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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of systemic arterial blood pressure by circulatory renin-angiotensin
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Accession:GO:0001991 term browser browse the term
Definition:The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.
Synonyms:exact_synonym: circulatory renin-angiotensin blood pressure regulation;   circulatory renin-angiotensin regulation of blood pressure
 related_synonym: circulatory renin-angiotensin control of blood pressure;   control of blood pressure by circulatory renin-angiotensin;   renin-angiotensin blood pressure control


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regulation of systemic arterial blood pressure by circulatory renin-angiotensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within ISO MGI:1857121|MGI:2136636|MGI:2183545 (PMID:10076178), (PMID:11606482), (PMID:12574102), (PMID:7989296), (PMID:9466969), (PMID:9507198), (PMID:9852267) RGD PMID:7989296 PMID:9466969 PMID:9507198 PMID:9852267 PMID:10076178 More... NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a acts_upstream_of_or_within ISO
IEA 		MGI:87965 (PMID:9466969)
GO_REF:0000107 		RGD
Ensembl		 PMID:9466969 GO_REF:0000107 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b acts_upstream_of_or_within ISO MGI:87964 (PMID:9466969) RGD PMID:9466969 NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 involved_in ISO (PMID:7477267) RGD PMID:7477267 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 acts_upstream_of_or_within ISO
IEA 		MGI:3582593 (PMID:16118390)
GO_REF:0000107 		RGD
Ensembl		 PMID:16118390 GO_REF:0000107 NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
angiotensin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:11432860), (PMID:1320019), (PMID:4322742), (PMID:6270633)
(PMID:11303049), (PMID:14757757), (PMID:18158355), (PMID:27649628) 		UniProt
Ensembl
RGD		 PMID:1320019 PMID:4322742 PMID:6270633 PMID:11303049 PMID:11432860 More... GO_REF:0000024 GO_REF:0000107 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 involved_in ISO
IEA 		UniProtKB:Q9BYF1 (PMID:18263657), (PMID:20357030), (PMID:23462816)
GO_REF:0000107 		RGD
Ensembl		 PMID:18263657 PMID:20357030 PMID:23462816 GO_REF:0000107 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Anpep alanyl aminopeptidase, membrane involved_in ISO
IEA 		(PMID:8876246)
GO_REF:0000107 		RGD
Ensembl		 PMID:8876246 GO_REF:0000107 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789 		JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in ISO (PMID:12045255), (PMID:15746149) RGD PMID:12045255 PMID:15746149 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918 		JBrowse link
G Cpa3 carboxypeptidase A3 involved_in ISO (PMID:15173164) RGD PMID:15173164 NCBI chr 2:102,712,483...102,744,219
Ensembl chr 2:102,712,589...102,744,203 		JBrowse link
G Enpep glutamyl aminopeptidase involved_in ISO
IEA 		MGI:2182774 (PMID:16889841), (PMID:19228697)
GO_REF:0000107 		RGD
Ensembl		 PMID:16889841 PMID:19228697 GO_REF:0000107 NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947 		JBrowse link
G Mme membrane metallo-endopeptidase involved_in ISO
IEA 		MGI:1917258|MGI:2137696 (PMID:27649628), (PMID:28559246)
GO_REF:0000107 		RGD
Ensembl		 PMID:27649628 PMID:28559246 GO_REF:0000107 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Prcp prolylcarboxypeptidase involved_in ISO
IEA 		(PMID:27649628)
GO_REF:0000107 		RGD
Ensembl		 PMID:27649628 GO_REF:0000107 NCBI chr 1:156,343,894...156,396,295
Ensembl chr 1:146,930,561...146,984,530 		JBrowse link
G Prep prolyl endopeptidase involved_in ISO
IEA 		(PMID:27649628)
GO_REF:0000107 		RGD
Ensembl		 PMID:27649628 GO_REF:0000107 NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466 		JBrowse link
G Ren renin involved_in
acts_upstream_of_or_within 		IDA
IEA
ISO
IBA 		GO_REF:0000107
(PMID:27649628), (PMID:6337154)
MGI:2136642 (PMID:10617578)
GO_REF:0000033
(PMID:12045255) 		Ensembl
RGD
GO_Central		 PMID:6337154 PMID:10617578 PMID:12045255 PMID:27649628 PMID:21321306 GO_REF:0000033 GO_REF:0000107, RGD:5132599 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
negative regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2r coagulation factor II (thrombin) receptor involved_in IEA
