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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of T cell mediated cytotoxicity
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Accession:GO:0001916 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
Synonyms:exact_synonym: positive regulation of T cell mediated apoptosis;   positive regulation of T-cell mediated cell death;   positive regulation of T-cell mediated cell killing;   positive regulation of T-lymphocyte mediated cytotoxicity;   up regulation of T cell mediated cytotoxicity;   upregulation of T cell mediated cytotoxicity
 narrow_synonym: activation of T cell mediated cytotoxicity;   stimulation of T cell mediated cytotoxicity
 related_synonym: positive regulation of T-cell mediated cytolysis


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positive regulation of T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07000147.1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G AABR07001348.1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 1:39,668,472...39,670,153 JBrowse link
G AABR07044308.1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr20:1,789,779...1,793,115 JBrowse link
G AABR07044383.1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr20:3,403,777...3,436,874 JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091 		JBrowse link
G B2m beta-2 microglobulin acts_upstream_of_or_within ISO (PMID:16299293) RGD PMID:16299293 NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Cd1d1 CD1d1 molecule involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
(PMID:10201995) 		GO_Central
RGD		 PMID:10201995 GO_REF:0000033 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Cyrib CYFIP related Rac1 interactor B involved_in ISO
IEA 		(PMID:22522492)
GO_REF:0000107 		RGD
Ensembl		 PMID:22522492 GO_REF:0000107 NCBI chr 7:95,633,876...95,760,588
Ensembl chr 7:95,633,876...95,697,686 		JBrowse link
G ENSRNOG00000064836 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr20:2,606,621...2,618,153 JBrowse link
G ENSRNOG00000070971 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 1:1,841,026...1,859,446 JBrowse link
G Fadd Fas associated via death domain involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:21876153) 		UniProt
Ensembl
RGD		 PMID:21876153 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G H2-m10.6l histocompatibility 2, M region locus 10.6 like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:1,958,270...1,965,247
Ensembl chr20:1,925,049...1,966,105 		JBrowse link
G H60al histocompatibility 60a like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:1,382,896...1,386,846
Ensembl chr 1:1,588,152...1,590,424 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B IDA prevention of heat shock-induced resistance to CTL-mediated killing RGD PMID:10679071 RGD:1298959 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 IMP RGD PMID:8871636 RGD:10059395 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Il12a interleukin 12A involved_in ISO
IEA 		(PMID:1674604), (PMID:2204066)
GO_REF:0000107 		RGD
Ensembl		 PMID:1674604 PMID:2204066 GO_REF:0000107 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:14688363) RGD PMID:14688363 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO
IEA 		(PMID:14688363)
GO_REF:0000107 		RGD
Ensembl		 PMID:14688363 GO_REF:0000107 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G LOC120093164 retinoic acid early-inducible protein 1-gamma-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:1,807,226...1,812,755
Ensembl chr 1:1,807,644...1,812,755 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:3042190 (PMID:14761980) RGD PMID:14761980 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO (PMID:6233370) RGD PMID:6233370 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Raet1l retinoic acid early transcript 1L involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:1,979,433...1,984,410
Ensembl chr 1:1,979,443...1,984,410 		JBrowse link
G Raet1ll1 retinoic acid early transcript 1L like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:1,397,219...1,437,802
Ensembl chr 1:1,397,230...1,402,656 		JBrowse link
G RT1-A RT1 class I, locus A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G RT1-A-ps RT1 class I, A, pseudogene involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr20:2,630,622...2,634,751 JBrowse link
G RT1-A1 RT1 class Ia, locus A1 IDA RGD PMID:11773898 RGD:2313503 NCBI chr20:4,905,309...4,914,593 JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in
acts_upstream_of_or_within 		ISO
IBA 		(PMID:20195504), (PMID:25631937)
GO_REF:0000033
(PMID:1538753) 		RGD
GO_Central		 PMID:1538753 PMID:20195504 PMID:25631937 GO_REF:0000033 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-CE1 RT1 class I, locus 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:3,555,779...3,559,487
Ensembl chr20:3,555,782...3,559,486 		JBrowse link
G RT1-CE10 RT1 class I, locus CE10 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:3,377,284...3,380,301 JBrowse link
G RT1-CE11 RT1 class I, locus CE11 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:3,355,393...3,358,520
Ensembl chr20:3,350,937...3,380,362 		JBrowse link
G RT1-CE12 RT1 class I, locus CE12 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:3,338,907...3,342,547 JBrowse link
G RT1-CE14 RT1 class I, locus CE14 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:3,296,654...3,300,795
Ensembl chr20:3,297,196...3,305,134 		JBrowse link
G RT1-CE16 RT1 class I, locus CE16 involved_in ISO
IBA 		(PMID:22031944), (PMID:2420472), (PMID:25631937), (PMID:8805302)
GO_REF:0000033 		RGD
GO_Central		 PMID:2420472 PMID:8805302 PMID:22031944 PMID:25631937 GO_REF:0000033 NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563 		JBrowse link
G RT1-CE3 RT1 class I, locus CE3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:3,516,647...3,520,938
