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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation, lectin pathway
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Accession:GO:0001867 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Comment:Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway.
Synonyms:exact_synonym: complement cascade, lectin pathway
 xref: Reactome:R-HSA-166662 "Lectin pathway of complement activation"

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complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Colec10 collectin subfamily member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:27,416,471...27,449,206
Ensembl chrNW_004936470:27,416,494...27,449,206 		JBrowse link
G Colec11 collectin subfamily member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:1,757,288...1,776,053
Ensembl chrNW_004936532:1,749,894...1,776,001 		JBrowse link
G Fcn3 ficolin 3 involved_in ISO (PMID:11907111) UniProt PMID:11907111 NCBI chrNW_004936474:11,680,166...11,685,214 JBrowse link
G Krt1 keratin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936512:10,084,764...10,090,312
Ensembl chrNW_004936512:10,084,763...10,090,414 		JBrowse link
G LOC101963221 mannose-binding protein C-like involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004937400:70,215...73,305 JBrowse link
G LOC101965964 ficolin-1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936669:2,421,092...2,428,240
Ensembl chrNW_004936669:2,421,087...2,431,714 		JBrowse link
G LOC101977501 mannose-binding protein A-like acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936716:89,232...91,728 JBrowse link
G Masp1 MBL associated serine protease 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936578:2,804,460...2,857,731
Ensembl chrNW_004936578:2,804,460...2,869,582 		JBrowse link
G Masp2 MBL associated serine protease 2 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936474:100,584...113,781
Ensembl chrNW_004936474:101,402...114,313 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101959212 alpha-2-macroglobulin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936870:424,832...468,303
Ensembl chrNW_004936870:424,951...468,167 		JBrowse link
G Serping1 serpin family G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:4,911,403...4,924,484
Ensembl chrNW_004936581:4,908,458...4,924,645 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17413
    immune system process 2310
      immune response 1463
        innate immune response 745
          complement activation, lectin pathway 11
            negative regulation of complement activation, lectin pathway 2
            positive regulation of complement activation, lectin pathway 0
            regulation of complement activation, lectin pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 17413
    biological regulation 11396
      regulation of biological process 11032
        positive regulation of biological process 6175
          positive regulation of response to stimulus 2338
            positive regulation of immune response 701
              activation of immune response 515
                complement activation 45
                  complement activation, lectin pathway 11
                    negative regulation of complement activation, lectin pathway 2
                    positive regulation of complement activation, lectin pathway 0
                    regulation of complement activation, lectin pathway + 2
paths to the root