:0000107		 RGD
Ensembl		 PMID:19646991 GO_REF:0000107 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Nmu neuromedin U involved_in IDA PMID:11853869 UniProt PMID:11853869 RGD:13461753 NCBI chr14:31,844,564...31,872,196
Ensembl chr14:31,844,728...31,872,192 		JBrowse link
G Nppa natriuretic peptide A involved_in ISO
IEA		 (PMID:19646991)
GO_REF:0000107		 RGD
Ensembl		 PMID:19646991 GO_REF:0000107 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Pde4d phosphodiesterase 4D involved_in IMP PMID:19801680 BHF-UCL PMID:19801680 RGD:7327160 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 IMP RGD PMID:22569287 RGD:401976380 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 IMP RGD PMID:25844489 RGD:13524517 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Ryr2 ryanodine receptor 2 acts_upstream_of_or_within ISO MGI:2183509|MGI:3713774 (PMID:12089338), (PMID:17431507) RGD PMID:12089338 PMID:17431507 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:19796257) RGD PMID:19796257 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 IMP RGD PMID:17259145 RGD:6484226 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Sirt1 sirtuin 1 IMP RGD PMID:22113495 RGD:7240568 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 involved_in ISO (PMID:23361868) RGD PMID:23361868 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Tacr3 tachykinin receptor 3 IDA RGD PMID:2471579 RGD:2305984 NCBI chr 2:223,266,536...223,363,791
Ensembl chr 2:223,266,536...223,363,791 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IMP RGD PMID:23954346 RGD:10003031 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
G Uts2 urotensin 2 IDA RGD PMID:18597948 PMID:12217424 RGD:2306810, RGD:2306871 NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237 		JBrowse link
positive regulation of heart rate by epinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tpm1 tropomyosin 1 involved_in ISO (PMID:17556658) RGD PMID:17556658 NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802 		JBrowse link
positive regulation of heart rate by epinephrine-norepinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:104774 (PMID:12782680)		 Ensembl
RGD		 PMID:12782680 GO_REF:0000107 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B acts_upstream_of_or_within ISO MGI:104773 (PMID:12782680) RGD PMID:12782680 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adrb1 adrenoceptor beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857120 (PMID:10358009), (PMID:8693001)		 Ensembl
RGD		 PMID:8693001 PMID:10358009 GO_REF:0000107 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1888407 (PMID:10942027)		 Ensembl
RGD		 PMID:10942027 GO_REF:0000107 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
regulation of heart rate by cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme involved_in IEA
ISO		 GO_REF:0000107
(PMID:25017399)		 Ensembl
RGD		 PMID:25017399 GO_REF:0000107 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Akap9 A-kinase anchoring protein 9 involved_in ISO (PMID:18093912) RGD PMID:18093912 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606 		JBrowse link
G Ank2 ankyrin 2 involved_in ISO (PMID:12571597), (PMID:15178757), (PMID:17242276), (PMID:21859974)
(PMID:11781319), (PMID:12571597), (PMID:15178757)		 RGD PMID:11781319 PMID:12571597 PMID:15178757 PMID:17242276 PMID:21859974 NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923 		JBrowse link
G Bin1 bridging integrator 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:24836577)		 Ensembl
RGD		 PMID:24836577 GO_REF:0000107 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISO
ISS		 (PMID:15454078), (PMID:15863612), (PMID:17224476), (PMID:26253506)
GO_REF:0000024		 RGD
BHF-UCL		 PMID:15454078 PMID:15863612 PMID:17224476 PMID:26253506 GO_REF:0000024 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:21131953)
GO_REF:0000107
MGI:2180141 (PMID:12700358)		 RGD
Ensembl		 PMID:12700358 PMID:21131953 GO_REF:0000107 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in ISS GO_REF:0000024 BHF-UCL GO_REF:0000024 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in ISO
IEA		 (PMID:25527503)
GO_REF:0000107		 RGD
Ensembl		 PMID:25527503 GO_REF:0000107 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in ISO
ISS
IEA		 (PMID:17224476)
GO_REF:0000024
GO_REF:0000107		 RGD
BHF-UCL
Ensembl		 PMID:17224476 GO_REF:0000024 GO_REF:0000107 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106 		JBrowse link
G Cav1 caveolin 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:25017399)		 Ensembl
RGD		 PMID:25017399 GO_REF:0000107 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ctnna3 catenin alpha 3 involved_in ISO (PMID:23136403) RGD PMID:23136403 NCBI chr20:23,614,469...25,200,026
Ensembl chr20:23,623,560...25,199,978 		JBrowse link
G Dsc2 desmocollin 2 involved_in ISO (PMID:23863954) RGD PMID:23863954 NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392 		JBrowse link
G Dsg2 desmoglein 2 involved_in ISO (PMID:16505173), (PMID:23381804) RGD PMID:16505173 PMID:23381804 NCBI chr18:11,846,207...11,904,630
Ensembl chr18:11,846,183...11,904,156 		JBrowse link
G Dsp desmoplakin involved_in ISO (PMID:12373648) RGD PMID:12373648 NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800 		JBrowse link
G Gja5 gap junction protein, alpha 5 acts_upstream_of_or_within ISO MGI:2445466 (PMID:11046183) RGD PMID:11046183 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 involved_in ISO
IEA		 (PMID:12750403)
GO_REF:0000107		 RGD
Ensembl		 PMID:12750403 GO_REF:0000107 NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639 		JBrowse link
G Isl1 ISL LIM homeobox 1 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
(PMID:26193633)		 Ensembl
RGD		 PMID:26193633 GO_REF:0000107 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584 		JBrowse link
G Jup junction plakoglobin involved_in ISO
