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ONTOLOGY REPORT - ANNOTATIONS

Term:activation of membrane attack complex
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Accession:GO:0001905 term browser browse the term
Definition:The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.
Synonyms:exact_synonym: MAC assembly;   MAC formation;   activation of MAC;   membrane attack complex assembly;   membrane attack complex formation
 narrow_synonym: activation of TCC;   activation of terminal complement complex;   activation of the terminal complement cascade


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activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H acts_upstream_of_or_within ISO (PMID:20813971) RGD PMID:20813971 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59b CD59b molecule involved_in
acts_upstream_of_or_within		 IDA
IBA
ISO		 GO_REF:0000033
(PMID:10946279), (PMID:11471050)		 GO_Central
RGD		 PMID:10946279 PMID:11471050 PMID:15843577 GO_REF:0000033, RGD:1600482 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G LOC134480016 urinary protein 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Rup2l2 urinary protein 2 like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:35,750,482...35,754,083
Ensembl chr 8:35,750,482...35,754,071 		JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:15611275)		 Ensembl
RGD		 PMID:15611275 GO_REF:0000107 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    immune system process 3130
      immune effector process 844
        complement activation 66
          activation of membrane attack complex 5
            negative regulation of activation of membrane attack complex 3
            positive regulation of activation of membrane attack complex 1
            regulation of activation of membrane attack complex + 4
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        positive regulation of biological process 6766
          positive regulation of response to stimulus 2577
            positive regulation of immune response 833
              activation of immune response 598
                complement activation 66
                  activation of membrane attack complex 5
                    negative regulation of activation of membrane attack complex 3
                    positive regulation of activation of membrane attack complex 1
                    regulation of activation of membrane attack complex + 4
paths to the root