Ensembl chr20:2,623,953...2,692,081 		JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:23851683) RGD PMID:23851683 NCBI chr20:3,403,418...3,479,476 JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO
IEA 		(PMID:29884618)
GO_REF:0000107 		RGD
Ensembl		 PMID:29884618 GO_REF:0000107 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:29884618) RGD PMID:29884618 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G Rt1-ec3 RT1 class I, locus EC3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr20:3,310,825...3,421,372 JBrowse link
G RT1-M1-2 RT1 class I, locus M1, gene 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:1,909,506...1,913,423
Ensembl chr20:1,910,656...1,917,936 		JBrowse link
G RT1-M1-4 RT1 class I, locus M1, gene 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:1,891,365...1,893,585
Ensembl chr20:1,889,164...1,893,815 		JBrowse link
G RT1-M1-5 RT1 class I, M1, gene 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:1,858,608...1,860,708
Ensembl chr20:1,811,604...1,860,708 		JBrowse link
G RT1-M10-ps1 RT1 class I, locus M10, pseudogene 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:1,986,817...1,988,908
Ensembl chr20:1,986,788...2,020,117 		JBrowse link
G RT1-M10-ps5 RT1 class I, locus M10, pseudogene 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr20:1,768,641...1,772,357 JBrowse link
G RT1-M2 RT1 class Ib, locus M2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:978,918...981,510
Ensembl chr20:978,935...981,723 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 acts_upstream_of_or_within
involved_in 		ISO
IBA 		MGI:3701255 (PMID:16299293), (PMID:16461341), (PMID:16476767), (PMID:8464890)
GO_REF:0000033 		RGD
GO_Central		 PMID:8464890 PMID:16299293 PMID:16461341 PMID:16476767 GO_REF:0000033 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G RT1-M5 RT1 class Ib, locus M5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:1,546,496...1,548,948
Ensembl chr20:1,546,511...1,548,775 		JBrowse link
G RT1-M6-2 RT1 class I, locus M6, gene 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:1,583,267...1,587,099
Ensembl chr20:1,583,299...1,586,215 		JBrowse link
G RT1-N1 RT1 class Ib, locus N1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G RT1-N2 RT1 class Ib, locus N2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:2,641,157...2,645,439
Ensembl chr20:2,641,202...2,644,900 		JBrowse link
G RT1-N3 RT1 class Ib, locus N3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:2,659,132...2,665,536
Ensembl chr20:2,661,584...2,665,530 		JBrowse link
G RT1-O1l1 RT1 class Ib, locus O1 like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:2,624,073...2,658,023
Ensembl chr20:2,623,953...2,692,081 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411 		JBrowse link
G RT1-T24-1 RT1 class I, locus T24, gene 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:2,761,495...2,774,871
Ensembl chr20:2,718,279...2,776,154 		JBrowse link
G RT1-T24-3 RT1 class I, locus T24, gene 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:2,718,210...2,730,604
Ensembl chr20:2,718,279...2,776,154 		JBrowse link
G RT1-T24-4 RT1 class I, locus T24, gene 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:2,684,515...2,747,878
Ensembl chr20:2,684,515...2,692,511
Ensembl chr20:2,684,515...2,692,511 		JBrowse link
G Stx7 syntaxin 7 involved_in ISO
IEA 		(PMID:21438968)
GO_REF:0000107 		RGD
Ensembl		 PMID:21438968 GO_REF:0000107 NCBI chr 1:21,197,075...21,237,320
Ensembl chr 1:21,197,075...21,237,279 		JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member acts_upstream_of_or_within IDA
IEA
ISO 		PMID:1758495
GO_REF:0000107
(PMID:1538753), (PMID:16299293) 		Ensembl
RGD		 PMID:1538753 PMID:16299293 PMID:1758495 GO_REF:0000107, RGD:1299069 NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407 		JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in ISO (PMID:18832695) RGD PMID:18832695 NCBI chr13:77,248,687...77,252,343
Ensembl chr13:77,248,717...77,252,329 		JBrowse link
positive regulation of T cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mr1 major histocompatibility complex, class I-related involved_in ISO
IEA 		(PMID:31959982)
GO_REF:0000107 		RGD
Ensembl		 PMID:31959982 GO_REF:0000107 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970 		JBrowse link
G Slc22a13 solute carrier family 22 member 13 involved_in ISO (PMID:19282870) RGD PMID:19282870 NCBI chr 8:118,922,367...118,934,020
Ensembl chr 8:118,922,367...118,953,635 		JBrowse link
susceptibility to T cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO
IEA 		(PMID:15039383)
GO_REF:0000107 		RGD
Ensembl		 PMID:15039383 GO_REF:0000107 NCBI chr 1:88,500,086...88,535,474
Ensembl chr 1:79,372,119...79,407,360 		JBrowse link
G Pvr PVR cell adhesion molecule involved_in ISO (PMID:15039383) RGD PMID:15039383 NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      cell killing 245
        leukocyte mediated cytotoxicity 188
          positive regulation of leukocyte mediated cytotoxicity 103
            positive regulation of T cell mediated cytotoxicity 62
              positive regulation of T cell mediated cytotoxicity directed against tumor cell target 2
              positive regulation of cytotoxic T cell degranulation 0
              susceptibility to T cell mediated cytotoxicity 2
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        regulation of immune system process 1746
          regulation of immune effector process 484
            regulation of leukocyte mediated immunity 320
              regulation of lymphocyte mediated immunity 248
                regulation of T cell mediated immunity 132
                  regulation of T cell mediated cytotoxicity 71
                    positive regulation of T cell mediated cytotoxicity 62
                      positive regulation of T cell mediated cytotoxicity directed against tumor cell target 2
                      positive regulation of cytotoxic T cell degranulation 0
                      susceptibility to T cell mediated cytotoxicity 2
paths to the root