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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation, lectin pathway
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Accession:GO:0001867 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Comment:Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway.
Synonyms:exact_synonym: complement cascade, lectin pathway
 xref: Reactome:R-HSA-166662 "Lectin pathway of complement activation"


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complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COLEC10 collectin subfamily member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:19,692,990...20,143,740
Ensembl chr 4:19,692,830...19,744,135 		JBrowse link
G COLEC11 collectin subfamily member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:131,226,941...131,254,555
Ensembl chr 3:131,226,956...131,254,553 		JBrowse link
G FCN1 ficolin (collagen/fibrinogen domain containing) 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:274,125,666...274,132,917 JBrowse link
G FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) involved_in IEA
IBA 		UniProt
GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr 1:274,106,276...274,111,970
Ensembl chr 1:274,103,877...274,111,970 		JBrowse link
G KRT1 keratin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:18,012,922...18,018,582
Ensembl chr 5:18,012,925...18,018,582 		JBrowse link
G MASP1 MBL associated serine protease 1 involved_in IBA
IEA 		GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr13:124,938,469...125,028,440
Ensembl chr13:124,955,030...125,054,463 		JBrowse link
G MASP2 MBL associated serine protease 2 involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:71,224,637...71,243,041
Ensembl chr 6:71,224,637...71,243,874 		JBrowse link
G MBL1 mannose binding lectin 1 involved_in
acts_upstream_of_or_within 		IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr14:82,080,232...82,085,174
Ensembl chr14:82,010,028...82,085,305 		JBrowse link
G MBL2 mannose binding lectin 2 involved_in
acts_upstream_of_or_within 		IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:62,406,928...62,483,690
Ensembl chr 5:62,440,810...62,483,678 		JBrowse link
G SERPING1 serpin family G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:13,324,160...13,338,826
Ensembl chr 2:13,324,158...13,338,663 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18944
    immune system process 2590
      immune response 1711
        innate immune response 911
          complement activation, lectin pathway 11
            negative regulation of complement activation, lectin pathway 2
            positive regulation of complement activation, lectin pathway 0
            regulation of complement activation, lectin pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 18944
    biological regulation 13005
      regulation of biological process 12624
        positive regulation of biological process 6475
          positive regulation of response to stimulus 2445
            positive regulation of immune response 739
              activation of immune response 540
                complement activation 51
                  complement activation, lectin pathway 11
                    negative regulation of complement activation, lectin pathway 2
                    positive regulation of complement activation, lectin pathway 0
                    regulation of complement activation, lectin pathway + 2
paths to the root