ISS
ISO 		GO_REF:0000107
GO_REF:0000024
(PMID:21859963) 		Ensembl
UniProt
RGD		 PMID:21859963 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:28,604,066...28,620,579
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
positive regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:21859963)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:21859963 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:28,507,003...28,519,954
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Olr59 olfactory receptor 59 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:23401498) 		UniProt
Ensembl
RGD		 PMID:23401498 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:157,193,080...157,211,179 		JBrowse link
regulation of angiotensin levels in blood term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpa3 carboxypeptidase A3 acts_upstream_of_or_within ISO MGI:96940 (PMID:15173164) RGD PMID:15173164 NCBI chr 2:102,712,483...102,744,219
Ensembl chr 2:102,712,589...102,744,203 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 IMP RGD PMID:25715999 RGD:401794570 NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 acts_upstream_of_or_within ISO
IEA 		(PMID:15173164)
GO_REF:0000107 		RGD
Ensembl		 PMID:15173164 GO_REF:0000107 NCBI chr15:3,563,515...3,573,801
Ensembl chr15:3,563,358...3,573,801 		JBrowse link
regulation of renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 acts_upstream_of_or_within ISO
IEA 		MGI:2445238 (PMID:17255527)
GO_REF:0000107 		RGD
Ensembl		 PMID:17255527 GO_REF:0000107 NCBI chr 2:187,291,227...187,310,770
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 IMP RGD PMID:25715999 RGD:401794570 NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within ISO (PMID:11606482) RGD PMID:11606482 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS RGD PMID:10484527 RGD:1357917 NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
renin secretion into blood stream term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a acts_upstream_of_or_within ISO
IEA 		MGI:1857147 (PMID:12167595)
GO_REF:0000107 		RGD
Ensembl		 PMID:12167595 GO_REF:0000107 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Comt catechol-O-methyltransferase acts_upstream_of_or_within ISO MGI:2178542 (PMID:19139376) RGD PMID:19139376 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Ednrb endothelin receptor type B involved_in ISO
IEA 		MGI:3693642 (PMID:16868309)
GO_REF:0000107 		RGD
Ensembl		 PMID:16868309 GO_REF:0000107 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 involved_in ISO (PMID:8901832) RGD PMID:8901832 NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600 		JBrowse link
G Sucnr1 succinate receptor 1 acts_upstream_of_or_within ISO
IEA 		MGI:3528754 (PMID:18535668)
GO_REF:0000107 		RGD
Ensembl		 PMID:18535668 GO_REF:0000107 NCBI chr 2:144,219,066...144,230,568
Ensembl chr 2:144,219,122...144,230,034 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    multicellular organismal process 9031
      system process 3587
        endocrine process 130
          regulation of systemic arterial blood pressure by hormone 53
            regulation of systemic arterial blood pressure by renin-angiotensin 39
              regulation of systemic arterial blood pressure by circulatory renin-angiotensin 26
                regulation of angiotensin levels in blood + 12
                renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure + 12
Path 2
Term Annotations click to browse term
  biological_process 20543
    multicellular organismal process 9031
      system process 3587
        circulatory system process 639
          blood circulation 609
            regulation of blood pressure 243
              regulation of systemic arterial blood pressure 142
                regulation of systemic arterial blood pressure mediated by a chemical signal 64
                  regulation of systemic arterial blood pressure by hormone 53
                    regulation of systemic arterial blood pressure by renin-angiotensin 39
                      regulation of systemic arterial blood pressure by circulatory renin-angiotensin 26
                        regulation of angiotensin levels in blood + 12
                        renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure + 12
paths to the root