IEA		 (PMID:17924338)
GO_REF:0000107		 RGD
Ensembl		 PMID:17924338 GO_REF:0000107 NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057 		JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 involved_in ISO (PMID:19343045), (PMID:23264583) RGD PMID:19343045 PMID:23264583 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697 		JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 involved_in ISO
IEA		 (PMID:21349352)
GO_REF:0000107		 RGD
Ensembl		 PMID:21349352 GO_REF:0000107 NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345 		JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:10400998)
GO_REF:0000033
MGI:1857442 (PMID:14561835)		 RGD
GO_Central		 PMID:10400998 PMID:14561835 GO_REF:0000033 NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901 		JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 involved_in ISO
IBA		 (PMID:10219239)
GO_REF:0000033		 RGD
GO_Central		 PMID:10219239 GO_REF:0000033 NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043 		JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 involved_in ISO
IBA		 (PMID:22987075)
GO_REF:0000033		 RGD
GO_Central		 PMID:22987075 GO_REF:0000033 NCBI chr 1:154,523,903...154,530,865
Ensembl chr 1:154,523,830...154,532,020 		JBrowse link
G Kcne4 potassium voltage-gated channel subfamily E regulatory subunit 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:80,243,429...80,251,533
Ensembl chr 9:80,247,379...80,250,979 		JBrowse link
G Kcne5 potassium voltage-gated channel subfamily E regulatory subunit 5 involved_in ISO
IBA		 (PMID:18313602), (PMID:21493962)
GO_REF:0000033		 RGD
GO_Central		 PMID:18313602 PMID:21493962 GO_REF:0000033 NCBI chr  X:105,930,398...105,931,013
Ensembl chr  X:105,930,398...105,931,013 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:21536673)
(PMID:7889573)
GO_REF:0000033
(PMID:10843886)		 RGD
GO_Central		 PMID:7889573 PMID:10843886 PMID:21536673 GO_REF:0000033 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnh6 potassium voltage-gated channel subfamily H member 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:90,949,240...90,970,746
Ensembl chr10:90,949,846...90,970,701 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 involved_in ISO (PMID:15761194) RGD PMID:15761194 NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445 		JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 involved_in ISO
IEA		 (PMID:20560207)
GO_REF:0000107		 RGD
Ensembl		 PMID:20560207 GO_REF:0000107 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO
IEA		 (PMID:8528244)
GO_REF:0000107		 RGD
Ensembl		 PMID:8528244 GO_REF:0000107 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Pkp2 plakophilin 2 involved_in ISO (PMID:17980246), (PMID:22889254) RGD PMID:17980246 PMID:22889254 NCBI chr11:84,661,783...84,727,730
Ensembl chr11:84,661,783...84,727,730 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO
IEA
IBA		 (PMID:19808477)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:19808477 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in ISO (PMID:19808477) RGD PMID:19808477 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO
IBA		 (PMID:20042427), (PMID:21051419)
GO_REF:0000033		 RGD
GO_Central		 PMID:20042427 PMID:21051419 GO_REF:0000033 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868 		JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 involved_in ISO (PMID:17592081) RGD PMID:17592081 NCBI chr 8:45,446,580...45,462,294
Ensembl chr 8:45,446,215...45,462,292 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 GO_REF:0000024
(PMID:21895525)
GO_REF:0000107
MGI:2179753 (PMID:11972032), (PMID:15809371), (PMID:15932895), (PMID:16172272)		 BHF-UCL
RGD
Ensembl		 PMID:11972032 PMID:15809371 PMID:15932895 PMID:16172272 PMID:21895525 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO UniProtKB:P49817 (PMID:25017399) RGD PMID:25017399 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 involved_in ISO
IEA		 (PMID:27207958)
GO_REF:0000107		 RGD
Ensembl		 PMID:27207958 GO_REF:0000107 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
regulation of heart rate by chemical signal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ffar3 free fatty acid receptor 3 acts_upstream_of_or_within ISO MGI:5013799 (PMID:21518883) RGD PMID:21518883 NCBI chr 1:86,105,388...86,106,728
Ensembl chr 1:86,104,920...86,106,849 		JBrowse link
G Nos1ap nitric oxide synthase 1 adaptor protein involved_in ISO (PMID:19247217) RGD PMID:19247217 NCBI chr13:82,547,799...82,820,999
Ensembl chr13:82,530,577...82,820,949 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 acts_upstream_of_or_within ISO MGI:2177773 (PMID:18060044) RGD PMID:18060044 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    biological regulation 13819
      regulation of biological quality 3445
        regulation of heart rate 116
          circadian regulation of heart rate + 0
          modulation of heart rate in another organism + 0
          negative regulation of heart rate + 16
          positive regulation of heart rate + 32
          regulation of heart rate by cardiac conduction 38
          regulation of heart rate by chemical signal + 5
Path 2
Term Annotations click to browse term
  biological_process 20536
    multicellular organismal process 8962
      system process 3557
        circulatory system process 626
          blood circulation 597
            heart contraction 256
              regulation of heart contraction 210
                regulation of heart rate 116
                  circadian regulation of heart rate + 0
                  modulation of heart rate in another organism + 0
                  negative regulation of heart rate + 16
                  positive regulation of heart rate + 32
                  regulation of heart rate by cardiac conduction 38
                  regulation of heart rate by chemical signal + 5
paths to the root